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Aliases for C10orf76 Gene

Aliases for C10orf76 Gene

  • Chromosome 10 Open Reading Frame 76 2 3 5

External Ids for C10orf76 Gene

Previous GeneCards Identifiers for C10orf76 Gene

  • GC10M103270
  • GC10M103595
  • GC10M097236

Summaries for C10orf76 Gene

GeneCards Summary for C10orf76 Gene

C10orf76 (Chromosome 10 Open Reading Frame 76) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf76 Gene

Genomics for C10orf76 Gene

Regulatory Elements for C10orf76 Gene

Promoters for C10orf76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C10orf76 on UCSC Golden Path with GeneCards custom track

Genomic Location for C10orf76 Gene

101,845,599 bp from pter
102,056,232 bp from pter
210,634 bases
Minus strand

Genomic View for C10orf76 Gene

Genes around C10orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf76 Gene

Proteins for C10orf76 Gene

  • Protein details for C10orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0668 protein C10orf76
    Protein Accession:
    Secondary Accessions:
    • Q2TB87
    • Q9H8Z9

    Protein attributes for C10orf76 Gene

    689 amino acids
    Molecular mass:
    78710 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C10orf76 Gene


neXtProt entry for C10orf76 Gene

Proteomics data for C10orf76 Gene at MOPED

Post-translational modifications for C10orf76 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C10orf76 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C10orf76 Gene

Domains & Families for C10orf76 Gene

Protein Domains for C10orf76 Gene


Suggested Antigen Peptide Sequences for C10orf76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0668 family.
  • Belongs to the UPF0668 family.
genes like me logo Genes that share domains with C10orf76: view

No data available for Gene Families for C10orf76 Gene

Function for C10orf76 Gene

genes like me logo Genes that share phenotypes with C10orf76: view

Animal Models for C10orf76 Gene

MGI Knock Outs for C10orf76:

Animal Model Products

CRISPR Products

miRNA for C10orf76 Gene

miRTarBase miRNAs that target C10orf76

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C10orf76 Gene

Localization for C10orf76 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf76 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for C10orf76 Gene COMPARTMENTS Subcellular localization image for C10orf76 gene
Compartment Confidence
plasma membrane 3
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for C10orf76 Gene

Pathways & Interactions for C10orf76 Gene

SuperPathways for C10orf76 Gene

No Data Available

Interacting Proteins for C10orf76 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359050 for C10orf76 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C10orf76 Gene


No data available for Pathways by source and SIGNOR curated interactions for C10orf76 Gene

Drugs & Compounds for C10orf76 Gene

No Compound Related Data Available

Transcripts for C10orf76 Gene

Unigene Clusters for C10orf76 Gene

Chromosome 10 open reading frame 76:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf76 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP3: - -
SP5: - - -

Relevant External Links for C10orf76 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C10orf76 Gene

mRNA expression in normal human tissues for C10orf76 Gene

Protein differential expression in normal tissues from HIPED for C10orf76 Gene

This gene is overexpressed in Cervix (16.5), Peripheral blood mononuclear cells (9.1), and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C10orf76 Gene

SOURCE GeneReport for Unigene cluster for C10orf76 Gene Hs.16004

genes like me logo Genes that share expression patterns with C10orf76: view

Protein tissue co-expression partners for C10orf76 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C10orf76 Gene

Orthologs for C10orf76 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C10orf76 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C26H10orf76 35
  • 95.21 (n)
  • 99.71 (a)
C10orf76 36
  • 100 (a)
(Canis familiaris)
Mammalia C28H10orf76 35
  • 94.82 (n)
  • 99.71 (a)
C10orf76 36
  • 100 (a)
(Mus musculus)
Mammalia 9130011E15Rik 35
  • 91.39 (n)
  • 98.55 (a)
9130011E15Rik 16
9130011E15Rik 36
  • 99 (a)
(Pan troglodytes)
Mammalia C10H10orf76 35
  • 99.9 (n)
  • 100 (a)
C10orf76 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1564887 35
  • 91.39 (n)
  • 98.26 (a)
(Monodelphis domestica)
Mammalia C10orf76 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia C10orf76 36
  • 93 (a)
(Gallus gallus)
Aves C6H10ORF76 35
  • 82.54 (n)
  • 96.37 (a)
C10orf76 36
  • 96 (a)
(Anolis carolinensis)
Reptilia C10orf76 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488528 35
  • 79.25 (n)
  • 91.44 (a)
Str.10588 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32918 35
(Danio rerio)
Actinopterygii zgc63733 35
zgc:63733 35
  • 74.94 (n)
  • 85.05 (a)
C22H10orf76 (1 of 2) 36
  • 85 (a)
C22H10orf76 (2 of 2) 36
  • 82 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012485 35
  • 50.43 (n)
  • 44.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8379 35
  • 55.59 (n)
  • 49.54 (a)
CG8379 36
  • 46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08708 35
  • 42.72 (n)
  • 29.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC20F10.02c 35
  • 38.32 (n)
  • 23.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for C10orf76:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf76 Gene

Gene Tree for C10orf76 (if available)
Gene Tree for C10orf76 (if available)

Paralogs for C10orf76 Gene

No data available for Paralogs for C10orf76 Gene

Variants for C10orf76 Gene

Sequence variations from dbSNP and Humsavar for C10orf76 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1364 -- 102,039,718(-) AAGAA(A/G)GACTT intron-variant
rs727314 -- 101,920,154(-) GGCTG(A/T)GAGCT intron-variant
rs1374473 -- 101,921,004(-) acaac(C/T)cccca intron-variant
rs1374474 -- 101,920,797(-) ATGTT(C/G)CATTG intron-variant
rs2095706 -- 101,997,760(-) AGTTT(A/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf76 Gene

Variant ID Type Subtype PubMed ID
nsv513016 CNV Insertion 21212237
esv1400220 CNV Insertion 17803354
esv270180 CNV Insertion 20981092
esv273373 CNV Insertion 20981092
nsv895968 CNV Loss 21882294
nsv895969 CNV Loss 21882294

Variation tolerance for C10orf76 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf76 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf76 Gene

Disorders for C10orf76 Gene

Relevant External Links for C10orf76

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C10orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf76 Gene

Publications for C10orf76 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski M.K. … Reilly M.P. (BMC Med. Genet. 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for C10orf76 Gene

Sources for C10orf76 Gene

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