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Aliases for RNF128 Gene

Aliases for RNF128 Gene

  • Ring Finger Protein 128, E3 Ubiquitin Protein Ligase 2 3
  • GRAIL 3 4 6
  • Gene Related To Anergy In Lymphocytes Protein 3 4
  • E3 Ubiquitin-Protein Ligase RNF128 3
  • Ring Finger Protein 128 2
  • RING Finger Protein 128 4
  • EC 6.3.2.- 4
  • EC 6.3.2 64

External Ids for RNF128 Gene

Summaries for RNF128 Gene

Entrez Gene Summary for RNF128 Gene

  • The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF128 Gene

RNF128 (Ring Finger Protein 128, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is RNF167.

UniProtKB/Swiss-Prot for RNF128 Gene

  • E3 ubiquitin-protein ligase that catalyzes Lys-48- and Lys-63-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with Lys-48 linkages and COR1A with Lys-63 linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.

Gene Wiki entry for RNF128 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF128 Gene

Genomics for RNF128 Gene

Genomic Location for RNF128 Gene

Start:
106,693,794 bp from pter
End:
106,797,016 bp from pter
Size:
103,223 bases
Orientation:
Plus strand

Genomic View for RNF128 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF128 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF128 Gene

Regulatory Elements for RNF128 Gene

Proteins for RNF128 Gene

  • Protein details for RNF128 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEB7-RN128_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF128
    Protein Accession:
    Q8TEB7
    Secondary Accessions:
    • A0PJI4
    • Q6PH80
    • Q6ZTJ8
    • Q96RF3
    • Q9H5E4

    Protein attributes for RNF128 Gene

    Size:
    428 amino acids
    Molecular mass:
    46521 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15682.1; Type=Frameshift; Positions=291; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF128 Gene

    Alternative splice isoforms for RNF128 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF128 Gene

Proteomics data for RNF128 Gene at MOPED

Post-translational modifications for RNF128 Gene

  • Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn48, Asn59, and Asn101

Other Protein References for RNF128 Gene

Domains for RNF128 Gene

Gene Families for RNF128 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF128 Gene

UniProtKB/Swiss-Prot:

RN128_HUMAN
Domain:
  • Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain:
    • Q8TEB7
  • Contains 1 PA (protease associated) domain.:
    • Q8TEB7
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8TEB7
genes like me logo Genes that share domains with RNF128: view

Function for RNF128 Gene

Molecular function for RNF128 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that catalyzes Lys-48- and Lys-63-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with Lys-48 linkages and COR1A with Lys-63 linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
UniProtKB/Swiss-Prot Induction: Induced under anergic conditions. Up-regulated during T-cell anergy induction following signaling through the T-cell antigen receptor.

Enzyme Numbers (IUBMB) for RNF128 Gene

Gene Ontology (GO) - Molecular Function for RNF128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF128: view
genes like me logo Genes that share phenotypes with RNF128: view

Animal Models for RNF128 Gene

MGI Knock Outs for RNF128:

miRNA for RNF128 Gene

miRTarBase miRNAs that target RNF128

No data available for Transcription Factor Targeting and HOMER Transcription for RNF128 Gene

Localization for RNF128 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF128 Gene

Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF128 Gene COMPARTMENTS Subcellular localization image for RNF128 gene
Compartment Confidence
endoplasmic reticulum 2
endosome 2
extracellular 2
golgi apparatus 2
plasma membrane 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RNF128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005770 late endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005856 cytoskeleton IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF128: view

Pathways for RNF128 Gene

genes like me logo Genes that share pathways with RNF128: view

Pathways by source for RNF128 Gene

UniProtKB/Swiss-Prot Q8TEB7-RN128_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0042036 negative regulation of cytokine biosynthetic process IEA --
genes like me logo Genes that share ontologies with RNF128: view

Compounds for RNF128 Gene

(4) HMDB Compounds for RNF128 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with RNF128: view

Transcripts for RNF128 Gene

mRNA/cDNA for RNF128 Gene

Unigene Clusters for RNF128 Gene

Ring finger protein 128, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF128 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for RNF128 Gene

GeneLoc Exon Structure for
RNF128
ECgene alternative splicing isoforms for
RNF128

Expression for RNF128 Gene

mRNA expression in normal human tissues for RNF128 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF128 Gene

This gene is overexpressed in Liver (9.0) and Adrenal Gland (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF128 Gene

SOURCE GeneReport for Unigene cluster for RNF128 Gene Hs.496542

genes like me logo Genes that share expressions with RNF128: view

Orthologs for RNF128 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF128 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF128 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF128 36
  • 92.29 (n)
  • 94.63 (a)
RNF128 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF128 36
  • 93.38 (n)
  • 96.73 (a)
RNF128 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf128 36
  • 91.51 (n)
  • 95.33 (a)
Rnf128 16
Rnf128 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF128 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF128 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf128 36
  • 90.73 (n)
  • 95.33 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 63 (a)
OneToMany
RNF128 36
  • 71.97 (n)
  • 69.44 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 56 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia rnf128-A 36
zebrafish
(Danio rerio)
Actinopterygii rnf128a 36
  • 59.04 (n)
  • 58.13 (a)
rnf128a 37
  • 53 (a)
ManyToMany
si:dkeyp-86f7.4 37
  • 39 (a)
ManyToMany
wufb57h05 36
worm
(Caenorhabditis elegans)
Secernentea H10E21.5 37
  • 18 (a)
OneToMany
Species with no ortholog for RNF128:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF128 Gene

ENSEMBL:
Gene Tree for RNF128 (if available)
TreeFam:
Gene Tree for RNF128 (if available)

Paralogs for RNF128 Gene

Selected SIMAP similar genes for RNF128 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF128: view

Variants for RNF128 Gene

Sequence variations from dbSNP and Humsavar for RNF128 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1954612 -- 106,752,747(+) cagag(A/G)tatgt intron-variant
rs1991340 -- 106,693,176(-) CCCCA(C/T)GTGTT upstream-variant-2KB
rs2880013 -- 106,773,321(-) ATAAA(A/C)CTTTG intron-variant
rs3037086 -- 106,693,399(-) TCTCT(C/G)TGTGT upstream-variant-2KB
rs3037090 -- 106,693,361(-) tgtgt(-/GT)tTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF128 Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV Gain 17911159
nsv510852 CNV Loss 20534489
esv2667443 CNV Deletion 23128226

Relevant External Links for RNF128 Gene

HapMap Linkage Disequilibrium report
RNF128
Human Gene Mutation Database (HGMD)
RNF128
Locus Specific Mutation Databases (LSDB)
RNF128

Disorders for RNF128 Gene

No disorders were found for RNF128 Gene.

No data available for UniProtKB/Swiss-Prot for RNF128 Gene

Publications for RNF128 Gene

  1. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. (PMID: 12705856) Anandasabapathy N. … Soares L. (Immunity 2003) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes. (PMID: 17114425) Su L. … Fathman C.G. (J. Immunol. 2006) 3

Products for RNF128 Gene

Sources for RNF128 Gene

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