Aliases for RNF128 Gene
External Ids for RNF128 Gene
Previous GeneCards Identifiers for RNF128 Gene
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF128 Gene
RNF128 (Ring Finger Protein 128, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with RNF128 include Hartnup Disorder. Among its related pathways are Deubiquitination and Metabolism of proteins. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF133.
UniProtKB/Swiss-Prot for RNF128 Gene
E3 ubiquitin-protein ligase that catalyzes Lys-48- and Lys-63-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with Lys-48 linkages and COR1A with Lys-63 linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.