Aliases for RNF128 Gene
External Ids for RNF128 Gene
Previous GeneCards Identifiers for RNF128 Gene
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF128 Gene
RNF128 (Ring Finger Protein 128, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with RNF128 include Hartnup Disorder. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF133.
UniProtKB/Swiss-Prot for RNF128 Gene
E3 ubiquitin-protein ligase that catalyzes Lys-48- and Lys-63-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with Lys-48 linkages and COR1A with Lys-63 linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.