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Aliases for PLA2G7 Gene

Aliases for PLA2G7 Gene

  • Phospholipase A2, Group VII (Platelet-Activating Factor Acetylhydrolase, Plasma) 2 3
  • PAFAH 3 4 6
  • 1-Alkyl-2-Acetylglycerophosphocholine Esterase 3 4
  • 2-Acetyl-1-Alkylglycerophosphocholine Esterase 3 4
  • LDL-Associated Phospholipase A2 3 4
  • Group-VIIA Phospholipase A2 3 4
  • PAF 2-Acylhydrolase 3 4
  • PAF Acetylhydrolase 3 4
  • EC 3.1.1.47 4 64
  • LDL-PLA(2) 3 4
  • GVIIA-PLA2 3 4
  • PAFAD 3 6
  • Platelet-Activating Factor Acetylhydrolase 3
  • Lipoprotein-Associated Phospholipase A2 3
  • LDL-PLA2 3
  • EC 3.1.1 64
  • LP-PLA2 3

External Ids for PLA2G7 Gene

Summaries for PLA2G7 Gene

Entrez Gene Summary for PLA2G7 Gene

  • The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]

GeneCards Summary for PLA2G7 Gene

PLA2G7 (Phospholipase A2, Group VII (Platelet-Activating Factor Acetylhydrolase, Plasma)) is a Protein Coding gene. Diseases associated with PLA2G7 include platelet-activating factor acetylhydrolase deficiency and asthma. Among its related pathways are PAK Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PAFAH2.

UniProtKB/Swiss-Prot for PLA2G7 Gene

  • Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids

Tocris Summary for PLA2G7 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G7 Gene

Genomics for PLA2G7 Gene

Genomic Location for PLA2G7 Gene

Start:
46,704,201 bp from pter
End:
46,735,693 bp from pter
Size:
31,493 bases
Orientation:
Minus strand

Genomic View for PLA2G7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G7 Gene

Regulatory Elements for PLA2G7 Gene

Proteins for PLA2G7 Gene

  • Protein details for PLA2G7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13093-PAFA_HUMAN
    Recommended name:
    Platelet-activating factor acetylhydrolase
    Protein Accession:
    Q13093
    Secondary Accessions:
    • A5HTT5
    • Q15692
    • Q5VTT1
    • Q8IVA2

    Protein attributes for PLA2G7 Gene

    Size:
    441 amino acids
    Molecular mass:
    50077 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLA2G7 Gene

neXtProt entry for PLA2G7 Gene

Proteomics data for PLA2G7 Gene at MOPED

Selected DME Specific Peptides for PLA2G7 Gene

Post-translational modifications for PLA2G7 Gene

  • Glycosylation at Asn423 and Asn433

Other Protein References for PLA2G7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PLA2G7 Gene

Gene Families for PLA2G7 Gene

UniProtKB/Swiss-Prot:

PAFA_HUMAN
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.:
    • Q13093
genes like me logo Genes that share domains with PLA2G7: view

Function for PLA2G7 Gene

Molecular function for PLA2G7 Gene

GENATLAS Biochemistry: phospholipase A2,groupVII,platelet activating factor acetylhydrolase plasma,inhibiting the proinflammatory properties of PAH.The mutation V279 is a risk factor for stroke
UniProtKB/Swiss-Prot CatalyticActivity: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate
UniProtKB/Swiss-Prot Function: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids

Enzyme Numbers (IUBMB) for PLA2G7 Gene

Gene Ontology (GO) - Molecular Function for PLA2G7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA --
GO:0005543 phospholipid binding IDA 8624782
GO:0047499 calcium-independent phospholipase A2 activity IDA 8624782
genes like me logo Genes that share ontologies with PLA2G7: view

Phenotypes for PLA2G7 Gene

GenomeRNAi human phenotypes for PLA2G7:
genes like me logo Genes that share phenotypes with PLA2G7: view

miRNA for PLA2G7 Gene

miRTarBase miRNAs that target PLA2G7

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PLA2G7 Gene

Localization for PLA2G7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G7 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G7 Gene COMPARTMENTS Subcellular localization image for PLA2G7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PLA2G7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space --
GO:0005737 cytoplasm IEA --
GO:0034362 low-density lipoprotein particle IDA 8624782
genes like me logo Genes that share ontologies with PLA2G7: view

Pathways for PLA2G7 Gene

genes like me logo Genes that share pathways with PLA2G7: view

Pathways by source for PLA2G7 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for PLA2G7 Gene

Interacting Proteins for PLA2G7 Gene

Gene Ontology (GO) - Biological Process for PLA2G7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016042 lipid catabolic process IEA --
GO:0034374 low-density lipoprotein particle remodeling IDA 8624782
GO:0034440 lipid oxidation IDA 8624782
GO:0034441 plasma lipoprotein particle oxidation IDA 8624782
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PLA2G7: view

Compounds for PLA2G7 Gene

(5) Tocris Compounds for PLA2G7 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
FIPI Phospholipase D inhibitor [939055-18-2]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]

(36) HMDB Compounds for PLA2G7 Gene

Compound Synonyms Cas Number PubMed IDs
Acetic acid
  • Acetate
64-19-7
LysoPC(0:0/18:0)
  • 1-Hydroxy-2-stearoyl-sn-glycero-3-phosphocholine
Not Available
LysoPC(10:0)
  • 1-Decanoyllysolecithin
22248-63-1
LysoPC(14:0)
  • LysoPC(14:0)
Not Available
LysoPC(14:1(9Z))
  • LysoPC(14:1)
Not Available

(1) Drugbank Compounds for PLA2G7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE
target

(57) Novoseek inferred chemical compound relationships for PLA2G7 Gene

Compound -log(P) Hits PubMed IDs
oxpl 84.5 5
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine 77.6 1
lysophosphatidylcholine 72 15
phospholipid 70 16
aebsf 65.4 3
genes like me logo Genes that share compounds with PLA2G7: view

Transcripts for PLA2G7 Gene

Unigene Clusters for PLA2G7 Gene

Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3: -
SP4:

Relevant External Links for PLA2G7 Gene

GeneLoc Exon Structure for
PLA2G7
ECgene alternative splicing isoforms for
PLA2G7

Expression for PLA2G7 Gene

mRNA expression in normal human tissues for PLA2G7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G7 Gene

This gene is overexpressed in Spleen (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLA2G7 Gene

SOURCE GeneReport for Unigene cluster for PLA2G7 Gene Hs.584823

mRNA Expression by UniProt/SwissProt for PLA2G7 Gene

Q13093-PAFA_HUMAN
Tissue specificity: Plasma
genes like me logo Genes that share expressions with PLA2G7: view

Orthologs for PLA2G7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G7 36
  • 99.7 (n)
  • 99.32 (a)
PLA2G7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLA2G7 36
  • 86.62 (n)
  • 82.77 (a)
PLA2G7 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G7 36
  • 86.24 (n)
  • 81.18 (a)
PLA2G7 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g7 36
  • 75.38 (n)
  • 67.5 (a)
Pla2g7 16
Pla2g7 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA2G7 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G7 37
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g7 36
  • 74.64 (n)
  • 68.79 (a)
chicken
(Gallus gallus)
Aves PLA2G7 36
  • 63.77 (n)
  • 58.82 (a)
PLA2G7 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G7 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g7 36
  • 61.53 (n)
  • 56.49 (a)
zebrafish
(Danio rerio)
Actinopterygii pla2g7 36
  • 62.81 (n)
  • 57.8 (a)
pla2g7 37
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea paf-1 37
  • 29 (a)
ManyToMany
paf-2 37
  • 31 (a)
ManyToMany
paf-1 38
  • 33 (a)
paf-2 38
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for PLA2G7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G7 Gene

ENSEMBL:
Gene Tree for PLA2G7 (if available)
TreeFam:
Gene Tree for PLA2G7 (if available)

Paralogs for PLA2G7 Gene

Paralogs for PLA2G7 Gene

Selected SIMAP similar genes for PLA2G7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2G7: view

Variants for PLA2G7 Gene

Sequence variations from dbSNP and Humsavar for PLA2G7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs918300 -- 46,734,611(+) AGGTC(A/G)GGAGA intron-variant
rs962105 -- 46,732,002(+) tctct(C/T)tataa intron-variant
rs1051931 other, - 46,705,206(+) TAGCT(A/G)CATTT missense, reference
rs1362931 -- 46,714,342(+) AGGAA(A/C)CCCAA intron-variant
rs1421367 -- 46,728,255(+) ttttg(C/G)ccccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G7 Gene

Variant ID Type Subtype PubMed ID
nsv885868 CNV Gain 21882294
nsv523148 CNV Loss 19592680
esv2732030 CNV Deletion 23290073
nsv885869 CNV Loss 21882294
nsv885870 CNV Loss 21882294
nsv428147 CNV Gain 18775914
dgv1948e1 CNV Complex 17122850
nsv7894 CNV Loss 18304495

Relevant External Links for PLA2G7 Gene

HapMap Linkage Disequilibrium report
PLA2G7
Human Gene Mutation Database (HGMD)
PLA2G7

Disorders for PLA2G7 Gene

(3) OMIM Diseases for PLA2G7 Gene (601690)

UniProtKB/Swiss-Prot

PAFA_HUMAN
  • Platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:614278]: An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms. {ECO:0000269 PubMed:8675689, ECO:0000269 PubMed:9245731, ECO:0000269 PubMed:9412624, ECO:0000269 PubMed:9472966, ECO:0000269 PubMed:9759612}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:10733466}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Atopic hypersensitivity (ATOPY) [MIM:147050]: A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(67) Novoseek inferred disease relationships for PLA2G7 Gene

Disease -log(P) Hits PubMed IDs
lissencephaly sequence, isolated 77.7 2
atherosclerosis 65.3 39
cerebral thrombosis 55.6 2
inflammation 54.2 40
enterocolitis necrotizing 46.6 2

Relevant External Links for PLA2G7

Genetic Association Database (GAD)
PLA2G7
Human Genome Epidemiology (HuGE) Navigator
PLA2G7
genes like me logo Genes that share disorders with PLA2G7: view

Publications for PLA2G7 Gene

  1. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. (PMID: 7700381) Tjoelker L.W. … Gray P.W. (Nature 1995) 2 3 4 23
  2. Purification, properties, sequencing, and cloning of a lipoprotein- associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins. (PMID: 8624782) Tew D.G. … Macphee C.H. (Arterioscler. Thromb. Vasc. Biol. 1996) 2 3 4 23
  3. A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension. (PMID: 9759612) Yoshida H. … Satoh K. (Thromb. Haemost. 1998) 3 4 23
  4. The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. (PMID: 10733466) Kruse S. … Deichmann K.A. (Am. J. Hum. Genet. 2000) 3 4 23
  5. Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men. (PMID: 9472966) Yamada Y. … Yokota M. (Metabolism 1998) 3 4 23

Products for PLA2G7 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PLA2G7
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G7
    • Block miRNA regulation of PLA2G7 using miScript Target Protectors

    Sources for PLA2G7 Gene

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