Aliases for PLA2G7 Gene
- Phospholipase A2 Group VII 2 3 5
- Phospholipase A2, Group VII (Platelet-Activating Factor Acetylhydrolase, Plasma) 2 3
- 1-Alkyl-2-Acetylglycerophosphocholine Esterase 3 4
- 2-Acetyl-1-Alkylglycerophosphocholine Esterase 3 4
- LDL-Associated Phospholipase A2 3 4
- Group-VIIA Phospholipase A2 3 4
- PAF 2-Acylhydrolase 3 4
- PAF Acetylhydrolase 3 4
- EC 188.8.131.52 4 63
External Ids for PLA2G7 Gene
Previous GeneCards Identifiers for PLA2G7 Gene
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
GeneCards Summary for PLA2G7 Gene
PLA2G7 (Phospholipase A2 Group VII) is a Protein Coding gene. Diseases associated with PLA2G7 include platelet-activating factor acetylhydrolase deficiency and atopy. Among its related pathways are Acyl chain remodelling of PC and Metabolism. GO annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PAFAH2.
UniProtKB/Swiss-Prot for PLA2G7 Gene
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.