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Aliases for NOX5 Gene

Aliases for NOX5 Gene

  • NADPH Oxidase 5 2 3 5
  • NADPH Oxidase, EF-Hand Calcium Binding Domain 5 2
  • EC 1.6.3.- 4

External Ids for NOX5 Gene

Previous GeneCards Identifiers for NOX5 Gene

  • GC15P065065
  • GC15P062322
  • GC15P066801
  • GC15P066939
  • GC15P066940
  • GC15P067009
  • GC15P069222
  • GC15P046055

Summaries for NOX5 Gene

Entrez Gene Summary for NOX5 Gene

  • This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NOX5 Gene

NOX5 (NADPH Oxidase 5) is a Protein Coding gene. Among its related pathways are Cellular Senescence and PAK Pathway. GO annotations related to this gene include calcium ion binding and heme binding. An important paralog of this gene is DUOX1.

UniProtKB/Swiss-Prot for NOX5 Gene

  • Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.

Gene Wiki entry for NOX5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOX5 Gene

Genomics for NOX5 Gene

Regulatory Elements for NOX5 Gene

Enhancers for NOX5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G069758 2 FANTOM5 Ensembl ENCODE dbSUPER 11 +829.5 829539 3.8 HDGF CREB3L1 SIN3A YBX1 FEZF1 ZNF766 CBX5 ZNF416 FOS DEK TLE3 LOC145694 NOX5 GC15P069737 GC15P069802
GH15G069087 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11 +160.5 160465 6.0 HDGF ATF1 PKNOX1 ZNF133 GLI4 YBX1 ZNF2 ZBTB7B GATA2 FOS CORO2B LOC145694 NOX5 CLN6 ENSG00000259222 GC15M069102
GH15G069725 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 +796.0 796035 1.9 CTCF HDGF KLF1 ZNF473 BMI1 ZNF121 GATA3 ZNF776 ZNF571 ZNF621 TLE3 LOC145694 NOX5 GC15P069737 GC15M069642
GH15G068275 1.7 Ensembl ENCODE dbSUPER 9.9 -651.1 -651090 8.8 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 ENSG00000260657 SKOR1 PIAS1 CORO2B IQCH-AS1 NOX5 GC15M068298
GH15G069451 1.7 Ensembl ENCODE dbSUPER 9.9 +522.7 522682 4.1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 NFYC ZFP41 CORO2B NOX5 GC15M069460 RPLP1 ENSG00000207119
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOX5 on UCSC Golden Path with GeneCards custom track

Promoters for NOX5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078568 400 1000 MAZ PKNOX1 ZNF687 RFX1 NRF1 SIN3A MAX MNT ZBTB40 ZNF592

Genomic Location for NOX5 Gene

Chromosome:
15
Start:
68,930,500 bp from pter
End:
69,062,743 bp from pter
Size:
132,244 bases
Orientation:
Plus strand

Genomic View for NOX5 Gene

Genes around NOX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOX5 Gene

Proteins for NOX5 Gene

  • Protein details for NOX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PH1-NOX5_HUMAN
    Recommended name:
    NADPH oxidase 5
    Protein Accession:
    Q96PH1
    Secondary Accessions:
    • B2RBJ4
    • Q08AN2
    • Q08AN3
    • Q8TEQ1
    • Q8TER4
    • Q96PH2
    • Q96PJ8
    • Q96PJ9
    • Q9H6E0
    • Q9HAM8

    Protein attributes for NOX5 Gene

    Size:
    765 amino acids
    Molecular mass:
    86439 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG33638.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15319.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB84897.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NOX5 Gene

neXtProt entry for NOX5 Gene

Post-translational modifications for NOX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOX5 Gene

Domains & Families for NOX5 Gene

Gene Families for NOX5 Gene

Suggested Antigen Peptide Sequences for NOX5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PH1

UniProtKB/Swiss-Prot:

NOX5_HUMAN :
  • Isoform v1 and isoform v2 of this protein have four functional EF-hand calcium-binding domains. Isoform v3 and isoform v4 have the third EF-hand domain interrupted by an insert.
Domain:
  • Isoform v1 and isoform v2 of this protein have four functional EF-hand calcium-binding domains. Isoform v3 and isoform v4 have the third EF-hand domain interrupted by an insert.
genes like me logo Genes that share domains with NOX5: view

Function for NOX5 Gene

Molecular function for NOX5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.06 uM for calcium {ECO:0000269 PubMed:14982937};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by calcium which induces conformational changes and interaction between the N-terminal regulatory region and the C-terminal catalytic region. Inhibited by diphenylene iodonium.
UniProtKB/Swiss-Prot Function:
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.

Enzyme Numbers (IUBMB) for NOX5 Gene

Gene Ontology (GO) - Molecular Function for NOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0015252 hydrogen ion channel activity IDA 11483596
GO:0016175 superoxide-generating NADPH oxidase activity TAS,IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0020037 heme binding NAS 11483596
genes like me logo Genes that share ontologies with NOX5: view
genes like me logo Genes that share phenotypes with NOX5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOX5 Gene

Localization for NOX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOX5 Gene

Membrane; Multi-pass membrane protein.
Isoform v2: Endoplasmic reticulum.
Isoform v5: Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOX5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NOX5: view

Pathways & Interactions for NOX5 Gene

genes like me logo Genes that share pathways with NOX5: view

Pathways by source for NOX5 Gene

SIGNOR curated interactions for NOX5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis NAS 11483596
GO:0001525 angiogenesis IEA --
GO:0001935 endothelial cell proliferation IDA 17275676
GO:0006811 ion transport IEA --
GO:0006915 apoptotic process NAS 11483596
genes like me logo Genes that share ontologies with NOX5: view

Drugs & Compounds for NOX5 Gene

(4) Drugs for NOX5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
heme Pharma Agonist 0
calcium Nutra 0
Magnesium Nutra 0

(2) Additional Compounds for NOX5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with NOX5: view

Transcripts for NOX5 Gene

Unigene Clusters for NOX5 Gene

NADPH oxidase, EF-hand calcium binding domain 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOX5 Gene

No ASD Table

Relevant External Links for NOX5 Gene

GeneLoc Exon Structure for
NOX5
ECgene alternative splicing isoforms for
NOX5

Expression for NOX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOX5 Gene

mRNA differential expression in normal tissues according to GTEx for NOX5 Gene

This gene is overexpressed in Spleen (x14.8) and Testis (x9.1).

Protein differential expression in normal tissues from HIPED for NOX5 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOX5 Gene



Protein tissue co-expression partners for NOX5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOX5 Gene:

NOX5

SOURCE GeneReport for Unigene cluster for NOX5 Gene:

Hs.657932

mRNA Expression by UniProt/SwissProt for NOX5 Gene:

Q96PH1-NOX5_HUMAN
Tissue specificity: Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level).

Evidence on tissue expression from TISSUES for NOX5 Gene

  • Kidney(4.1)
  • Spleen(4)
genes like me logo Genes that share expression patterns with NOX5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOX5 Gene

Orthologs for NOX5 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOX5 34 35
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia NOX5 34 35
  • 86.79 (n)
dog
(Canis familiaris)
Mammalia NOX5 34 35
  • 86.32 (n)
oppossum
(Monodelphis domestica)
Mammalia NOX5 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOX5 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOX5 34 35
  • 69.84 (n)
lizard
(Anolis carolinensis)
Reptilia NOX5 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nox5 34
  • 68.15 (n)
zebrafish
(Danio rerio)
Actinopterygii nox5 34
  • 69.13 (n)
NOX5 35
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008072 34
  • 59.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nox 34 35
  • 56.89 (n)
CG3896 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 12 (a)
ManyToMany
Species where no ortholog for NOX5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOX5 Gene

ENSEMBL:
Gene Tree for NOX5 (if available)
TreeFam:
Gene Tree for NOX5 (if available)

Paralogs for NOX5 Gene

Paralogs for NOX5 Gene

genes like me logo Genes that share paralogs with NOX5: view

Variants for NOX5 Gene

Sequence variations from dbSNP and Humsavar for NOX5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000025783 -- 68,958,160(+) TTCAC(A/G)CATGC intron-variant
rs1000057724 -- 69,018,588(+) GAACC(A/G)TGCTT intron-variant
rs1000107522 -- 68,944,900(+) GGAAA(-/CT)CTGAT intron-variant
rs1000109545 -- 69,018,267(+) GGGAC(C/T)GGGTA intron-variant
rs1000109715 -- 69,009,654(+) CCTCC(A/G)GGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOX5 Gene

Variant ID Type Subtype PubMed ID
esv2669530 CNV deletion 23128226
esv275002 CNV gain+loss 21479260
esv33141 CNV gain 17666407
esv33333 CNV gain 17666407
esv33369 CNV gain 17666407
esv3636816 CNV loss 21293372
esv3636817 CNV loss 21293372
nsv1584 CNV deletion 18451855
nsv521203 CNV loss 19592680
nsv569808 CNV loss 21841781
nsv984088 CNV duplication 23825009

Variation tolerance for NOX5 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.03; 90.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOX5 Gene

Disorders for NOX5 Gene

Relevant External Links for NOX5

Genetic Association Database (GAD)
NOX5
Human Genome Epidemiology (HuGE) Navigator
NOX5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOX5

No disorders were found for NOX5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOX5 Gene

Publications for NOX5 Gene

  1. A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. (PMID: 11483596) Banfi B. … Krause K.-H. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). (PMID: 14982937) Banfi B. … Cox J.A. (J. Biol. Chem. 2004) 3 4 22 64
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  4. NOX5 variants are functionally active in endothelial cells. (PMID: 17275676) BelAiba R.S. … Gorlach A. (Free Radic. Biol. Med. 2007) 3 4 64
  5. NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin. (PMID: 17346712) Tirone F. … Cox J.A. (FEBS Lett. 2007) 3 22 64

Products for NOX5 Gene

Sources for NOX5 Gene

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