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BCL2L14 Gene(Protein Coding)

BCL2 Like 14

GCID:
GC12P012049
GIFtS:
55
Genes Participants
UDN Logo

Aliases for BCL2L14 Gene

Aliases for BCL2L14 Gene

  • BCL2 Like 14 2 3
  • BCL2-Like 14 (Apoptosis Facilitator) 2 3 5
  • Bcl2-L-14 3 4
  • BCLG 3 4
  • Testicular Tissue Protein Li 26 3
  • Apoptosis Regulator BCL-G 3
  • Apoptosis Regulator Bcl-G 4

External Ids for BCL2L14 Gene

Previous GeneCards Identifiers for BCL2L14 Gene

  • GC12P012115
  • GC12P011989
  • GC12P012202

Summaries for BCL2L14 Gene

Entrez Gene Summary for BCL2L14 Gene

  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for BCL2L14 Gene

BCL2L14 (BCL2 Like 14) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for BCL2L14 Gene

  • Plays a role in apoptosis.

Gene Wiki entry for BCL2L14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L14 Gene

Genomics for BCL2L14 Gene

Products:

  1. Regulatory Element

Regulatory Elements for BCL2L14 Gene

Enhancers for BCL2L14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BCL2L14 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BCL2L14 gene promoter:

Genomic Location for BCL2L14 Gene

Chromosome:
12
Start:
12,049,844 bp from pter
End:
12,211,084 bp from pter
Size:
161,241 bases
Orientation:
Plus strand

Genomic View for BCL2L14 Gene

Genes around BCL2L14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L14 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BCL2L14 Gene

Proteins for BCL2L14 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for BCL2L14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZR8-B2L14_HUMAN
    Recommended name:
    Apoptosis facilitator Bcl-2-like protein 14
    Protein Accession:
    Q9BZR8
    Secondary Accessions:
    • A8KAD0
    • Q96QR5
    • Q9BZR7

    Protein attributes for BCL2L14 Gene

    Size:
    327 amino acids
    Molecular mass:
    36598 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL2L14 Gene

Proteomics data for BCL2L14 Gene at MOPED

Protein Expression for BCL2L14 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for BCL2L14 Gene

  • Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL2L14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BCL2L14 Gene

Domains & Families for BCL2L14 Gene

Gene Families for BCL2L14 Gene

HGNC:

Protein Domains for BCL2L14 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCL2L14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZR8

UniProtKB/Swiss-Prot:

B2L14_HUMAN :
  • Belongs to the Bcl-2 family.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L14: view

Function for BCL2L14 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for BCL2L14 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in apoptosis.

Phenotypes for BCL2L14 Gene

GenomeRNAi human phenotypes for BCL2L14:
genes like me logo Genes that share phenotypes with BCL2L14: view

Animal Model Products

CRISPR Products

miRNA for BCL2L14 Gene

miRTarBase miRNAs that target BCL2L14

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L14 Gene

Localization for BCL2L14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L14 Gene

Cytoplasm.
Isoform 1: Cytoplasm, cytosol. Note=Diffusely distributed throughout the cytosol.
Isoform 2: Endomembrane system. Note=Predominantly localized to cytosolic organelles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL2L14 Gene COMPARTMENTS Subcellular localization image for BCL2L14 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA,TAS --
GO:0043229 intracellular organelle IDA 11054413
genes like me logo Genes that share ontologies with BCL2L14: view

Pathways & Interactions for BCL2L14 Gene

genes like me logo Genes that share pathways with BCL2L14: view

Gene Ontology (GO) - Biological Process for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway IDA 11054413
genes like me logo Genes that share ontologies with BCL2L14: view

No data available for SIGNOR curated interactions for BCL2L14 Gene

Drugs & Compounds for BCL2L14 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for BCL2L14 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for BCL2L14 Gene

(10) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BCL2L14 Gene

BCL2-like 14 (apoptosis facilitator):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for BCL2L14 Gene

GeneLoc Exon Structure for
BCL2L14
ECgene alternative splicing isoforms for
BCL2L14

Expression for BCL2L14 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for BCL2L14 Gene

mRNA expression in normal human tissues for BCL2L14 Gene
mRNA expression by BioGPS for BCL2L14 GenemRNA expression by GTEx for BCL2L14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2L14 Gene

This gene is overexpressed in Testis (x19.7), Colon - Transverse (x10.8), Small Intestine - Terminal Ileum (x5.2), and Stomach (x5.0).

Protein differential expression in normal tissues from HIPED for BCL2L14 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BCL2L14 Gene



SOURCE GeneReport for Unigene cluster for BCL2L14 Gene Hs.210343

mRNA Expression by UniProt/SwissProt for BCL2L14 Gene

Q9BZR8-B2L14_HUMAN
Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is testis-specific.
genes like me logo Genes that share expression patterns with BCL2L14: view

Protein tissue co-expression partners for BCL2L14 Gene

Primer Products

Orthologs for BCL2L14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia BCL2L14 35
  • 78.05 (n)
  • 68.63 (a)
BCL2L14 36
  • 61 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia BCL2L14 35
  • 79.14 (n)
  • 69.02 (a)
BCL2L14 36
  • 68 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Bcl2l14 35
  • 77.43 (n)
  • 69.57 (a)
Bcl2l14 16
Bcl2l14 36
  • 68 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia BCL2L14 35
  • 98.88 (n)
  • 97.86 (a)
BCL2L14 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Bcl2l14 35
  • 77.16 (n)
  • 69.44 (a)
chicken
(Gallus gallus)
 Aves BCL2L14 35
  • 50.22 (n)
  • 33.55 (a)
BCL2L14 36
  • 28 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC101732952 35
  • 55.19 (n)
  • 40.16 (a)
zebrafish
(Danio rerio)
 Actinopterygii CABZ01020840.1 36
  • 22 (a)
 OneToOne
Species with no ortholog for BCL2L14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL2L14 Gene

ENSEMBL:
Gene Tree for BCL2L14 (if available)
TreeFam:
Gene Tree for BCL2L14 (if available)

Paralogs for BCL2L14 Gene

(1) SIMAP similar genes for BCL2L14 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with BCL2L14: view

No data available for Paralogs for BCL2L14 Gene

Variants for BCL2L14 Gene

Sequence variations from dbSNP and Humsavar for BCL2L14 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1990699 -- 12,070,329(+) TCTCT(C/G)AGCCT intron-variant, upstream-variant-2KB
rs2016891 -- 12,068,496(+) ctcct(A/G)ggctc intron-variant
rs2058773 -- 12,053,443(+) gagac(A/G)aagtt intron-variant
rs2058774 -- 12,053,454(+) TCACT(A/C/G)TTGTT intron-variant
rs7137432 -- 12,092,454(+) CTGCA(A/G)AGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L14 Gene

Variant ID Type Subtype PubMed ID
esv2676351 CNV Deletion 23128226

Variation tolerance for BCL2L14 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BCL2L14 Gene

Disorders for BCL2L14 Gene

Relevant External Links for BCL2L14

Genetic Association Database (GAD)
BCL2L14
Human Genome Epidemiology (HuGE) Navigator
BCL2L14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL2L14

No disorders were found for BCL2L14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L14 Gene

Publications for BCL2L14 Gene

  1. Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. (PMID: 11054413) Guo B. … Reed J.C. (J. Biol. Chem. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia. (PMID: 23077088) Al-Shehhi H. … Moorman A.V. (Genes Chromosomes Cancer 2013) 3
  4. Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers. (PMID: 22573796) Spitz M.R. … Amos C.I. (Cancer Epidemiol. Biomarkers Prev. 2012) 3
  5. Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G. (PMID: 21550398) Pickard M.R. … Williams G.T. (Biochim. Biophys. Acta 2011) 3

Products for BCL2L14 Gene

Sources for BCL2L14 Gene

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