Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC39A7 Gene

Aliases for SLC39A7 Gene

  • Solute Carrier Family 39 Member 7 2 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 7 2 3 5
  • HLA Class II Region Expressed Gene KE4 2 3
  • Really Interesting New Gene 5 Protein 3 4
  • Histidine-Rich Membrane Protein Ke4 3 4
  • Zrt-, Irt-Like Protein 7 3 4
  • RING5 3 4
  • HKE4 3 4
  • ZIP7 3 4
  • Ke4 Gene, Mouse, Human Homolog Of 3
  • D6S2244E 3
  • D6S115E 3
  • H2-KE4 3
  • KE4 3

External Ids for SLC39A7 Gene

Previous HGNC Symbols for SLC39A7 Gene

  • HKE4

Previous GeneCards Identifiers for SLC39A7 Gene

  • GC06P033215
  • GC06P033276
  • GC06P033168
  • GC06P032910

Summaries for SLC39A7 Gene

Entrez Gene Summary for SLC39A7 Gene

  • The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for SLC39A7 Gene

SLC39A7 (Solute Carrier Family 39 Member 7) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A7 Gene

  • Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).

Gene Wiki entry for SLC39A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A7 Gene

Genomics for SLC39A7 Gene

Regulatory Elements for SLC39A7 Gene

Enhancers for SLC39A7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC39A7 on UCSC Golden Path with GeneCards custom track

Promoters for SLC39A7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC39A7 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SLC39A7 gene promoter:

Genomic Location for SLC39A7 Gene

Chromosome:
6
Start:
33,200,445 bp from pter
End:
33,204,439 bp from pter
Size:
3,995 bases
Orientation:
Plus strand

Genomic View for SLC39A7 Gene

Genes around SLC39A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for SLC39A7 Gene

  • Protein details for SLC39A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92504-S39A7_HUMAN
    Recommended name:
    Zinc transporter SLC39A7
    Protein Accession:
    Q92504
    Secondary Accessions:
    • B0UXF6
    • Q5STP8
    • Q9UIQ0

    Protein attributes for SLC39A7 Gene

    Size:
    469 amino acids
    Molecular mass:
    50118 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC39A7 Gene

Proteomics data for SLC39A7 Gene at MOPED

Post-translational modifications for SLC39A7 Gene

  • Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release.
  • Ubiquitination at Lys 310
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC39A7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC39A7 (SLC39A7)

No data available for DME Specific Peptides for SLC39A7 Gene

Domains & Families for SLC39A7 Gene

Gene Families for SLC39A7 Gene

Protein Domains for SLC39A7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC39A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92504

UniProtKB/Swiss-Prot:

S39A7_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
genes like me logo Genes that share domains with SLC39A7: view

Function for SLC39A7 Gene

Molecular function for SLC39A7 Gene

UniProtKB/Swiss-Prot Function:
Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).
UniProtKB/Swiss-Prot Induction:
Down-regulated by Zn(+2).
genes like me logo Genes that share phenotypes with SLC39A7: view

Animal Models for SLC39A7 Gene

MGI Knock Outs for SLC39A7:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A7

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC39A7 Gene

Localization for SLC39A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A7 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A7 Gene COMPARTMENTS Subcellular localization image for SLC39A7 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC39A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,TAS 8812499
genes like me logo Genes that share ontologies with SLC39A7: view

Pathways & Interactions for SLC39A7 Gene

genes like me logo Genes that share pathways with SLC39A7: view

Interacting Proteins for SLC39A7 Gene

Gene Ontology (GO) - Biological Process for SLC39A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
GO:0071577 zinc II ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC39A7: view

No data available for SIGNOR curated interactions for SLC39A7 Gene

Drugs & Compounds for SLC39A7 Gene

(1) Drugs for SLC39A7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC39A7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC39A7: view

Transcripts for SLC39A7 Gene

Unigene Clusters for SLC39A7 Gene

Solute carrier family 39 (zinc transporter), member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: - -

Relevant External Links for SLC39A7 Gene

GeneLoc Exon Structure for
SLC39A7
ECgene alternative splicing isoforms for
SLC39A7

Expression for SLC39A7 Gene

mRNA expression in normal human tissues for SLC39A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC39A7 Gene

This gene is overexpressed in Nasal epithelium (23.7) and Fetal gut (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A7 Gene



SOURCE GeneReport for Unigene cluster for SLC39A7 Gene Hs.631995

mRNA Expression by UniProt/SwissProt for SLC39A7 Gene

Q92504-S39A7_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SLC39A7: view

Protein tissue co-expression partners for SLC39A7 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SLC39A7 Gene

Orthologs for SLC39A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC39A7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC39A7 35
  • 90.41 (n)
  • 93.39 (a)
SLC39A7 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A7 35
  • 90.41 (n)
  • 92.11 (a)
SLC39A7 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a7 35
  • 84.05 (n)
  • 85.26 (a)
Slc39a7 16
Slc39a7 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC39A7 35
  • 98.91 (n)
  • 98.5 (a)
SLC39A7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc39a7 35
  • 83.15 (n)
  • 85.96 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC39A7 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a7 35
  • 64.04 (n)
  • 65.3 (a)
Str.13 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19342 35
zebrafish
(Danio rerio)
Actinopterygii ke4 35
slc39a7 35
  • 63.27 (n)
  • 63.17 (a)
slc39a7 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Catsup 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hke-4.2 35
  • 56.81 (n)
  • 55.79 (a)
hke-4.1 36
  • 46 (a)
OneToMany
hke-4.2 36
  • 47 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL096W 35
  • 46.85 (n)
  • 41.22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17886g 35
  • 42.79 (n)
  • 33.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE4 35
  • 44.4 (n)
  • 36.82 (a)
YKE4 36
  • 30 (a)
OneToMany
YKE4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons IAR1 35
  • 47.23 (n)
  • 43 (a)
rice
(Oryza sativa)
Liliopsida Os08g0467400 35
  • 50.53 (n)
  • 44.27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3262 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06380 35
  • 49.21 (n)
  • 43.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAP8A3.03 35
  • 44.49 (n)
  • 36.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
Species with no ortholog for SLC39A7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A7 Gene

ENSEMBL:
Gene Tree for SLC39A7 (if available)
TreeFam:
Gene Tree for SLC39A7 (if available)

Paralogs for SLC39A7 Gene

genes like me logo Genes that share paralogs with SLC39A7: view

Variants for SLC39A7 Gene

Sequence variations from dbSNP and Humsavar for SLC39A7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_050034 -
VAR_050035 -
VAR_050036 -

Structural Variations from Database of Genomic Variants (DGV) for SLC39A7 Gene

Variant ID Type Subtype PubMed ID
nsv885768 CNV Loss 21882294
nsv830634 CNV Loss 17160897
nsv522719 CNV Loss 19592680

Variation tolerance for SLC39A7 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC39A7 Gene

Disorders for SLC39A7 Gene

Relevant External Links for SLC39A7

Genetic Association Database (GAD)
SLC39A7
Human Genome Epidemiology (HuGE) Navigator
SLC39A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A7

No disorders were found for SLC39A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A7 Gene

Publications for SLC39A7 Gene

  1. The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. (PMID: 15705588) Huang L. … Yu Y.Y. (J. Biol. Chem. 2005) 2 3 4 23 67
  2. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PMID: 8812499) Ando A. … Inoko H. (Genomics 1996) 2 3 23
  3. Colinearity of novel genes in the class II regions of the MHC in mouse and human. (PMID: 1855816) Hanson I.M. … Trowsdale J. (Immunogenetics 1991) 2 3 23
  4. Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. (PMID: 19246244) Hogstrand C. … Taylor K.M. (Trends Mol Med 2009) 2 3
  5. ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in antihormone-resistant breast cancer Cells. (PMID: 18583420) Taylor K.M. … Nicholson R.I. (Endocrinology 2008) 3 23

Products for SLC39A7 Gene

Sources for SLC39A7 Gene

Content