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Aliases for SLC39A7 Gene

Aliases for SLC39A7 Gene

  • Solute Carrier Family 39 (Zinc Transporter), Member 7 2 3
  • HKE4 3 4 6
  • HLA Class II Region Expressed Gene KE4 2 3
  • Really Interesting New Gene 5 Protein 3 4
  • Histidine-Rich Membrane Protein Ke4 3 4
  • Solute Carrier Family 39 Member 7 3 4
  • Zrt-, Irt-Like Protein 7 3 4
  • D6S2244E 3 6
  • RING5 3 4
  • ZIP7 3 4
  • Ke4 Gene, Mouse, Human Homolog Of 3
  • Zinc Transporter SLC39A7 3
  • D6S115E 3
  • H2-KE4 3
  • KE4 3

External Ids for SLC39A7 Gene

Previous Symbols for SLC39A7 Gene

  • HKE4

Summaries for SLC39A7 Gene

Entrez Gene Summary for SLC39A7 Gene

  • The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for SLC39A7 Gene

SLC39A7 (Solute Carrier Family 39 (Zinc Transporter), Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A7 Gene

  • Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).

Gene Wiki entry for SLC39A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A7 Gene

Genomics for SLC39A7 Gene

Genomic Location for SLC39A7 Gene

33,200,445 bp from pter
33,204,439 bp from pter
3,995 bases
Plus strand

Genomic View for SLC39A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC39A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for SLC39A7 Gene

Transcription factor binding sites by QIAGEN in the SLC39A7 gene promoter:

Proteins for SLC39A7 Gene

  • Protein details for SLC39A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter SLC39A7
    Protein Accession:
    Secondary Accessions:
    • B0UXF6
    • Q5STP8
    • Q9UIQ0

    Protein attributes for SLC39A7 Gene

    469 amino acids
    Molecular mass:
    50118 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC39A7 Gene

Proteomics data for SLC39A7 Gene at MOPED

Post-translational modifications for SLC39A7 Gene

  • Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys310

Other Protein References for SLC39A7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC39A7 Gene

Domains for SLC39A7 Gene

Gene Families for SLC39A7 Gene

Protein Domains for SLC39A7 Gene



  • Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.:
    • Q92504
genes like me logo Genes that share domains with SLC39A7: view

Function for SLC39A7 Gene

Molecular function for SLC39A7 Gene

UniProtKB/Swiss-Prot Function: Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).
UniProtKB/Swiss-Prot Induction: Down-regulated by Zn(+2).

Gene Ontology (GO) - Molecular Function for SLC39A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22317921
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A7: view

miRNA for SLC39A7 Gene

miRTarBase miRNAs that target SLC39A7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC39A7 Gene

Localization for SLC39A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A7 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane.

Subcellular locations from

Jensen Localization Image for SLC39A7 Gene COMPARTMENTS Subcellular localization image for SLC39A7 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
cytosol 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC39A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane TAS 8812499
genes like me logo Genes that share ontologies with SLC39A7: view

Pathways for SLC39A7 Gene

genes like me logo Genes that share pathways with SLC39A7: view

Interacting Proteins for SLC39A7 Gene

Gene Ontology (GO) - Biological Process for SLC39A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006829 zinc II ion transport IEA --
GO:0030001 metal ion transport --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC39A7: view

Compounds for SLC39A7 Gene

(2) Novoseek inferred chemical compound relationships for SLC39A7 Gene

Compound -log(P) Hits PubMed IDs
zinc 40 14
steroid 23.5 1
genes like me logo Genes that share compounds with SLC39A7: view

Transcripts for SLC39A7 Gene

Unigene Clusters for SLC39A7 Gene

Solute carrier family 39 (zinc transporter), member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP3: - -

Relevant External Links for SLC39A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC39A7 Gene

mRNA expression in normal human tissues for SLC39A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A7 Gene

SOURCE GeneReport for Unigene cluster for SLC39A7 Gene Hs.631995

mRNA Expression by UniProt/SwissProt for SLC39A7 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SLC39A7: view

Orthologs for SLC39A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC39A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC39A7 36
  • 98.91 (n)
  • 98.5 (a)
SLC39A7 37
  • 99 (a)
(Bos Taurus)
Mammalia SLC39A7 36
  • 90.41 (n)
  • 93.39 (a)
SLC39A7 37
  • 93 (a)
(Canis familiaris)
Mammalia SLC39A7 36
  • 90.41 (n)
  • 92.11 (a)
SLC39A7 37
  • 83 (a)
(Mus musculus)
Mammalia Slc39a7 36
  • 84.05 (n)
  • 85.26 (a)
Slc39a7 16
Slc39a7 37
  • 86 (a)
(Monodelphis domestica)
Mammalia SLC39A7 37
  • 73 (a)
(Rattus norvegicus)
Mammalia Slc39a7 36
  • 83.15 (n)
  • 85.96 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19342 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a7 36
  • 64.04 (n)
  • 65.3 (a)
Str.13 36
(Danio rerio)
Actinopterygii ke4 36
slc39a7 36
  • 63.27 (n)
  • 63.17 (a)
slc39a7 37
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Catsup 37
  • 50 (a)
(Caenorhabditis elegans)
Secernentea hke-4.1 37
  • 46 (a)
hke-4.2 36
  • 56.81 (n)
  • 55.79 (a)
hke-4.2 37
  • 47 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL096W 36
  • 46.85 (n)
  • 41.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE4 36
  • 44.4 (n)
  • 36.82 (a)
YKE4 37
  • 30 (a)
YKE4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17886g 36
  • 42.79 (n)
  • 33.56 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons IAR1 36
  • 47.23 (n)
  • 43 (a)
(Oryza sativa)
Liliopsida Os08g0467400 36
  • 50.53 (n)
  • 44.27 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06380 36
  • 49.21 (n)
  • 43.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAP8A3.03 36
  • 44.49 (n)
  • 36.47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3262 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
Species with no ortholog for SLC39A7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A7 Gene

Gene Tree for SLC39A7 (if available)
Gene Tree for SLC39A7 (if available)

Paralogs for SLC39A7 Gene

genes like me logo Genes that share paralogs with SLC39A7: view

Variants for SLC39A7 Gene

Sequence variations from dbSNP and Humsavar for SLC39A7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_050036 -
VAR_050035 -
VAR_050034 -

Structural Variations from Database of Genomic Variants (DGV) for SLC39A7 Gene

Variant ID Type Subtype PubMed ID
nsv885768 CNV Loss 21882294
nsv830634 CNV Loss 17160897
nsv522719 CNV Loss 19592680

Relevant External Links for SLC39A7 Gene

HapMap Linkage Disequilibrium report

Disorders for SLC39A7 Gene

Relevant External Links for SLC39A7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC39A7: view

No data available for UniProtKB/Swiss-Prot for SLC39A7 Gene

Publications for SLC39A7 Gene

  1. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PMID: 8812499) Ando A. … Inoko H. (Genomics 1996) 2 3 4 23
  2. The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. (PMID: 15705588) Huang L. … Yu Y.Y. (J. Biol. Chem. 2005) 2 3 4 23
  3. Colinearity of novel genes in the class II regions of the MHC in mouse and human. (PMID: 1855816) Hanson I.M. … Trowsdale J. (Immunogenetics 1991) 2 3 23
  4. Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. (PMID: 14525538) Taylor K.M. … Nicholson R.I. (Biochem. J. 2004) 3 4 23
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49

Products for SLC39A7 Gene

Sources for SLC39A7 Gene

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