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Aliases for GPANK1 Gene

Aliases for GPANK1 Gene

  • G-Patch Domain And Ankyrin Repeats 1 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 59 3 4
  • G Patch Domain-Containing Protein 10 3 4
  • HLA-B-Associated Transcript 4 3 4
  • G Patch Domain Containing 10 2 3
  • Protein G5 3 4
  • GPATCH10 3 4
  • ANKRD59 3 4
  • BAT4 3 4
  • G5 3 4
  • G Patch Domain And Ankyrin Repeats-Containing Protein 1 3
  • G Patch Domain And Ankyrin Repeats 1 3
  • HLA-B Associated Transcript 4 2
  • Ankyrin Repeat Domain 59 2
  • Protein BAT4 3
  • D6S54E 3

External Ids for GPANK1 Gene

Previous HGNC Symbols for GPANK1 Gene

  • BAT4

Previous GeneCards Identifiers for GPANK1 Gene

  • GC06M031417
  • GC06M031631
  • GC06M031635
  • GC06M031638
  • GC06M031642
  • GC06M031647
  • GC06M031651
  • GC06M031695
  • GC06M031668
  • GC06M031675

Summaries for GPANK1 Gene

Entrez Gene Summary for GPANK1 Gene

  • This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2010]

GeneCards Summary for GPANK1 Gene

GPANK1 (G-Patch Domain And Ankyrin Repeats 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

Gene Wiki entry for GPANK1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPANK1 Gene

Genomics for GPANK1 Gene

Regulatory Elements for GPANK1 Gene

Enhancers for GPANK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPANK1 on UCSC Golden Path with GeneCards custom track

Promoters for GPANK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPANK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPANK1 Gene

Chromosome:
6
Start:
31,661,229 bp from pter
End:
31,666,283 bp from pter
Size:
5,055 bases
Orientation:
Minus strand

Genomic View for GPANK1 Gene

Genes around GPANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for GPANK1 Gene

  • Protein details for GPANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95872-GPAN1_HUMAN
    Recommended name:
    G patch domain and ankyrin repeat-containing protein 1
    Protein Accession:
    O95872
    Secondary Accessions:
    • A6NG25
    • B0UXA2
    • Q5SQ49

    Protein attributes for GPANK1 Gene

    Size:
    356 amino acids
    Molecular mass:
    39314 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPANK1 Gene

Proteomics data for GPANK1 Gene at MOPED

Post-translational modifications for GPANK1 Gene

  • Ubiquitination at Lys 103 and Lys 261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPANK1 Gene

Domains & Families for GPANK1 Gene

Protein Domains for GPANK1 Gene

Graphical View of Domain Structure for InterPro Entry

O95872

UniProtKB/Swiss-Prot:

GPAN1_HUMAN :
  • Contains 1 G-patch domain.
  • Contains 2 ANK repeats.
Domain:
  • Contains 1 G-patch domain.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with GPANK1: view

Function for GPANK1 Gene

Gene Ontology (GO) - Molecular Function for GPANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with GPANK1: view
genes like me logo Genes that share phenotypes with GPANK1: view

Animal Model Products

CRISPR Products

miRNA for GPANK1 Gene

miRTarBase miRNAs that target GPANK1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPANK1 Gene

Localization for GPANK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPANK1 Gene COMPARTMENTS Subcellular localization image for GPANK1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPANK1 Gene

Pathways & Interactions for GPANK1 Gene

SuperPathways for GPANK1 Gene

No Data Available

Interacting Proteins for GPANK1 Gene

Gene Ontology (GO) - Biological Process for GPANK1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPANK1 Gene

Drugs & Compounds for GPANK1 Gene

No Compound Related Data Available

Transcripts for GPANK1 Gene

Unigene Clusters for GPANK1 Gene

G patch domain and ankyrin repeats 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPANK1 Gene

No ASD Table

Relevant External Links for GPANK1 Gene

GeneLoc Exon Structure for
GPANK1
ECgene alternative splicing isoforms for
GPANK1

Expression for GPANK1 Gene

mRNA expression in normal human tissues for GPANK1 Gene

Protein differential expression in normal tissues from HIPED for GPANK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.7), CD8 Tcells (21.5), and Liver (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPANK1 Gene



SOURCE GeneReport for Unigene cluster for GPANK1 Gene Hs.247478

genes like me logo Genes that share expression patterns with GPANK1: view

Protein tissue co-expression partners for GPANK1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPANK1 Gene

Orthologs for GPANK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPANK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPANK1 35
  • 84.62 (n)
  • 83.48 (a)
BAT4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPANK1 35
  • 85.09 (n)
  • 85.19 (a)
GPANK1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpank1 35
  • 80.6 (n)
  • 80.98 (a)
Gpank1 16
Gpank1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPANK1 35
  • 99.72 (n)
  • 99.16 (a)
GPANK1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpank1 35
  • 81.03 (n)
  • 81.32 (a)
oppossum
(Monodelphis domestica)
Mammalia GPANK1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpank1 35
  • 48.51 (n)
  • 42.26 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:171777 35
  • 49.59 (n)
  • 41.46 (a)
GPANK1 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8152 35
  • 44.93 (n)
  • 34.8 (a)
CG8152 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK1320.7 36
  • 23 (a)
OneToOne
Species with no ortholog for GPANK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPANK1 Gene

ENSEMBL:
Gene Tree for GPANK1 (if available)
TreeFam:
Gene Tree for GPANK1 (if available)

Paralogs for GPANK1 Gene

No data available for Paralogs for GPANK1 Gene

Variants for GPANK1 Gene

Sequence variations from dbSNP and Humsavar for GPANK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_020096 -
VAR_048291 -
VAR_048292 -
VAR_048293 -
VAR_064698 -

Structural Variations from Database of Genomic Variants (DGV) for GPANK1 Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294
nsv462871 CNV Loss 19166990
dgv6581n71 CNV Loss 21882294

Variation tolerance for GPANK1 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPANK1 Gene

Human Gene Mutation Database (HGMD)
GPANK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPANK1 Gene

Disorders for GPANK1 Gene

Relevant External Links for GPANK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPANK1

No disorders were found for GPANK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPANK1 Gene

Publications for GPANK1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. (PMID: 2813433) Spies T. … Strominger J.L. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3
  3. A new cluster of genes within the human major histocompatibility complex. (PMID: 2911734) Spies T. … Strominger J.L. (Science 1989) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Common variants associated with general and MMR vaccine-related febrile seizures. (PMID: 25344690) Feenstra B. … Hviid A. (Nat. Genet. 2014) 3

Products for GPANK1 Gene

Sources for GPANK1 Gene

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