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Aliases for CENPO Gene

Aliases for CENPO Gene

  • Centromere Protein O 2 3
  • Interphase Centromere Complex Protein 36 3 4
  • CENP-O 3 4
  • MCM21R 3 4
  • Centromeric Protein O 3
  • ICEN-36 3
  • ICEN36 4

External Ids for CENPO Gene

Previous GeneCards Identifiers for CENPO Gene

  • GC02P024869
  • GC02P025016

Summaries for CENPO Gene

Entrez Gene Summary for CENPO Gene

  • This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CENPO Gene

CENPO (Centromere Protein O) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CENPO Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.

Gene Wiki entry for CENPO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPO Gene

Genomics for CENPO Gene

Regulatory Elements for CENPO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CENPO Gene

Start:
24,793,136 bp from pter
End:
24,822,376 bp from pter
Size:
29,241 bases
Orientation:
Plus strand

Genomic View for CENPO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPO Gene

Proteins for CENPO Gene

  • Protein details for CENPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU64-CENPO_HUMAN
    Recommended name:
    Centromere protein O
    Protein Accession:
    Q9BU64
    Secondary Accessions:
    • B2RDC0
    • D6W536
    • Q53T55
    • Q96JV3

    Protein attributes for CENPO Gene

    Size:
    300 amino acids
    Molecular mass:
    33786 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.

    Alternative splice isoforms for CENPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPO Gene

Proteomics data for CENPO Gene at MOPED

Post-translational modifications for CENPO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPO Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CENPO Gene

Domains for CENPO Gene

Protein Domains for CENPO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPO: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CENPO Gene

Function for CENPO Gene

Molecular function for CENPO Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.

Gene Ontology (GO) - Molecular Function for CENPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CENPO: view

Phenotypes for CENPO Gene

GenomeRNAi human phenotypes for CENPO:
genes like me logo Genes that share phenotypes with CENPO: view

Animal Model Products

miRNA for CENPO Gene

miRTarBase miRNAs that target CENPO

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPO

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CENPO Gene

Localization for CENPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPO Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPO Gene COMPARTMENTS Subcellular localization image for CENPO gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for CENPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPO: view

Pathways for CENPO Gene

genes like me logo Genes that share pathways with CENPO: view

Pathways by source for CENPO Gene

Gene Ontology (GO) - Biological Process for CENPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0034508 centromere complex assembly --
genes like me logo Genes that share ontologies with CENPO: view

Transcripts for CENPO Gene

Unigene Clusters for CENPO Gene

Centromere protein O:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPO

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPO Gene

No ASD Table

Relevant External Links for CENPO Gene

GeneLoc Exon Structure for
CENPO
ECgene alternative splicing isoforms for
CENPO

Expression for CENPO Gene

mRNA expression in normal human tissues for CENPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPO Gene

SOURCE GeneReport for Unigene cluster for CENPO Gene Hs.731569

genes like me logo Genes that share expressions with CENPO: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for CENPO Gene

Orthologs for CENPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CENPO 35
  • 82.09 (n)
  • 79.73 (a)
CENPO 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPO 35
  • 81.75 (n)
  • 77.21 (a)
CENPO 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpo 35
  • 75.39 (n)
  • 67.45 (a)
Cenpo 16
Cenpo 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CENPO 35
  • 99.56 (n)
  • 99.33 (a)
CENPO 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpo 35
  • 74.94 (n)
  • 65.77 (a)
oppossum
(Monodelphis domestica)
Mammalia CENPO 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPO 36
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPO 35
  • 57.39 (n)
  • 46.52 (a)
CENPO 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPO 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpo 35
  • 51.5 (n)
  • 40.97 (a)
zebrafish
(Danio rerio)
Actinopterygii cenpo 35
  • 46.41 (n)
  • 33.33 (a)
cenpo 36
  • 23 (a)
OneToOne
Species with no ortholog for CENPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPO Gene

ENSEMBL:
Gene Tree for CENPO (if available)
TreeFam:
Gene Tree for CENPO (if available)

Paralogs for CENPO Gene

Pseudogenes.org Pseudogenes for CENPO Gene

genes like me logo Genes that share paralogs with CENPO: view

No data available for Paralogs for CENPO Gene

Variants for CENPO Gene

Sequence variations from dbSNP and Humsavar for CENPO Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4429431 -- 24,817,464(+) TCCAG(A/C)CCAAA intron-variant
rs4419197 -- 24,804,040(+) tagga(C/T)agtta intron-variant
rs4417677 -- 24,801,449(+) gattt(G/T)tatgg intron-variant
rs3037272 -- 24,818,651(+) TTAGT(-/TAGT)TAGAA intron-variant
rs3037271 -- 24,818,483(+) GTTTG(-/TTTG)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPO Gene

Variant ID Type Subtype PubMed ID
nsv508831 CNV Insertion 20534489

Relevant External Links for CENPO Gene

HapMap Linkage Disequilibrium report
CENPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPO Gene

Disorders for CENPO Gene

Relevant External Links for CENPO

Genetic Association Database (GAD)
CENPO
Human Genome Epidemiology (HuGE) Navigator
CENPO

No disorders were found for CENPO Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CENPO Gene

Publications for CENPO Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3 4
  3. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H. … Yoda K. (Genes Cells 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for CENPO Gene

Sources for CENPO Gene

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