Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRRC2A Gene

Aliases for PRRC2A Gene

  • Proline-Rich Coiled-Coil 2A 2 3
  • BAT2 3 4 6
  • Proline-Rich And Coiled-Coil-Containing Protein 2A 3 4
  • Large Proline-Rich Protein BAT2 3 4
  • HLA-B Associated Transcript 2 2 3
  • HLA-B-Associated Transcript 2 3 4
  • Protein G2 3 4
  • D6S51E 3 6
  • G2 3 4
  • Protein PRRC2A 3
  • D6S51 3

External Ids for PRRC2A Gene

Previous Symbols for PRRC2A Gene

  • BAT2

Summaries for PRRC2A Gene

Entrez Gene Summary for PRRC2A Gene

  • A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for PRRC2A Gene

PRRC2A (Proline-Rich Coiled-Coil 2A) is a Protein Coding gene. Diseases associated with PRRC2A include coronary artery aneurysm and rheumatoid arthritis. An important paralog of this gene is PRRC2B.

UniProtKB/Swiss-Prot for PRRC2A Gene

  • May play a role in the regulation of pre-mRNA splicing.

Gene Wiki entry for PRRC2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRC2A Gene

Genomics for PRRC2A Gene

Genomic Location for PRRC2A Gene

Start:
31,620,673 bp from pter
End:
31,637,777 bp from pter
Size:
17,105 bases
Orientation:
Plus strand

Genomic View for PRRC2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRRC2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for Regulatory Elements for PRRC2A Gene

Proteins for PRRC2A Gene

  • Protein details for PRRC2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48634-PRC2A_HUMAN
    Recommended name:
    Protein PRRC2A
    Protein Accession:
    P48634
    Secondary Accessions:
    • B0UX77
    • B0UZE9
    • B0UZL3
    • O95875
    • Q05BK4
    • Q4LE37
    • Q5SQ29
    • Q5SQ30
    • Q5ST84
    • Q5STX6
    • Q5STX7
    • Q68DW9
    • Q6P9P7
    • Q6PIN1
    • Q8MGQ9
    • Q96QC6

    Protein attributes for PRRC2A Gene

    Size:
    2157 amino acids
    Molecular mass:
    228863 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA35585.1; Type=Frameshift; Positions=38, 58; Evidence={ECO:0000305}; Sequence=AAA35586.1; Type=Frameshift; Positions=38, 58; Evidence={ECO:0000305}; Sequence=BAE06116.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA78744.1; Type=Frameshift; Positions=38, 58; Evidence={ECO:0000305};

    Alternative splice isoforms for PRRC2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRRC2A Gene

Proteomics data for PRRC2A Gene at MOPED

Post-translational modifications for PRRC2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRRC2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRRC2A Gene

Domains for PRRC2A Gene

Protein Domains for PRRC2A Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with PRRC2A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRRC2A Gene

Function for PRRC2A Gene

Molecular function for PRRC2A Gene

UniProtKB/Swiss-Prot Function: May play a role in the regulation of pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for PRRC2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PRRC2A: view

Phenotypes for PRRC2A Gene

genes like me logo Genes that share phenotypes with PRRC2A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRRC2A Gene

Localization for PRRC2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRC2A Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for PRRC2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PRRC2A: view

Pathways for PRRC2A Gene

SuperPathways for PRRC2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRRC2A Gene

None

No data available for Pathways by source for PRRC2A Gene

Compounds for PRRC2A Gene

(1) PharmGKB related drug/compound annotations for PRRC2A Gene

Drug/compound Annotation
carbamazepine CA
genes like me logo Genes that share compounds with PRRC2A: view

Transcripts for PRRC2A Gene

mRNA/cDNA for PRRC2A Gene

(16) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRRC2A Gene

Proline-rich coiled-coil 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRRC2A Gene

No ASD Table

Relevant External Links for PRRC2A Gene

GeneLoc Exon Structure for
PRRC2A
ECgene alternative splicing isoforms for
PRRC2A

Expression for PRRC2A Gene

mRNA expression in normal human tissues for PRRC2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRRC2A Gene

SOURCE GeneReport for Unigene cluster for PRRC2A Gene Hs.436093

mRNA Expression by UniProt/SwissProt for PRRC2A Gene

P48634-PRC2A_HUMAN
Tissue specificity: Limited to cell-lines of leukemic origin
genes like me logo Genes that share expressions with PRRC2A: view

Orthologs for PRRC2A Gene

This gene was present in the common ancestor of animals.

Orthologs for PRRC2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRRC2A 36
  • 99.4 (n)
  • 99.12 (a)
PRRC2A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRRC2A 36
  • 90.11 (n)
  • 91.78 (a)
PRRC2A 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRRC2A 36
  • 89.92 (n)
  • 90.52 (a)
PRRC2A 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prrc2a 36
  • 87.88 (n)
  • 89.61 (a)
Prrc2a 16
Prrc2a 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRRC2A 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prrc2a 36
  • 87.53 (n)
  • 89.06 (a)
lizard
(Anolis carolinensis)
Reptilia PRRC2A 37
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia bat2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia prrc2a 36
  • 55.53 (n)
  • 52.21 (a)
zebrafish
(Danio rerio)
Actinopterygii nfkbil1 36
prrc2a 37
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F52G3.1 37
  • 19 (a)
OneToMany
Species with no ortholog for PRRC2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRRC2A Gene

ENSEMBL:
Gene Tree for PRRC2A (if available)
TreeFam:
Gene Tree for PRRC2A (if available)

Paralogs for PRRC2A Gene

Paralogs for PRRC2A Gene

Selected SIMAP similar genes for PRRC2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRRC2A: view

Variants for PRRC2A Gene

Sequence variations from dbSNP and Humsavar for PRRC2A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7889 -- 31,637,671(+) GGGTT(C/G)TGGGG utr-variant-3-prime
rs10885 - 31,636,814(+) CACCT(C/T)CCCTT reference, missense, intron-variant
rs11229 -- 31,635,993(+) TCTCA(A/G)TTACA reference, synonymous-codon
rs13716 -- 31,636,233(+) CCCCC(C/G/T)GGCCC reference, synonymous-codon
rs1046077 -- 31,628,031(+) CCAGC(C/T)CCACC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for PRRC2A Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294
nsv462871 CNV Loss 19166990
dgv6581n71 CNV Loss 21882294
nsv884423 CNV Loss 21882294

Relevant External Links for PRRC2A Gene

HapMap Linkage Disequilibrium report
PRRC2A
Human Gene Mutation Database (HGMD)
PRRC2A

Disorders for PRRC2A Gene

genes like me logo Genes that share disorders with PRRC2A: view

No data available for UniProtKB/Swiss-Prot for PRRC2A Gene

Publications for PRRC2A Gene

  1. A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain. (PMID: 2156268) Banerji J. … Spies T. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 23
  2. Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. (PMID: 8499947) Iris F.J.M. … Cohen D. (Nat. Genet. 1993) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide. (PMID: 15752841) Schneiders A. … Koch N. (Vaccine 2005) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for PRRC2A Gene

Sources for PRRC2A Gene

Back to Top

Content