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Aliases for PRRC2A Gene

Aliases for PRRC2A Gene

  • Proline Rich Coiled-Coil 2A 2 3
  • Proline-Rich Coiled-Coil 2A 2 3 5
  • Proline-Rich And Coiled-Coil-Containing Protein 2A 3 4
  • Large Proline-Rich Protein BAT2 3 4
  • HLA-B Associated Transcript 2 2 3
  • HLA-B-Associated Transcript 2 3 4
  • Protein G2 3 4
  • BAT2 3 4
  • G2 3 4
  • D6S51E 3
  • D6S51 3

External Ids for PRRC2A Gene

Previous HGNC Symbols for PRRC2A Gene

  • BAT2

Previous GeneCards Identifiers for PRRC2A Gene

  • GC06P031374
  • GC06P031592
  • GC06P031594
  • GC06P031600
  • GC06P031719
  • GC06P031761
  • GC06P031685
  • GC06P031752

Summaries for PRRC2A Gene

Entrez Gene Summary for PRRC2A Gene

  • A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for PRRC2A Gene

PRRC2A (Proline Rich Coiled-Coil 2A) is a Protein Coding gene. Diseases associated with PRRC2A include coronary artery aneurysm and spondylolisthesis. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PRRC2B.

UniProtKB/Swiss-Prot for PRRC2A Gene

  • May play a role in the regulation of pre-mRNA splicing.

Gene Wiki entry for PRRC2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRC2A Gene

Genomics for PRRC2A Gene

Regulatory Elements for PRRC2A Gene

Promoters for PRRC2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRRC2A on UCSC Golden Path with GeneCards custom track

Genomic Location for PRRC2A Gene

Chromosome:
6
Start:
31,620,673 bp from pter
End:
31,637,777 bp from pter
Size:
17,105 bases
Orientation:
Plus strand

Genomic View for PRRC2A Gene

Genes around PRRC2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRC2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRC2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PRRC2A Gene

  • Protein details for PRRC2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48634-PRC2A_HUMAN
    Recommended name:
    Protein PRRC2A
    Protein Accession:
    P48634
    Secondary Accessions:
    • B0UX77
    • B0UZE9
    • B0UZL3
    • O95875
    • Q05BK4
    • Q4LE37
    • Q5SQ29
    • Q5SQ30
    • Q5ST84
    • Q5STX6
    • Q5STX7
    • Q68DW9
    • Q6P9P7
    • Q6PIN1
    • Q8MGQ9
    • Q96QC6

    Protein attributes for PRRC2A Gene

    Size:
    2157 amino acids
    Molecular mass:
    228863 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA35585.1; Type=Frameshift; Positions=38, 58; Evidence={ECO:0000305}; Sequence=AAA35586.1; Type=Frameshift; Positions=38, 58; Evidence={ECO:0000305}; Sequence=BAE06116.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA78744.1; Type=Frameshift; Positions=38, 58; Evidence={ECO:0000305};

    Alternative splice isoforms for PRRC2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRRC2A Gene

Proteomics data for PRRC2A Gene at MOPED

Post-translational modifications for PRRC2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRRC2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRRC2A Gene

Domains & Families for PRRC2A Gene

Protein Domains for PRRC2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRRC2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRC2A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRRC2A Gene

Function for PRRC2A Gene

Molecular function for PRRC2A Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of pre-mRNA splicing.
genes like me logo Genes that share phenotypes with PRRC2A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRC2A Gene

Localization for PRRC2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRC2A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRRC2A Gene COMPARTMENTS Subcellular localization image for PRRC2A gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PRRC2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PRRC2A: view

Pathways & Interactions for PRRC2A Gene

SuperPathways for PRRC2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRRC2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRRC2A Gene

Drugs & Compounds for PRRC2A Gene

(1) Drugs for PRRC2A Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbamazepine Approved, Investigational Pharma 118
genes like me logo Genes that share compounds with PRRC2A: view

Transcripts for PRRC2A Gene

mRNA/cDNA for PRRC2A Gene

(16) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRRC2A Gene

Proline-rich coiled-coil 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRRC2A Gene

No ASD Table

Relevant External Links for PRRC2A Gene

GeneLoc Exon Structure for
PRRC2A
ECgene alternative splicing isoforms for
PRRC2A

Expression for PRRC2A Gene

mRNA expression in normal human tissues for PRRC2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRRC2A Gene

This gene is overexpressed in Adrenal (15.3), Bone marrow mesenchymal stem cell (7.6), Urine (6.7), Peripheral blood mononuclear cells (6.6), Cervix (6.4), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRRC2A Gene



SOURCE GeneReport for Unigene cluster for PRRC2A Gene Hs.436093

mRNA Expression by UniProt/SwissProt for PRRC2A Gene

P48634-PRC2A_HUMAN
Tissue specificity: Limited to cell-lines of leukemic origin.
genes like me logo Genes that share expression patterns with PRRC2A: view

Protein tissue co-expression partners for PRRC2A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRRC2A Gene

Orthologs for PRRC2A Gene

This gene was present in the common ancestor of animals.

Orthologs for PRRC2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRRC2A 36
  • 99 (a)
OneToOne
PRRC2A 35
  • 99.4 (n)
  • 99.12 (a)
cow
(Bos Taurus)
Mammalia PRRC2A 35
  • 90.11 (n)
  • 91.78 (a)
PRRC2A 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRRC2A 36
  • 91 (a)
OneToOne
PRRC2A 35
  • 89.92 (n)
  • 90.52 (a)
mouse
(Mus musculus)
Mammalia Prrc2a 36
  • 90 (a)
OneToOne
Prrc2a 16
Prrc2a 35
  • 87.88 (n)
  • 89.61 (a)
oppossum
(Monodelphis domestica)
Mammalia PRRC2A 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prrc2a 35
  • 87.53 (n)
  • 89.06 (a)
lizard
(Anolis carolinensis)
Reptilia PRRC2A 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia bat2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prrc2a 35
  • 55.53 (n)
  • 52.21 (a)
zebrafish
(Danio rerio)
Actinopterygii prrc2a 36
  • 40 (a)
OneToOne
nfkbil1 35
worm
(Caenorhabditis elegans)
Secernentea F52G3.1 36
  • 19 (a)
OneToMany
Species with no ortholog for PRRC2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRRC2A Gene

ENSEMBL:
Gene Tree for PRRC2A (if available)
TreeFam:
Gene Tree for PRRC2A (if available)

Paralogs for PRRC2A Gene

Paralogs for PRRC2A Gene

(1) SIMAP similar genes for PRRC2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRRC2A: view

Variants for PRRC2A Gene

Sequence variations from dbSNP and Humsavar for PRRC2A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1062968 - 31,623,789(-) TATGC(C/G)ACCTC upstream-variant-2KB, reference, missense
rs2280801 - 31,624,287(-) ATTCC(A/G)GCGGC upstream-variant-2KB, reference, missense
rs1046080 - 31,628,105(+) AGAGA(A/C)AGAAC reference, missense
rs2844469 - 31,629,671(-) AGCCT(G/T)TGGAG reference, missense
rs1046081 - 31,629,817(+) CTAGA(C/G/T)TTCTA reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for PRRC2A Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294
nsv462871 CNV Loss 19166990
dgv6581n71 CNV Loss 21882294
nsv884423 CNV Loss 21882294

Variation tolerance for PRRC2A Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.21; 99.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRRC2A Gene

HapMap Linkage Disequilibrium report
PRRC2A
Human Gene Mutation Database (HGMD)
PRRC2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRC2A Gene

Disorders for PRRC2A Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRRC2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
coronary artery aneurysm
  • coronary artery aneurysms
spondylolisthesis
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRRC2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRRC2A
genes like me logo Genes that share disorders with PRRC2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRRC2A Gene

Publications for PRRC2A Gene

  1. A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain. (PMID: 2156268) Banerji J. … Spies T. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 23 67
  2. Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. (PMID: 8499947) Iris F.J.M. … Cohen D. (Nat. Genet. 1993) 2 3
  3. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PRRC2A Gene

Sources for PRRC2A Gene

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