Aliases for DEK Gene
External Ids for DEK Gene
Previous GeneCards Identifiers for DEK Gene
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for DEK Gene
DEK (DEK Proto-Oncogene) is a Protein Coding gene. Diseases associated with DEK include acute myeloid leukemia with t(6;9)(p23;q34) and iridocyclitis. Among its related pathways are Chromatin Regulation / Acetylation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include nucleic acid binding and histone binding.
UniProtKB/Swiss-Prot for DEK Gene
Involved in chromatin organization.