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Aliases for DEK Gene

Aliases for DEK Gene

  • DEK Proto-Oncogene 2 3 5
  • DEK Oncogene (DNA Binding) 2 3
  • DEK Oncogene 2
  • D6S231E 3

External Ids for DEK Gene

Previous GeneCards Identifiers for DEK Gene

  • GC06M018280
  • GC06M018332

Summaries for DEK Gene

Entrez Gene Summary for DEK Gene

  • This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for DEK Gene

DEK (DEK Proto-Oncogene) is a Protein Coding gene. Diseases associated with DEK include Acute Myeloid Leukemia With T(6;9)(P23;Q34) and Iridocyclitis. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include nucleic acid binding and histone binding.

UniProtKB/Swiss-Prot for DEK Gene

  • Involved in chromatin organization.

Gene Wiki entry for DEK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEK Gene

Genomics for DEK Gene

Regulatory Elements for DEK Gene

Enhancers for DEK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DEK on UCSC Golden Path with GeneCards custom track

Promoters for DEK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DEK on UCSC Golden Path with GeneCards custom track

Genomic Location for DEK Gene

Chromosome:
6
Start:
18,223,868 bp from pter
End:
18,264,823 bp from pter
Size:
40,956 bases
Orientation:
Minus strand

Genomic View for DEK Gene

Genes around DEK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEK Gene

Proteins for DEK Gene

  • Protein details for DEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35659-DEK_HUMAN
    Recommended name:
    Protein DEK
    Protein Accession:
    P35659
    Secondary Accessions:
    • B2R6K6
    • B4DN37
    • Q5TGV4
    • Q5TGV5

    Protein attributes for DEK Gene

    Size:
    375 amino acids
    Molecular mass:
    42674 Da
    Quaternary structure:
    • Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.

    Three dimensional structures from OCA and Proteopedia for DEK Gene

    Alternative splice isoforms for DEK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEK Gene

Proteomics data for DEK Gene at MOPED

Post-translational modifications for DEK Gene

  • Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
  • Ubiquitination at Lys 111, Lys 125, Lys 137, Lys 331, and Lys 349
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DEK (DEK)
  • Abcam antibodies for DEK

No data available for DME Specific Peptides for DEK Gene

Domains & Families for DEK Gene

Protein Domains for DEK Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DEK Gene

Graphical View of Domain Structure for InterPro Entry

P35659

UniProtKB/Swiss-Prot:

DEK_HUMAN :
  • Contains 1 SAP domain.
Domain:
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with DEK: view

No data available for Gene Families for DEK Gene

Function for DEK Gene

Molecular function for DEK Gene

GENATLAS Biochemistry:
nuclear protein of unknown function,likely associated to chromatin
UniProtKB/Swiss-Prot Function:
Involved in chromatin organization.
genes like me logo Genes that share phenotypes with DEK: view

Animal Models for DEK Gene

MGI Knock Outs for DEK:

Animal Model Products

miRNA for DEK Gene

miRTarBase miRNAs that target DEK

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DEK Gene

Localization for DEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEK Gene

Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEK Gene COMPARTMENTS Subcellular localization image for DEK gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for DEK Gene

Pathways & Interactions for DEK Gene

genes like me logo Genes that share pathways with DEK: view

SIGNOR curated interactions for DEK Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9050861
GO:0006366 transcription from RNA polymerase II promoter TAS 9050861
GO:0016568 chromatin modification IEA --
GO:0045815 positive regulation of gene expression, epigenetic TAS --
genes like me logo Genes that share ontologies with DEK: view

Drugs & Compounds for DEK Gene

(1) Additional Compounds for DEK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DEK: view

Transcripts for DEK Gene

Unigene Clusters for DEK Gene

DEK oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2:
SP3: - - -

Relevant External Links for DEK Gene

GeneLoc Exon Structure for
DEK
ECgene alternative splicing isoforms for
DEK

Expression for DEK Gene

mRNA expression in normal human tissues for DEK Gene

Protein differential expression in normal tissues from HIPED for DEK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.7) and Tlymphocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DEK Gene



SOURCE GeneReport for Unigene cluster for DEK Gene Hs.484813

mRNA Expression by UniProt/SwissProt for DEK Gene

P35659-DEK_HUMAN
Tissue specificity: Ubiquitous. Expressed at relatively high levels.
genes like me logo Genes that share expression patterns with DEK: view

Protein tissue co-expression partners for DEK Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DEK Gene

Orthologs for DEK Gene

This gene was present in the common ancestor of animals.

Orthologs for DEK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DEK 35
  • 92.27 (n)
  • 94.13 (a)
DEK 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DEK 35
  • 94.05 (n)
  • 97.23 (a)
DEK 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dek 35
  • 86.36 (n)
  • 88.24 (a)
Dek 16
Dek 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DEK 35
  • 98.84 (n)
  • 98.66 (a)
DEK 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dek 35
  • 87.08 (n)
  • 89.84 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DEK 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DEK 35
  • 79.44 (n)
  • 86.6 (a)
DEK 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DEK 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dek 35
  • 66.56 (n)
  • 64.71 (a)
Str.6224 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398543 35
zebrafish
(Danio rerio)
Actinopterygii dek 36
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dek 36
  • 17 (a)
OneToOne
Species with no ortholog for DEK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEK Gene

ENSEMBL:
Gene Tree for DEK (if available)
TreeFam:
Gene Tree for DEK (if available)

Paralogs for DEK Gene

(1) SIMAP similar genes for DEK Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DEK: view

No data available for Paralogs for DEK Gene

Variants for DEK Gene

Sequence variations from dbSNP and Humsavar for DEK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17336208 - 18,256,394(+) ATTGG(A/C/G)CACTT nc-transcript-variant, reference, missense
rs1013062 -- 18,237,430(+) GCTTT(C/T)TTAAC nc-transcript-variant, reference, synonymous-codon
rs1132870 -- 18,255,826(-) AGAGC(A/C/G)TCTGT nc-transcript-variant, reference, missense
rs1207037 -- 18,243,042(-) agatc(A/G)tgcca intron-variant
rs1207038 -- 18,242,942(-) gcact(A/G)tggcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEK Gene

Variant ID Type Subtype PubMed ID
esv271692 CNV Insertion 20981092

Variation tolerance for DEK Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DEK Gene

Disorders for DEK Gene

MalaCards: The human disease database

(4) MalaCards diseases for DEK Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myeloid leukemia with t(6;9)(p23;q34)
  • aml with t(6;9)(p23;q34)
iridocyclitis
  • primary iridocyclitis
juvenile rheumatoid arthritis
  • rheumatoid arthritis, systemic juvenile
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search DEK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DEK_HUMAN
  • Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122). {ECO:0000269 PubMed:1549122}.

Genatlas disease for DEK Gene

myelodysplastic syndrome,refractory anemia with excess of blasts in transformation (MDS/RAEBT),acute myeloid leukemia of poor prognosis (AML),with t(6;9)(p23;q34) translocation

Relevant External Links for DEK

Genetic Association Database (GAD)
DEK
Human Genome Epidemiology (HuGE) Navigator
DEK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEK
genes like me logo Genes that share disorders with DEK: view

Publications for DEK Gene

  1. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (PMID: 1549122) Von Lindern M. … Grosveld G. (Mol. Cell. Biol. 1992) 2 3 4 23 67
  2. A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. (PMID: 20040570) Sawatsubashi S. … Kato S. (Genes Dev. 2010) 3 23
  3. The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells. (PMID: 20215548) Secchiero P. … Zauli G. (Clin. Cancer Res. 2010) 3 23
  4. Control of tumorigenesis and chemoresistance by the DEK oncogene. (PMID: 20501624) Riveiro-Falkenbach E. … Soengas M.S. (Clin. Cancer Res. 2010) 3 23
  5. DEK proto-oncogene expression interferes with the normal epithelial differentiation program. (PMID: 19036808) Wise-Draper T.M. … Wells S.I. (Am. J. Pathol. 2009) 3 23

Products for DEK Gene

Sources for DEK Gene

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