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Aliases for MAPKAP1 Gene

Aliases for MAPKAP1 Gene

  • Mitogen-Activated Protein Kinase Associated Protein 1 2 3
  • MIP1 3 4 6
  • SIN1 3 4 6
  • Mitogen-Activated Protein Kinase 2-Associated Protein 1 3 4
  • Stress-Activated Map Kinase-Interacting Protein 1 3 4
  • Stress-Activated Protein Kinase-Interacting 1 2 3
  • SAPK-Interacting Protein 1 3 4
  • TORC2 Subunit MAPKAP1 3 4
  • JC310 3 6
  • MSIN1 3 4
  • Stress-Activated Map Kinase Interacting Protein 1 3
  • Target Of Rapamycin Complex 2 Subunit MAPKAP1 3
  • MEKK2-Interacting Protein 1 3
  • Ras Inhibitor MGC2745 3
  • SIN1b 3
  • SIN1g 3

External Ids for MAPKAP1 Gene

Previous GeneCards Identifiers for MAPKAP1 Gene

  • GC09M119314
  • GC09M119846
  • GC09M121653
  • GC09M123576
  • GC09M125280
  • GC09M127239
  • GC09M128199
  • GC09M097812

Summaries for MAPKAP1 Gene

Entrez Gene Summary for MAPKAP1 Gene

  • This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPKAP1 Gene

MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1) is a Protein Coding gene. Diseases associated with MAPKAP1 include bronchiolitis obliterans organizing pneumonia and nephrogenic systemic fibrosis. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and phosphatidylinositol-3,4-bisphosphate binding.

UniProtKB/Swiss-Prot for MAPKAP1 Gene

  • Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

Gene Wiki entry for MAPKAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPKAP1 Gene

Genomics for MAPKAP1 Gene

Regulatory Elements for MAPKAP1 Gene

Transcription factor binding sites by QIAGEN in the MAPKAP1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAPKAP1 Gene

Start:
125,437,393 bp from pter
End:
125,707,234 bp from pter
Size:
269,842 bases
Orientation:
Minus strand

Genomic View for MAPKAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPKAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKAP1 Gene

Proteins for MAPKAP1 Gene

  • Protein details for MAPKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPZ7-SIN1_HUMAN
    Recommended name:
    Target of rapamycin complex 2 subunit MAPKAP1
    Protein Accession:
    Q9BPZ7
    Secondary Accessions:
    • A8K1Z5
    • B1AMA4
    • B7Z309
    • Q00426
    • Q5JSV5
    • Q5JSV6
    • Q5JSV9
    • Q658R0
    • Q699U1
    • Q699U2
    • Q699U3
    • Q699U4
    • Q6GVJ0
    • Q6GVJ1
    • Q6GVJ2

    Protein attributes for MAPKAP1 Gene

    Size:
    522 amino acids
    Molecular mass:
    59123 Da
    Quaternary structure:
    • All isoforms except isoform 4 can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2 and SGK1. Isoform 2 interacts with NBN. Isoform 1 interacts with CCDC28B.

    Three dimensional structures from OCA and Proteopedia for MAPKAP1 Gene

    Alternative splice isoforms for MAPKAP1 Gene

neXtProt entry for MAPKAP1 Gene

Proteomics data for MAPKAP1 Gene at MOPED

Post-translational modifications for MAPKAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for MAPKAP1 (Sin1/MAPKAP1)
  • Cell Signaling Technology (CST) Antibodies for MAPKAP1 (Sin1)

No data available for DME Specific Peptides for MAPKAP1 Gene

Domains for MAPKAP1 Gene

Protein Domains for MAPKAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BPZ7

UniProtKB/Swiss-Prot:

SIN1_HUMAN :
  • Q9BPZ7
Family:
  • Belongs to the SIN1 family.
genes like me logo Genes that share domains with MAPKAP1: view

No data available for Gene Families for MAPKAP1 Gene

Function for MAPKAP1 Gene

Molecular function for MAPKAP1 Gene

UniProtKB/Swiss-Prot Function:
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

Gene Ontology (GO) - Molecular Function for MAPKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24365180
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 17303383
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 17303383
GO:0017016 Ras GTPase binding IDA 17303383
GO:0019901 protein kinase binding IPI 21177249
genes like me logo Genes that share ontologies with MAPKAP1: view

Phenotypes for MAPKAP1 Gene

MGI mutant phenotypes for MAPKAP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for MAPKAP1:
genes like me logo Genes that share phenotypes with MAPKAP1: view

Animal Model Products

miRNA for MAPKAP1 Gene

miRTarBase miRNAs that target MAPKAP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPKAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAPKAP1 Gene

Localization for MAPKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAP1 Gene

Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPKAP1 Gene COMPARTMENTS Subcellular localization image for MAPKAP1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for MAPKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA 17303383
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPKAP1: view

Pathways for MAPKAP1 Gene

genes like me logo Genes that share pathways with MAPKAP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAPKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0021762 substantia nigra development IEP 22926577
GO:0031295 T cell costimulation TAS --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MAPKAP1: view

Compounds for MAPKAP1 Gene

(1) HMDB Compounds for MAPKAP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for MAPKAP1 Gene

Compound -log(P) Hits PubMed IDs
sin-1 87.9 16
rantes 62.5 1
genes like me logo Genes that share compounds with MAPKAP1: view

Transcripts for MAPKAP1 Gene

Unigene Clusters for MAPKAP1 Gene

Mitogen-activated protein kinase associated protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPKAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: - -
SP3: - - -
SP4: - - -

Relevant External Links for MAPKAP1 Gene

GeneLoc Exon Structure for
MAPKAP1
ECgene alternative splicing isoforms for
MAPKAP1

Expression for MAPKAP1 Gene

mRNA expression in normal human tissues for MAPKAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MAPKAP1 Gene

This gene is overexpressed in Heart (24.9) and Placenta (11.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPKAP1 Gene

SOURCE GeneReport for Unigene cluster for MAPKAP1 Gene Hs.495138

mRNA Expression by UniProt/SwissProt for MAPKAP1 Gene

Q9BPZ7-SIN1_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle.
genes like me logo Genes that share expressions with MAPKAP1: view

Expression partners for MAPKAP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAPKAP1 Gene

Orthologs for MAPKAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPKAP1 35
  • 95.15 (n)
  • 99.23 (a)
MAPKAP1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPKAP1 35
  • 95.34 (n)
  • 99.04 (a)
MAPKAP1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapkap1 35
  • 92.46 (n)
  • 97.13 (a)
Mapkap1 16
Mapkap1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPKAP1 35
  • 99.68 (n)
  • 100 (a)
MAPKAP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapkap1 35
  • 92.59 (n)
  • 96.93 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPKAP1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPKAP1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPKAP1 35
  • 82.76 (n)
  • 89.85 (a)
MAPKAP1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPKAP1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkap1 35
  • 76.09 (n)
  • 85.19 (a)
Str.16707 35
African clawed frog
(Xenopus laevis)
Amphibia mapkap1-prov 35
zebrafish
(Danio rerio)
Actinopterygii LOC100537196 35
  • 74.81 (n)
  • 82.88 (a)
mapkap1 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008831 35
  • 45.92 (n)
  • 34.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sin1 35
  • 44.78 (n)
  • 34.34 (a)
Sin1 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sinh-1 36
  • 19 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1005 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for MAPKAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPKAP1 Gene

ENSEMBL:
Gene Tree for MAPKAP1 (if available)
TreeFam:
Gene Tree for MAPKAP1 (if available)

Paralogs for MAPKAP1 Gene

No data available for Paralogs for MAPKAP1 Gene

Variants for MAPKAP1 Gene

Sequence variations from dbSNP and Humsavar for MAPKAP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1129 -- 125,437,594(+) ACGCT(C/T)CTGTT utr-variant-3-prime
rs12202 -- 125,438,020(-) AAGGG(C/G)CCACA utr-variant-3-prime
rs471625 -- 125,588,685(+) TGTTT(C/T)ATCTG intron-variant
rs473137 -- 125,528,680(-) tagta(A/G)agatg intron-variant
rs473426 -- 125,644,709(+) TATTG(C/G)AAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPKAP1 Gene

Variant ID Type Subtype PubMed ID
nsv831722 CNV Gain 17160897
nsv515979 CNV Loss 19592680
esv2659060 CNV Deletion 23128226
esv1597155 CNV Insertion 17803354
esv2665863 CNV Deletion 23128226
nsv6714 CNV Insertion 18451855
nsv825077 CNV Gain 20364138
esv2662785 CNV Deletion 23128226
nsv466560 CNV Loss 19166990

Relevant External Links for MAPKAP1 Gene

HapMap Linkage Disequilibrium report
MAPKAP1
Human Gene Mutation Database (HGMD)
MAPKAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAP1 Gene

Disorders for MAPKAP1 Gene

(1) University of Copenhagen DISEASES for MAPKAP1 Gene

(2) Novoseek inferred disease relationships for MAPKAP1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 23.6 1
tumors 0 1

Relevant External Links for MAPKAP1

Genetic Association Database (GAD)
MAPKAP1
Human Genome Epidemiology (HuGE) Navigator
MAPKAP1
genes like me logo Genes that share disorders with MAPKAP1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for MAPKAP1 Gene

Publications for MAPKAP1 Gene

  1. Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene. (PMID: 15363842) Schroder W. … Sculley T. (Gene 2004) 2 3 4 23
  2. Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. (PMID: 15988011) Cheng J. … Su B. (Mol. Cell. Biol. 2005) 3 4 23
  3. Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. (PMID: 17303383) Schroder W.A. … Bushell G. (Cell. Signal. 2007) 3 4 23
  4. The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins. (PMID: 15722200) Schroder W. … Sculley T. (Cell. Signal. 2005) 3 23
  5. A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress. (PMID: 18687895) Ghosh D. … Roberts R.M. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23

Products for MAPKAP1 Gene

Sources for MAPKAP1 Gene

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