Aliases for MAPKAP1 Gene
External Ids for MAPKAP1 Gene
Previous GeneCards Identifiers for MAPKAP1 Gene
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAPKAP1 Gene
MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1) is a Protein Coding gene. Diseases associated with MAPKAP1 include Nephrogenic Systemic Fibrosis and Scleral Disease. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein kinase binding and phosphatidylinositol-3,4,5-trisphosphate binding.
UniProtKB/Swiss-Prot for MAPKAP1 Gene
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.