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Aliases for C9orf16 Gene

Aliases for C9orf16 Gene

  • Chromosome 9 Open Reading Frame 16 2 3 5
  • UPF0184 Protein C9orf16 3
  • EST00098 3

External Ids for C9orf16 Gene

Previous GeneCards Identifiers for C9orf16 Gene

  • GC09P122037
  • GC09P122569
  • GC09P124376
  • GC09P126298
  • GC09P128002
  • GC09P129963
  • GC09P130922
  • GC09P100536

Summaries for C9orf16 Gene

GeneCards Summary for C9orf16 Gene

C9orf16 (Chromosome 9 Open Reading Frame 16) is a Protein Coding gene.

Additional gene information for C9orf16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf16 Gene

Genomics for C9orf16 Gene

Regulatory Elements for C9orf16 Gene

Enhancers for C9orf16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H127962 2 FANTOM5 Ensembl ENCODE dbSUPER 10 -186.1 -186078 22 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 PIP5KL1 NAIF1 DPM2 ENSG00000272593 NUP188 ENSG00000227218 ZNF79 ODF2 GLE1 SLC25A25
GH09H128097 1.6 Ensembl ENCODE dbSUPER 11.3 -58.6 -58552 8 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 NAIF1 PTGES2 CIZ1 ZNF79 PTGES2-AS1 NUP188 SLC25A25-AS1 SLC25A25 LCN2 C9orf16
GH09H128070 1.6 FANTOM5 ENCODE dbSUPER 10.6 -86.6 -86594 4 FOXA2 ATF1 ARID4B YY1 ZNF766 ZNF143 ATF7 RUNX3 SP5 REST ENSG00000227218 DPM2 LCN2 C9orf16 CIZ1 ENSG00000230536 SLC25A25-AS1 SLC25A25 TOR2A SH2D3C
GH09H127951 1.6 Ensembl ENCODE dbSUPER 10.2 -204.9 -204941 5 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 PIP5KL1 ZNF79 NUP188 FAM102A ENSG00000230848 GLE1 LCN2 C9orf16 CIZ1 DPM2
GH09H128077 1.5 Ensembl ENCODE dbSUPER 10.7 -79.2 -79156 5 HDGF PKNOX1 ARNT ARID4B YY1 TCF12 ZNF121 ZNF766 GATA2 FOS ENSG00000230848 SLC25A25-AS1 ENSG00000227218 DPM2 LCN2 C9orf16 CIZ1 ENSG00000230536 NAIF1 GC09P128094
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C9orf16 on UCSC Golden Path with GeneCards custom track

Promoters for C9orf16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241826 875 1401 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 SP3 SP5

Genomic Location for C9orf16 Gene

Chromosome:
9
Start:
128,159,425 bp from pter
End:
128,163,928 bp from pter
Size:
4,504 bases
Orientation:
Plus strand

Genomic View for C9orf16 Gene

Genes around C9orf16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf16 Gene

Proteins for C9orf16 Gene

  • Protein details for C9orf16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUW7-CI016_HUMAN
    Recommended name:
    UPF0184 protein C9orf16
    Protein Accession:
    Q9BUW7
    Secondary Accessions:
    • Q5SYV8
    • Q9Y3F7

    Protein attributes for C9orf16 Gene

    Size:
    83 amino acids
    Molecular mass:
    9054 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C9orf16 Gene

Post-translational modifications for C9orf16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C9orf16 Gene

Domains & Families for C9orf16 Gene

Gene Families for C9orf16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C9orf16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C9orf16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUW7

UniProtKB/Swiss-Prot:

CI016_HUMAN :
  • Belongs to the UPF0184 (EST00098) family.
Family:
  • Belongs to the UPF0184 (EST00098) family.
genes like me logo Genes that share domains with C9orf16: view

Function for C9orf16 Gene

Gene Ontology (GO) - Molecular Function for C9orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C9orf16: view
genes like me logo Genes that share phenotypes with C9orf16: view

Animal Model Products

CRISPR Products

miRNA for C9orf16 Gene

miRTarBase miRNAs that target C9orf16

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C9orf16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf16 Gene

Localization for C9orf16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C9orf16 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C9orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C9orf16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C9orf16 Gene

Pathways & Interactions for C9orf16 Gene

SuperPathways for C9orf16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C9orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C9orf16: view

No data available for Pathways by source and SIGNOR curated interactions for C9orf16 Gene

Drugs & Compounds for C9orf16 Gene

No Compound Related Data Available

Transcripts for C9orf16 Gene

Unigene Clusters for C9orf16 Gene

Chromosome 9 open reading frame 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C9orf16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for C9orf16 Gene

GeneLoc Exon Structure for
C9orf16
ECgene alternative splicing isoforms for
C9orf16

Expression for C9orf16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C9orf16 Gene

mRNA differential expression in normal tissues according to GTEx for C9orf16 Gene

This gene is overexpressed in Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for C9orf16 Gene

This gene is overexpressed in Fetal Brain (51.5) and Adrenal (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C9orf16 Gene



Protein tissue co-expression partners for C9orf16 Gene

NURSA nuclear receptor signaling pathways regulating expression of C9orf16 Gene:

C9orf16

SOURCE GeneReport for Unigene cluster for C9orf16 Gene:

Hs.522412

Evidence on tissue expression from TISSUES for C9orf16 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with C9orf16: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C9orf16 Gene

Orthologs for C9orf16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9ORF16 34
  • 100 (a)
OneToOne
LOC740632 33
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia C11H9orf16 33 34
  • 93.57 (n)
dog
(Canis familiaris)
Mammalia C9H9orf16 33
  • 92.77 (n)
C9orf16 34
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1561113 33
  • 91.16 (n)
mouse
(Mus musculus)
Mammalia 1110008P14Rik 33 16 34
  • 90.36 (n)
oppossum
(Monodelphis domestica)
Mammalia C9orf16 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf16 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9ORF16 33 34
  • 80.37 (n)
lizard
(Anolis carolinensis)
Reptilia C9orf16 34
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C5H9orf16 34
  • 60 (a)
OneToOne
Species where no ortholog for C9orf16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf16 Gene

ENSEMBL:
Gene Tree for C9orf16 (if available)
TreeFam:
Gene Tree for C9orf16 (if available)

Paralogs for C9orf16 Gene

Pseudogenes.org Pseudogenes for C9orf16 Gene

genes like me logo Genes that share paralogs with C9orf16: view

No data available for Paralogs for C9orf16 Gene

Variants for C9orf16 Gene

Sequence variations from dbSNP and Humsavar for C9orf16 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000077164 -- 128,159,037(+) TAATT(A/T)ATTTT upstream-variant-2KB
rs1001073189 -- 128,160,214(+) CGGGG(C/G)GGGGC intron-variant, upstream-variant-2KB
rs1001408930 -- 128,164,238(+) CAAGA(C/T)AGCCA downstream-variant-500B
rs1001567191 -- 128,158,289(+) AGTCA(C/G)GAGTT upstream-variant-2KB
rs1001867983 -- 128,159,767(+) CCCCC(A/C/G/T)CCCCG intron-variant, upstream-variant-2KB

Variation tolerance for C9orf16 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C9orf16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C9orf16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C9orf16 Gene

Disorders for C9orf16 Gene

Relevant External Links for C9orf16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf16

No disorders were found for C9orf16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf16 Gene

Publications for C9orf16 Gene

  1. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J … Fried M (Human molecular genetics 1999) 2 3 4 60
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for C9orf16 Gene

Sources for C9orf16 Gene

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