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Aliases for WDR77 Gene

Aliases for WDR77 Gene

  • WD Repeat Domain 77 2 3
  • MEP50 3 4 6
  • WD Repeat-Containing Protein 77 3 4
  • Androgen Receptor Cofactor P44 3 4
  • P44/Mep50 3 4
  • MEP-50 3 4
  • Methylosome Protein 50 3
  • Nbla10071 3
  • HKMT1069 3
  • WD45 4
  • P44 3

External Ids for WDR77 Gene

Previous GeneCards Identifiers for WDR77 Gene

  • GC01M111695
  • GC01M111784
  • GC01M111983
  • GC01M109853

Summaries for WDR77 Gene

Entrez Gene Summary for WDR77 Gene

  • WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WDR77 Gene

WDR77 (WD Repeat Domain 77) is a Protein Coding gene. Among its related pathways are Gene Expression and Chromatin Regulation / Acetylation. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot for WDR77 Gene

  • Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Gene Wiki entry for WDR77 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR77 Gene

Genomics for WDR77 Gene

Regulatory Elements for WDR77 Gene

Genomic Location for WDR77 Gene

Start:
111,439,890 bp from pter
End:
111,449,376 bp from pter
Size:
9,487 bases
Orientation:
Minus strand

Genomic View for WDR77 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR77 Gene

Proteins for WDR77 Gene

  • Protein details for WDR77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQA1-MEP50_HUMAN
    Recommended name:
    Methylosome protein 50
    Protein Accession:
    Q9BQA1
    Secondary Accessions:
    • B3KMW6
    • B4DP38
    • Q3LID2
    • Q53FU2
    • Q6JZZ5
    • Q96GK4
    • Q9BWY3

    Protein attributes for WDR77 Gene

    Size:
    342 amino acids
    Molecular mass:
    36724 Da
    Quaternary structure:
    • Component of the methylosome, a 20S complex containing at least PRMT5, CLNS1A and WDR77. Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE. Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts with SUZ12 and histone H2A/HIST2H2AC, but not with histones H2B, H3 nor H4. Interacts with CTDP1 and LSM11. Interacts with APEX1, AR and NKX3-1.

    Three dimensional structures from OCA and Proteopedia for WDR77 Gene

    Alternative splice isoforms for WDR77 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR77 Gene

Proteomics data for WDR77 Gene at MOPED

Post-translational modifications for WDR77 Gene

  • Ubiquitination at Lys121
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR77 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR77 Gene

Domains for WDR77 Gene

Gene Families for WDR77 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR77 Gene

Suggested Antigen Peptide Sequences for WDR77 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQA1

UniProtKB/Swiss-Prot:

MEP50_HUMAN :
  • Q9BQA1
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR77: view

Function for WDR77 Gene

Molecular function for WDR77 Gene

UniProtKB/Swiss-Prot Function: Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Gene Ontology (GO) - Molecular Function for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16087681
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IGI 12972618
genes like me logo Genes that share ontologies with WDR77: view
genes like me logo Genes that share phenotypes with WDR77: view

Animal Models for WDR77 Gene

MGI Knock Outs for WDR77:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WDR77 Gene

Localization for WDR77 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR77 Gene

Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR77 Gene COMPARTMENTS Subcellular localization image for WDR77 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IGI 12972618
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IGI 12972618
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with WDR77: view

Pathways for WDR77 Gene

genes like me logo Genes that share pathways with WDR77: view

Pathways by source for WDR77 Gene

1 Cell Signaling Technology pathway for WDR77 Gene
1 BioSystems pathway for WDR77 Gene
3 Reactome pathways for WDR77 Gene

Gene Ontology (GO) - Biological Process for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0006325 chromatin organization TAS --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation --
genes like me logo Genes that share ontologies with WDR77: view

Transcripts for WDR77 Gene

Unigene Clusters for WDR77 Gene

WD repeat domain 77:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR77 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6: -

Relevant External Links for WDR77 Gene

GeneLoc Exon Structure for
WDR77
ECgene alternative splicing isoforms for
WDR77

Expression for WDR77 Gene

mRNA expression in normal human tissues for WDR77 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR77 Gene

SOURCE GeneReport for Unigene cluster for WDR77 Gene Hs.204773

mRNA Expression by UniProt/SwissProt for WDR77 Gene

Q9BQA1-MEP50_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.
genes like me logo Genes that share expressions with WDR77: view

No data available for mRNA differential expression in normal tissues for WDR77 Gene

Orthologs for WDR77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR77 35
  • 99.32 (n)
  • 99.42 (a)
WDR77 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR77 35
  • 91.03 (n)
  • 91.81 (a)
WDR77 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
WDR77 35
  • 89.86 (n)
  • 92.4 (a)
mouse
(Mus musculus)
Mammalia Wdr77 35
  • 88.01 (n)
  • 89.77 (a)
Wdr77 16
Wdr77 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR77 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR77 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr77 35
  • 88.79 (n)
  • 90.35 (a)
chicken
(Gallus gallus)
Aves WDR77 35
  • 68.63 (n)
  • 68.73 (a)
WDR77 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR77 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8563 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19030 35
wdr77 35
  • 62.88 (n)
  • 61.83 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
wdr77 35
  • 58.31 (n)
  • 53.33 (a)
WDR77 36
  • 48 (a)
OneToOne
Species with no ortholog for WDR77:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR77 Gene

ENSEMBL:
Gene Tree for WDR77 (if available)
TreeFam:
Gene Tree for WDR77 (if available)

Paralogs for WDR77 Gene

Selected SIMAP similar genes for WDR77 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WDR77 Gene

genes like me logo Genes that share paralogs with WDR77: view

No data available for Paralogs for WDR77 Gene

Variants for WDR77 Gene

Sequence variations from dbSNP and Humsavar for WDR77 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10014 -- 111,440,525(+) ACTTT(C/T)CCCTA utr-variant-3-prime
rs14545 -- 111,440,436(+) GGGGT(G/T)GGAAA utr-variant-3-prime
rs1044438 -- 111,440,408(-) GACAT(C/T)TTCTG utr-variant-3-prime
rs1044441 -- 111,440,405(-) ATCTT(C/T)TGCCC utr-variant-3-prime
rs1044469 -- 111,440,348(-) GACTT(C/T)TAAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR77 Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV Loss 19166990
nsv819848 CNV Loss 19587683

Relevant External Links for WDR77 Gene

HapMap Linkage Disequilibrium report
WDR77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR77 Gene

Disorders for WDR77 Gene

Relevant External Links for WDR77

Genetic Association Database (GAD)
WDR77
Human Genome Epidemiology (HuGE) Navigator
WDR77
genes like me logo Genes that share disorders with WDR77: view

No data available for UniProtKB/Swiss-Prot for WDR77 Gene

Publications for WDR77 Gene

  1. A novel WD repeat protein component of the methylosome binds Sm proteins. (PMID: 11756452) Friesen W.J. … Dreyfuss G. (J. Biol. Chem. 2002) 2 3 4 23
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP. (PMID: 12560496) Licciardo P. … Majello B. (Nucleic Acids Res. 2003) 3 4
  4. Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. (PMID: 12972618) Hosohata K. … Wang Z. (Mol. Cell. Biol. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for WDR77 Gene

Sources for WDR77 Gene

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