Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR77 Gene

Aliases for WDR77 Gene

  • WD Repeat Domain 77 2 3 5
  • WD Repeat-Containing Protein 77 3 4
  • Androgen Receptor Cofactor P44 3 4
  • Methylosome Protein 50 2 3
  • P44/Mep50 3 4
  • MEP-50 3 4
  • MEP50 3 4
  • Testis Tissue Sperm-Binding Protein Li 44a 3
  • Nbla10071 3
  • HKMT1069 3
  • WD45 4
  • P44 3

External Ids for WDR77 Gene

Previous GeneCards Identifiers for WDR77 Gene

  • GC01M111695
  • GC01M111784
  • GC01M111983
  • GC01M109853

Summaries for WDR77 Gene

Entrez Gene Summary for WDR77 Gene

  • The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for WDR77 Gene

WDR77 (WD Repeat Domain 77) is a Protein Coding gene. Diseases associated with WDR77 include Prostate Cancer. Among its related pathways are Gene Expression and Chromatin organization. Gene Ontology (GO) annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot for WDR77 Gene

  • Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Gene Wiki entry for WDR77 Gene

Additional gene information for WDR77 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR77 Gene

Genomics for WDR77 Gene

GeneHancer (GH) Regulatory Elements for WDR77 Gene

Promoters and enhancers for WDR77 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I111445 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.1 1090 4.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ATP5PB PIR44385 WDR77 GC01P111451 GC01P111450 GC01P111447 ENSG00000199890 OVGP1 ENSG00000260948 DENND2D
GH01I111618 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -171.2 -171235 4.6 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 SLC30A9 POLR2B ZNF766 ZNF213 RAP1A KRT18P57 RNU6-151P ATP5PB WDR77 FAM212B UBE2FP3 LINC01160 PIFO C1orf162
GH01I111212 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +227.6 227629 19.3 HDGF PKNOX1 FOXA2 SMAD1 FEZF1 YBX1 ZNF2 IRF4 ZNF213 ZNF207 CHI3L2 DDX20 ENSG00000232240 LOC105378903 PIFO ATP5PB WDR77 OVGP1 DENND2D CEPT1
GH01I111615 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 -167.0 -166963 2.2 HDGF PKNOX1 SMAD1 RB1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RAP1A RNU6-151P KRT18P57 ATP5PB WDR77 UBE2FP3 PIFO LINC01160 GC01P111550
GH01I111469 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.4 -22.0 -22033 3 HDGF PKNOX1 EBF1 NFIC IKZF1 TARDBP HMBOX1 ZNF24 RUNX3 ENSG00000260948 RAP1A ATP5PB WDR77 OVGP1 FAM212B C1orf162 GC01M111493 RNU6-792P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR77 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR77 gene promoter:

Genomic Locations for WDR77 Gene

Genomic Locations for WDR77 Gene
chr1:111,439,890-111,449,376
(GRCh38/hg38)
Size:
9,487 bases
Orientation:
Minus strand
chr1:111,982,512-111,991,998
(GRCh37/hg19)

Genomic View for WDR77 Gene

Genes around WDR77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR77 Gene

Proteins for WDR77 Gene

  • Protein details for WDR77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQA1-MEP50_HUMAN
    Recommended name:
    Methylosome protein 50
    Protein Accession:
    Q9BQA1
    Secondary Accessions:
    • B3KMW6
    • B4DP38
    • Q3LID2
    • Q53FU2
    • Q6JZZ5
    • Q96GK4
    • Q9BWY3

    Protein attributes for WDR77 Gene

    Size:
    342 amino acids
    Molecular mass:
    36724 Da
    Quaternary structure:
    • Component of the methylosome, a 20S complex containing at least PRMT5, CLNS1A, WDR77, PRMT1 and ERH (PubMed:25284789). Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE. Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts with SUZ12 and histone H2A/HIST2H2AC, but not with histones H2B, H3 nor H4. Interacts with CTDP1 and LSM11. Interacts with APEX1, AR and NKX3-1. Interacts with CHTOP (PubMed:25284789).

    Three dimensional structures from OCA and Proteopedia for WDR77 Gene

    Alternative splice isoforms for WDR77 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR77 Gene

Post-translational modifications for WDR77 Gene

Other Protein References for WDR77 Gene

No data available for DME Specific Peptides for WDR77 Gene

Domains & Families for WDR77 Gene

Gene Families for WDR77 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR77 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR77: view

No data available for UniProtKB/Swiss-Prot for WDR77 Gene

Function for WDR77 Gene

Molecular function for WDR77 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Gene Ontology (GO) - Molecular Function for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11756452
GO:0008327 methyl-CpG binding IDA 25284789
GO:0016274 protein-arginine N-methyltransferase activity TAS --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IGI 12972618
genes like me logo Genes that share ontologies with WDR77: view
genes like me logo Genes that share phenotypes with WDR77: view

Animal Models for WDR77 Gene

MGI Knock Outs for WDR77:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR77 Gene

Localization for WDR77 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR77 Gene

Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR77 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
extracellular 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IGI 12972618
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IGI 12972618
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with WDR77: view

Pathways & Interactions for WDR77 Gene

genes like me logo Genes that share pathways with WDR77: view

Pathways by source for WDR77 Gene

Gene Ontology (GO) - Biological Process for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0035246 peptidyl-arginine N-methylation IEA --
genes like me logo Genes that share ontologies with WDR77: view

No data available for SIGNOR curated interactions for WDR77 Gene

Drugs & Compounds for WDR77 Gene

No Compound Related Data Available

Transcripts for WDR77 Gene

Unigene Clusters for WDR77 Gene

WD repeat domain 77:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR77 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6: -

Relevant External Links for WDR77 Gene

GeneLoc Exon Structure for
WDR77
ECgene alternative splicing isoforms for
WDR77

Expression for WDR77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR77 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR77 Gene

This gene is overexpressed in Ovary (8.7) and Fetal testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR77 Gene



Protein tissue co-expression partners for WDR77 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR77 Gene:

WDR77

SOURCE GeneReport for Unigene cluster for WDR77 Gene:

Hs.204773

mRNA Expression by UniProt/SwissProt for WDR77 Gene:

Q9BQA1-MEP50_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.

Evidence on tissue expression from TISSUES for WDR77 Gene

  • Skin(4.6)
  • Nervous system(4.6)
  • Intestine(4.5)
  • Lung(4.4)
  • Kidney(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with WDR77: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR77 Gene

Orthologs for WDR77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR77 33 34
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia WDR77 33 34
  • 91.03 (n)
dog
(Canis familiaris)
Mammalia WDR77 33
  • 89.86 (n)
-- 34
  • 74 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wdr77 33
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Wdr77 33 16 34
  • 88.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR77 34
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR77 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR77 33 34
  • 68.63 (n)
lizard
(Anolis carolinensis)
Reptilia WDR77 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr77 33
  • 62.88 (n)
Str.19030 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8563 33
zebrafish
(Danio rerio)
Actinopterygii wdr77 33
  • 58.31 (n)
WDR77 34
  • 48 (a)
OneToOne
-- 33
Species where no ortholog for WDR77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR77 Gene

ENSEMBL:
Gene Tree for WDR77 (if available)
TreeFam:
Gene Tree for WDR77 (if available)

Paralogs for WDR77 Gene

(1) SIMAP similar genes for WDR77 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WDR77 Gene

genes like me logo Genes that share paralogs with WDR77: view

No data available for Paralogs for WDR77 Gene

Variants for WDR77 Gene

Sequence variations from dbSNP and Humsavar for WDR77 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000142370 -- 111,448,548(-) C/G intron_variant
rs1000195140 -- 111,448,116(-) G/A intron_variant
rs1000369635 -- 111,446,229(-) A/G intron_variant
rs1000417950 -- 111,441,243(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000419911 -- 111,449,784(-) G/GAGCCTGGCGGGG upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR77 Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV loss 19166990
nsv547535 CNV loss 21841781
nsv819848 CNV loss 19587683

Variation tolerance for WDR77 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR77 Gene

Disorders for WDR77 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR77 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search WDR77 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR77

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WDR77: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR77 Gene

Publications for WDR77 Gene

  1. A novel WD repeat protein component of the methylosome binds Sm proteins. (PMID: 11756452) Friesen WJ … Dreyfuss G (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. (PMID: 25284789) Takai H … Akiyama T (Cell reports 2014) 3 4 58
  3. Crystal structure of the human PRMT5:MEP50 complex. (PMID: 23071334) Antonysamy S … Emtage S (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4 58
  4. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PMID: 19188445) Vascotto C … Tell G (Molecular and cellular biology 2009) 3 4 58
  5. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PMID: 18984161) Chari A … Fischer U (Cell 2008) 3 4 58

Products for WDR77 Gene

Sources for WDR77 Gene

Content
Loading form....