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Aliases for WDR77 Gene

Aliases for WDR77 Gene

  • WD Repeat Domain 77 2 3 5
  • WD Repeat-Containing Protein 77 3 4
  • Androgen Receptor Cofactor P44 3 4
  • Methylosome Protein 50 2 3
  • P44/Mep50 3 4
  • MEP-50 3 4
  • MEP50 3 4
  • Testis Tissue Sperm-Binding Protein Li 44a 3
  • Nbla10071 3
  • HKMT1069 3
  • WD45 4
  • P44 3

External Ids for WDR77 Gene

Previous GeneCards Identifiers for WDR77 Gene

  • GC01M111695
  • GC01M111784
  • GC01M111983
  • GC01M109853

Summaries for WDR77 Gene

Entrez Gene Summary for WDR77 Gene

  • The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for WDR77 Gene

WDR77 (WD Repeat Domain 77) is a Protein Coding gene. Diseases associated with WDR77 include Prostate Cancer. Among its related pathways are Gene Expression and Transport of the SLBP independent Mature mRNA. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot for WDR77 Gene

  • Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Gene Wiki entry for WDR77 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR77 Gene

Genomics for WDR77 Gene

Regulatory Elements for WDR77 Gene

Enhancers for WDR77 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G111212 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +227.6 227630 19.3 CREB3L1 MLX DMAP1 FEZF1 YBX1 YY1 ZNF143 ZNF263 SP3 TBX21 CHI3L2 DDX20 CEPT1 LOC105378903 ENSG00000232240 PIFO ATP5F1 WDR77 ENSG00000243960 OVGP1
GH01G111618 1.7 FANTOM5 ENCODE dbSUPER 10.5 -171.2 -171236 4.6 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YY1 SLC30A9 ZNF766 RAP1A RNU6-151P KRT18P57 ATP5F1 WDR77 FAM212B UBE2FP3 LINC01160 PIFO C1orf162
GH01G111406 1 Ensembl ENCODE 15.3 +42.8 42798 0.6 HDGF PKNOX1 SUZ12 NFIB BHLHE40 KLF17 MAX KLF4 ZIC2 RAD21 ENSG00000260948 WDR77 ATP5F1 DENND2D PGCP1 OVGP1
GH01G111469 1.3 FANTOM5 ENCODE dbSUPER 11.4 -22.0 -22033 3.0 HDGF PKNOX1 MTA2 HCFC1 SP1 NFIC NFYB TARDBP IKZF1 HMBOX1 ENSG00000260948 RAP1A WDR77 ATP5F1 OVGP1 FAM212B C1orf162 GC01M111493 RNU6-792P
GH01G111615 1.3 Ensembl ENCODE dbSUPER 10.5 -167.0 -166963 2.2 HDGF TBP PKNOX1 WRNIP1 RELB ETV6 IKZF2 CREM CBFB JUNB RAP1A RNU6-151P KRT18P57 ATP5F1 WDR77 UBE2FP3 PIFO LINC01160
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR77 on UCSC Golden Path with GeneCards custom track

Promoters for WDR77 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011365 8 2401 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for WDR77 Gene

Chromosome:
1
Start:
111,439,890 bp from pter
End:
111,449,376 bp from pter
Size:
9,487 bases
Orientation:
Minus strand

Genomic View for WDR77 Gene

Genes around WDR77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR77 Gene

Proteins for WDR77 Gene

  • Protein details for WDR77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQA1-MEP50_HUMAN
    Recommended name:
    Methylosome protein 50
    Protein Accession:
    Q9BQA1
    Secondary Accessions:
    • B3KMW6
    • B4DP38
    • Q3LID2
    • Q53FU2
    • Q6JZZ5
    • Q96GK4
    • Q9BWY3

    Protein attributes for WDR77 Gene

    Size:
    342 amino acids
    Molecular mass:
    36724 Da
    Quaternary structure:
    • Component of the methylosome, a 20S complex containing at least PRMT5, CLNS1A, WDR77, PRMT1 and ERH (PubMed:25284789). Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE. Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts with SUZ12 and histone H2A/HIST2H2AC, but not with histones H2B, H3 nor H4. Interacts with CTDP1 and LSM11. Interacts with APEX1, AR and NKX3-1. Interacts with CHTOP (PubMed:25284789).

    Three dimensional structures from OCA and Proteopedia for WDR77 Gene

    Alternative splice isoforms for WDR77 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR77 Gene

Post-translational modifications for WDR77 Gene

  • Ubiquitination at Lys121
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR77 Gene

No data available for DME Specific Peptides for WDR77 Gene

Domains & Families for WDR77 Gene

Gene Families for WDR77 Gene

Protein Domains for WDR77 Gene

Suggested Antigen Peptide Sequences for WDR77 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR77: view

No data available for UniProtKB/Swiss-Prot for WDR77 Gene

Function for WDR77 Gene

Molecular function for WDR77 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Gene Ontology (GO) - Molecular Function for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11756452
GO:0008327 methyl-CpG binding IDA 25284789
GO:0016274 protein-arginine N-methyltransferase activity TAS --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IGI 12972618
genes like me logo Genes that share ontologies with WDR77: view
genes like me logo Genes that share phenotypes with WDR77: view

Animal Models for WDR77 Gene

MGI Knock Outs for WDR77:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR77 Gene

Localization for WDR77 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR77 Gene

Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR77 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IGI 12972618
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IGI 12972618
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with WDR77: view

Pathways & Interactions for WDR77 Gene

genes like me logo Genes that share pathways with WDR77: view

Pathways by source for WDR77 Gene

Gene Ontology (GO) - Biological Process for WDR77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0035246 peptidyl-arginine N-methylation IEA --
genes like me logo Genes that share ontologies with WDR77: view

No data available for SIGNOR curated interactions for WDR77 Gene

Transcripts for WDR77 Gene

Unigene Clusters for WDR77 Gene

WD repeat domain 77:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR77 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6: -

Relevant External Links for WDR77 Gene

GeneLoc Exon Structure for
WDR77
ECgene alternative splicing isoforms for
WDR77

Expression for WDR77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR77 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR77 Gene

This gene is overexpressed in Ovary (8.7) and Fetal testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR77 Gene



Protein tissue co-expression partners for WDR77 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR77 Gene:

WDR77

SOURCE GeneReport for Unigene cluster for WDR77 Gene:

Hs.204773

mRNA Expression by UniProt/SwissProt for WDR77 Gene:

Q9BQA1-MEP50_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.

Evidence on tissue expression from TISSUES for WDR77 Gene

  • Skin(4.6)
  • Nervous system(4.6)
  • Intestine(4.5)
  • Lung(4.4)
  • Kidney(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with WDR77: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR77 Gene

Orthologs for WDR77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR77 34 35
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia WDR77 34 35
  • 91.03 (n)
dog
(Canis familiaris)
Mammalia WDR77 34
  • 89.86 (n)
-- 35
  • 74 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wdr77 34
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Wdr77 34 16 35
  • 88.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR77 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR77 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR77 34 35
  • 68.63 (n)
lizard
(Anolis carolinensis)
Reptilia WDR77 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr77 34
  • 62.88 (n)
Str.19030 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8563 34
zebrafish
(Danio rerio)
Actinopterygii wdr77 34
  • 58.31 (n)
WDR77 35
  • 48 (a)
OneToOne
-- 34
Species where no ortholog for WDR77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR77 Gene

ENSEMBL:
Gene Tree for WDR77 (if available)
TreeFam:
Gene Tree for WDR77 (if available)

Paralogs for WDR77 Gene

(1) SIMAP similar genes for WDR77 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WDR77 Gene

genes like me logo Genes that share paralogs with WDR77: view

No data available for Paralogs for WDR77 Gene

Variants for WDR77 Gene

Sequence variations from dbSNP and Humsavar for WDR77 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000142370 -- 111,448,548(+) CAACC(C/G)TACGG intron-variant, upstream-variant-2KB
rs1000195140 -- 111,448,116(+) AGAGA(A/G)GTTAA intron-variant, upstream-variant-2KB
rs1000369635 -- 111,446,229(+) GAACC(A/G)CAGTG intron-variant
rs1000417950 -- 111,441,243(+) TAACA(C/T)TTGCA nc-transcript-variant, reference, missense
rs1000419911 -- 111,449,783(+) GGAAA(-/GAGCCTGGCGGG)GGGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR77 Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV loss 19166990
nsv547535 CNV loss 21841781
nsv819848 CNV loss 19587683

Variation tolerance for WDR77 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR77 Gene

Disorders for WDR77 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR77 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search WDR77 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDR77

Genetic Association Database (GAD)
WDR77
Human Genome Epidemiology (HuGE) Navigator
WDR77
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR77
genes like me logo Genes that share disorders with WDR77: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR77 Gene

Publications for WDR77 Gene

  1. A novel WD repeat protein component of the methylosome binds Sm proteins. (PMID: 11756452) Friesen W.J. … Dreyfuss G. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. (PMID: 25284789) Takai H. … Akiyama T. (Cell Rep 2014) 3 4 64
  3. Crystal structure of the human PRMT5:MEP50 complex. (PMID: 23071334) Antonysamy S. … Emtage S. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 64
  4. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PMID: 19188445) Vascotto C. … Tell G. (Mol. Cell. Biol. 2009) 3 4 64
  5. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PMID: 18984161) Chari A. … Fischer U. (Cell 2008) 3 4 64

Products for WDR77 Gene

Sources for WDR77 Gene

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