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Aliases for ST8SIA4 Gene

Aliases for ST8SIA4 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 4 2 3
  • PST1 3 4 6
  • PST 3 4 6
  • Sialyltransferase 8 (Alpha-2, 8-Polysialytransferase) D 2 3
  • Alpha-2,8-Sialyltransferase 8D 3 4
  • Sialyltransferase St8Sia IV 3 4
  • Polysialyltransferase-1 3 4
  • Sialyltransferase 8D 3 4
  • ST8SiaIV 3 4
  • SIAT8-D 3 4
  • SIAT8D 3 4
  • CMP-N-Acetylneuraminate-Poly-Alpha-2,8-Sialyl Transferase 3
  • CMP-N-Acetylneuraminate-Poly-Alpha-2,8-Sialyltransferase 3
  • Sialytransferase St8Sia IV 3
  • EC 2.4.99.- 4
  • ST8Sia IV 2
  • ST8SIA-IV 3
  • EC 2.4.99 63

External Ids for ST8SIA4 Gene

Previous HGNC Symbols for ST8SIA4 Gene

  • SIAT8D

Previous GeneCards Identifiers for ST8SIA4 Gene

  • GC05M100171
  • GC05M095326

Summaries for ST8SIA4 Gene

Entrez Gene Summary for ST8SIA4 Gene

  • The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST8SIA4 Gene

ST8SIA4 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 4) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include sialic acid binding and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA1.

UniProtKB/Swiss-Prot for ST8SIA4 Gene

  • Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells

Gene Wiki entry for ST8SIA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA4 Gene

Genomics for ST8SIA4 Gene

Regulatory Elements for ST8SIA4 Gene

Genomic Location for ST8SIA4 Gene

Start:
100,806,935 bp from pter
End:
100,903,285 bp from pter
Size:
96,351 bases
Orientation:
Minus strand

Genomic View for ST8SIA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST8SIA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA4 Gene

Proteins for ST8SIA4 Gene

  • Protein details for ST8SIA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92187-SIA8D_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
    Protein Accession:
    Q92187
    Secondary Accessions:
    • A8KA07
    • G3V104
    • Q8N1F4
    • Q92693

    Protein attributes for ST8SIA4 Gene

    Size:
    359 amino acids
    Molecular mass:
    41295 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST8SIA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST8SIA4 Gene

Proteomics data for ST8SIA4 Gene at MOPED

Post-translational modifications for ST8SIA4 Gene

  • Glycosylation at Asn50, Asn74, Asn119, Asn204, and Asn219
  • Modification sites at PhosphoSitePlus

Other Protein References for ST8SIA4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ST8SIA4 Gene

Gene Families for ST8SIA4 Gene

HGNC:
  • ST3G :Sialyltransferases

Protein Domains for ST8SIA4 Gene

Suggested Antigen Peptide Sequences for ST8SIA4 Gene

Graphical View of Domain Structure for InterPro Entry

Q92187

UniProtKB/Swiss-Prot:

SIA8D_HUMAN :
  • Q92187
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA4: view

Function for ST8SIA4 Gene

Molecular function for ST8SIA4 Gene

UniProtKB/Swiss-Prot Function: Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells

Enzyme Numbers (IUBMB) for ST8SIA4 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA 10766765
GO:0008373 sialyltransferase activity --
GO:0033691 sialic acid binding IC 10766765
genes like me logo Genes that share ontologies with ST8SIA4: view
genes like me logo Genes that share phenotypes with ST8SIA4: view

Animal Models for ST8SIA4 Gene

MGI Knock Outs for ST8SIA4:

miRNA for ST8SIA4 Gene

miRTarBase miRNAs that target ST8SIA4

No data available for Transcription Factor Targeting and HOMER Transcription for ST8SIA4 Gene

Localization for ST8SIA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST8SIA4 Gene COMPARTMENTS Subcellular localization image for ST8SIA4 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ST8SIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST8SIA4: view

Pathways for ST8SIA4 Gene

genes like me logo Genes that share pathways with ST8SIA4: view

Pathways by source for ST8SIA4 Gene

UniProtKB/Swiss-Prot Q92187-SIA8D_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST8SIA4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000231461%0d%0a9606.ENSP00000358565%0d%0a9606.ENSP00000318472%0d%0a
Selected Interacting proteins: ENSP00000231461 Q92187-SIA8D_HUMAN for ST8SIA4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ST8SIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IDA 10766765
GO:0006464 cellular protein modification process TAS 7854457
GO:0006486 protein glycosylation IDA 10766765
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006491 N-glycan processing IDA 10766765
genes like me logo Genes that share ontologies with ST8SIA4: view

Compounds for ST8SIA4 Gene

(4) Novoseek inferred chemical compound relationships for ST8SIA4 Gene

Compound -log(P) Hits PubMed IDs
sialic acid 73.4 9
polysaccharide 46.4 3
valproic acid 34 3
galactose 19.8 1
genes like me logo Genes that share compounds with ST8SIA4: view

Transcripts for ST8SIA4 Gene

Unigene Clusters for ST8SIA4 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2:
SP3: -

Relevant External Links for ST8SIA4 Gene

GeneLoc Exon Structure for
ST8SIA4
ECgene alternative splicing isoforms for
ST8SIA4

Expression for ST8SIA4 Gene

mRNA expression in normal human tissues for ST8SIA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST8SIA4 Gene

This gene is overexpressed in Whole Blood (13.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ST8SIA4 Gene

SOURCE GeneReport for Unigene cluster for ST8SIA4 Gene Hs.308628

mRNA Expression by UniProt/SwissProt for ST8SIA4 Gene

Q92187-SIA8D_HUMAN
Tissue specificity: Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes
genes like me logo Genes that share expressions with ST8SIA4: view

Orthologs for ST8SIA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST8SIA4 35
  • 99.91 (n)
  • 100 (a)
ST8SIA4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST8SIA4 35
  • 93.13 (n)
  • 98.61 (a)
ST8SIA4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST8SIA4 35
  • 94.89 (n)
  • 99.16 (a)
ST8SIA4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St8sia4 35
  • 91.74 (n)
  • 97.77 (a)
St8sia4 16
St8sia4 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST8SIA4 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST8SIA4 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St8sia4 35
  • 90.06 (n)
  • 97.77 (a)
chicken
(Gallus gallus)
Aves ST8SIA4 35
  • 85.61 (n)
  • 93.31 (a)
ST8SIA4 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST8SIA4 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia4 35
  • 79.48 (n)
  • 87.74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11824 35
zebrafish
(Danio rerio)
Actinopterygii st8sia4 35
  • 64.97 (n)
  • 70.06 (a)
st8sia4 36
  • 69 (a)
OneToOne
Species with no ortholog for ST8SIA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA4 Gene

ENSEMBL:
Gene Tree for ST8SIA4 (if available)
TreeFam:
Gene Tree for ST8SIA4 (if available)

Paralogs for ST8SIA4 Gene

Paralogs for ST8SIA4 Gene

Selected SIMAP similar genes for ST8SIA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ST8SIA4: view

Variants for ST8SIA4 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3076 -- 100,811,694(+) TATTT(C/T)ATCAG utr-variant-3-prime
rs11584 -- 100,809,684(+) TTATT(A/C)AGTAA utr-variant-3-prime
rs13857 -- 100,807,380(-) CTGCA(C/G)AGAAT utr-variant-3-prime
rs26084 -- 100,830,686(-) TTCTT(G/T)ATGGT intron-variant
rs26085 -- 100,830,718(-) TCTAA(C/G)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA4 Gene

Variant ID Type Subtype PubMed ID
nsv882471 CNV Loss 21882294
dgv6238n71 CNV Loss 21882294

Relevant External Links for ST8SIA4 Gene

HapMap Linkage Disequilibrium report
ST8SIA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST8SIA4 Gene

Disorders for ST8SIA4 Gene

(2) Novoseek inferred disease relationships for ST8SIA4 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 7.73 1
tumors 0 4

Relevant External Links for ST8SIA4

Genetic Association Database (GAD)
ST8SIA4
Human Genome Epidemiology (HuGE) Navigator
ST8SIA4
genes like me logo Genes that share disorders with ST8SIA4: view

No data available for UniProtKB/Swiss-Prot for ST8SIA4 Gene

Publications for ST8SIA4 Gene

  1. Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity. (PMID: 11279095) Angata K. … Fukuda M. (J. Biol. Chem. 2001) 3 4 23
  2. Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia. (PMID: 16229822) Arai M. … Itokawa M. (Biol. Psychiatry 2006) 3 23 48
  3. Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain. (PMID: 7624364) Nakayama J. … Fukuda M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. N-CAM dysfunction and unexpected accumulation of PSA-NCAM in brain of adult-onset autosomal-dominant leukodystrophy. (PMID: 19725832) Piccinini M. … Rinaudo M.T. (Brain Pathol. 2010) 3 23

Products for ST8SIA4 Gene

Sources for ST8SIA4 Gene

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