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Aliases for ZNF655 Gene

Aliases for ZNF655 Gene

  • Zinc Finger Protein 655 2 3 5
  • VIK 3 4
  • Vav-1 Interacting Kruppel-Like Protein 3
  • Vav-Interacting Krueppel-Like Protein 4
  • VIK-1 3

External Ids for ZNF655 Gene

Previous GeneCards Identifiers for ZNF655 Gene

  • GC07P098801
  • GC07P098993
  • GC07P099156
  • GC07P093793

Summaries for ZNF655 Gene

Entrez Gene Summary for ZNF655 Gene

  • This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF655 Gene

ZNF655 (Zinc Finger Protein 655) is a Protein Coding gene. Diseases associated with ZNF655 include Ichthyosis, Congenital, Autosomal Recessive 11. Among its related pathways are Retinoblastoma (RB) in Cancer and Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ENSG00000272647.

UniProtKB/Swiss-Prot for ZNF655 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF655 Gene

Additional gene information for ZNF655 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF655 Gene

Genomics for ZNF655 Gene

Regulatory Elements for ZNF655 Gene

Enhancers for ZNF655 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H100475 1.4 ENCODE dbSUPER 86 +919.3 919349 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZSCAN25 TRIM4 GIGYF1 ZNF3 ZNF655 SRRT AP4M1 ENSG00000242798 STAG3L5P PILRA
GH07H099579 1.4 FANTOM5 Ensembl ENCODE 84.3 +22.0 21995 1 ZNF2 ZBTB40 RAD21 ZNF366 ZNF354C ZNF202 ZNF680 ELF4 REST ZNF518A ZSCAN25 TRRAP TRIM4 LOC100131859 ZNF3 ZNF655 ENSG00000242798 STAG3L5P AP4M1 LOC101927550
GH07H099464 1.2 ENCODE 62 -92.6 -92602 1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZSCAN25 ZNF3 ZNF655 TRIM4 TRRAP LOC101927550 LOC100131859 ENSG00000242798 STAG3L5P SMURF1
GH07H099223 1.5 Ensembl ENCODE dbSUPER 48 -333.5 -333462 1 PKNOX1 ATF1 ARNT YBX1 TCF12 GTF3C2 CBX5 ATF7 FOS TSHZ1 ZSCAN25 TRIM4 ZNF655 SMURF1 ZNF3 PTCD1 TRRAP LOC100419643 LOC101927550 ENSG00000242798
GH07H099373 1.8 FANTOM5 ENCODE dbSUPER 36.3 -180.1 -180098 8 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 ZNF207 ZSCAN25 TRRAP LOC101927550 ZNF655 ZNF394 TRIM4 ENSG00000242798 AP4M1 PTCD1 ZNF3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF655 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF655 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215676 394 2401 HNRNPUL1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for ZNF655 Gene

Chromosome:
7
Start:
99,558,406 bp from pter
End:
99,576,453 bp from pter
Size:
18,048 bases
Orientation:
Plus strand

Genomic View for ZNF655 Gene

Genes around ZNF655 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF655 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF655 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF655 Gene

Proteins for ZNF655 Gene

  • Protein details for ZNF655 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N720-ZN655_HUMAN
    Recommended name:
    Zinc finger protein 655
    Protein Accession:
    Q8N720
    Secondary Accessions:
    • A4D291
    • A6NGD3
    • B4E3M4
    • B7Z9Q9
    • D6W5T4
    • Q8IV00
    • Q8TA89
    • Q96EZ3
    • Q9BQ85

    Protein attributes for ZNF655 Gene

    Size:
    491 amino acids
    Molecular mass:
    57407 Da
    Quaternary structure:
    • Interacts with VAV1 and CDK4.

    Alternative splice isoforms for ZNF655 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF655 Gene

Post-translational modifications for ZNF655 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF655 Gene

Domains & Families for ZNF655 Gene

Gene Families for ZNF655 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF655 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N720

UniProtKB/Swiss-Prot:

ZN655_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF655: view

Function for ZNF655 Gene

Molecular function for ZNF655 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF655 Gene

Gene Ontology (GO) - Molecular Function for ZNF655 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 15558030
genes like me logo Genes that share ontologies with ZNF655: view
genes like me logo Genes that share phenotypes with ZNF655: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF655
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF655 Gene

Localization for ZNF655 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF655 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF655 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF655 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 15558030
GO:0005730 nucleolus IDA 15558030
GO:0005737 cytoplasm IDA 15558030
genes like me logo Genes that share ontologies with ZNF655: view

Pathways & Interactions for ZNF655 Gene

genes like me logo Genes that share pathways with ZNF655: view

Pathways by source for ZNF655 Gene

2 BioSystems pathways for ZNF655 Gene
2 Reactome pathways for ZNF655 Gene

Gene Ontology (GO) - Biological Process for ZNF655 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA 15558030
genes like me logo Genes that share ontologies with ZNF655: view

No data available for SIGNOR curated interactions for ZNF655 Gene

Drugs & Compounds for ZNF655 Gene

No Compound Related Data Available

Transcripts for ZNF655 Gene

Unigene Clusters for ZNF655 Gene

Zinc finger protein 655:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF655
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF655 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - -
SP19: - -
SP20: - - - - - - -
SP21: - - - - - - -
SP22: - - - - -
SP23:
SP24: - - - - -

ExUns: 7f · 7g · 7h ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h
SP1:
SP2:
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6:
SP7: - - - - -
SP8:
SP9: - - - - -
SP10: - - - - -
SP11:
SP12:
SP13: - - - - -
SP14: - - - - -
SP15:
SP16: - - - - - -
SP17: - - -
SP18: - - - - - -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for ZNF655 Gene

GeneLoc Exon Structure for
ZNF655
ECgene alternative splicing isoforms for
ZNF655

Expression for ZNF655 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF655 Gene

Protein differential expression in normal tissues from HIPED for ZNF655 Gene

This gene is overexpressed in Adipocyte (54.1) and Placenta (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF655 Gene



Protein tissue co-expression partners for ZNF655 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF655 Gene:

ZNF655

SOURCE GeneReport for Unigene cluster for ZNF655 Gene:

Hs.599798

Evidence on tissue expression from TISSUES for ZNF655 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Skin(4.3)
  • Pancreas(4.2)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with ZNF655: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF655 Gene

Orthologs for ZNF655 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF655 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF655 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp655 33 16 34
  • 85.71 (n)
rat
(Rattus norvegicus)
Mammalia Zfp655 33
  • 85.64 (n)
dog
(Canis familiaris)
Mammalia ZNF655 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX927130.1 34
  • 24 (a)
OneToMany
Species where no ortholog for ZNF655 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF655 Gene

ENSEMBL:
Gene Tree for ZNF655 (if available)
TreeFam:
Gene Tree for ZNF655 (if available)

Paralogs for ZNF655 Gene

Paralogs for ZNF655 Gene

Pseudogenes.org Pseudogenes for ZNF655 Gene

genes like me logo Genes that share paralogs with ZNF655: view

Variants for ZNF655 Gene

Sequence variations from dbSNP and Humsavar for ZNF655 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000018298 -- 99,568,666(+) TTCCC(C/T)AAGCA intron-variant
rs1000051968 -- 99,558,820(+) CGCAG(C/T)GGGGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000485501 -- 99,568,284(+) GAAAT(A/G)GAGTC intron-variant
rs1000654673 -- 99,570,294(+) AAACT(G/T)CTGAA intron-variant
rs1000722854 -- 99,558,609(+) CGGGA(C/T)CCTCA upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for ZNF655 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF655 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF655

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF655 Gene

Disorders for ZNF655 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF655 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ichthyosis, congenital, autosomal recessive 11
  • autosomal recessive congenital ichthyosis 11
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF655

Genetic Association Database (GAD)
ZNF655
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF655
genes like me logo Genes that share disorders with ZNF655: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF655 Gene

Publications for ZNF655 Gene

  1. Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. (PMID: 15558030) Houlard M … Varin-Blank N (Oncogene 2005) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60

Products for ZNF655 Gene

Sources for ZNF655 Gene

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