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Aliases for CENPM Gene

Aliases for CENPM Gene

  • Centromere Protein M 2 3
  • C22orf18 3 4 6
  • PANE1 3 4 6
  • Proliferation-Associated Nuclear Element Protein 1 3 4
  • Interphase Centromere Complex Protein 39 3 4
  • CENP-M 3 4
  • Chromosome 22 Open Reading Frame 18 2
  • ICEN39 4

External Ids for CENPM Gene

Previous Symbols for CENPM Gene

  • C22orf18

Summaries for CENPM Gene

Entrez Gene Summary for CENPM Gene

  • The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for CENPM Gene

CENPM (Centromere Protein M) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CENPM Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

Gene Wiki entry for CENPM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPM Gene

Genomics for CENPM Gene

Genomic Location for CENPM Gene

41,938,527 bp from pter
41,947,164 bp from pter
8,638 bases
Minus strand

Genomic View for CENPM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPM Gene

Regulatory Elements for CENPM Gene

Proteins for CENPM Gene

  • Protein details for CENPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centromere protein M
    Protein Accession:
    Secondary Accessions:
    • A7LM22
    • B1AHQ9
    • Q6I9W3

    Protein attributes for CENPM Gene

    180 amino acids
    Molecular mass:
    19737 Da
    Quaternary structure:
    • Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.

    Three dimensional structures from OCA and Proteopedia for CENPM Gene

    Alternative splice isoforms for CENPM Gene


neXtProt entry for CENPM Gene

Proteomics data for CENPM Gene at MOPED

Post-translational modifications for CENPM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CENPM Gene

Domains for CENPM Gene

Protein Domains for CENPM Gene

genes like me logo Genes that share domains with CENPM: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CENPM Gene

Function for CENPM Gene

Molecular function for CENPM Gene

UniProtKB/Swiss-Prot Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

Phenotypes for CENPM Gene

GenomeRNAi human phenotypes for CENPM:
genes like me logo Genes that share phenotypes with CENPM: view

miRNA for CENPM Gene

miRTarBase miRNAs that target CENPM

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CENPM Gene

Localization for CENPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPM Gene

Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CENPM Gene COMPARTMENTS Subcellular localization image for CENPM gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CENPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPM: view

Pathways for CENPM Gene

genes like me logo Genes that share pathways with CENPM: view

Pathways by source for CENPM Gene

Gene Ontology (GO) - Biological Process for CENPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPM: view

Transcripts for CENPM Gene

Unigene Clusters for CENPM Gene

Centromere protein M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPM Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -

Relevant External Links for CENPM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CENPM Gene

mRNA expression in normal human tissues for CENPM Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPM Gene

SOURCE GeneReport for Unigene cluster for CENPM Gene Hs.208912

mRNA Expression by UniProt/SwissProt for CENPM Gene

Tissue specificity: Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells
genes like me logo Genes that share expressions with CENPM: view

Orthologs for CENPM Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CENPM 36
  • 99.63 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia CENPM 36
  • 85.93 (n)
  • 87.22 (a)
  • 87 (a)
(Canis familiaris)
Mammalia CENPM 36
  • 87.78 (n)
  • 87.22 (a)
  • 87 (a)
(Mus musculus)
Mammalia Cenpm 36
  • 82.41 (n)
  • 79.44 (a)
Cenpm 16
Cenpm 37
  • 79 (a)
(Monodelphis domestica)
Mammalia CENPM 37
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia CENPM 37
  • 59 (a)
(Rattus norvegicus)
Mammalia Cenpm 36
  • 83.52 (n)
  • 80.56 (a)
(Gallus gallus)
Aves CENPM 36
  • 65.62 (n)
  • 59.37 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 53 (a)
-- 37
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpm 36
  • 58.54 (n)
  • 51.25 (a)
(Danio rerio)
Actinopterygii pane1 36
  • 53.8 (n)
  • 43.67 (a)
pane1 37
  • 41 (a)
Species with no ortholog for CENPM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPM Gene

Gene Tree for CENPM (if available)
Gene Tree for CENPM (if available)

Paralogs for CENPM Gene

No data available for Paralogs for CENPM Gene

Variants for CENPM Gene

Sequence variations from dbSNP and Humsavar for CENPM Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1023497 -- 41,944,504(+) CTCTA(A/C/G)CACTT intron-variant, nc-transcript-variant
rs1023498 -- 41,944,565(+) AATAA(C/T)ACCTA intron-variant, nc-transcript-variant
rs1023499 -- 41,944,578(+) TCCAA(C/T)AGGAA intron-variant, nc-transcript-variant
rs1023500 -- 41,944,840(+) CCAAG(C/T)AATGG intron-variant, nc-transcript-variant
rs1047997 -- 41,938,949(-) AGCCC(C/G)CCGTG utr-variant-3-prime, downstream-variant-500B, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPM Gene

Variant ID Type Subtype PubMed ID
nsv508736 CNV Insertion 20534489
dgv4979n71 CNV Loss 21882294
esv2543828 CNV Insertion 19546169
esv1711771 CNV Insertion 17803354

Relevant External Links for CENPM Gene

HapMap Linkage Disequilibrium report

Disorders for CENPM Gene

Relevant External Links for CENPM

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CENPM: view

No data available for UniProtKB/Swiss-Prot for CENPM Gene

Publications for CENPM Gene

  1. The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. (PMID: 16391015) Brickner A.G. … Warren E.H. (Blood 2006) 3 4 23
  2. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4
  3. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3
  4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H. … Yoda K. (Genes Cells 2006) 3 4
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for CENPM Gene

Sources for CENPM Gene

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