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Aliases for USP7 Gene

Aliases for USP7 Gene

  • Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) 2 3
  • HAUSP 3 4 6
  • Ubiquitin Specific Protease 7 (Herpes Virus-Associated) 2 3
  • Herpesvirus-Associated Ubiquitin-Specific Protease 3 4
  • Ubiquitin-Specific-Processing Protease 7 3 4
  • Deubiquitinating Enzyme 7 3 4
  • Ubiquitin Thioesterase 7 3 4
  • Herpes Virus-Associated Ubiquitin-Specific Protease 3
  • Ubiquitin Carboxyl-Terminal Hydrolase 7 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • TEF1 3

External Ids for USP7 Gene

Previous HGNC Symbols for USP7 Gene

  • HAUSP

Previous GeneCards Identifiers for USP7 Gene

  • GC16M008792
  • GC16M009087
  • GC16M008953
  • GC16M008954
  • GC16M008894
  • GC16M008985
  • GC16M008907

Summaries for USP7 Gene

GeneCards Summary for USP7 Gene

USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated)) is a Protein Coding gene. Diseases associated with USP7 include uv-sensitive syndrome. Among its related pathways are Epstein-Barr virus infection and Protein Stability. GO annotations related to this gene include transcription factor binding and ubiquitin protein ligase binding. An important paralog of this gene is USP41.

UniProtKB/Swiss-Prot for USP7 Gene

  • Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards Lys-48-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).

Tocris Summary for USP7 Gene

  • Deubiquitinating enzymes (DUBs) are a group of proteases that catalyze the cleavage of protein-ubiquitin bonds. By removing these modifications, DUBs counteract the activity of ubiquitin ligases, which add ubiquitin molecules to target proteins

Gene Wiki entry for USP7 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP7 Gene

Genomics for USP7 Gene

Regulatory Elements for USP7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP7 Gene

Start:
8,892,094 bp from pter
End:
8,964,514 bp from pter
Size:
72,421 bases
Orientation:
Minus strand

Genomic View for USP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP7 Gene

Proteins for USP7 Gene

  • Protein details for USP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93009-UBP7_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 7
    Protein Accession:
    Q93009
    Secondary Accessions:
    • A6NMY8
    • B7Z815
    • H0Y3G8

    Protein attributes for USP7 Gene

    Size:
    1102 amino acids
    Molecular mass:
    128302 Da
    Quaternary structure:
    • Monomer. Homodimer. Part of a complex with DAXX, MDM2, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts with MDM2; the interaction is independent of p53/TP53. Interacts with DAXX; the interaction is direct and independent of MDM2 and p53/TP53. Interacts with FOXO4; the interaction is enhanced in presence of hydrogen peroxide and occurs independently of p53/TP53. Interacts with p53/TP53; the interaction is enhanced in response to DNA damage; the interaction is impaired by TSPYL5. Interacts with PTEN; the interaction is direct. Interacts with UBXN6. Interacts with ATXN1 and the strength of interaction is influenced by the length of the poly-Gln region in ATXN1. A weaker interaction seen with mutants having longer poly-Gln regions. Interacts with KIAA1530/UVSSA. Isoform 1 and isoform 2 interact with herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110. Interacts with Epstein-Barr virus EBNA1. EBNA1 shows a 10-fold higher affinity than p53/TP53 and can compete with it for USP7 binding. Binding to ICP0/VMW110 may modulate the substrate specificity or activity of USP7 to stabilize viral proteins. Interacts with MEX3C and antagonizes its ability to degrade mRNA. Interacts with DNMT1 and UHRF1. Interacts with FOXP3. Interacts (via MATH domain) with RNF220 (PubMed:25266658).

    Three dimensional structures from OCA and Proteopedia for USP7 Gene

    Alternative splice isoforms for USP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP7 Gene

Proteomics data for USP7 Gene at MOPED

Post-translational modifications for USP7 Gene

  • Isoform 1 and isoform 2: Not sumoylated
  • Isoform 1 and isoform 2: Polyubiquitinated by herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110; leading to its subsequent proteasomal degradation. Isoform 1: Ubiquitinated at Lys-869.
  • Isoform 1: Phosphorylated. Isoform 1 is phosphorylated at positions Ser-18 and Ser-963. Isoform 2: Not phosphorylated.
  • Isoform 1: Polyneddylated. Isoform 2: Not Polyneddylated
  • Ubiquitination at Lys98, Lys148, Lys335, Lys420, Lys476, Lys479, Lys490, Lys523, Lys824, Lys841, Lys882, Lys934, Lys1033, and Lys1096
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for USP7 (USP7)

Domains for USP7 Gene

Gene Families for USP7 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

Graphical View of Domain Structure for InterPro Entry

Q93009

UniProtKB/Swiss-Prot:

UBP7_HUMAN :
  • Q93009
Domain:
  • The C-terminus plays a role in its oligomerization.
  • Contains 1 MATH domain.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP7: view

Function for USP7 Gene

Molecular function for USP7 Gene

GENATLAS Biochemistry: ubiquitin-specific protease 7,cellular,135kDa,transitory component of discrete nuclear structures (ND10),binding herpes virus type 1 immediate early protein Vmw 110,stimulating viral gene expression,deubiquitin enzyme family
UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Active from pH 7.0 to 9.5. {ECO:0000269 PubMed:14506283};
UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by N-ethyl-maleimide (NEM) and divalent cations. Tolerates high concentrations of NaCl but is inhibited at concentrations of 195 mM and higher.
UniProtKB/Swiss-Prot Function: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards Lys-48-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).
UniProtKB/Swiss-Prot Induction: Up-regulated in regulatory T-cells (Treg).

Enzyme Numbers (IUBMB) for USP7 Gene

Gene Ontology (GO) - Molecular Function for USP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 20096447
GO:0004197 cysteine-type endopeptidase activity IMP 21745816
GO:0004221 ubiquitin thiolesterase activity --
GO:0004843 ubiquitin-specific protease activity IMP 11923872
GO:0005515 protein binding IPI 11279055
genes like me logo Genes that share ontologies with USP7: view
genes like me logo Genes that share phenotypes with USP7: view

Animal Models for USP7 Gene

MGI Knock Outs for USP7:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for USP7 Gene

Localization for USP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP7 Gene

Nucleus. Cytoplasm. Nucleus, PML body. Note=Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP7 Gene COMPARTMENTS Subcellular localization image for USP7 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for USP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11279055
GO:0005737 cytoplasm --
GO:0005829 cytosol IDA 11279055
GO:0016604 nuclear body IDA 16791210
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with USP7: view

Pathways for USP7 Gene

genes like me logo Genes that share pathways with USP7: view

Pathways by source for USP7 Gene

1 Qiagen pathway for USP7 Gene
1 Cell Signaling Technology pathway for USP7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for USP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006283 transcription-coupled nucleotide-excision repair IMP 22466612
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0007275 multicellular organismal development IEA --
GO:0010216 maintenance of DNA methylation IMP 21745816
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with USP7: view

Compounds for USP7 Gene

(5) Tocris Compounds for USP7 Gene

Compound Action Cas Number
HBX 41108 Selective USP7 inhibitor [924296-39-9]
IU1 USP14 inhibitor [314245-33-5]
NSC 687852 Inhibitor of UCHL5 and USP14 [1009817-63-3]
P 22077 USP7 inhibitor [1247819-59-5]
Spautin 1 USP10 and USP13 inhibitor; inhibits autophagy [1262888-28-7]

(9) ApexBio Compounds for USP7 Gene

Compound Action Cas Number
IU1 potent and selective small-molecule inhibitor of Usp14 [314245-33-5]
LDN 57444 Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity [668467-91-2]
NSC 632839 hydrochloride Inhibitor of ubiquitin isopeptidase activity [157654-67-6]
P 22077 Inhibitor of ubiquitin-specific protease (USP) 7. [1247819-59-5]
P005091 Ubiquitin-specific protease 7 (USP7) inhibitor [882257-11-6]
PR-619 Cell-permeable, non selective, reversible deubiquitinases/deubiquitylases (DUBs) inhibitor [2645-32-1]
SJB2-043 novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. [63388-44-3]
Vialinin A Inhibitor of USP4, USP5/isopeptidase T (IsoT) and UCH-L1 DUB activity [858134-23-3]
WP1130 Cell permeable deubiquitinase (DUB) inhibitor [856243-80-6]

(1) HMDB Compounds for USP7 Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with USP7: view

Transcripts for USP7 Gene

Unigene Clusters for USP7 Gene

Ubiquitin specific peptidase 7 (herpes virus-associated):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for USP7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a ·
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c · 25d ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34a · 34b
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8: -
SP9: -
SP10: - -

Relevant External Links for USP7 Gene

GeneLoc Exon Structure for
USP7
ECgene alternative splicing isoforms for
USP7

Expression for USP7 Gene

mRNA expression in normal human tissues for USP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP7 Gene

SOURCE GeneReport for Unigene cluster for USP7 Gene Hs.386939

mRNA Expression by UniProt/SwissProt for USP7 Gene

Q93009-UBP7_HUMAN
Tissue specificity: Widely expressed. Overexpressed in prostate cancer.
genes like me logo Genes that share expressions with USP7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for USP7 Gene

Orthologs for USP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP7 35
  • 99.76 (n)
  • 99.91 (a)
USP7 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP7 35
  • 90.65 (n)
  • 99.07 (a)
USP7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP7 35
  • 91.58 (n)
  • 99.17 (a)
USP7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp7 35
  • 92.56 (n)
  • 99.18 (a)
Usp7 16
Usp7 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP7 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP7 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp7 35
  • 91.77 (n)
  • 99.09 (a)
chicken
(Gallus gallus)
Aves USP7 35
  • 85.95 (n)
  • 96 (a)
USP7 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP7 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29048 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.80 35
usp7 35
  • 82.49 (n)
  • 95.55 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17905 35
usp7 35
  • 79.53 (n)
  • 94.01 (a)
usp7 36
  • 93 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008530 35
  • 53.6 (n)
  • 52.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Usp7 35
  • 55.02 (n)
  • 50.91 (a)
Usp7 36
  • 48 (a)
OneToOne
Ubp64E 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea math-33 35
  • 48.03 (n)
  • 38.45 (a)
math-33 36
  • 31 (a)
OneToOne
H19N07.2b 37
  • 33 (a)
H19N07.2a 37
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL357W 35
  • 48.07 (n)
  • 37.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP15 35
  • 48.83 (n)
  • 36.62 (a)
UBP15 36
  • 26 (a)
OneToMany
UBP15 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP13 35
  • 49.25 (n)
  • 39.08 (a)
rice
(Oryza sativa)
Liliopsida Os.2185 35
Os12g0489100 35
  • 54.09 (n)
  • 48.04 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03797 35
  • 47.75 (n)
  • 38.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp15 35
  • 47.77 (n)
  • 37.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4025 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for USP7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP7 Gene

ENSEMBL:
Gene Tree for USP7 (if available)
TreeFam:
Gene Tree for USP7 (if available)

Paralogs for USP7 Gene

Paralogs for USP7 Gene

Pseudogenes.org Pseudogenes for USP7 Gene

genes like me logo Genes that share paralogs with USP7: view

Variants for USP7 Gene

Sequence variations from dbSNP and Humsavar for USP7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11801 -- 8,896,382(-) AATCT(A/G)TTACC intron-variant
rs30761 -- 8,921,395(+) TTATG(A/T)TTTCA intron-variant
rs30762 -- 8,922,359(+) GGCAC(A/T)CGCCT intron-variant
rs30763 -- 8,922,767(+) ATATA(C/T)ATGAA intron-variant
rs30764 -- 8,954,495(-) ATCCT(A/G)AAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP7 Gene

Variant ID Type Subtype PubMed ID
nsv457394 CNV Gain 19166990
dgv2598n71 CNV Gain 21882294
nsv905311 CNV Gain 21882294
esv27013 CNV Gain 19812545
nsv833135 CNV Loss 17160897
esv2665907 CNV Deletion 23128226
nsv457399 CNV Loss 19166990
esv26318 CNV Loss 19812545
nsv827548 CNV Gain 20364138
esv987802 CNV Insertion 20482838
esv1715688 CNV Insertion 17803354
dgv2600n71 CNV Gain 21882294
nsv905324 CNV Gain 21882294
nsv827549 CNV Gain 20364138

Relevant External Links for USP7 Gene

HapMap Linkage Disequilibrium report
USP7
Human Gene Mutation Database (HGMD)
USP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP7 Gene

Disorders for USP7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for USP7 Gene including...

Search for USP7 Gene in MalaCards »

(8) Novoseek inferred disease relationships for USP7 Gene

Disease -log(P) Hits PubMed IDs
tumors 23.9 13
nsclc 13.9 3
solid tumor 13.8 1
herpes simplex 12.5 1
cancer 7.09 2

Relevant External Links for USP7

Genetic Association Database (GAD)
USP7
Human Genome Epidemiology (HuGE) Navigator
USP7
genes like me logo Genes that share disorders with USP7: view

No data available for UniProtKB/Swiss-Prot for USP7 Gene

Publications for USP7 Gene

  1. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. (PMID: 11923872) Li M. … Gu W. (Nature 2002) 3 4 23
  2. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. (PMID: 12507430) Hu M. … Shi Y. (Cell 2002) 3 4 23
  3. Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. (PMID: 14506283) Holowaty M.N. … Frappier L. (J. Biol. Chem. 2003) 3 4 23
  4. A dynamic role of HAUSP in the p53-Mdm2 pathway. (PMID: 15053880) Li M. … Gu W. (Mol. Cell 2004) 3 4 23
  5. Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. (PMID: 16402859) Hu M. … Shi Y. (PLoS Biol. 2006) 3 4 23

Products for USP7 Gene

  • Addgene plasmids for USP7

Sources for USP7 Gene

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