Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BTG2 Gene

Aliases for BTG2 Gene

  • BTG Family, Member 2 2 3
  • NGF-Inducible Anti-Proliferative Protein PC3 2 3 4
  • PC3 3 4 6
  • Nerve Growth Factor-Inducible Anti-Proliferative 2 3
  • B-Cell Translocation Gene 2 2 3
  • Pheochromacytoma Cell-3 2 3
  • BTG Family Member 2 4
  • Protein BTG2 3
  • TIS21 3

External Ids for BTG2 Gene

Summaries for BTG2 Gene

Entrez Gene Summary for BTG2 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTG2 Gene

BTG2 (BTG Family, Member 2) is a Protein Coding gene. Among its related pathways are Spinal Cord Injury and Direct p53 effectors. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot for BTG2 Gene

  • Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.

Gene Wiki entry for BTG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG2 Gene

Genomics for BTG2 Gene

Genomic Location for BTG2 Gene

Start:
203,305,491 bp from pter
End:
203,309,602 bp from pter
Size:
4,112 bases
Orientation:
Plus strand

Genomic View for BTG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG2 Gene

Regulatory Elements for BTG2 Gene

Proteins for BTG2 Gene

  • Protein details for BTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78543-BTG2_HUMAN
    Recommended name:
    Protein BTG2
    Protein Accession:
    P78543
    Secondary Accessions:
    • A0A024R986
    • Q3KR25
    • Q5VUT0

    Protein attributes for BTG2 Gene

    Size:
    158 amino acids
    Molecular mass:
    17416 Da
    Quaternary structure:
    • Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an asscociation with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.

    Three dimensional structures from OCA and Proteopedia for BTG2 Gene

neXtProt entry for BTG2 Gene

Proteomics data for BTG2 Gene at MOPED

Post-translational modifications for BTG2 Gene

  • Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTG2 Gene

Domains for BTG2 Gene

Protein Domains for BTG2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

BTG2_HUMAN
Family:
  • Belongs to the BTG family.:
    • P78543
genes like me logo Genes that share domains with BTG2: view

No data available for Gene Families for BTG2 Gene

Function for BTG2 Gene

Molecular function for BTG2 Gene

GENATLAS Biochemistry: B cell transition gene 2,preferentially expressed in quiescent cells,antiproliferative p53 dependent component of the DNA damage cellular response pathway,homolog to murine Pc3/Tis21 and human BTG1 (see symbol),at the onset of neurogenesis in single neuroepithelial cells that switch from proliferative to neuron-generating division,Tob/BTG1 family
UniProtKB/Swiss-Prot Function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.

Gene Ontology (GO) - Molecular Function for BTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0005515 protein binding IPI 11136725
genes like me logo Genes that share ontologies with BTG2: view

Phenotypes for BTG2 Gene

genes like me logo Genes that share phenotypes with BTG2: view

Animal Models for BTG2 Gene

MGI Knock Outs for BTG2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BTG2 Gene

Localization for BTG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTG2 Gene COMPARTMENTS Subcellular localization image for BTG2 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BTG2: view

Pathways for BTG2 Gene

genes like me logo Genes that share pathways with BTG2: view

Pathways by source for BTG2 Gene

1 Qiagen pathway for BTG2 Gene
2 BioSystems pathways for BTG2 Gene
1 KEGG pathway for BTG2 Gene

Gene Ontology (GO) - Biological Process for BTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS 8944033
GO:0006351 transcription, DNA-templated IEA --
GO:0006479 protein methylation IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 8944033
GO:0008285 negative regulation of cell proliferation IMP 23236473
genes like me logo Genes that share ontologies with BTG2: view

Compounds for BTG2 Gene

(2) Novoseek inferred chemical compound relationships for BTG2 Gene

Compound -log(P) Hits PubMed IDs
estrogen 16.6 6
oligonucleotide 0 1
genes like me logo Genes that share compounds with BTG2: view

Transcripts for BTG2 Gene

mRNA/cDNA for BTG2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(470) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTG2 Gene

BTG family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTG2 Gene

No ASD Table

Relevant External Links for BTG2 Gene

GeneLoc Exon Structure for
BTG2
ECgene alternative splicing isoforms for
BTG2

Expression for BTG2 Gene

mRNA expression in normal human tissues for BTG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTG2 Gene

This gene is overexpressed in Fallopian Tube (4.2).

SOURCE GeneReport for Unigene cluster for BTG2 Gene Hs.519162

genes like me logo Genes that share expressions with BTG2: view

Orthologs for BTG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTG2 36
  • 99.79 (n)
  • 100 (a)
BTG2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BTG2 36
  • 88.67 (n)
  • 91.33 (a)
BTG2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTG2 36
  • 90.72 (n)
  • 90.51 (a)
BTG2 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btg2 36
  • 89.87 (n)
  • 93.67 (a)
Btg2 16
Btg2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTG2 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btg2 36
  • 89.66 (n)
  • 92.41 (a)
chicken
(Gallus gallus)
Aves BTG2 36
  • 80.38 (n)
  • 82.28 (a)
BTG2 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTG2 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btg2 36
  • 61.45 (n)
  • 65.31 (a)
MGC75753 36
zebrafish
(Danio rerio)
Actinopterygii btg2 36
  • 65.19 (n)
  • 61.39 (a)
btg2 37
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tob 37
  • 10 (a)
OneToMany
Species with no ortholog for BTG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG2 Gene

ENSEMBL:
Gene Tree for BTG2 (if available)
TreeFam:
Gene Tree for BTG2 (if available)

Paralogs for BTG2 Gene

Paralogs for BTG2 Gene

Selected SIMAP similar genes for BTG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BTG2: view

Variants for BTG2 Gene

Sequence variations from dbSNP and Humsavar for BTG2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1130691 -- 203,309,486(+) CTATT(C/T)TGACA utr-variant-3-prime
rs1804734 -- 203,309,478(+) TTTGT(A/G)AGCTA utr-variant-3-prime
rs1804735 -- 203,309,343(+) CCTCA(C/T)GGTCT utr-variant-3-prime
rs1804736 -- 203,309,264(+) TTGAA(A/G)CAAAG utr-variant-3-prime
rs1804737 -- 203,309,347(+) ATGGT(A/C)TCATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BTG2 Gene

Variant ID Type Subtype PubMed ID
esv2721696 CNV Deletion 23290073

Relevant External Links for BTG2 Gene

HapMap Linkage Disequilibrium report
BTG2

Disorders for BTG2 Gene

(9) Novoseek inferred disease relationships for BTG2 Gene

Disease -log(P) Hits PubMed IDs
hyperalgesia 34.4 2
breast carcinoma 28.6 3
tumors 11.6 16
atrophy 0 1
cancer lung 0 1

Relevant External Links for BTG2

Genetic Association Database (GAD)
BTG2
genes like me logo Genes that share disorders with BTG2: view

No data available for UniProtKB/Swiss-Prot for BTG2 Gene

Publications for BTG2 Gene

  1. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. (PMID: 8944033) Rouault J.-P. … Puisieux A. (Nat. Genet. 1996) 2 3 4 23
  2. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PMID: 11136725) Prevot D. … Corbo L. (J. Biol. Chem. 2001) 3 4 23
  3. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. (PMID: 12771185) Morel A.-P. … Corbo L. (J. Cell Sci. 2003) 3 4 23
  4. The BTG2 protein is a general activator of mRNA deadenylation. (PMID: 18337750) Mauxion F. … Seraphin B. (EMBO J. 2008) 3 4 23
  5. Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity. (PMID: 18974182) Yang X. … Rao Z. (Nucleic Acids Res. 2008) 3 4 23

Products for BTG2 Gene

Sources for BTG2 Gene

Back to Top

Content