Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF202 Gene

Aliases for ZNF202 Gene

  • Zinc Finger Protein 202 2 3
  • Zinc Finger Protein With KRAB And SCAN Domains 10 3 4
  • ZKSCAN10 3 4
  • ZSCAN42 3

External Ids for ZNF202 Gene

Previous GeneCards Identifiers for ZNF202 Gene

  • GC11M125595
  • GC11M125107
  • GC11M123628
  • GC11M123132
  • GC11M123099
  • GC11M123594
  • GC11M119536

Summaries for ZNF202 Gene

GeneCards Summary for ZNF202 Gene

ZNF202 (Zinc Finger Protein 202) is a Protein Coding gene. Diseases associated with ZNF202 include ischemic heart disease. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZNF496.

UniProtKB/Swiss-Prot for ZNF202 Gene

  • Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease

Gene Wiki entry for ZNF202 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF202 Gene

Genomics for ZNF202 Gene

Regulatory Elements for ZNF202 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF202 Gene

Start:
123,724,177 bp from pter
End:
123,741,675 bp from pter
Size:
17,499 bases
Orientation:
Minus strand

Genomic View for ZNF202 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF202 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF202 Gene

Proteins for ZNF202 Gene

  • Protein details for ZNF202 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95125-ZN202_HUMAN
    Recommended name:
    Zinc finger protein 202
    Protein Accession:
    O95125
    Secondary Accessions:
    • B0LPH9
    • Q4JG21
    • Q9H1B9
    • Q9NSM4

    Protein attributes for ZNF202 Gene

    Size:
    648 amino acids
    Molecular mass:
    74720 Da
    Quaternary structure:
    • Interacts with SDP1

    Alternative splice isoforms for ZNF202 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF202 Gene

Proteomics data for ZNF202 Gene at MOPED

Post-translational modifications for ZNF202 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF202 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF202 Gene

Domains for ZNF202 Gene

Gene Families for ZNF202 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF202 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95125

UniProtKB/Swiss-Prot:

ZN202_HUMAN :
  • O95125
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF202: view

Function for ZNF202 Gene

Molecular function for ZNF202 Gene

GENATLAS Biochemistry:
zinc finger protein C2H2 type,specifically expressed in testis with two alternatively spliced isoforms alpha and beta
UniProtKB/Swiss-Prot Function:
Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease

Gene Ontology (GO) - Molecular Function for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10748193
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF202: view

Phenotypes for ZNF202 Gene

MGI mutant phenotypes for ZNF202:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ZNF202: view

Animal Models for ZNF202 Gene

MGI Knock Outs for ZNF202:

Animal Model Products

CRISPR Products

miRNA for ZNF202 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF202

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZNF202 Gene

Localization for ZNF202 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF202 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF202 Gene COMPARTMENTS Subcellular localization image for ZNF202 gene
Compartment Confidence
nucleus 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ZNF202: view

Pathways for ZNF202 Gene

SuperPathways for ZNF202 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF202: view

Pathways by source for ZNF202 Gene

2 Reactome pathways for ZNF202 Gene

Gene Ontology (GO) - Biological Process for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 10748193
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 10748193
GO:0006629 lipid metabolic process TAS 10748193
genes like me logo Genes that share ontologies with ZNF202: view

Compounds for ZNF202 Gene

(5) Novoseek inferred chemical compound relationships for ZNF202 Gene

Compound -log(P) Hits PubMed IDs
zinc 58 8
lipid 40.1 5
retinoic acid 38.4 1
cholesterol 34.4 2
atp 20 3
genes like me logo Genes that share compounds with ZNF202: view

Transcripts for ZNF202 Gene

Unigene Clusters for ZNF202 Gene

Zinc finger protein 202:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF202

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF202 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - -
SP8: - - - - -
SP9:

Relevant External Links for ZNF202 Gene

GeneLoc Exon Structure for
ZNF202
ECgene alternative splicing isoforms for
ZNF202

Expression for ZNF202 Gene

mRNA expression in normal human tissues for ZNF202 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF202 Gene

SOURCE GeneReport for Unigene cluster for ZNF202 Gene Hs.112556

mRNA Expression by UniProt/SwissProt for ZNF202 Gene

O95125-ZN202_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in breast carcinoma cell lines
genes like me logo Genes that share expressions with ZNF202: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Expression partners for ZNF202 Gene

Orthologs for ZNF202 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF202 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF202 35
  • 85.39 (n)
  • 87.96 (a)
ZNF202 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF202 35
  • 89.04 (n)
  • 90.12 (a)
ZNF202 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp202 35
  • 81.59 (n)
  • 79.81 (a)
Zfp202 16
Zfp202 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF202 35
  • 99.18 (n)
  • 99.23 (a)
ZNF202 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp202 35
  • 81.74 (n)
  • 80.13 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF202 36
  • 73 (a)
OneToOne
Species with no ortholog for ZNF202:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF202 Gene

ENSEMBL:
Gene Tree for ZNF202 (if available)
TreeFam:
Gene Tree for ZNF202 (if available)

Paralogs for ZNF202 Gene

Paralogs for ZNF202 Gene

genes like me logo Genes that share paralogs with ZNF202: view

Variants for ZNF202 Gene

Sequence variations from dbSNP and Humsavar for ZNF202 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10904 -- 123,725,347(-) CCAGC(A/G)TCAAA utr-variant-3-prime
rs546218 -- 123,728,897(+) CATTT(G/T)GTTAG intron-variant
rs663471 -- 123,728,807(-) AAATT(G/T)GATAG intron-variant
rs663487 -- 123,728,796(-) TCATT(G/T)GTAAG intron-variant
rs671898 -- 123,729,078(-) GAACC(A/C)CTGGG intron-variant

Relevant External Links for ZNF202 Gene

HapMap Linkage Disequilibrium report
ZNF202
Human Gene Mutation Database (HGMD)
ZNF202

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF202 Gene

Disorders for ZNF202 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ZNF202 Gene in MalaCards »

(1) Diseases for ZNF202 Gene including...

Relevant External Links for ZNF202

Genetic Association Database (GAD)
ZNF202
Human Genome Epidemiology (HuGE) Navigator
ZNF202
genes like me logo Genes that share disorders with ZNF202: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF202 Gene

Publications for ZNF202 Gene

  1. Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study. (PMID: 16289551) Stene M.C. … Tybjaerg-Hansen A. (Atherosclerosis 2006) 3 23 48
  2. Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population. (PMID: 16467280) Stene M.C. … Tybjaerg-Hansen A. (J. Lipid Res. 2006) 3 23 48
  3. Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease. (PMID: 18652945) Stene M.C. … Tybjaerg-Hansen A. (J. Am. Coll. Cardiol. 2008) 3 23 48
  4. Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins. (PMID: 9790754) Monaco C. … Negrini M. (Genomics 1998) 2 3 4
  5. A broad role for the zinc finger protein ZNF202 in human lipid metabolism. (PMID: 10748193) Wagner S. … Bowen B.R. (J. Biol. Chem. 2000) 3 4 23

Products for ZNF202 Gene

Sources for ZNF202 Gene

Back to Top

Content