Aliases for CA12 Gene
External Ids for CA12 Gene
Previous GeneCards Identifiers for CA12 Gene
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]
GeneCards Summary for CA12 Gene
CA12 (Carbonic Anhydrase XII) is a Protein Coding gene. Diseases associated with CA12 include hyperchlorhidrosis, isolated and vulva squamous cell carcinoma. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.
UniProtKB/Swiss-Prot for CA12 Gene
Reversible hydration of carbon dioxide
Carbonic anhydrases (EC 22.214.171.124) are zinc-containing enzymes belonging to the lyases family, and are primarily responsible for catalyzing the reversible hydration of carbon dioxide to form bicarbonate (HCO3-) and hydrogen (H+) ions.