Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF146 Gene

Aliases for ZNF146 Gene

  • Zinc Finger Protein 146 2 3 4
  • OZF 3 4 6
  • Only Zinc Finger Protein 3 4
  • Zinc Finger Protein OZF 3

External Ids for ZNF146 Gene

Summaries for ZNF146 Gene

GeneCards Summary for ZNF146 Gene

ZNF146 (Zinc Finger Protein 146) is a Protein Coding gene. GO annotations related to this gene include heparin binding. An important paralog of this gene is ZNF260.

Gene Wiki entry for ZNF146 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF146 Gene

Genomics for ZNF146 Gene

Genomic Location for ZNF146 Gene

Start:
36,214,602 bp from pter
End:
36,238,774 bp from pter
Size:
24,173 bases
Orientation:
Plus strand

Genomic View for ZNF146 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF146 Gene

Regulatory Elements for ZNF146 Gene

Proteins for ZNF146 Gene

  • Protein details for ZNF146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15072-OZF_HUMAN
    Recommended name:
    Zinc finger protein OZF
    Protein Accession:
    Q15072
    Secondary Accessions:
    • Q2TB94

    Protein attributes for ZNF146 Gene

    Size:
    292 amino acids
    Molecular mass:
    33308 Da
    Quaternary structure:
    • Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.

neXtProt entry for ZNF146 Gene

Proteomics data for ZNF146 Gene at MOPED

Post-translational modifications for ZNF146 Gene

Other Protein References for ZNF146 Gene

No data available for DME Specific Peptides for ZNF146 Gene

Domains for ZNF146 Gene

Gene Families for ZNF146 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF146 Gene

UniProtKB/Swiss-Prot:

OZF_HUMAN
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q15072
Similarity:
  • Contains 10 C2H2-type zinc fingers.:
    • Q15072
genes like me logo Genes that share domains with ZNF146: view

Function for ZNF146 Gene

Molecular function for ZNF146 Gene

GENATLAS Biochemistry: only zinc finger protein 145,(C2H2 type),Kruppel-like,expressed in liver,skeletal muscle,mammary cells,amplified or overexpressed in pancreatic carcinoma and contributing to the progression of tumour

Gene Ontology (GO) - Molecular Function for ZNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0008201 heparin binding TAS 8665923
GO:0008270 zinc ion binding TAS 8665923
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF146: view

Phenotypes for ZNF146 Gene

GenomeRNAi human phenotypes for ZNF146:
genes like me logo Genes that share phenotypes with ZNF146: view

miRNA for ZNF146 Gene

miRTarBase miRNAs that target ZNF146

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF146 Gene

Localization for ZNF146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF146 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF146 Gene COMPARTMENTS Subcellular localization image for ZNF146 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8665923
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF146: view

Pathways for ZNF146 Gene

SuperPathways for ZNF146 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF146: view

No data available for Pathways by source for ZNF146 Gene

Compounds for ZNF146 Gene

(1) HMDB Compounds for ZNF146 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6
genes like me logo Genes that share compounds with ZNF146: view

Transcripts for ZNF146 Gene

Unigene Clusters for ZNF146 Gene

Zinc finger protein 146:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF146 Gene

No ASD Table

Relevant External Links for ZNF146 Gene

GeneLoc Exon Structure for
ZNF146
ECgene alternative splicing isoforms for
ZNF146

Expression for ZNF146 Gene

mRNA expression in normal human tissues for ZNF146 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF146 Gene

SOURCE GeneReport for Unigene cluster for ZNF146 Gene Hs.643436

mRNA Expression by UniProt/SwissProt for ZNF146 Gene

Q15072-OZF_HUMAN
Tissue specificity: Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.
genes like me logo Genes that share expressions with ZNF146: view

Orthologs for ZNF146 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF146 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF146 36
  • 99.66 (n)
  • 100 (a)
ZNF146 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 98 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
ZNF146 36
  • 93.15 (n)
  • 97.95 (a)
dog
(Canis familiaris)
Mammalia ZNF146 36
  • 93.49 (n)
  • 98.97 (a)
ZNF146 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp146 36
  • 85.73 (n)
  • 95.55 (a)
Zfp146 16
Zfp146 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 45 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102555183 36
  • 87.56 (n)
  • 96.92 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF146 37
  • 29 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11398 37
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F35H8.3 38
  • 35 (a)
Species with no ortholog for ZNF146:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF146 Gene

ENSEMBL:
Gene Tree for ZNF146 (if available)
TreeFam:
Gene Tree for ZNF146 (if available)

Paralogs for ZNF146 Gene

Paralogs for ZNF146 Gene

Selected SIMAP similar genes for ZNF146 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF146 Gene

genes like me logo Genes that share paralogs with ZNF146: view

Variants for ZNF146 Gene

Sequence variations from dbSNP and Humsavar for ZNF146 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2070132 - 36,236,463(+) GCAGA(A/G)AATTT missense, reference
rs2310856 -- 36,227,059(-) GTTGC(C/T)CAGGC intron-variant
rs2432041 -- 36,218,949(+) GACTA(C/T)GGGCG intron-variant
rs2432042 -- 36,218,990(+) TTTTT(A/C)GTAGA intron-variant
rs2432043 -- 36,221,381(+) cctcc(C/T)gggtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF146 Gene

Variant ID Type Subtype PubMed ID
nsv509739 CNV Insertion 20534489
nsv520020 CNV Loss 19592680

Relevant External Links for ZNF146 Gene

HapMap Linkage Disequilibrium report
ZNF146

Disorders for ZNF146 Gene

Relevant External Links for ZNF146

Genetic Association Database (GAD)
ZNF146
genes like me logo Genes that share disorders with ZNF146: view

No data available for UniProtKB/Swiss-Prot for ZNF146 Gene

Publications for ZNF146 Gene

  1. Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains. (PMID: 11306801) Pibouin L. … Goubin G. (Cytogenet. Cell Genet. 2001) 3 4 23
  2. Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene. (PMID: 10449921) BlottiA"re L. … Goubin G. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer. (PMID: 12754738) Ferbus D. … Goubin G. (J. Pathol. 2003) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. The OZF gene encodes a protein consisting essentially of zinc finger motifs. (PMID: 8107129) le Chalony C. … Goubin G. (J. Mol. Biol. 1994) 3 4

Products for ZNF146 Gene

  • antibodies-online peptides for ZNF146
  • antibodies-online antibodies for ZNF146
  • antibodies-online kits for ZNF146

Sources for ZNF146 Gene

Back to Top

Content