Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF143 Gene

Aliases for ZNF143 Gene

  • Zinc Finger Protein 143 2 3
  • SBF 3 4 6
  • Selenocysteine TRNA Gene Transcription-Activating Factor 3 4
  • SPH-Binding Factor 3 4
  • HStaf 3 4
  • STAF 3 4
  • Zinc Finger Protein 143 (Clone PHZ-1) 2
  • Transcriptional Activator Staf 3
  • PHZ-1 3

External Ids for ZNF143 Gene

Previous GeneCards Identifiers for ZNF143 Gene

  • GC11P010122
  • GC11P009522
  • GC11P009446
  • GC11P009439
  • GC11P009153

Summaries for ZNF143 Gene

GeneCards Summary for ZNF143 Gene

ZNF143 (Zinc Finger Protein 143) is a Protein Coding gene. Diseases associated with ZNF143 include roberts syndrome. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. An important paralog of this gene is ZIC4.

UniProtKB/Swiss-Prot for ZNF143 Gene

  • Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.

Gene Wiki entry for ZNF143 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF143 Gene

Genomics for ZNF143 Gene

Regulatory Elements for ZNF143 Gene

Genomic Location for ZNF143 Gene

Start:
9,460,319 bp from pter
End:
9,528,524 bp from pter
Size:
68,206 bases
Orientation:
Plus strand

Genomic View for ZNF143 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF143 Gene

Proteins for ZNF143 Gene

  • Protein details for ZNF143 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52747-ZN143_HUMAN
    Recommended name:
    Zinc finger protein 143
    Protein Accession:
    P52747
    Secondary Accessions:
    • A8K518
    • B4DLY5
    • E7ER34
    • O75559
    • Q8WUK9

    Protein attributes for ZNF143 Gene

    Size:
    638 amino acids
    Molecular mass:
    68896 Da
    Quaternary structure:
    • Interacts with CHD8.
    SequenceCaution:
    • Sequence=AAC50266.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH20219.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF83822.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF143 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF143 Gene

Proteomics data for ZNF143 Gene at MOPED

Post-translational modifications for ZNF143 Gene

  • Ubiquitination at Lys375
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF143 Gene

Domains for ZNF143 Gene

Gene Families for ZNF143 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF143 Gene

Suggested Antigen Peptide Sequences for ZNF143 Gene

Graphical View of Domain Structure for InterPro Entry

P52747

UniProtKB/Swiss-Prot:

ZN143_HUMAN :
  • P52747
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF143: view

Function for ZNF143 Gene

Molecular function for ZNF143 Gene

GENATLAS Biochemistry: zinc finger protein 143,GLI-Kruppel family member,homolog of Xenopus laevis STAF transcriptional activator ortholog
UniProtKB/Swiss-Prot Function: Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.

Gene Ontology (GO) - Molecular Function for ZNF143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 17938208
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF143: view

Phenotypes for ZNF143 Gene

MGI mutant phenotypes for ZNF143:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ZNF143: view

miRNA for ZNF143 Gene

miRTarBase miRNAs that target ZNF143
Targeting motifs for ZNF143 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF143
  • Consensus sequence: ATTTCCCAGVAKSCY Submotif: canonical Cell Type: CUTLL GeoId: GSE29600

No data available for Enzyme Numbers (IUBMB) , Animal Models and Transcription Factor Targeting for ZNF143 Gene

Localization for ZNF143 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF143 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF143 Gene COMPARTMENTS Subcellular localization image for ZNF143 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZNF143: view

Pathways for ZNF143 Gene

genes like me logo Genes that share pathways with ZNF143: view

Gene Ontology (GO) - Biological Process for ZNF143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9566884
GO:0006359 regulation of transcription from RNA polymerase III promoter TAS 9566884
GO:0006366 transcription from RNA polymerase II promoter TAS 9009278
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with ZNF143: view

Compounds for ZNF143 Gene

(1) Novoseek inferred chemical compound relationships for ZNF143 Gene

Compound -log(P) Hits PubMed IDs
zinc 55.7 20
genes like me logo Genes that share compounds with ZNF143: view

Transcripts for ZNF143 Gene

Unigene Clusters for ZNF143 Gene

Zinc finger protein 143:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF143 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ZNF143 Gene

GeneLoc Exon Structure for
ZNF143
ECgene alternative splicing isoforms for
ZNF143

Expression for ZNF143 Gene

mRNA expression in normal human tissues for ZNF143 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF143 Gene

SOURCE GeneReport for Unigene cluster for ZNF143 Gene Hs.523471

mRNA Expression by UniProt/SwissProt for ZNF143 Gene

P52747-ZN143_HUMAN
Tissue specificity: Expressed in all tissues tested, with the strongest expression in ovary
genes like me logo Genes that share expressions with ZNF143: view

No data available for mRNA differential expression in normal tissues for ZNF143 Gene

Orthologs for ZNF143 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF143 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF143 35
  • 99.42 (n)
  • 99.53 (a)
ZNF143 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF143 35
  • 93.14 (n)
  • 98.04 (a)
ZNF143 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF143 35
  • 93.5 (n)
  • 99.06 (a)
ZNF143 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp143 35
  • 90.63 (n)
  • 97.02 (a)
Zfp143 16
Zfp143 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF143 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF143 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp143 35
  • 90.4 (n)
  • 96.48 (a)
chicken
(Gallus gallus)
Aves ZNF143 35
  • 82.26 (n)
  • 93.72 (a)
ZNF143 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF143 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23822 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3450 35
znf143 35
  • 73.03 (n)
  • 83.96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13634 35
zebrafish
(Danio rerio)
Actinopterygii wee1 36
  • 74 (a)
OneToMany
zgc66276 35
znf143a 36
  • 64 (a)
OneToMany
znf143b 35
  • 70.1 (n)
  • 74.42 (a)
znf143b 36
  • 71 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for ZNF143:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF143 Gene

ENSEMBL:
Gene Tree for ZNF143 (if available)
TreeFam:
Gene Tree for ZNF143 (if available)

Paralogs for ZNF143 Gene

Paralogs for ZNF143 Gene

genes like me logo Genes that share paralogs with ZNF143: view

Variants for ZNF143 Gene

Sequence variations from dbSNP and Humsavar for ZNF143 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1543 -- 9,492,829(-) TTTAT(A/G)TTTCC intron-variant
rs1546 -- 9,492,814(-) CTTCC(C/T)TATTA intron-variant
rs716238 -- 9,528,783(-) CCATA(C/G)CTGTG downstream-variant-500B
rs716239 -- 9,528,608(-) ATTAG(C/G)TTACA downstream-variant-500B
rs723297 -- 9,493,772(-) AAAAT(A/C/G/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF143 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv7670 CNV Loss 18451855
esv2486941 CNV Deletion 19546169
esv24739 CNV Loss 19812545
esv2675320 CNV Deletion 23128226
nsv7671 CNV Insertion 18451855
nsv512209 CNV Loss 21212237
esv2744093 CNV Deletion 23290073

Relevant External Links for ZNF143 Gene

HapMap Linkage Disequilibrium report
ZNF143

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF143 Gene

Disorders for ZNF143 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZNF143 Gene including...

Search for ZNF143 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ZNF143 Gene

genes like me logo Genes that share disorders with ZNF143: view

No data available for UniProtKB/Swiss-Prot for ZNF143 Gene

Publications for ZNF143 Gene

  1. Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter. (PMID: 9776743) Rincon J.C. … Kunkel G.R. (Nucleic Acids Res. 1998) 3 4 23
  2. CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription. (PMID: 17938208) Yuan C.-C. … Hernandez N. (Mol. Cell. Biol. 2007) 3 4 23
  3. ZNF143 mediates basal and tissue-specific expression of human transaldolase. (PMID: 14702349) Grossman C.E. … Perl A. (J. Biol. Chem. 2004) 3 23
  4. Transcriptional regulation of the human establishment of cohesion 1 homolog 2 gene. (PMID: 20116366) Nishihara M. … Yanagihara I. (Biochem. Biophys. Res. Commun. 2010) 3 23
  5. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 3 4

Products for ZNF143 Gene

  • antibodies-online proteins for ZNF143
  • antibodies-online antibodies for ZNF143
  • antibodies-online kits for ZNF143

Sources for ZNF143 Gene

Back to Top

Content