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Aliases for PRCD Gene

Aliases for PRCD Gene

  • Progressive Rod-Cone Degeneration 2 3
  • RP36 3 6
  • Progressive Rod-Cone Degeneration Protein 3

External Ids for PRCD Gene

Summaries for PRCD Gene

Entrez Gene Summary for PRCD Gene

  • This gene is predominantly expressed in the retina, and mutations in this gene are the cause of autosomal recessive retinal degeneration in both humans and dogs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for PRCD Gene

PRCD (Progressive Rod-Cone Degeneration) is a Protein Coding gene. Diseases associated with PRCD include retinitis pigmentosa 36 and prcd-related retinitis pigmentosa.

UniProtKB/Swiss-Prot for PRCD Gene

  • Involved in vision

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRCD Gene

Genomics for PRCD Gene

Genomic Location for PRCD Gene

Start:
76,527,586 bp from pter
End:
76,553,578 bp from pter
Size:
25,993 bases
Orientation:
Plus strand

Genomic View for PRCD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRCD Gene

Regulatory Elements for PRCD Gene

Proteins for PRCD Gene

  • Protein details for PRCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00LT1-PRCD_HUMAN
    Recommended name:
    Progressive rod-cone degeneration protein
    Protein Accession:
    Q00LT1
    Secondary Accessions:
    • B9EJD4

    Protein attributes for PRCD Gene

    Size:
    54 amino acids
    Molecular mass:
    6007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRCD Gene

Proteomics data for PRCD Gene at MOPED

Post-translational modifications for PRCD Gene

No Post-translational modifications

Other Protein References for PRCD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRCD Gene

Domains for PRCD Gene

Protein Domains for PRCD Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with PRCD: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRCD Gene

Function for PRCD Gene

Molecular function for PRCD Gene

UniProtKB/Swiss-Prot Function: Involved in vision

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRCD Gene

Localization for PRCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRCD Gene

Membrane; Single-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRCD Gene COMPARTMENTS Subcellular localization image for PRCD gene
Compartment Confidence
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PRCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRCD: view

Pathways for PRCD Gene

SuperPathways for PRCD Gene

No Data Available

Interacting Proteins for PRCD Gene

Gene Ontology (GO) - Biological Process for PRCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with PRCD: view

No data available for Pathways by source for PRCD Gene

Transcripts for PRCD Gene

mRNA/cDNA for PRCD Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRCD Gene

Progressive rod-cone degeneration:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRCD Gene

No ASD Table

Relevant External Links for PRCD Gene

GeneLoc Exon Structure for
PRCD
ECgene alternative splicing isoforms for
PRCD

Expression for PRCD Gene

mRNA expression in normal human tissues for PRCD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRCD Gene

This gene is overexpressed in Brain - Cerebellum (4.8) and Brain - Cerebellar Hemisphere (4.4).

SOURCE GeneReport for Unigene cluster for PRCD Gene Hs.634380

genes like me logo Genes that share expressions with PRCD: view

Orthologs for PRCD Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRCD 36
  • 99.38 (n)
  • 98.15 (a)
PRCD 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRCD 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRCD 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm11744 16
Gm11744 37
  • 74 (a)
OneToOne
Species with no ortholog for PRCD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRCD Gene

ENSEMBL:
Gene Tree for PRCD (if available)
TreeFam:
Gene Tree for PRCD (if available)

Paralogs for PRCD Gene

No data available for Paralogs for PRCD Gene

Variants for PRCD Gene

Sequence variations from dbSNP and Humsavar for PRCD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs874264 -- 76,542,770(+) TAGGC(A/G)GATGG intron-variant
rs895156 -- 76,545,801(-) ACAGT(G/T)CAAAC downstream-variant-500B
rs895157 -- 76,544,835(-) TGGCC(G/T)GACAA utr-variant-3-prime, nc-transcript-variant
rs2278639 -- 76,544,410(-) TGAGC(A/G)CCTCC utr-variant-3-prime, nc-transcript-variant
rs2278640 -- 76,543,775(-) AAAGC(G/T)AGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRCD Gene

Variant ID Type Subtype PubMed ID
nsv833549 CNV Gain 17160897
nsv908831 CNV Loss 21882294

Relevant External Links for PRCD Gene

HapMap Linkage Disequilibrium report
PRCD
Human Gene Mutation Database (HGMD)
PRCD

Disorders for PRCD Gene

(1) OMIM Diseases for PRCD Gene (610598)

UniProtKB/Swiss-Prot

PRCD_HUMAN
  • Retinitis pigmentosa 36 (RP36) [MIM:610599]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269 PubMed:16938425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for PRCD Gene

genes like me logo Genes that share disorders with PRCD: view

Publications for PRCD Gene

  1. Identical mutation in a novel retinal gene causes progressive rod- cone degeneration in dogs and retinitis pigmentosa in humans. (PMID: 16938425) Zangerl B. … Aguirre G.D. (Genomics 2006) 2 3 4
  2. Retinitis Pigmentosa Overview (PMID: 20301590) Pagon R.A. … Stephens K. ( 1993) 3
  3. Identification of a prevalent founder mutation in an Israeli Muslim Arab village confirms the role of PRCD in the aetiology of retinitis pigmentosa in humans. (PMID: 20507925) Nevet M.J. … Ben-Yosef T. (J. Med. Genet. 2010) 3
  4. Identification of a novel mutation in the PRCD gene causing autosomal recessive retinitis pigmentosa in a Turkish family. (PMID: 23805042) Pach J. … Zobor D. (Mol. Vis. 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for PRCD Gene

Sources for PRCD Gene

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