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Aliases for ZNF74 Gene

Aliases for ZNF74 Gene

  • Zinc Finger Protein 74 2 3
  • Zinc Finger Protein 520 3 4
  • ZNF520 3 4
  • HZNF7 3 4
  • Zinc Finger Protein 74 (Cos52) 2
  • ZFP520 3
  • COS52 3

External Ids for ZNF74 Gene

Previous GeneCards Identifiers for ZNF74 Gene

  • GC22P017450
  • GC22P019073
  • GC22P020748
  • GC22P004012

Summaries for ZNF74 Gene

GeneCards Summary for ZNF74 Gene

ZNF74 (Zinc Finger Protein 74) is a Protein Coding gene. Diseases associated with ZNF74 include atrioventricular septal defect and tetralogy of fallot. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include RNA binding. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF74 Gene

  • May play a role in RNA metabolism

Gene Wiki entry for ZNF74 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF74 Gene

Genomics for ZNF74 Gene

Regulatory Elements for ZNF74 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF74 Gene

Start:
20,394,115 bp from pter
End:
20,408,463 bp from pter
Size:
14,349 bases
Orientation:
Plus strand

Genomic View for ZNF74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF74 Gene

Proteins for ZNF74 Gene

  • Protein details for ZNF74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16587-ZNF74_HUMAN
    Recommended name:
    Zinc finger protein 74
    Protein Accession:
    Q16587
    Secondary Accessions:
    • B5MCE3
    • B7Z5Y2
    • Q6IBV2
    • Q6PJP1
    • Q9UC04
    • Q9UF05
    • Q9UF06
    • Q9UF07

    Protein attributes for ZNF74 Gene

    Size:
    644 amino acids
    Molecular mass:
    72207 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF21777.1; Type=Frameshift; Positions=164, 173; Evidence={ECO:0000305}; Sequence=AAF21778.1; Type=Frameshift; Positions=164, 173; Evidence={ECO:0000305}; Sequence=AAF21779.1; Type=Frameshift; Positions=164, 173; Evidence={ECO:0000305}; Sequence=AAF21780.1; Type=Frameshift; Positions=164, 173; Evidence={ECO:0000305}; Sequence=CAA50632.1; Type=Frameshift; Positions=164, 173; Evidence={ECO:0000305}; Sequence=CAA63379.1; Type=Frameshift; Positions=164, 173; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF74 Gene

Proteomics data for ZNF74 Gene at MOPED

Post-translational modifications for ZNF74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF74 Gene

Domains for ZNF74 Gene

Gene Families for ZNF74 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16587

UniProtKB/Swiss-Prot:

ZNF74_HUMAN :
  • Q16587
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF74: view

Function for ZNF74 Gene

Molecular function for ZNF74 Gene

GENATLAS Biochemistry: zinc finger protein 74,64kDa (C2H2 type,Kruppel associated box),commonly deleted in DiGeorge syndrome,including ZNF74-1 and ZNF74-2,expressed only in neural crest-derived tissues and neuroepithelium of spinal cord as well as to foregut endoderm epithelia (esophagus,respiratory tract,putatively involved in the DiGeorge
UniProtKB/Swiss-Prot Function: May play a role in RNA metabolism

Gene Ontology (GO) - Molecular Function for ZNF74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0003723 RNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF74: view

Phenotypes for ZNF74 Gene

GenomeRNAi human phenotypes for ZNF74:
genes like me logo Genes that share phenotypes with ZNF74: view

Animal Model Products

CRISPR Products

miRNA for ZNF74 Gene

miRTarBase miRNAs that target ZNF74

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF74 Gene

Localization for ZNF74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF74 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF74 Gene COMPARTMENTS Subcellular localization image for ZNF74 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF74: view

Pathways for ZNF74 Gene

SuperPathways for ZNF74 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF74: view

Pathways by source for ZNF74 Gene

2 Reactome pathways for ZNF74 Gene

Gene Ontology (GO) - Biological Process for ZNF74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007275 multicellular organismal development TAS 1639391
genes like me logo Genes that share ontologies with ZNF74: view

Transcripts for ZNF74 Gene

Unigene Clusters for ZNF74 Gene

Zinc finger protein 74:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF74

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF74 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9:

Relevant External Links for ZNF74 Gene

GeneLoc Exon Structure for
ZNF74
ECgene alternative splicing isoforms for
ZNF74

Expression for ZNF74 Gene

mRNA expression in normal human tissues for ZNF74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF74 Gene

SOURCE GeneReport for Unigene cluster for ZNF74 Gene Hs.517418

mRNA Expression by UniProt/SwissProt for ZNF74 Gene

Q16587-ZNF74_HUMAN
Tissue specificity: Highly expressed in the fetal brain
genes like me logo Genes that share expressions with ZNF74: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF74 Gene

Orthologs for ZNF74 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF74 35
  • 99.79 (n)
  • 99.69 (a)
ZNF74 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF74 35
  • 76.01 (n)
  • 68.58 (a)
ZNF74 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF74 35
  • 81.54 (n)
  • 78.29 (a)
ZNF74 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6654 36
  • 22 (a)
OneToMany
CG9797 37
  • 38 (a)
Species with no ortholog for ZNF74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF74 Gene

ENSEMBL:
Gene Tree for ZNF74 (if available)
TreeFam:
Gene Tree for ZNF74 (if available)

Paralogs for ZNF74 Gene

Selected SIMAP similar genes for ZNF74 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF74: view

Variants for ZNF74 Gene

Sequence variations from dbSNP and Humsavar for ZNF74 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4014 -- 20,407,073(+) GTGTG(G/T)GAGCC utr-variant-3-prime, nc-transcript-variant
rs4020 -- 20,407,094(+) ACCCC(A/C)ATCAG utr-variant-3-prime, nc-transcript-variant
rs361563 -- 20,398,815(-) AAATT(-/T)ACAAC intron-variant
rs361591 -- 20,396,965(+) CCCTA(C/T)CCTAC intron-variant
rs361613 -- 20,398,981(+) tccag(A/T)taact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF74 Gene

Variant ID Type Subtype PubMed ID
nsv518950 CNV Gain 19592680
nsv436867 CNV Insertion 17901297
nsv436864 CNV Insertion 17901297
nsv828952 CNV Gain 20364138
nsv828954 CNV Gain 20364138
nsv914390 CNV Gain 21882294
dgv4867n71 CNV Gain 21882294
nsv914393 CNV Gain 21882294
nsv834135 CNV Gain 17160897
nsv519901 CNV Gain 19592680
nsv834136 CNV Loss 17160897
dgv4868n71 CNV Loss 21882294
nsv509809 CNV Insertion 20534489
nsv523162 CNV Loss 19592680
nsv914395 CNV Loss 21882294
nsv834138 CNV Loss 17160897

Relevant External Links for ZNF74 Gene

HapMap Linkage Disequilibrium report
ZNF74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF74 Gene

Disorders for ZNF74 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ZNF74 Gene including...

Search for ZNF74 Gene in MalaCards »

Relevant External Links for ZNF74

Genetic Association Database (GAD)
ZNF74
Human Genome Epidemiology (HuGE) Navigator
ZNF74
genes like me logo Genes that share disorders with ZNF74: view

No data available for UniProtKB/Swiss-Prot for ZNF74 Gene

Publications for ZNF74 Gene

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M. … Rouleau G.A. (Genomics 1992) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  3. Association of ZNF74 gene genotypes with age-at-onset of schizophrenia. (PMID: 11705709) Takase K. … Arinami T. (Schizophr. Res. 2001) 3 4 48
  4. Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome. (PMID: 8268910) Aubry M. … Rouleau G.A. (Hum. Mol. Genet. 1993) 3 4
  5. The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix. (PMID: 8663113) Grondin B. … Aubry M. (J. Biol. Chem. 1996) 3 4

Products for ZNF74 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF74
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF74
  • Block miRNA regulation of ZNF74 using miScript Target Protectors

Sources for ZNF74 Gene

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