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Aliases for ZNF43 Gene

Aliases for ZNF43 Gene

  • Zinc Finger Protein 43 2 3 5
  • Zinc Finger Protein 39-Like 1 (KOX 27) 2 3
  • Zinc Finger Protein KOX27 3 4
  • Zinc Finger Protein HTF6 3 4
  • ZNF39L1 3 4
  • KOX27 3 4
  • Zinc Finger Protein 43 (HTF6) 2
  • Zinc Finger Protein 39 4
  • ZNF39 4
  • HTF6 3

External Ids for ZNF43 Gene

Previous HGNC Symbols for ZNF43 Gene

  • ZNF39L1

Previous GeneCards Identifiers for ZNF43 Gene

  • GC19M022439
  • GC19M022321
  • GC19M021682
  • GC19M021781
  • GC19M021987
  • GC19M021526
  • GC19M021911

Summaries for ZNF43 Gene

Entrez Gene Summary for ZNF43 Gene

  • This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF43 Gene

ZNF43 (Zinc Finger Protein 43) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF45.

UniProtKB/Swiss-Prot for ZNF43 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF43 Gene

Additional gene information for ZNF43 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF43 Gene

Genomics for ZNF43 Gene

Regulatory Elements for ZNF43 Gene

Enhancers for ZNF43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H021328 1 ENCODE 10.6 +523.0 522956 2 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 YY1 ELK1 ZNF143 ZNF207 LOC105372321 ZNF708 ZNF100 ZNF43 ZNF66 ENSG00000213976 GC19P021323
GH19H021396 1 ENCODE 10.6 +454.8 454804 1 PKNOX1 ATF1 ARID4B DMAP1 YY1 ETS1 ZNF143 ZNF207 FOS ATF7 LOC105372321 ZNF100 RPL7AP10 ZNF431 LOC641367 ZNF43 ZNF66 MTDHP4 ZNF493 ENSG00000269237
GH19H020922 0.9 ENCODE 10.6 +928.7 928698 1 PKNOX1 RB1 ARID4B SIN3A ZBTB40 YY1 SCRT2 ZNF350 ZNF207 FOS ZNF100 ZNF66 ZNF90 RPL7AP10 ZNF431 LOC641367 ZNF43 ZNF486 ENSG00000268416 ZNF85
GH19H021358 0.8 ENCODE 10.6 +492.9 492932 1 TBP PKNOX1 SIN3A ZBTB40 RFX5 ZNF350 ZNF143 FOS SMAD5 NFYA LOC105372321 ZNF708 ZNF100 ZNF738 LOC641367 ZNF43 ZNF66 LOC100422298
GH19H021850 0.9 ENCODE 0.7 +0.4 395 2 HDAC1 TBP PKNOX1 ATF1 ARID4B ZNF76 SIN3A FEZF1 YY1 SCRT2 MTDHP4 ZNF100 VN1R84P ZNF43 GC19P021843
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF43 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF43 Gene

Chromosome:
19
Start:
21,804,949 bp from pter
End:
21,852,125 bp from pter
Size:
47,177 bases
Orientation:
Minus strand

Genomic View for ZNF43 Gene

Genes around ZNF43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF43 Gene

Proteins for ZNF43 Gene

  • Protein details for ZNF43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17038-ZNF43_HUMAN
    Recommended name:
    Zinc finger protein 43
    Protein Accession:
    P17038
    Secondary Accessions:
    • A8K5N8
    • P28160
    • Q53XQ2
    • Q5H9T3
    • Q96DG1

    Protein attributes for ZNF43 Gene

    Size:
    809 amino acids
    Molecular mass:
    94124 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF43 Gene

Post-translational modifications for ZNF43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF43 Gene

Domains & Families for ZNF43 Gene

Gene Families for ZNF43 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF43 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17038

UniProtKB/Swiss-Prot:

ZNF43_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF43: view

Function for ZNF43 Gene

Molecular function for ZNF43 Gene

GENATLAS Biochemistry:
zinc finger protein 43 (HTF6),KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF43 Gene

Gene Ontology (GO) - Molecular Function for ZNF43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF43: view
genes like me logo Genes that share phenotypes with ZNF43: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF43 Gene

Localization for ZNF43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF43 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF43 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF43: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF43 Gene

Pathways & Interactions for ZNF43 Gene

SuperPathways for ZNF43 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF43: view

Pathways by source for ZNF43 Gene

2 Reactome pathways for ZNF43 Gene

Gene Ontology (GO) - Biological Process for ZNF43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF43: view

No data available for SIGNOR curated interactions for ZNF43 Gene

Drugs & Compounds for ZNF43 Gene

(1) Drugs for ZNF43 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2359
genes like me logo Genes that share compounds with ZNF43: view

Transcripts for ZNF43 Gene

Unigene Clusters for ZNF43 Gene

Zinc finger protein 43:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF43 Gene

No ASD Table

Relevant External Links for ZNF43 Gene

GeneLoc Exon Structure for
ZNF43
ECgene alternative splicing isoforms for
ZNF43

Expression for ZNF43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF43 Gene

Protein differential expression in normal tissues from HIPED for ZNF43 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF43 Gene



Protein tissue co-expression partners for ZNF43 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF43 Gene:

ZNF43

SOURCE GeneReport for Unigene cluster for ZNF43 Gene:

Hs.534365

mRNA Expression by UniProt/SwissProt for ZNF43 Gene:

P17038-ZNF43_HUMAN
Tissue specificity: T- and B-cell lines.

Evidence on tissue expression from TISSUES for ZNF43 Gene

  • Nervous system(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with ZNF43: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF43 Gene

Orthologs for ZNF43 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF43 34
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp458 33
  • 67.92 (n)
mouse
(Mus musculus)
Mammalia Zfp458 33 16 34
  • 67.34 (n)
Zfp457 34
  • 55 (a)
ManyToMany
Zfp759 34
  • 51 (a)
ManyToMany
Zfp738 34
  • 50 (a)
ManyToMany
A530054K11Rik 34
  • 45 (a)
ManyToMany
Zfp748 34
  • 43 (a)
ManyToMany
AA987161 34
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 52 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9650 35
  • 48 (a)
CG4936 35
  • 45 (a)
CG4854 35
  • 42 (a)
Meics 35
  • 39 (a)
rgr 35
  • 37 (a)
wdn 35
  • 37 (a)
CG10959 35
  • 35 (a)
D19B 35
  • 32 (a)
grau 35
  • 32 (a)
zf30C 35
  • 31 (a)
CG10543 35
  • 30 (a)
CG15073 35
  • 30 (a)
CG11902 35
  • 27 (a)
CG8388 35
  • 27 (a)
CG18011 35
  • 25 (a)
Species where no ortholog for ZNF43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF43 Gene

ENSEMBL:
Gene Tree for ZNF43 (if available)
TreeFam:
Gene Tree for ZNF43 (if available)

Paralogs for ZNF43 Gene

Paralogs for ZNF43 Gene

(468) SIMAP similar genes for ZNF43 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF43: view

Variants for ZNF43 Gene

Sequence variations from dbSNP and Humsavar for ZNF43 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs200399581 A colorectal cancer sample 21,809,307(+) AAGGC(A/G)TGAGG reference, missense
rs1000014656 -- 21,847,163(+) ATGTG(C/G)CTCAA intron-variant
rs1000036987 -- 21,814,129(+) ACATT(-/A)AAAAA intron-variant
rs1000042857 -- 21,812,992(+) GTTGA(C/T)GGAAA intron-variant
rs1000048760 -- 21,835,336(+) AGAAA(A/T)AAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF43 Gene

Variant ID Type Subtype PubMed ID
dgv511e201 CNV deletion 23290073
esv2718335 CNV deletion 23290073
esv2718343 CNV deletion 23290073
esv2718346 CNV deletion 23290073
esv2758750 CNV gain+loss 17122850
esv34340 CNV loss 17911159
esv3583306 CNV loss 25503493
esv3584735 CNV loss 24956385
esv3643936 CNV loss 21293372
esv4924 OTHER complex 18987735
nsv1061327 CNV gain 25217958
nsv1063115 CNV gain 25217958
nsv578969 CNV loss 21841781
nsv578971 CNV loss 21841781
nsv7306 OTHER inversion 18451855
nsv833783 CNV loss 17160897
nsv833784 CNV loss 17160897
nsv961194 CNV duplication 23825009

Variation tolerance for ZNF43 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF43 Gene

Disorders for ZNF43 Gene

Relevant External Links for ZNF43

Genetic Association Database (GAD)
ZNF43
Human Genome Epidemiology (HuGE) Navigator
ZNF43
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF43

No disorders were found for ZNF43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF43 Gene

Publications for ZNF43 Gene

  1. A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines. (PMID: 1711675) Lovering R … Trowsdale J (Nucleic acids research 1991) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid EJ … Martial JA (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 60
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 60

Products for ZNF43 Gene

Sources for ZNF43 Gene

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