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Aliases for ZNF43 Gene

Aliases for ZNF43 Gene

  • Zinc Finger Protein 43 2 3
  • Zinc Finger Protein 39-Like 1 (KOX 27) 2 3
  • Zinc Finger Protein KOX27 3 4
  • Zinc Finger Protein HTF6 3 4
  • ZNF39L1 3 4
  • KOX27 3 4
  • Zinc Finger Protein 43 (HTF6) 2
  • Zinc Finger Protein 39 4
  • ZNF39 4
  • HTF6 3

External Ids for ZNF43 Gene

Previous HGNC Symbols for ZNF43 Gene

  • ZNF39L1

Previous GeneCards Identifiers for ZNF43 Gene

  • GC19M022439
  • GC19M022321
  • GC19M021682
  • GC19M021987
  • GC19M021526

Summaries for ZNF43 Gene

Entrez Gene Summary for ZNF43 Gene

  • This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF43 Gene

ZNF43 (Zinc Finger Protein 43) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot for ZNF43 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF43 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF43 Gene

Genomics for ZNF43 Gene

Regulatory Elements for ZNF43 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF43 Gene

21,804,949 bp from pter
21,852,125 bp from pter
47,177 bases
Minus strand

Genomic View for ZNF43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF43 Gene

Proteins for ZNF43 Gene

  • Protein details for ZNF43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 43
    Protein Accession:
    Secondary Accessions:
    • A8K5N8
    • P28160
    • Q53XQ2
    • Q5H9T3
    • Q96DG1

    Protein attributes for ZNF43 Gene

    809 amino acids
    Molecular mass:
    94124 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF43 Gene


neXtProt entry for ZNF43 Gene

Proteomics data for ZNF43 Gene at MOPED

Post-translational modifications for ZNF43 Gene

  • Ubiquitination at Lys679
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF43 Gene

Domains for ZNF43 Gene

Gene Families for ZNF43 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF43 Gene

Suggested Antigen Peptide Sequences for ZNF43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P17038
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF43: view

Function for ZNF43 Gene

Molecular function for ZNF43 Gene

GENATLAS Biochemistry: zinc finger protein 43 (HTF6),KRAB subfamily
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF43: view
genes like me logo Genes that share phenotypes with ZNF43: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF43 Gene

Localization for ZNF43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF43 Gene

Subcellular locations from

Jensen Localization Image for ZNF43 Gene COMPARTMENTS Subcellular localization image for ZNF43 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF43: view

Pathways for ZNF43 Gene

SuperPathways for ZNF43 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF43: view

Pathways by source for ZNF43 Gene

2 Reactome pathways for ZNF43 Gene

Interacting Proteins for ZNF43 Gene

Gene Ontology (GO) - Biological Process for ZNF43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF43: view

Compounds for ZNF43 Gene

(1) HMDB Compounds for ZNF43 Gene

Compound Synonyms Cas Number PubMed IDs
  • Zinc
genes like me logo Genes that share compounds with ZNF43: view

Transcripts for ZNF43 Gene

Unigene Clusters for ZNF43 Gene

Zinc finger protein 43:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF43

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF43 Gene

No ASD Table

Relevant External Links for ZNF43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF43 Gene

mRNA expression in normal human tissues for ZNF43 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF43 Gene

SOURCE GeneReport for Unigene cluster for ZNF43 Gene Hs.534365

mRNA Expression by UniProt/SwissProt for ZNF43 Gene

Tissue specificity: T- and B-cell lines
genes like me logo Genes that share expressions with ZNF43: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF43 Gene

Orthologs for ZNF43 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF43 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF43 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
(Mus musculus)
Mammalia A530054K11Rik 36
  • 45 (a)
AA987161 36
  • 41 (a)
Zfp457 36
  • 55 (a)
Zfp458 35
  • 67.34 (n)
  • 56.76 (a)
Zfp458 36
  • 54 (a)
Zfp738 36
  • 50 (a)
Zfp748 36
  • 43 (a)
Zfp759 36
  • 51 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Zfp458 35
  • 67.92 (n)
  • 56.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11902 37
  • 27 (a)
CG9650 37
  • 48 (a)
CG4854 37
  • 42 (a)
CG15073 37
  • 30 (a)
Meics 37
  • 39 (a)
CG10959 37
  • 35 (a)
zf30C 37
  • 31 (a)
CG18011 37
  • 25 (a)
CG10543 37
  • 30 (a)
grau 37
  • 32 (a)
CG8388 37
  • 27 (a)
rgr 37
  • 37 (a)
D19B 37
  • 32 (a)
CG4936 37
  • 45 (a)
wdn 37
  • 37 (a)
Species with no ortholog for ZNF43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF43 Gene

Gene Tree for ZNF43 (if available)
Gene Tree for ZNF43 (if available)

Paralogs for ZNF43 Gene

Selected SIMAP similar genes for ZNF43 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF43: view

Variants for ZNF43 Gene

Sequence variations from dbSNP and Humsavar for ZNF43 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs907202 -- 21,846,703(+) aatca(A/C)atcag intron-variant
rs1049168 -- 21,807,914(-) CAAAT(A/G)TGAAA missense, reference
rs1049169 -- 21,807,913(-) AAATG(A/T)GAAAA stop-gained, reference
rs1063324 -- 21,807,930(-) CTGGA(A/G)AGAAA missense, reference
rs1138277 -- 21,806,437(-) ctgtg(A/G)tccca utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF43 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
esv2718335 CNV Deletion 23290073
dgv552e201 CNV Deletion 23290073
nsv7306 OTHER Inversion 18451855
dgv3808n71 CNV Gain 21882294
esv2718343 CNV Deletion 23290073
nsv833783 CNV Loss 17160897
nsv833784 CNV Loss 17160897
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
dgv3810n71 CNV Loss 21882294

Relevant External Links for ZNF43 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF43 Gene

Disorders for ZNF43 Gene

Relevant External Links for ZNF43

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZNF43: view

No data available for UniProtKB/Swiss-Prot for ZNF43 Gene

Publications for ZNF43 Gene

  1. A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines. (PMID: 1711675) Lovering R. … Trowsdale J. (Nucleic Acids Res. 1991) 2 3 4
  2. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF43 Gene

Sources for ZNF43 Gene

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