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Aliases for ZNF43 Gene

Aliases for ZNF43 Gene

  • Zinc Finger Protein 43 2 3 5
  • Zinc Finger Protein 39-Like 1 (KOX 27) 2 3
  • Zinc Finger Protein KOX27 3 4
  • Zinc Finger Protein HTF6 3 4
  • ZNF39L1 3 4
  • KOX27 3 4
  • Zinc Finger Protein 43 (HTF6) 2
  • Zinc Finger Protein 39 4
  • ZNF39 4
  • HTF6 3

External Ids for ZNF43 Gene

Previous HGNC Symbols for ZNF43 Gene

  • ZNF39L1

Previous GeneCards Identifiers for ZNF43 Gene

  • GC19M022439
  • GC19M022321
  • GC19M021682
  • GC19M021987
  • GC19M021526

Summaries for ZNF43 Gene

Entrez Gene Summary for ZNF43 Gene

  • This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF43 Gene

ZNF43 (Zinc Finger Protein 43) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF43 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF43 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF43 Gene

Genomics for ZNF43 Gene

Regulatory Elements for ZNF43 Gene

Enhancers for ZNF43 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF43 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF43 Gene

21,804,949 bp from pter
21,852,125 bp from pter
47,177 bases
Minus strand

Genomic View for ZNF43 Gene

Genes around ZNF43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF43 Gene

Proteins for ZNF43 Gene

  • Protein details for ZNF43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 43
    Protein Accession:
    Secondary Accessions:
    • A8K5N8
    • P28160
    • Q53XQ2
    • Q5H9T3
    • Q96DG1

    Protein attributes for ZNF43 Gene

    809 amino acids
    Molecular mass:
    94124 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF43 Gene


neXtProt entry for ZNF43 Gene

Proteomics data for ZNF43 Gene at MOPED

Post-translational modifications for ZNF43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF43 Gene

Domains & Families for ZNF43 Gene

Gene Families for ZNF43 Gene

Protein Domains for ZNF43 Gene

Suggested Antigen Peptide Sequences for ZNF43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 22 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF43: view

Function for ZNF43 Gene

Molecular function for ZNF43 Gene

GENATLAS Biochemistry:
zinc finger protein 43 (HTF6),KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF43: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF43 Gene

Localization for ZNF43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF43 Gene

Subcellular locations from

Jensen Localization Image for ZNF43 Gene COMPARTMENTS Subcellular localization image for ZNF43 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF43 Gene

Pathways & Interactions for ZNF43 Gene

SuperPathways for ZNF43 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF43: view

Pathways by source for ZNF43 Gene

2 Reactome pathways for ZNF43 Gene

Interacting Proteins for ZNF43 Gene

Gene Ontology (GO) - Biological Process for ZNF43 Gene


No data available for SIGNOR curated interactions for ZNF43 Gene

Drugs & Compounds for ZNF43 Gene

(1) Drugs for ZNF43 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
genes like me logo Genes that share compounds with ZNF43: view

Transcripts for ZNF43 Gene

Unigene Clusters for ZNF43 Gene

Zinc finger protein 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF43 Gene

No ASD Table

Relevant External Links for ZNF43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF43 Gene

mRNA expression in normal human tissues for ZNF43 Gene

Protein differential expression in normal tissues from HIPED for ZNF43 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF43 Gene

SOURCE GeneReport for Unigene cluster for ZNF43 Gene Hs.534365

mRNA Expression by UniProt/SwissProt for ZNF43 Gene

Tissue specificity: T- and B-cell lines.
genes like me logo Genes that share expression patterns with ZNF43: view

Protein tissue co-expression partners for ZNF43 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF43 Gene

Orthologs for ZNF43 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF43 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Zfp458 35
  • 67.34 (n)
  • 56.76 (a)
Zfp458 16
A530054K11Rik 36
  • 45 (a)
AA987161 36
  • 41 (a)
Zfp457 36
  • 55 (a)
Zfp458 36
  • 54 (a)
Zfp738 36
  • 50 (a)
Zfp748 36
  • 43 (a)
Zfp759 36
  • 51 (a)
(Rattus norvegicus)
Mammalia Zfp458 35
  • 67.92 (n)
  • 56.18 (a)
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
(Pan troglodytes)
Mammalia ZNF43 36
  • 99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10543 37
  • 30 (a)
CG10959 37
  • 35 (a)
CG11902 37
  • 27 (a)
CG15073 37
  • 30 (a)
CG18011 37
  • 25 (a)
CG4854 37
  • 42 (a)
CG4936 37
  • 45 (a)
CG8388 37
  • 27 (a)
CG9650 37
  • 48 (a)
D19B 37
  • 32 (a)
grau 37
  • 32 (a)
Meics 37
  • 39 (a)
rgr 37
  • 37 (a)
wdn 37
  • 37 (a)
zf30C 37
  • 31 (a)
Species with no ortholog for ZNF43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF43 Gene

Gene Tree for ZNF43 (if available)
Gene Tree for ZNF43 (if available)

Paralogs for ZNF43 Gene

(468) SIMAP similar genes for ZNF43 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF43: view

Variants for ZNF43 Gene

Sequence variations from dbSNP and Humsavar for ZNF43 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035569 A colorectal cancer sample
VAR_054794 -
rs7256996 -- 21,823,379(+) CACAA(C/G)ATGAG intron-variant
rs7257470 -- 21,810,792(+) ataat(A/G)ataaa intron-variant
rs7260253 -- 21,835,820(+) tgccc(A/C)cagag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF43 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
esv2718335 CNV Deletion 23290073
dgv552e201 CNV Deletion 23290073
nsv7306 OTHER Inversion 18451855
dgv3808n71 CNV Gain 21882294
esv2718343 CNV Deletion 23290073
nsv833783 CNV Loss 17160897
nsv833784 CNV Loss 17160897
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
dgv3810n71 CNV Loss 21882294

Variation tolerance for ZNF43 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF43 Gene

Disorders for ZNF43 Gene

Relevant External Links for ZNF43

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF43 Gene

Publications for ZNF43 Gene

  1. A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines. (PMID: 1711675) Lovering R. … Trowsdale J. (Nucleic Acids Res. 1991) 2 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  4. Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells. (PMID: 17178891) Takahashi T. … Naganuma A. (Cancer Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF43 Gene

Sources for ZNF43 Gene