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Aliases for ZNF41 Gene

Aliases for ZNF41 Gene

  • Zinc Finger Protein 41 2 3
  • MRX89 3

External Ids for ZNF41 Gene

Summaries for ZNF41 Gene

Entrez Gene Summary for ZNF41 Gene

  • This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. Several alternatively spliced transcript variants have been described, however, the full-length nature of only some of them is known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF41 Gene

ZNF41 (Zinc Finger Protein 41) is a Protein Coding gene. Diseases associated with ZNF41 include aland island eye disease and eye disease. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot for ZNF41 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF41 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF41 Gene

Genomics for ZNF41 Gene

Genomic Location for ZNF41 Gene

Start:
47,445,879 bp from pter
End:
47,483,671 bp from pter
Size:
37,793 bases
Orientation:
Minus strand

Genomic View for ZNF41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF41 Gene

Regulatory Elements for ZNF41 Gene

Proteins for ZNF41 Gene

  • Protein details for ZNF41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51814-ZNF41_HUMAN
    Recommended name:
    Zinc finger protein 41
    Protein Accession:
    P51814
    Secondary Accessions:
    • A8K1V6
    • B4DH01
    • Q96LE8
    • Q9UMC4
    • Q9UMV5
    • Q9UMV6
    • Q9UMV7
    • Q9UMV8
    • Q9UMV9
    • Q9UMW0
    • Q9UMW1

    Protein attributes for ZNF41 Gene

    Size:
    821 amino acids
    Molecular mass:
    93728 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF41 Gene

neXtProt entry for ZNF41 Gene

Proteomics data for ZNF41 Gene at MOPED

Post-translational modifications for ZNF41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF41 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF41 Gene

Domains for ZNF41 Gene

Gene Families for ZNF41 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZNF41_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • P51814
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P51814
Similarity:
  • Contains 18 C2H2-type zinc fingers.:
    • P51814
genes like me logo Genes that share domains with ZNF41: view

Function for ZNF41 Gene

Molecular function for ZNF41 Gene

GENATLAS Biochemistry: zinc finger protein 41 (C2H2 type,Kruppel-like),involved in gene-specific transcriptional repression
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF41: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF41 Gene

Localization for ZNF41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF41 Gene COMPARTMENTS Subcellular localization image for ZNF41 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF41: view

Pathways for ZNF41 Gene

SuperPathways for ZNF41 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF41: view

Pathways by source for ZNF41 Gene

2 Reactome pathways for ZNF41 Gene

Gene Ontology (GO) - Biological Process for ZNF41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF41: view

Transcripts for ZNF41 Gene

Unigene Clusters for ZNF41 Gene

Zinc finger protein 41:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF41 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7: -
SP8: - -
SP9: - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - -
SP14: - - - - -
SP15: - - - - -

Relevant External Links for ZNF41 Gene

GeneLoc Exon Structure for
ZNF41
ECgene alternative splicing isoforms for
ZNF41

Expression for ZNF41 Gene

mRNA expression in normal human tissues for ZNF41 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF41 Gene

SOURCE GeneReport for Unigene cluster for ZNF41 Gene Hs.496074

mRNA Expression by UniProt/SwissProt for ZNF41 Gene

P51814-ZNF41_HUMAN
Tissue specificity: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with ZNF41: view

Orthologs for ZNF41 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF41 36
  • 99.7 (n)
  • 99.49 (a)
ZNF41 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF41 36
  • 87.03 (n)
  • 84.18 (a)
ZNF41 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF41 36
  • 88.83 (n)
  • 85.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11247 38
  • 35 (a)
zf30C 38
  • 30 (a)
CG18011 38
  • 24 (a)
BG:DS04929.3 38
  • 45 (a)
CG9797 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.14 38
  • 38 (a)
Species with no ortholog for ZNF41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF41 Gene

ENSEMBL:
Gene Tree for ZNF41 (if available)
TreeFam:
Gene Tree for ZNF41 (if available)

Paralogs for ZNF41 Gene

Selected SIMAP similar genes for ZNF41 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF41 Gene

genes like me logo Genes that share paralogs with ZNF41: view

Variants for ZNF41 Gene

Sequence variations from dbSNP and Humsavar for ZNF41 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2071778 -- 47,483,855(-) AAATG(A/G)TGTTA upstream-variant-2KB
rs2071779 -- 47,482,486(-) TCGAA(A/G)CAGTT utr-variant-5-prime, intron-variant
rs2071780 -- 47,482,422(-) AAGCA(C/T)TGAGA intron-variant
rs2498170 Benign, - 47,448,825(+) TGTAC(A/C)TCAAC missense, reference
rs2498488 -- 47,452,299(+) agttc(C/T)tgcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF41 Gene

Variant ID Type Subtype PubMed ID
esv2664341 CNV Deletion 23128226

Relevant External Links for ZNF41 Gene

HapMap Linkage Disequilibrium report
ZNF41
Human Gene Mutation Database (HGMD)
ZNF41
Locus Specific Mutation Databases (LSDB)
ZNF41

Disorders for ZNF41 Gene

UniProtKB/Swiss-Prot

ZNF41_HUMAN
  • Note=A chromosomal aberration involving ZNF41 has been found in a patient with severe mental retardation. Translocation t(X;7)(p11.3;q11.21).

(2) University of Copenhagen DISEASES for ZNF41 Gene

genes like me logo Genes that share disorders with ZNF41: view

Publications for ZNF41 Gene

  1. Coding region intron/exon organization, alternative splicing and X- chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41. (PMID: 10449920) Rosati M. … Grimaldi G. (Cytogenet. Cell Genet. 1999) 3 4 23
  2. Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation. (PMID: 14628291) Shoichet S.A. … Kalscheuer V.M. (Am. J. Hum. Genet. 2003) 3 4 23
  3. Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome. (PMID: 2037297) Franze A. … Grimaldi G. (Genomics 1991) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for ZNF41 Gene

Sources for ZNF41 Gene

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