Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CA1 Gene

Aliases for CA1 Gene

  • Carbonic Anhydrase I 2 3 4
  • Carbonate Dehydratase I 3 4
  • Carbonic Anhydrase B 3 4
  • EC 4.2.1.1 4 63
  • CA-I 3 4
  • CAB 3 4
  • Epididymis Secretory Protein Li 11 3
  • Carbonic Anhydrase 1 3
  • HEL-S-11 3
  • CAR1 3

External Ids for CA1 Gene

Previous GeneCards Identifiers for CA1 Gene

  • GC08M085064
  • GC08M086197
  • GC08M086020
  • GC08M086315
  • GC08M086427
  • GC08M081734

Summaries for CA1 Gene

Entrez Gene Summary for CA1 Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for CA1 Gene

CA1 (Carbonic Anhydrase I) is a Protein Coding gene. Diseases associated with CA1 include subacute thyroiditis and amnestic disorder. Among its related pathways are Metabolism and C-MYB transcription factor network. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot for CA1 Gene

  • Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.

Gene Wiki entry for CA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA1 Gene

Genomics for CA1 Gene

Regulatory Elements for CA1 Gene

Genomic Location for CA1 Gene

Start:
85,327,608 bp from pter
End:
85,379,014 bp from pter
Size:
51,407 bases
Orientation:
Minus strand

Genomic View for CA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA1 Gene

Proteins for CA1 Gene

  • Protein details for CA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00915-CAH1_HUMAN
    Recommended name:
    Carbonic anhydrase 1
    Protein Accession:
    P00915
    Secondary Accessions:

    Protein attributes for CA1 Gene

    Size:
    261 amino acids
    Molecular mass:
    28870 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA1 Gene

neXtProt entry for CA1 Gene

Proteomics data for CA1 Gene at MOPED

Post-translational modifications for CA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for CA1 (Carbonic Anhydrase I/CA1)

Domains for CA1 Gene

Gene Families for CA1 Gene

HGNC:
  • CA :Carbonic anhydrases

Suggested Antigen Peptide Sequences for CA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00915

UniProtKB/Swiss-Prot:

CAH1_HUMAN :
  • P00915
Family:
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA1: view

Function for CA1 Gene

Molecular function for CA1 Gene

GENATLAS Biochemistry: carbonic anhydrase I,cytosolic,erythrocyte
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=4.0 mM for CO(2) {ECO:0000269 PubMed:10550681, ECO:0000269 PubMed:18618712}; KM=15 mM for 4-nitrophenyl acetate {ECO:0000269 PubMed:10550681, ECO:0000269 PubMed:18618712};
UniProtKB/Swiss-Prot CatalyticActivity: H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by histamine, imidazole, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide, benzenesulfonamide and derivatives (4-carboxyethylbenzene-sulfonamide, 4-carboxyethylbenzene-sulfonamide ethyl ester, 4-(acetyl-2-aminoethyl)benzene-sulfonamide, 4-aminoethylbenzene-sulfonamide), and prong inhibitors BR15, BR17, BR22 and BR30. Activated by a short exposition to Foscarnet (phosphonoformate trisodium salt), but inhibited by a long one. Esterase activity weakly reduced by cyanamide.
UniProtKB/Swiss-Prot Function: Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.

Enzyme Numbers (IUBMB) for CA1 Gene

Gene Ontology (GO) - Molecular Function for CA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004064 arylesterase activity IMP 7758465
GO:0004089 carbonate dehydratase activity IMP 7758465
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016836 hydro-lyase activity IDA 2114290
genes like me logo Genes that share ontologies with CA1: view

Phenotypes for CA1 Gene

GenomeRNAi human phenotypes for CA1:
genes like me logo Genes that share phenotypes with CA1: view

Animal Model Products

CRISPR Products

miRNA for CA1 Gene

miRTarBase miRNAs that target CA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CA1 Gene

Localization for CA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CA1 Gene COMPARTMENTS Subcellular localization image for CA1 gene
Compartment Confidence
cytosol 4
golgi apparatus 4
chloroplast 2
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CA1: view

Pathways for CA1 Gene

genes like me logo Genes that share pathways with CA1: view

Interacting Proteins for CA1 Gene

Selected Interacting proteins: P00915-CAH1_HUMAN for CA1 Gene via MINT UniProtKB I2D

Gene Ontology (GO) - Biological Process for CA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CA1: view

Compounds for CA1 Gene

(7) HMDB Compounds for CA1 Gene

Compound Synonyms Cas Number PubMed IDs
Amlodipine
  • AMVAZ
88150-42-9
Carbon dioxide
  • Carbon oxide
124-38-9
Carbonic acid
  • acid of air
463-79-6
Hydrochlorothiazide
  • 3,4-Dihydrochlorothiazide
58-93-5
Verapamil
  • Akilen
52-53-9

(24) Drugbank Compounds for CA1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID
target
Acetazolamide
  • Acetamidothiadiazolesulfonamide
59-66-5 target inhibitor
Amlodipine
  • Amlodipine Benzenesulfonate
88150-42-9 target inhibitor
Bendroflumethiazide
  • Bendrofluazide
73-48-3 target inhibitor
Benzthiazide
91-33-8 target inhibitor

(23) Novoseek inferred chemical compound relationships for CA1 Gene

Compound -log(P) Hits PubMed IDs
benzenesulfonamide 86 1
p-nitrophenyl acetate 80.3 1
sulfonamide 79.6 7
dansylamide 78.4 2
sulfamide 73.3 2
genes like me logo Genes that share compounds with CA1: view

Transcripts for CA1 Gene

Unigene Clusters for CA1 Gene

Carbonic anhydrase I:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - -
SP11: - - - - - - - - -
SP12:
SP13: - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - -
SP16: - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - - - - - -
SP19: - -
SP20: -

ExUns: 16b · 16c · 16d · 16e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for CA1 Gene

GeneLoc Exon Structure for
CA1
ECgene alternative splicing isoforms for
CA1

Expression for CA1 Gene

mRNA expression in normal human tissues for CA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA1 Gene

This gene is overexpressed in Colon - Transverse (34.8) and Whole Blood (14.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CA1 Gene

SOURCE GeneReport for Unigene cluster for CA1 Gene Hs.23118

genes like me logo Genes that share expressions with CA1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CA1 Gene

Orthologs for CA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA1 35
  • 99.62 (n)
  • 99.23 (a)
CA1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 79 (a)
OneToMany
CA1 35
  • 83.14 (n)
  • 79.31 (a)
CA1 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CA1 35
  • 86.97 (n)
  • 84.29 (a)
CA1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Car1 35
  • 81.86 (n)
  • 78.16 (a)
Car1 16
Car1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CA1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ca1 35
  • 82.25 (n)
  • 81.23 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496485 35
  • 66.16 (n)
  • 62.07 (a)
Str.15630 35
zebrafish
(Danio rerio)
Actinopterygii ca2 36
  • 62 (a)
ManyToMany
cahz 36
  • 61 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CAH1 36
  • 43 (a)
OneToMany
CAH1 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea cah-3 37
  • 33 (a)
Species with no ortholog for CA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA1 Gene

ENSEMBL:
Gene Tree for CA1 (if available)
TreeFam:
Gene Tree for CA1 (if available)

Paralogs for CA1 Gene

Paralogs for CA1 Gene

genes like me logo Genes that share paralogs with CA1: view

Variants for CA1 Gene

Sequence variations from dbSNP and Humsavar for CA1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs725605 -- 85,354,657(-) CAGAA(A/G)CTGGT intron-variant
rs924144 -- 85,347,247(-) GTGAC(A/G)CTGAA intron-variant
rs1032551 -- 85,342,850(-) AAATT(C/G)CTCCT intron-variant, upstream-variant-2KB
rs1045899 -- 85,338,400(-) AACCA(A/G)TCCCC synonymous-codon, reference, intron-variant
rs1045900 -- 85,337,017(-) CAGTT(C/T)CATTT reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA1 Gene

Variant ID Type Subtype PubMed ID
nsv831377 CNV Gain 17160897
esv2658426 CNV Deletion 23128226

Relevant External Links for CA1 Gene

HapMap Linkage Disequilibrium report
CA1
Human Gene Mutation Database (HGMD)
CA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA1 Gene

Disorders for CA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CA1 Gene including...

Search for CA1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CA1 Gene

(12) Novoseek inferred disease relationships for CA1 Gene

Disease -log(P) Hits PubMed IDs
hyperthyroidism 36.5 5
erythroleukemia 32.6 1
thyroid diseases 21.4 2
chronic pancreatitis 17.3 4
familial adenomatous polyposis 9.64 1

Relevant External Links for CA1

Genetic Association Database (GAD)
CA1
Human Genome Epidemiology (HuGE) Navigator
CA1
genes like me logo Genes that share disorders with CA1: view

No data available for UniProtKB/Swiss-Prot for CA1 Gene

Publications for CA1 Gene

  1. Structure and methylation patterns of the gene encoding human carbonic anhydrase I. (PMID: 2121614) Lowe N. … Butterworth P.H.W. (Gene 1990) 3 4 23
  2. Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I. (PMID: 7866410) Chegwidden W.R. … Tashian R.E. (Hum. Mutat. 1994) 3 4 23
  3. Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination. (PMID: 12009884) Ferraroni M. … Scozzafava A. (Biochemistry 2002) 3 4 23
  4. Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X- ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. (PMID: 17314045) Temperini C. … Supuran C.T. (Bioorg. Med. Chem. Lett. 2007) 3 4 23
  5. Vasoconstrictive drugs increase carbonic anhydrase I in vascular smooth muscle while vasodilating drugs reduce the activity of this isozyme by a direct mechanism of action. (PMID: 11392054) Puscas I. … Hecht A. (Drugs Exp Clin Res 2001) 3 23 25

Products for CA1 Gene

Sources for CA1 Gene

Back to Top

Content