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Aliases for ZNF35 Gene

Aliases for ZNF35 Gene

  • Zinc Finger Protein 35 2 3 5
  • Zinc Finger Protein 35 (Clone HF.10) 2 3
  • Zinc Finger Protein HF.10 3 4
  • Zfp105 3
  • HF.10 3
  • HF10 3

External Ids for ZNF35 Gene

Previous GeneCards Identifiers for ZNF35 Gene

  • GC03P044155
  • GC03P043870
  • GC03P044509
  • GC03P044650
  • GC03P044665
  • GC03P044690
  • GC03P044684
  • GC03P044807
  • GC03P044832
  • GC03P044906
  • GC03P044941

Summaries for ZNF35 Gene

GeneCards Summary for ZNF35 Gene

ZNF35 (Zinc Finger Protein 35) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is ZNF660.

UniProtKB/Swiss-Prot for ZNF35 Gene

  • May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

Gene Wiki entry for ZNF35 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF35 Gene

Genomics for ZNF35 Gene

Regulatory Elements for ZNF35 Gene

Enhancers for ZNF35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G043670 1 dbSUPER 12.5 -977.4 -977400 1.8 HDGF ATF1 ARNT TCF12 ZNF766 GATA2 KLF13 ZNF592 MBD2 CREB3 ZNF35 TUBAP3 RPL18AP9
GH03G043671 1 dbSUPER 12.5 -977.7 -977726 1.3 HDGF ATF1 ARNT TCF12 ZNF766 GATA2 KLF13 ZNF592 MBD2 CREB3 ZNF35 TUBAP3 RPL18AP9
GH03G044624 1.1 ENCODE 11.1 -23.4 -23394 2.1 PKNOX1 CREB3L1 ARNT ARID4B SIN3A YY1 ZNF766 CBX5 ZNF143 KLF13 ZNF197 KIAA1143 ZNF660 ZNF35 ZNF445 ZNF197-AS1
GH03G044532 1 ENCODE 9.6 -115.7 -115724 0.2 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF197 ZNF852 ZKSCAN7 ENSG00000235845 TGM4 ZNF445 ZNF660 ZNF501 CLEC3B RNU5B-3P
GH03G044584 0.9 ENCODE 10.2 -63.7 -63740 1.7 FOXA2 ARID4B SIN3A ETS1 ZNF143 ZNF207 CREM THAP11 SMAD5 NFYC ZNF197 ZNF197-AS1 ZKSCAN7 ZNF501 ZNF35 PIR39553
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF35 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151592 274 1600 PKNOX1 CREB3L1 ARNT AGO1 SIN3A YY1 ETS1 CBX5 ELK1 ZNF143

Genomic Location for ZNF35 Gene

Chromosome:
3
Start:
44,648,727 bp from pter
End:
44,660,791 bp from pter
Size:
12,065 bases
Orientation:
Plus strand

Genomic View for ZNF35 Gene

Genes around ZNF35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF35 Gene

Proteins for ZNF35 Gene

  • Protein details for ZNF35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13682-ZNF35_HUMAN
    Recommended name:
    Zinc finger protein 35
    Protein Accession:
    P13682
    Secondary Accessions:
    • B2RBU6
    • Q53Y54
    • Q96D01

    Protein attributes for ZNF35 Gene

    Size:
    527 amino acids
    Molecular mass:
    59089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA85451.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37343.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA30268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF35 Gene

Post-translational modifications for ZNF35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF35 Gene

Domains & Families for ZNF35 Gene

Gene Families for ZNF35 Gene

Protein Domains for ZNF35 Gene

Suggested Antigen Peptide Sequences for ZNF35 Gene

Graphical View of Domain Structure for InterPro Entry

P13682

UniProtKB/Swiss-Prot:

ZNF35_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF35: view

Function for ZNF35 Gene

Molecular function for ZNF35 Gene

GENATLAS Biochemistry:
zinc finger protein 35,cHF.10 (C2H2 type,Kruppel-like),expressed in testis,involved in germ cell differentiation process
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

Gene Ontology (GO) - Molecular Function for ZNF35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 2108922
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 1572646
GO:0043565 sequence-specific DNA binding IDA 8477855
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF35: view
genes like me logo Genes that share phenotypes with ZNF35: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF35 Gene

Localization for ZNF35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF35 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell ISS --
GO:0005634 nucleus IEA,IDA 20186958
GO:0048471 perinuclear region of cytoplasm IDA 20186958
genes like me logo Genes that share ontologies with ZNF35: view

Pathways & Interactions for ZNF35 Gene

SuperPathways for ZNF35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,TAS --
GO:0007283 spermatogenesis ISS 20186958
GO:0071300 cellular response to retinoic acid ISS 20186958
genes like me logo Genes that share ontologies with ZNF35: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF35 Gene

Transcripts for ZNF35 Gene

Unigene Clusters for ZNF35 Gene

Zinc finger protein 35:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF35 Gene

No ASD Table

Relevant External Links for ZNF35 Gene

GeneLoc Exon Structure for
ZNF35
ECgene alternative splicing isoforms for
ZNF35

Expression for ZNF35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF35 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF35 Gene



Protein tissue co-expression partners for ZNF35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF35 Gene:

ZNF35

SOURCE GeneReport for Unigene cluster for ZNF35 Gene:

Hs.288658

Evidence on tissue expression from TISSUES for ZNF35 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF35: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF35 Gene

Orthologs for ZNF35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF35 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia ZNF35 34 35
  • 90.64 (n)
cow
(Bos Taurus)
Mammalia ZNF35 34 35
  • 86.78 (n)
rat
(Rattus norvegicus)
Mammalia Zfp105 34
  • 85.56 (n)
mouse
(Mus musculus)
Mammalia Zfp105 34 16 35
  • 84.48 (n)
zebrafish
(Danio rerio)
Actinopterygii BX004879.1 35
  • 39 (a)
ManyToMany
BX005448.1 35
  • 39 (a)
ManyToMany
BX890548.2 35
  • 39 (a)
ManyToMany
gb:am422109 35
  • 39 (a)
ManyToMany
si:ch211-283l16.1 35
  • 39 (a)
ManyToMany
si:dkey-56m15.3 35
  • 39 (a)
ManyToMany
zgc:174700 35
  • 39 (a)
ManyToMany
CABZ01008480.1 35
  • 38 (a)
ManyToMany
CT573263.3 35
  • 38 (a)
ManyToMany
si:ch211-226o13.2 35
  • 38 (a)
ManyToMany
si:dkey-22h13.2 35
  • 38 (a)
ManyToMany
si:dkey-237m9.1 35
  • 37 (a)
ManyToMany
si:dkey-54j5.2 35
  • 37 (a)
ManyToMany
CR293532.1 35
  • 36 (a)
ManyToMany
si:dkey-16b10.2 35
  • 36 (a)
ManyToMany
zgc:173714 35
  • 36 (a)
ManyToMany
zgc:174694 35
  • 36 (a)
ManyToMany
BX005448.2 35
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF35 Gene

ENSEMBL:
Gene Tree for ZNF35 (if available)
TreeFam:
Gene Tree for ZNF35 (if available)

Paralogs for ZNF35 Gene

Paralogs for ZNF35 Gene

(523) SIMAP similar genes for ZNF35 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF35 Gene

genes like me logo Genes that share paralogs with ZNF35: view

Variants for ZNF35 Gene

Sequence variations from dbSNP and Humsavar for ZNF35 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000148749 -- 44,655,788(+) GTAAT(A/G)GTTTT intron-variant
rs1000256620 -- 44,653,048(+) GGCAG(C/T)GGACT intron-variant
rs1000490268 -- 44,652,498(+) AAATT(C/G)TAACC intron-variant
rs1000924911 -- 44,647,486(+) CACAC(-/A)AAAAC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000953859 -- 44,647,912(+) AATCT(A/G)TAGGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF35 Gene

Variant ID Type Subtype PubMed ID
esv3596037 CNV gain 21293372

Variation tolerance for ZNF35 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.43; 90.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF35 Gene

Disorders for ZNF35 Gene

Relevant External Links for ZNF35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF35

No disorders were found for ZNF35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF35 Gene

Publications for ZNF35 Gene

  1. Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22. (PMID: 1572646) Lanfrancone L. … Lania L. (Genomics 1992) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers. (PMID: 2108922) Donti E. … Pelicci P.G. (Hum. Genet. 1990) 2 3 64
  4. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. (PMID: 3380682) Pannuti A. … Lania L. (Nucleic Acids Res. 1988) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ZNF35 Gene

Sources for ZNF35 Gene

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