Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF33B Gene

Aliases for ZNF33B Gene

  • Zinc Finger Protein 33B 2 3 5
  • Zinc Finger Protein 33b (KOX 31) 2 3
  • Zinc Finger Protein 11B 2 4
  • ZNF11B 3 4
  • KOX2 3 4
  • Zinc Finger Protein 11b (KOX 2) 3
  • Zinc Finger Protein KOX2 4
  • KOX31 3

External Ids for ZNF33B Gene

Previous HGNC Symbols for ZNF33B Gene

  • ZNF11B

Previous GeneCards Identifiers for ZNF33B Gene

  • GC10M042377
  • GC10U900001
  • GC10P038188
  • GC07P006406
  • GC03P044571
  • GC10M042405
  • GC10M043069
  • GC10M039611
  • GC10M043084

Summaries for ZNF33B Gene

Entrez Gene Summary for ZNF33B Gene

  • This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for ZNF33B Gene

ZNF33B (Zinc Finger Protein 33B) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF33A.

UniProtKB/Swiss-Prot for ZNF33B Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF33B Gene

Additional gene information for ZNF33B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF33B Gene

Genomics for ZNF33B Gene

Regulatory Elements for ZNF33B Gene

Enhancers for ZNF33B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H043392 2.1 FANTOM5 Ensembl ENCODE dbSUPER 32.2 -762.9 -762854 18.3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF32-AS2 BMS1 EIF3LP2 ZNF37BP ZNF33B ZNF32-AS1 HNRNPA3P1 HNRNPF ZNF32 LOC105378272
GH10H042636 1.4 ENCODE dbSUPER 20.1 +0.5 478 3 HDGF FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 ZNF207 ZNF33B LINC00839 PIR61818 LOC105378268
GH10H042652 1.2 ENCODE dbSUPER 16.4 -14.9 -14912 3 HDAC1 ATF1 TBL1XR1 ARNT CHAMP1 TCF12 GATA2 EGR1 ATF7 CREM LINC00839 ZNF32-AS2 BMS1 ZNF33B ZNF485 PIR59472 PIR60642
GH10H042643 1.2 ENCODE dbSUPER 15.8 -7.0 -7007 3.9 HDGF PKNOX1 ATF1 ARNT TCF12 GATA2 ATF7 NCOA1 REST ZNF592 LINC00839 ZNF33B ZNF239 PIR40268 PIR60642
GH10H043416 1.7 FANTOM5 ENCODE dbSUPER 9.9 -780.7 -780708 6.1 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC PPARGC1A MEF2D SSRP1 BMS1 ZNF32-AS2 EIF3LP2 LOC105378272 ZNF33B ZNF239 ENSG00000259869 HNRNPF CSGALNACT2 GC10P043423
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF33B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF33B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ZNF33B Gene

Genomic Locations for ZNF33B Gene
64,652 bases
Minus strand

Genomic View for ZNF33B Gene

Genes around ZNF33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF33B Gene

Proteins for ZNF33B Gene

  • Protein details for ZNF33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 33B
    Protein Accession:
    Secondary Accessions:
    • Q06731
    • Q32MA2
    • Q86XY8
    • Q8NDW3

    Protein attributes for ZNF33B Gene

    778 amino acids
    Molecular mass:
    90683 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF33B Gene

Post-translational modifications for ZNF33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF33B Gene

Domains & Families for ZNF33B Gene

Gene Families for ZNF33B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF33B Gene

Suggested Antigen Peptide Sequences for ZNF33B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF33B: view

Function for ZNF33B Gene

Molecular function for ZNF33B Gene

GENATLAS Biochemistry:
zinc finger protein 33b (KOX31) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF33B: view
genes like me logo Genes that share phenotypes with ZNF33B: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF33B Gene

Localization for ZNF33B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF33B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF33B gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (1)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF33B: view

Pathways & Interactions for ZNF33B Gene

SuperPathways for ZNF33B Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF33B: view

Pathways by source for ZNF33B Gene

2 Reactome pathways for ZNF33B Gene

Gene Ontology (GO) - Biological Process for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF33B: view

No data available for SIGNOR curated interactions for ZNF33B Gene

Drugs & Compounds for ZNF33B Gene

(1) Drugs for ZNF33B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2359
genes like me logo Genes that share compounds with ZNF33B: view

Transcripts for ZNF33B Gene

mRNA/cDNA for ZNF33B Gene

(8) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF33B Gene

Zinc finger protein 33B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - - - -

Relevant External Links for ZNF33B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF33B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF33B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF33B Gene

This gene is overexpressed in Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF33B Gene

This gene is overexpressed in Ovary (54.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF33B Gene

Protein tissue co-expression partners for ZNF33B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF33B Gene:


SOURCE GeneReport for Unigene cluster for ZNF33B Gene:


Evidence on tissue expression from TISSUES for ZNF33B Gene

  • Intestine(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ZNF33B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF33B Gene

Orthologs for ZNF33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF33B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF33B 33 34
  • 99.4 (n)
(Bos Taurus)
Mammalia -- 34
  • 86 (a)
(Canis familiaris)
Mammalia -- 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
(Mus musculus)
Mammalia Zfp35 34
  • 46 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
(Gallus gallus)
Aves -- 34
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
(Danio rerio)
Actinopterygii BX004873.2 34
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 38 (a)
-- 34
  • 32 (a)
Species where no ortholog for ZNF33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF33B Gene

Gene Tree for ZNF33B (if available)
Gene Tree for ZNF33B (if available)

Paralogs for ZNF33B Gene

(487) SIMAP similar genes for ZNF33B Gene using alignment to 3 proteins: Pseudogenes for ZNF33B Gene

genes like me logo Genes that share paralogs with ZNF33B: view

Variants for ZNF33B Gene

Sequence variations from dbSNP and Humsavar for ZNF33B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000003382 -- 42,629,870(+) GTACA(C/T)ATGTA intron-variant
rs1000007341 -- 42,588,827(+) GTGCC(C/T)GGCCC intron-variant, downstream-variant-500B
rs1000059373 -- 42,623,481(+) ACAGA(C/T)GAATG intron-variant
rs1000137349 -- 42,620,689(+) ACCCA(A/G)CTTCA intron-variant
rs1000147841 -- 42,589,119(+) TGGTT(A/G)TTTAC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF33B Gene

Variant ID Type Subtype PubMed ID
nsv550672 CNV gain 21841781
nsv469725 CNV gain 16826518
nsv1042764 CNV gain 25217958
esv3891795 CNV gain 25118596
esv3623019 CNV loss 21293372
esv3623018 CNV gain 21293372
esv3623017 CNV loss 21293372
esv34929 CNV loss 17911159
esv2759746 CNV loss 17122850
esv2669368 CNV deletion 23128226
dgv1098n54 CNV gain 21841781

Variation tolerance for ZNF33B Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF33B Gene

Disorders for ZNF33B Gene

Relevant External Links for ZNF33B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF33B Gene

Publications for ZNF33B Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A … Ponder BA (Nucleic acids research 1993) 3 4 22 60
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. (PMID: 12566394) Guy J … Jackson MS (Genome research 2003) 3 4 60

Products for ZNF33B Gene

Sources for ZNF33B Gene

Loading form....