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Aliases for ZNF10 Gene

Aliases for ZNF10 Gene

  • Zinc Finger Protein 10 2 3 5
  • Zinc Finger Protein 10 (KOX 1) 2 3
  • Zinc Finger Protein KOX1 3 4
  • KOX1 3 4

External Ids for ZNF10 Gene

Previous GeneCards Identifiers for ZNF10 Gene

  • GC12P131228
  • GC12P133310
  • GC12P131897
  • GC12P131392
  • GC12P132317
  • GC12P133708
  • GC12P133709

Summaries for ZNF10 Gene

Entrez Gene Summary for ZNF10 Gene

  • The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF10 Gene

ZNF10 (Zinc Finger Protein 10) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF329.

UniProtKB/Swiss-Prot for ZNF10 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF10 Gene

Genomics for ZNF10 Gene

Regulatory Elements for ZNF10 Gene

Promoters for ZNF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF10 gene promoter:

Genomic Location for ZNF10 Gene

Chromosome:
12
Start:
133,130,575 bp from pter
End:
133,159,465 bp from pter
Size:
28,891 bases
Orientation:
Plus strand

Genomic View for ZNF10 Gene

Genes around ZNF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF10 Gene

Proteins for ZNF10 Gene

  • Protein details for ZNF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21506-ZNF10_HUMAN
    Recommended name:
    Zinc finger protein 10
    Protein Accession:
    P21506
    Secondary Accessions:
    • B2RBS1
    • Q8TC91

    Protein attributes for ZNF10 Gene

    Size:
    573 amino acids
    Molecular mass:
    66455 Da
    Quaternary structure:
    • Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain).

neXtProt entry for ZNF10 Gene

Proteomics data for ZNF10 Gene at MOPED

Post-translational modifications for ZNF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF10 Gene

No data available for DME Specific Peptides for ZNF10 Gene

Domains & Families for ZNF10 Gene

Gene Families for ZNF10 Gene

Protein Domains for ZNF10 Gene

Suggested Antigen Peptide Sequences for ZNF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21506

UniProtKB/Swiss-Prot:

ZNF10_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF10: view

Function for ZNF10 Gene

Molecular function for ZNF10 Gene

GENATLAS Biochemistry:
zinc finger protein 10 (KOX1) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF10 Gene

GenomeRNAi human phenotypes for ZNF10:
genes like me logo Genes that share phenotypes with ZNF10: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF10 Gene

Localization for ZNF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF10 Gene COMPARTMENTS Subcellular localization image for ZNF10 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF10 Gene

Pathways & Interactions for ZNF10 Gene

SuperPathways for ZNF10 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF10: view

Pathways by source for ZNF10 Gene

2 Reactome pathways for ZNF10 Gene

Gene Ontology (GO) - Biological Process for ZNF10 Gene

None

No data available for SIGNOR curated interactions for ZNF10 Gene

Drugs & Compounds for ZNF10 Gene

(1) Drugs for ZNF10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF10: view

Transcripts for ZNF10 Gene

Unigene Clusters for ZNF10 Gene

Zinc finger protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF10 Gene

No ASD Table

Relevant External Links for ZNF10 Gene

GeneLoc Exon Structure for
ZNF10
ECgene alternative splicing isoforms for
ZNF10

Expression for ZNF10 Gene

mRNA expression in normal human tissues for ZNF10 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF10 Gene

This gene is overexpressed in Pituitary (x4.2).

Protein differential expression in normal tissues from HIPED for ZNF10 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF10 Gene



SOURCE GeneReport for Unigene cluster for ZNF10 Gene Hs.573983

genes like me logo Genes that share expression patterns with ZNF10: view

Protein tissue co-expression partners for ZNF10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF10 Gene

Orthologs for ZNF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF10 35
  • 87.62 (n)
  • 86.51 (a)
ZNF10 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF10 35
  • 88.87 (n)
  • 87.76 (a)
ZNF10 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF10 35
  • 99.94 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF10 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
ZNF302 36
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
Species with no ortholog for ZNF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF10 Gene

ENSEMBL:
Gene Tree for ZNF10 (if available)
TreeFam:
Gene Tree for ZNF10 (if available)

Paralogs for ZNF10 Gene

Paralogs for ZNF10 Gene

(550) SIMAP similar genes for ZNF10 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZNF10 Gene

genes like me logo Genes that share paralogs with ZNF10: view

Variants for ZNF10 Gene

Sequence variations from dbSNP and Humsavar for ZNF10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11147259 - 133,155,926(+) TATTC(A/G)GTTTG reference, missense
rs1809942 -- 133,155,034(-) ATGAC(A/G)CAATC intron-variant
rs2270928 -- 133,152,014(-) GTCTT(C/T)CCAGG intron-variant
rs2292029 -- 133,157,527(-) GTAGT(A/G)GAGAT utr-variant-3-prime
rs3763150 -- 133,156,050(-) CATTC(C/T)TTACA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF10 Gene

Variant ID Type Subtype PubMed ID
dgv538e1 CNV Complex 17122850
nsv899835 CNV Loss 21882294
nsv899836 CNV Gain 21882294
esv27162 CNV Gain+Loss 19812545
essv8522 CNV CNV 17122850
nsv470337 CNV Loss 18288195
nsv518970 CNV Gain 19592680
dgv220n27 CNV Gain 19166990
nsv455818 CNV Loss 19166990
nsv9050 CNV Gain 18304495
nsv442301 CNV CNV 18776908

Variation tolerance for ZNF10 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF10 Gene

HapMap Linkage Disequilibrium report
ZNF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF10 Gene

Disorders for ZNF10 Gene

Relevant External Links for ZNF10

Genetic Association Database (GAD)
ZNF10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF10

No disorders were found for ZNF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF10 Gene

Publications for ZNF10 Gene

  1. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3 4 67
  2. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. (PMID: 10748030) Peng H. … Rauscher F.J. (J. Biol. Chem. 2000) 3 23
  3. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a KrA1ppel-type zinc finger factor. (PMID: 9278146) Moosmann P. … Schaffner W. (Biol. Chem. 1997) 3 23
  4. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3
  5. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. (PMID: 8262519) Rousseau-Merck M.F. … Berger R. (Hum. Genet. 1993) 2 3

Products for ZNF10 Gene

Sources for ZNF10 Gene

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