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Aliases for ZNF10 Gene

Aliases for ZNF10 Gene

  • Zinc Finger Protein 10 2 3
  • KOX1 3 4 6
  • Zinc Finger Protein 10 (KOX 1) 2 3
  • Zinc Finger Protein KOX1 3 4

External Ids for ZNF10 Gene

Previous GeneCards Identifiers for ZNF10 Gene

  • GC12P131228
  • GC12P133310
  • GC12P131897
  • GC12P131392
  • GC12P132317
  • GC12P133708
  • GC12P133709

Summaries for ZNF10 Gene

Entrez Gene Summary for ZNF10 Gene

  • The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF10 Gene

ZNF10 (Zinc Finger Protein 10) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF678.

UniProtKB/Swiss-Prot for ZNF10 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF10 Gene

Genomics for ZNF10 Gene

Regulatory Elements for ZNF10 Gene

Transcription factor binding sites by QIAGEN in the ZNF10 gene promoter:

Genomic Location for ZNF10 Gene

Start:
133,130,575 bp from pter
End:
133,159,465 bp from pter
Size:
28,891 bases
Orientation:
Plus strand

Genomic View for ZNF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF10 Gene

Proteins for ZNF10 Gene

  • Protein details for ZNF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21506-ZNF10_HUMAN
    Recommended name:
    Zinc finger protein 10
    Protein Accession:
    P21506
    Secondary Accessions:
    • B2RBS1
    • Q8TC91

    Protein attributes for ZNF10 Gene

    Size:
    573 amino acids
    Molecular mass:
    66455 Da
    Quaternary structure:
    • Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain).

neXtProt entry for ZNF10 Gene

Proteomics data for ZNF10 Gene at MOPED

Post-translational modifications for ZNF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF10 Gene

No data available for DME Specific Peptides for ZNF10 Gene

Domains for ZNF10 Gene

Gene Families for ZNF10 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21506

UniProtKB/Swiss-Prot:

ZNF10_HUMAN :
  • P21506
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF10: view

Function for ZNF10 Gene

Molecular function for ZNF10 Gene

GENATLAS Biochemistry: zinc finger protein 10 (KOX1) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 23665872
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF10: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF10 Gene

Localization for ZNF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF10 Gene COMPARTMENTS Subcellular localization image for ZNF10 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 23665872
genes like me logo Genes that share ontologies with ZNF10: view

Pathways for ZNF10 Gene

SuperPathways for ZNF10 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF10: view

Pathways by source for ZNF10 Gene

2 Reactome pathways for ZNF10 Gene

Gene Ontology (GO) - Biological Process for ZNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF10: view

Compounds for ZNF10 Gene

(1) Novoseek inferred chemical compound relationships for ZNF10 Gene

Compound -log(P) Hits PubMed IDs
zinc 55 3
genes like me logo Genes that share compounds with ZNF10: view

Transcripts for ZNF10 Gene

mRNA/cDNA for ZNF10 Gene

Unigene Clusters for ZNF10 Gene

Zinc finger protein 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF10

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF10 Gene

No ASD Table

Relevant External Links for ZNF10 Gene

GeneLoc Exon Structure for
ZNF10
ECgene alternative splicing isoforms for
ZNF10

Expression for ZNF10 Gene

mRNA expression in normal human tissues for ZNF10 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF10 Gene

This gene is overexpressed in Pituitary (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF10 Gene

SOURCE GeneReport for Unigene cluster for ZNF10 Gene Hs.573983

genes like me logo Genes that share expressions with ZNF10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF10 Gene

Orthologs for ZNF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF10 35
  • 99.94 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ZNF10 35
  • 87.62 (n)
  • 86.51 (a)
ZNF10 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF10 35
  • 88.87 (n)
  • 87.76 (a)
ZNF10 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF10 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
ZNF302 36
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
Species with no ortholog for ZNF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF10 Gene

ENSEMBL:
Gene Tree for ZNF10 (if available)
TreeFam:
Gene Tree for ZNF10 (if available)

Paralogs for ZNF10 Gene

Selected SIMAP similar genes for ZNF10 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZNF10 Gene

genes like me logo Genes that share paralogs with ZNF10: view

Variants for ZNF10 Gene

Sequence variations from dbSNP and Humsavar for ZNF10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1809942 -- 133,155,034(-) ATGAC(A/G)CAATC intron-variant
rs2270928 -- 133,152,014(-) GTCTT(C/T)CCAGG intron-variant
rs2292029 -- 133,157,527(-) GTAGT(A/G)GAGAT utr-variant-3-prime
rs3763150 -- 133,156,050(-) CATTC(C/T)TTACA synonymous-codon, reference
rs3763151 -- 133,156,038(-) TCATA(A/G)GGTTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF10 Gene

Variant ID Type Subtype PubMed ID
dgv538e1 CNV Complex 17122850
nsv899835 CNV Loss 21882294
nsv899836 CNV Gain 21882294
esv27162 CNV Gain+Loss 19812545
essv8522 CNV CNV 17122850
nsv470337 CNV Loss 18288195
nsv518970 CNV Gain 19592680
dgv220n27 CNV Gain 19166990
nsv455818 CNV Loss 19166990
nsv9050 CNV Gain 18304495
nsv442301 CNV CNV 18776908

Relevant External Links for ZNF10 Gene

HapMap Linkage Disequilibrium report
ZNF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF10 Gene

Disorders for ZNF10 Gene

Relevant External Links for ZNF10

Genetic Association Database (GAD)
ZNF10
genes like me logo Genes that share disorders with ZNF10: view

No data available for UniProtKB/Swiss-Prot for ZNF10 Gene

Publications for ZNF10 Gene

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3
  2. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. (PMID: 8262519) Rousseau-Merck M.F. … Berger R. (Hum. Genet. 1993) 2 3
  3. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a KrA1ppel-type zinc finger factor. (PMID: 9278146) Moosmann P. … Schaffner W. (Biol. Chem. 1997) 3 23
  4. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. (PMID: 10748030) Peng H. … Rauscher F.J. (J. Biol. Chem. 2000) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF10 Gene

Sources for ZNF10 Gene

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