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Aliases for CNBP Gene

Aliases for CNBP Gene

  • CCHC-Type Zinc Finger, Nucleic Acid Binding Protein 2 3
  • ZNF9 3 4 6
  • Zinc Finger Protein 9 (A Cellular Retroviral Nucleic Acid Binding Protein) 2 3
  • Zinc Finger Protein 9 2 4
  • RNF163 3 4
  • CNBP1 3 6
  • PROMM 3 6
  • DM2 3 6
  • Sterol Regulatory Element-Binding Protein 3
  • Cellular Nucleic Acid Binding Protein 3
  • Cellular Nucleic Acid-Binding Protein 3
  • Erythroid Differentiation-Related 3
  • Zinc Finger Protein 273 3
  • ZCCHC22 3

External Ids for CNBP Gene

Previous HGNC Symbols for CNBP Gene

  • DM2
  • ZNF9

Previous GeneCards Identifiers for CNBP Gene

  • GC03M130372
  • GC03M128886
  • GC03M126273

Summaries for CNBP Gene

Entrez Gene Summary for CNBP Gene

  • This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNBP Gene

CNBP (CCHC-Type Zinc Finger, Nucleic Acid Binding Protein) is a Protein Coding gene. Diseases associated with CNBP include myotonic dystrophy 2 and nondystrophic myotonia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and single-stranded RNA binding. An important paralog of this gene is ZCCHC13.

UniProtKB/Swiss-Prot for CNBP Gene

  • Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression

Gene Wiki entry for CNBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNBP Gene

Genomics for CNBP Gene

Regulatory Elements for CNBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNBP Gene

Start:
129,167,815 bp from pter
End:
129,183,967 bp from pter
Size:
16,153 bases
Orientation:
Minus strand

Genomic View for CNBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNBP Gene

Proteins for CNBP Gene

  • Protein details for CNBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62633-CNBP_HUMAN
    Recommended name:
    Cellular nucleic acid-binding protein
    Protein Accession:
    P62633
    Secondary Accessions:
    • A8K7V4
    • B2RAV9
    • B4DP17
    • D3DNB9
    • D3DNC0
    • D3DNC1
    • E9PDR7
    • P20694
    • Q4JGY0
    • Q4JGY1
    • Q5QJR0
    • Q5U0E9
    • Q6PJI7
    • Q96NV3

    Protein attributes for CNBP Gene

    Size:
    177 amino acids
    Molecular mass:
    19463 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNBP Gene

neXtProt entry for CNBP Gene

Proteomics data for CNBP Gene at MOPED

Post-translational modifications for CNBP Gene

  • Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.
  • Ubiquitination at Lys8, Lys103, Lys130, and Lys152
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNBP Gene

Domains for CNBP Gene

Gene Families for CNBP Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • ZCCHC :Zinc fingers, CCHC domain containing

Protein Domains for CNBP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P62633

UniProtKB/Swiss-Prot:

CNBP_HUMAN :
  • P62633
Similarity:
  • Contains 7 CCHC-type zinc fingers.
genes like me logo Genes that share domains with CNBP: view

Function for CNBP Gene

Molecular function for CNBP Gene

UniProtKB/Swiss-Prot Function: Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression

Gene Ontology (GO) - Molecular Function for CNBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003697 single-stranded DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 2562787
GO:0003727 single-stranded RNA binding IEA --
GO:0005515 protein binding IPI 24726729
genes like me logo Genes that share ontologies with CNBP: view
genes like me logo Genes that share phenotypes with CNBP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNBP Gene

Localization for CNBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNBP Gene

Cytoplasm. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNBP Gene COMPARTMENTS Subcellular localization image for CNBP gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
nucleus 4
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CNBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with CNBP: view

Pathways for CNBP Gene

SuperPathways for CNBP Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for CNBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 2562787
GO:0006695 cholesterol biosynthetic process TAS 2562787
GO:0008284 positive regulation of cell proliferation ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with CNBP: view

No data available for Pathways by source for CNBP Gene

Compounds for CNBP Gene

(8) Novoseek inferred chemical compound relationships for CNBP Gene

Compound -log(P) Hits PubMed IDs
zinc 62.8 35
poly c 36.8 1
sterol 23 3
arginine 17.9 5
phenol 7.4 1
genes like me logo Genes that share compounds with CNBP: view

Transcripts for CNBP Gene

Unigene Clusters for CNBP Gene

CCHC-type zinc finger, nucleic acid binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNBP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNBP Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ·
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12: - -
SP13: - - -
SP14: - - - - - -
SP15: - -
SP16:
SP17: - -

ExUns: 7h · 7i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for CNBP Gene

GeneLoc Exon Structure for
CNBP
ECgene alternative splicing isoforms for
CNBP

Expression for CNBP Gene

mRNA expression in normal human tissues for CNBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNBP Gene

This gene is overexpressed in Muscle - Skeletal (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNBP Gene

SOURCE GeneReport for Unigene cluster for CNBP Gene Hs.518249

mRNA Expression by UniProt/SwissProt for CNBP Gene

P62633-CNBP_HUMAN
Tissue specificity: Present in all tissues examined
genes like me logo Genes that share expressions with CNBP: view

In Situ Assay Products

Orthologs for CNBP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNBP 35
  • 99.25 (n)
  • 100 (a)
CNBP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNBP 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNBP 35
  • 96.61 (n)
  • 100 (a)
CNBP 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnbp 35
  • 93.73 (n)
  • 98.24 (a)
Cnbp 16
Cnbp 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNBP 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cnbp 35
  • 95.48 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves CNBP 35
  • 90.64 (n)
  • 97.66 (a)
CNBP 36
  • 98 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.985 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6124 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10040 35
zebrafish
(Danio rerio)
Actinopterygii cnbpa 36
  • 74 (a)
ManyToMany
cnbpb 35
  • 69.79 (n)
  • 73.75 (a)
cnbpb 36
  • 78 (a)
ManyToMany
wufe36b09 35
fruit fly
(Drosophila melanogaster)
Insecta CG3800 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K08D12.3 36
  • 36 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR646W 35
  • 51.8 (n)
  • 43.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIS2 35
  • 55.56 (n)
  • 48.25 (a)
GIS2 36
  • 37 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C02805g 35
  • 54.28 (n)
  • 52.21 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05800 35
  • 48.21 (n)
  • 38.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10180 36
  • 31 (a)
OneToMany
Species with no ortholog for CNBP:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNBP Gene

ENSEMBL:
Gene Tree for CNBP (if available)
TreeFam:
Gene Tree for CNBP (if available)

Paralogs for CNBP Gene

Paralogs for CNBP Gene

Selected SIMAP similar genes for CNBP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CNBP: view

Variants for CNBP Gene

Sequence variations from dbSNP and Humsavar for CNBP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1133046 -- 129,167,850(-) TTAAC(A/C)CAATA utr-variant-3-prime
rs1384313 -- 129,177,231(-) AGTAA(A/G)TGGTG intron-variant
rs1871922 -- 129,183,756(-) AGGGG(A/C)CCGGC intron-variant
rs3211324 -- 129,183,794(-) TGCGG(C/G)CCCGC utr-variant-5-prime
rs4303883 -- 129,171,507(-) CCAGA(C/T)ATTTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CNBP Gene

Variant ID Type Subtype PubMed ID
dgv5251n71 CNV Loss 21882294

Relevant External Links for CNBP Gene

HapMap Linkage Disequilibrium report
CNBP
Human Gene Mutation Database (HGMD)
CNBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNBP Gene

Disorders for CNBP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for CNBP Gene including...

Search for CNBP Gene in MalaCards »

(1) OMIM Diseases for CNBP Gene (116955)

UniProtKB/Swiss-Prot

CNBP_HUMAN
  • Dystrophia myotonica 2 (DM2) [MIM:602668]: A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. Note=The disease is caused by mutations affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.

(2) University of Copenhagen DISEASES for CNBP Gene

(13) Novoseek inferred disease relationships for CNBP Gene

Disease -log(P) Hits PubMed IDs
myotonic dystrophy 87.5 30
promm 87.4 6
cataract 20.6 1
creutzfeldt-jakob disease 11.2 1
immunodeficiency 8.84 2

Relevant External Links for CNBP

GeneTests
CNBP
GeneReviews
CNBP
Genetic Association Database (GAD)
CNBP
Human Genome Epidemiology (HuGE) Navigator
CNBP
genes like me logo Genes that share disorders with CNBP: view

Publications for CNBP Gene

  1. Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9. (PMID: 11486088) Liquori C.L. … Ranum L.P. (Science 2001) 2 3 4 23
  2. Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24. (PMID: 2249857) Lusis A.J. … Sparkes R.S. (Genomics 1990) 2 3 23
  3. Organization of the gene encoding cellular nucleic acid-binding protein. (PMID: 7590281) Flink I.L. … Morkin E. (Gene 1995) 3 4 23
  4. Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing. (PMID: 7896269) Warden C.H. … Lusis A.J. (Genomics 1994) 3 23
  5. Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein. (PMID: 12857921) McGrath C.F. … Gorelick R.J. (J. Virol. 2003) 3 23

Products for CNBP Gene

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