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Aliases for ZFY Gene

Aliases for ZFY Gene

  • Zinc Finger Protein, Y-Linked 2 3 5
  • ZNF911 3

External Ids for ZFY Gene

Previous GeneCards Identifiers for ZFY Gene

  • GC0YP002729
  • GC0YP002448
  • GC0YP000155

Summaries for ZFY Gene

Entrez Gene Summary for ZFY Gene

  • This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZFY Gene

ZFY (Zinc Finger Protein, Y-Linked) is a Protein Coding gene. Diseases associated with ZFY include Cystadenofibroma and Frasier Syndrome. An important paralog of this gene is ZNF711.

UniProtKB/Swiss-Prot for ZFY Gene

  • Probable transcriptional activator. Binds to the consensus sequence 5-AGGCCY-3.

Gene Wiki entry for ZFY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFY Gene

Genomics for ZFY Gene

Regulatory Elements for ZFY Gene

Enhancers for ZFY Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZFY on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFY Gene

2,934,416 bp from pter
2,982,508 bp from pter
48,093 bases
Plus strand

Genomic View for ZFY Gene

Genes around ZFY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFY Gene

Proteins for ZFY Gene

  • Protein details for ZFY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger Y-chromosomal protein
    Protein Accession:
    Secondary Accessions:
    • B4DVF7
    • Q14021
    • Q15558
    • Q1RME9
    • Q24JR0
    • Q96TF3

    Protein attributes for ZFY Gene

    801 amino acids
    Molecular mass:
    90505 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFY Gene

    Alternative splice isoforms for ZFY Gene


neXtProt entry for ZFY Gene

Proteomics data for ZFY Gene at MOPED

Post-translational modifications for ZFY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFY Gene

No data available for DME Specific Peptides for ZFY Gene

Domains & Families for ZFY Gene

Gene Families for ZFY Gene

Graphical View of Domain Structure for InterPro Entry



  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
  • Contains 13 C2H2-type zinc fingers.
  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFY: view

Function for ZFY Gene

Molecular function for ZFY Gene

GENATLAS Biochemistry:
zinc finger protein,Y-linked
UniProtKB/Swiss-Prot Function:
Probable transcriptional activator. Binds to the consensus sequence 5-AGGCCY-3.
genes like me logo Genes that share phenotypes with ZFY: view

Human Phenotype Ontology for ZFY Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ZFY Gene

miRTarBase miRNAs that target ZFY

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFY Gene

Localization for ZFY Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFY Gene


Subcellular locations from

Jensen Localization Image for ZFY Gene COMPARTMENTS Subcellular localization image for ZFY gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ZFY Gene

Pathways & Interactions for ZFY Gene

SuperPathways for ZFY Gene

No Data Available

Interacting Proteins for ZFY Gene

Gene Ontology (GO) - Biological Process for ZFY Gene


No data available for Pathways by source and SIGNOR curated interactions for ZFY Gene

Drugs & Compounds for ZFY Gene

(3) Drugs for ZFY Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
Beta-Cyclohexyl-Alanine Experimental Pharma Target 0
PCL-016 Investigational Pharma Target 0

(1) Additional Compounds for ZFY Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZFY: view

Transcripts for ZFY Gene

Unigene Clusters for ZFY Gene

Zinc finger protein, Y-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFY Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - -
SP3: -

Relevant External Links for ZFY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFY Gene

mRNA expression in normal human tissues for ZFY Gene

Protein differential expression in normal tissues from HIPED for ZFY Gene

This gene is overexpressed in Nasal epithelium (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFY Gene

SOURCE GeneReport for Unigene cluster for ZFY Gene Hs.522845

genes like me logo Genes that share expression patterns with ZFY: view

Protein tissue co-expression partners for ZFY Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFY Gene

Orthologs for ZFY Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFY 35
  • 99.5 (n)
  • 99.25 (a)
ZFY 36
  • 99 (a)
(Bos Taurus)
Mammalia ZFX 36
  • 94 (a)
(Canis familiaris)
Mammalia ZFX 36
  • 94 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
(Mus musculus)
Mammalia Zfy1 36
  • 70 (a)
Zfy2 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
(Gallus gallus)
Aves -- 36
  • 87 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
(Danio rerio)
Actinopterygii CABZ01079241.1 36
  • 64 (a)
zfx 36
  • 58 (a)
Species with no ortholog for ZFY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFY Gene

Gene Tree for ZFY (if available)
Gene Tree for ZFY (if available)

Paralogs for ZFY Gene

Paralogs for ZFY Gene

(10) SIMAP similar genes for ZFY Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZFY: view

Variants for ZFY Gene

Sequence variations from dbSNP and Humsavar for ZFY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs1270119 -- 2,935,676(+) GCCCG(C/T)TTGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1270120 -- 2,941,383(+) TTGGT(A/T)ATCTG intron-variant
rs1270121 -- 2,942,542(+) gggct(A/G)caggt intron-variant
rs1270122 -- 2,947,384(+) TAAAG(A/G)AAATA intron-variant
rs1270123 -- 2,949,388(+) ttagc(C/G)tccca intron-variant

Variation tolerance for ZFY Gene

Gene Damage Index Score: 0.06; 1.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZFY Gene

Disorders for ZFY Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZFY Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • cystadenofibroma, nos
frasier syndrome
  • fs
- elite association - COSMIC cancer census association via MalaCards
Search ZFY in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZFY

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZFY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFY Gene

Publications for ZFY Gene

  1. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PMID: 2041734) North M. … Ferguson-Smith M.A. (Nucleic Acids Res. 1991) 3 4 23 67
  2. Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. (PMID: 10779541) Erlandsson R. … Paabo S. (Mol. Biol. Evol. 2000) 3 23
  3. Comparison of human ZFY and ZFX transcripts. (PMID: 2308929) Palmer M.S. … Goodfellow P.N. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 23
  4. Mapping the human ZFX locus to Xp21.3 by in situ hybridization. (PMID: 2497060) MA1ller G. … Schempp W. (Hum. Genet. 1989) 2 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for ZFY Gene

Sources for ZFY Gene