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Aliases for ZFY Gene

Aliases for ZFY Gene

  • Zinc Finger Protein, Y-Linked 2 3
  • Zinc Finger Y-Chromosomal Protein 3
  • ZNF911 3

External Ids for ZFY Gene

Previous GeneCards Identifiers for ZFY Gene

  • GC0YP002729
  • GC0YP002448
  • GC0YP000155

Summaries for ZFY Gene

Entrez Gene Summary for ZFY Gene

  • This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZFY Gene

ZFY (Zinc Finger Protein, Y-Linked) is a Protein Coding gene. Diseases associated with ZFY include cystadenofibroma and campomelic dysplasia. An important paralog of this gene is ZNF711.

UniProtKB/Swiss-Prot for ZFY Gene

  • Probable transcriptional activator. Binds to the consensus sequence 5-AGGCCY-3.

Gene Wiki entry for ZFY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFY Gene

Genomics for ZFY Gene

Regulatory Elements for ZFY Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZFY Gene

Start:
2,935,071 bp from pter
End:
2,982,506 bp from pter
Size:
47,436 bases
Orientation:
Plus strand

Genomic View for ZFY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFY Gene

Proteins for ZFY Gene

  • Protein details for ZFY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08048-ZFY_HUMAN
    Recommended name:
    Zinc finger Y-chromosomal protein
    Protein Accession:
    P08048
    Secondary Accessions:
    • B4DVF7
    • Q14021
    • Q15558
    • Q1RME9
    • Q24JR0
    • Q96TF3

    Protein attributes for ZFY Gene

    Size:
    801 amino acids
    Molecular mass:
    90505 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFY Gene

    Alternative splice isoforms for ZFY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFY Gene

Proteomics data for ZFY Gene at MOPED

Post-translational modifications for ZFY Gene

  • Ubiquitination at Lys711
  • Modification sites at PhosphoSitePlus

Other Protein References for ZFY Gene

No data available for DME Specific Peptides for ZFY Gene

Domains for ZFY Gene

Gene Families for ZFY Gene

Graphical View of Domain Structure for InterPro Entry

P08048

UniProtKB/Swiss-Prot:

ZFY_HUMAN :
  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFY: view

Function for ZFY Gene

Molecular function for ZFY Gene

GENATLAS Biochemistry:
zinc finger protein,Y-linked
UniProtKB/Swiss-Prot Function:
Probable transcriptional activator. Binds to the consensus sequence 5-AGGCCY-3.

Gene Ontology (GO) - Molecular Function for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFY: view

Animal Model Products

CRISPR Products

miRNA for ZFY Gene

miRTarBase miRNAs that target ZFY

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFY

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFY Gene

Localization for ZFY Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFY Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFY Gene COMPARTMENTS Subcellular localization image for ZFY gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFY: view

Pathways for ZFY Gene

SuperPathways for ZFY Gene

No Data Available

Interacting Proteins for ZFY Gene

Gene Ontology (GO) - Biological Process for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFY: view

No data available for Pathways by source for ZFY Gene

Drugs for ZFY Gene

(2) Drugbank Compounds for ZFY Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Beta-Cyclohexyl-Alanine
712421 Target experimental
PCL-016
Target investigational

(1) HMDB Compounds for ZFY Gene

Compound Synonyms Cas Number PubMed IDs
Zinc (II) ion
  • Zinc
7440-66-6

(2) Novoseek inferred chemical compound relationships for ZFY Gene

Compound -log(P) Hits PubMed IDs
zinc 55.9 10
deoxyribonucleic acid 45.3 2
genes like me logo Genes that share compounds with ZFY: view

Transcripts for ZFY Gene

Unigene Clusters for ZFY Gene

Zinc finger protein, Y-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFY

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFY Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ZFY Gene

GeneLoc Exon Structure for
ZFY
ECgene alternative splicing isoforms for
ZFY

Expression for ZFY Gene

mRNA expression in normal human tissues for ZFY Gene

Protein differential expression in normal tissues for ZFY Gene

This gene is overexpressed in Nasal epithelium (67.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFY Gene

SOURCE GeneReport for Unigene cluster for ZFY Gene Hs.522845

genes like me logo Genes that share expressions with ZFY: view

Expression partners for ZFY Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFY Gene

Orthologs for ZFY Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFY 35
  • 99.5 (n)
  • 99.25 (a)
ZFY 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFX 36
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZFX 36
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfy1 36
  • 70 (a)
ManyToMany
Zfy2 36
  • 71 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01079241.1 36
  • 64 (a)
ManyToMany
zfx 36
  • 58 (a)
ManyToMany
Species with no ortholog for ZFY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFY Gene

ENSEMBL:
Gene Tree for ZFY (if available)
TreeFam:
Gene Tree for ZFY (if available)

Paralogs for ZFY Gene

Paralogs for ZFY Gene

(10) SIMAP similar genes for ZFY Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZFY: view

Variants for ZFY Gene

Sequence variations from dbSNP and Humsavar for ZFY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs1270119 -- 2,935,676(+) GCCCG(C/T)TTGTC utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs1270120 -- 2,941,383(+) TTGGT(A/T)ATCTG intron-variant
rs1270121 -- 2,942,542(+) gggct(A/G)caggt intron-variant
rs1270122 -- 2,947,384(+) TAAAG(A/G)AAATA intron-variant
rs1270123 -- 2,949,388(+) ttagc(C/G)tccca intron-variant

Relevant External Links for ZFY Gene

HapMap Linkage Disequilibrium report
ZFY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZFY Gene

Disorders for ZFY Gene

(5) University of Copenhagen DISEASES for ZFY Gene

genes like me logo Genes that share disorders with ZFY: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ZFY Gene

Publications for ZFY Gene

  1. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PMID: 2041734) North M. … Ferguson-Smith M.A. (Nucleic Acids Res. 1991) 3 4 23
  2. Comparison of human ZFY and ZFX transcripts. (PMID: 2308929) Palmer M.S. … Goodfellow P.N. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23
  3. Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. (PMID: 10779541) Erlandsson R. … Paabo S. (Mol. Biol. Evol. 2000) 3 4 23
  4. The sex-determining region of the human Y chromosome encodes a finger protein. (PMID: 3690661) Page D.C. … Brown L.G. (Cell 1987) 3 4
  5. The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. (PMID: 2511751) Lau Y.-F.C. … Chan K. (Am. J. Hum. Genet. 1989) 3 4

Products for ZFY Gene

Sources for ZFY Gene

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