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Aliases for ZFY Gene

Aliases for ZFY Gene

  • Zinc Finger Protein, Y-Linked 2 3
  • ZNF911 3

External Ids for ZFY Gene

Previous GeneCards Identifiers for ZFY Gene

  • GC0YP002729
  • GC0YP002448
  • GC0YP000155

Summaries for ZFY Gene

Entrez Gene Summary for ZFY Gene

  • This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZFY Gene

ZFY (Zinc Finger Protein, Y-Linked) is a Protein Coding gene. Diseases associated with ZFY include cystadenofibroma and frasier syndrome. An important paralog of this gene is ZNF711.

UniProtKB/Swiss-Prot for ZFY Gene

  • Probable transcriptional activator. Binds to the consensus sequence 5-AGGCCY-3.

Gene Wiki entry for ZFY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFY Gene

Genomics for ZFY Gene

Regulatory Elements for ZFY Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZFY Gene

Chromosome:
Y
Start:
2,934,416 bp from pter
End:
2,982,508 bp from pter
Size:
48,093 bases
Orientation:
Plus strand

Genomic View for ZFY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFY Gene

Proteins for ZFY Gene

  • Protein details for ZFY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08048-ZFY_HUMAN
    Recommended name:
    Zinc finger Y-chromosomal protein
    Protein Accession:
    P08048
    Secondary Accessions:
    • B4DVF7
    • Q14021
    • Q15558
    • Q1RME9
    • Q24JR0
    • Q96TF3

    Protein attributes for ZFY Gene

    Size:
    801 amino acids
    Molecular mass:
    90505 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFY Gene

    Alternative splice isoforms for ZFY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFY Gene

Proteomics data for ZFY Gene at MOPED

Post-translational modifications for ZFY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFY Gene

No data available for DME Specific Peptides for ZFY Gene

Domains & Families for ZFY Gene

Gene Families for ZFY Gene

Graphical View of Domain Structure for InterPro Entry

P08048

UniProtKB/Swiss-Prot:

ZFY_HUMAN :
  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFY: view

Function for ZFY Gene

Molecular function for ZFY Gene

GENATLAS Biochemistry:
zinc finger protein,Y-linked
UniProtKB/Swiss-Prot Function:
Probable transcriptional activator. Binds to the consensus sequence 5-AGGCCY-3.

Gene Ontology (GO) - Molecular Function for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFY: view
genes like me logo Genes that share phenotypes with ZFY: view

Animal Model Products

CRISPR Products

miRNA for ZFY Gene

miRTarBase miRNAs that target ZFY

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFY

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFY Gene

Localization for ZFY Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFY Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFY Gene COMPARTMENTS Subcellular localization image for ZFY gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IBA --
genes like me logo Genes that share ontologies with ZFY: view

Pathways & Interactions for ZFY Gene

SuperPathways for ZFY Gene

No Data Available

Interacting Proteins for ZFY Gene

Gene Ontology (GO) - Biological Process for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007275 multicellular organismal development IBA --
genes like me logo Genes that share ontologies with ZFY: view

No data available for Pathways by source and SIGNOR curated interactions for ZFY Gene

Drugs & Compounds for ZFY Gene

(3) Drugs for ZFY Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
Beta-Cyclohexyl-Alanine Experimental Pharma Target 0
PCL-016 Investigational Pharma Target 0

(1) Additional Compounds for ZFY Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
deoxyribonucleic acid
genes like me logo Genes that share compounds with ZFY: view

Transcripts for ZFY Gene

Unigene Clusters for ZFY Gene

Zinc finger protein, Y-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFY

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFY Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ZFY Gene

GeneLoc Exon Structure for
ZFY
ECgene alternative splicing isoforms for
ZFY

Expression for ZFY Gene

mRNA expression in normal human tissues for ZFY Gene

Protein differential expression in normal tissues from HIPED for ZFY Gene

This gene is overexpressed in Nasal epithelium (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFY Gene



SOURCE GeneReport for Unigene cluster for ZFY Gene Hs.522845

genes like me logo Genes that share expression patterns with ZFY: view

Protein tissue co-expression partners for ZFY Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFY Gene

Orthologs for ZFY Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFY 35
  • 99.5 (n)
  • 99.25 (a)
ZFY 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFX 36
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZFX 36
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfy1 36
  • 70 (a)
ManyToMany
Zfy2 36
  • 71 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01079241.1 36
  • 64 (a)
ManyToMany
zfx 36
  • 58 (a)
ManyToMany
Species with no ortholog for ZFY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFY Gene

ENSEMBL:
Gene Tree for ZFY (if available)
TreeFam:
Gene Tree for ZFY (if available)

Paralogs for ZFY Gene

Paralogs for ZFY Gene

(10) SIMAP similar genes for ZFY Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZFY: view

Variants for ZFY Gene

Sequence variations from dbSNP and Humsavar for ZFY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs1270119 -- 2,935,676(+) GCCCG(C/T)TTGTC utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs1270120 -- 2,941,383(+) TTGGT(A/T)ATCTG intron-variant
rs1270121 -- 2,942,542(+) gggct(A/G)caggt intron-variant
rs1270122 -- 2,947,384(+) TAAAG(A/G)AAATA intron-variant
rs1270123 -- 2,949,388(+) ttagc(C/G)tccca intron-variant

Variation tolerance for ZFY Gene

Gene Damage Index Score: 0.06; 1.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFY Gene

HapMap Linkage Disequilibrium report
ZFY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZFY Gene

Disorders for ZFY Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZFY Gene - From: DISEASES

Disorder Aliases PubMed IDs
cystadenofibroma
  • cystadenofibroma, nos
frasier syndrome
  • fs
- elite association
Search ZFY in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZFY

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFY
genes like me logo Genes that share disorders with ZFY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFY Gene

Publications for ZFY Gene

  1. Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY. (PMID: 15060604) Poloumienko A. (Genome 2004) 23 67
  2. Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. (PMID: 10779541) Erlandsson R. … Paabo S. (Mol. Biol. Evol. 2000) 23 67
  3. Y-chromosome identification by PCR and gonadal histopathology in Turner's syndrome without overt Y-mosaicism. (PMID: 10341852) Mendes J.R. … Verreschi I.T. (Clin. Endocrinol. (Oxf) 1999) 23 67
  4. The Y-chromosomal genes SRY and ZFY are transcribed in adult human brain. (PMID: 10732804) Mayer A. … Reisert I. (Neurogenetics 1998) 23 67
  5. A zinc finger domain gene in the lizard, Calotes versicolor, shows extensive homology with the mammalian ZFX and is expressed embryonically. (PMID: 9678340) Ganesh S. … Raman R. (Cytogenet. Cell Genet. 1998) 23 67

Products for ZFY Gene

Sources for ZFY Gene

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