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Aliases for ZFP36 Gene

Aliases for ZFP36 Gene

  • ZFP36 Ring Finger Protein 2 3 5
  • Growth Factor-Inducible Nuclear Protein NUP475 3 4
  • G0/G1 Switch Regulatory Protein 24 3 4
  • Zinc Finger Protein 36 Homolog 3 4
  • RNF162A 3 4
  • Zfp-36 3 4
  • G0S24 3 4
  • TIS11 3 4
  • TTP 3 4
  • Zinc Finger Protein 36, C3H Type, Homolog (Mouse) 2
  • Zinc Finger Protein 36, C3H Type, Homolog 3
  • Zinc Finger Protein, C3H Type, 36 Homolog 3
  • Tristetraproline 3
  • Tristetraprolin 2
  • Protein TIS11A 4
  • NUP475 3
  • TIS11A 4
  • GOS24 3

External Ids for ZFP36 Gene

Previous GeneCards Identifiers for ZFP36 Gene

  • GC19P040538
  • GC19P040288
  • GC19P044573
  • GC19P044589
  • GC19P039897
  • GC19P036344

Summaries for ZFP36 Gene

GeneCards Summary for ZFP36 Gene

ZFP36 (ZFP36 Ring Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and ErbB1 downstream signaling. GO annotations related to this gene include poly(A) RNA binding and enzyme binding. An important paralog of this gene is ZFP36L2.

UniProtKB/Swiss-Prot for ZFP36 Gene

  • mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Gene Wiki entry for ZFP36 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP36 Gene

Genomics for ZFP36 Gene

Regulatory Elements for ZFP36 Gene

Genomic Location for ZFP36 Gene

Chromosome:
19
Start:
39,406,813 bp from pter
End:
39,409,412 bp from pter
Size:
2,600 bases
Orientation:
Plus strand

Genomic View for ZFP36 Gene

Genes around ZFP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP36 Gene

Proteins for ZFP36 Gene

  • Protein details for ZFP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26651-TTP_HUMAN
    Recommended name:
    Tristetraprolin
    Protein Accession:
    P26651
    Secondary Accessions:
    • B2RA54

    Protein attributes for ZFP36 Gene

    Size:
    326 amino acids
    Molecular mass:
    34003 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CNOT1.

    Three dimensional structures from OCA and Proteopedia for ZFP36 Gene

neXtProt entry for ZFP36 Gene

Proteomics data for ZFP36 Gene at MOPED

Post-translational modifications for ZFP36 Gene

  • Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP36 Gene

Antibody Products

No data available for DME Specific Peptides for ZFP36 Gene

Domains & Families for ZFP36 Gene

Gene Families for ZFP36 Gene

Protein Domains for ZFP36 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZFP36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26651

UniProtKB/Swiss-Prot:

TTP_HUMAN :
  • Contains 2 C3H1-type zinc fingers.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZFP36: view

Function for ZFP36 Gene

Molecular function for ZFP36 Gene

GENATLAS Biochemistry:
zinc finger protein,proline rich,insulin and growth factor inducible,homologous to mouse tristetraprolin (ZFp-36)
UniProtKB/Swiss-Prot Function:
mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
UniProtKB/Swiss-Prot Induction:
By stimulation with various mitogens.

Gene Ontology (GO) - Molecular Function for ZFP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0019901 protein kinase binding IPI 15014438
GO:0035925 mRNA 3-UTR AU-rich region binding IEA,IDA 25038453
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZFP36: view
genes like me logo Genes that share phenotypes with ZFP36: view

Animal Models for ZFP36 Gene

MGI Knock Outs for ZFP36:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFP36 Gene

Localization for ZFP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP36 Gene

Nucleus. Cytoplasm. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP36 Gene COMPARTMENTS Subcellular localization image for ZFP36 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for ZFP36 Gene

Pathways & Interactions for ZFP36 Gene

genes like me logo Genes that share pathways with ZFP36: view

Pathways by source for ZFP36 Gene

Interacting Proteins for ZFP36 Gene

Gene Ontology (GO) - Biological Process for ZFP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 21784977
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA,IDA 23644599
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IEA,IMP 23644599
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006402 mRNA catabolic process IDA 10330172
genes like me logo Genes that share ontologies with ZFP36: view

No data available for SIGNOR curated interactions for ZFP36 Gene

Drugs & Compounds for ZFP36 Gene

(7) Drugs for ZFP36 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for ZFP36 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZFP36: view

Transcripts for ZFP36 Gene

mRNA/cDNA for ZFP36 Gene

Unigene Clusters for ZFP36 Gene

ZFP36 ring finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for ZFP36 Gene

GeneLoc Exon Structure for
ZFP36
ECgene alternative splicing isoforms for
ZFP36

Expression for ZFP36 Gene

mRNA expression in normal human tissues for ZFP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFP36 Gene

This gene is overexpressed in Fallopian Tube (x4.6).

SOURCE GeneReport for Unigene cluster for ZFP36 Gene Hs.534052

genes like me logo Genes that share expression patterns with ZFP36: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZFP36 Gene

Orthologs for ZFP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFP36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP36 36
  • 100 (a)
OneToOne
ZFP36 35
  • 99.58 (n)
  • 99.69 (a)
cow
(Bos Taurus)
Mammalia ZFP36 35
  • 84 (n)
  • 85.14 (a)
ZFP36 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP36 35
  • 84.35 (n)
  • 83.79 (a)
ZFP36 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp36 16
Zfp36 36
  • 86 (a)
OneToOne
Zfp36 35
  • 84.65 (n)
  • 86.44 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFP36 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp36 35
  • 85.44 (n)
  • 86.15 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfp36 35
  • 53.28 (n)
  • 53.69 (a)
zebrafish
(Danio rerio)
Actinopterygii ZFP36 36
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tis11 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35D6.4 36
  • 23 (a)
ManyToMany
ccch-1 36
  • 17 (a)
ManyToMany
ccch-2 36
  • 28 (a)
ManyToMany
ccch-5 36
  • 25 (a)
ManyToMany
dct-13 36
  • 20 (a)
ManyToMany
F38C2.7 36
  • 21 (a)
ManyToMany
mex-1 36
  • 15 (a)
ManyToMany
mex-5 36
  • 12 (a)
ManyToMany
mex-6 36
  • 11 (a)
ManyToMany
moe-3 36
  • 19 (a)
ManyToMany
oma-1 36
  • 16 (a)
ManyToMany
oma-2 36
  • 16 (a)
ManyToMany
pos-1 36
  • 19 (a)
ManyToMany
Y116A8C.19 36
  • 23 (a)
ManyToMany
Y116A8C.20 36
  • 22 (a)
ManyToMany
Y60A9.3 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTH1 36
  • 15 (a)
ManyToMany
TIS11 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6084 36
  • 22 (a)
OneToMany
Species with no ortholog for ZFP36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFP36 Gene

ENSEMBL:
Gene Tree for ZFP36 (if available)
TreeFam:
Gene Tree for ZFP36 (if available)

Paralogs for ZFP36 Gene

Paralogs for ZFP36 Gene

(1) SIMAP similar genes for ZFP36 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFP36: view

Variants for ZFP36 Gene

Sequence variations from dbSNP and Humsavar for ZFP36 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17878633 - 39,407,827(+) CGGGA(C/T)CCTGG reference, missense
rs17886974 - 39,408,493(+) CTCCT(A/G/T)TCAGC reference, missense
rs17884899 - 39,408,688(+) TCTCT(G/T)TTTCT reference, missense
rs2229272 - 39,407,881(+) GCCTG(C/T)CTGGC reference, missense
rs251864 -- 39,406,653(+) CGGTC(A/G)CGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZFP36 Gene

Variant ID Type Subtype PubMed ID
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
dgv3860n71 CNV Loss 21882294
dgv3861n71 CNV Loss 21882294
nsv911685 CNV Loss 21882294
dgv3862n71 CNV Loss 21882294

Variation tolerance for ZFP36 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP36 Gene

HapMap Linkage Disequilibrium report
ZFP36
Human Gene Mutation Database (HGMD)
ZFP36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP36 Gene

Disorders for ZFP36 Gene

Relevant External Links for ZFP36

Genetic Association Database (GAD)
ZFP36
Human Genome Epidemiology (HuGE) Navigator
ZFP36
Tumor Gene Database (TGDB):
ZFP36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP36

No disorders were found for ZFP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP36 Gene

Publications for ZFP36 Gene

  1. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. (PMID: 15014438) Stoecklin G. … Anderson P. (EMBO J. 2004) 3 4 23 67
  2. Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon cancer. (PMID: 19697322) Lee H.H. … Park J.W. (Int. J. Cancer 2010) 3 23
  3. Tristetraprolin regulates the stability of HIF-1alpha mRNA during prolonged hypoxia. (PMID: 19962963) Kim T.W. … Park K.C. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. IL-17 regulates CXCL1 mRNA stability via an AUUUA/tristetraprolin-independent sequence. (PMID: 20042592) Datta S. … Hamilton T. (J. Immunol. 2010) 3 23
  5. Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. (PMID: 20221403) Kedar V.P. … Blackshear P.J. (PLoS ONE 2010) 3 23

Products for ZFP36 Gene

Sources for ZFP36 Gene

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