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Aliases for ZFP36 Gene

Aliases for ZFP36 Gene

  • ZFP36 Ring Finger Protein 2 3 5
  • Tristetraprolin 2 3 4
  • Growth Factor-Inducible Nuclear Protein NUP475 3 4
  • G0/G1 Switch Regulatory Protein 24 3 4
  • RNF162A 3 4
  • Zfp-36 3 4
  • NUP475 3 4
  • G0S24 3 4
  • TTP 3 4
  • Zinc Finger Protein 36, C3H Type, Homolog (Mouse) 2
  • Zinc Finger Protein 36, C3H Type, Homolog 3
  • Zinc Finger Protein, C3H Type, 36 Homolog 3
  • MRNA Decay Activator Protein ZFP36 3
  • Zinc Finger Protein 36 Homolog 3
  • Zinc Finger Protein 36 4
  • Tristetraproline 3
  • TIS11A 4
  • GOS24 3
  • TIS11 3

External Ids for ZFP36 Gene

Previous GeneCards Identifiers for ZFP36 Gene

  • GC19P040538
  • GC19P040288
  • GC19P044573
  • GC19P044589
  • GC19P039897
  • GC19P036344

Summaries for ZFP36 Gene

GeneCards Summary for ZFP36 Gene

ZFP36 (ZFP36 Ring Finger Protein) is a Protein Coding gene. Among its related pathways are HTLV-I infection and Spinal Cord Injury. GO annotations related to this gene include poly(A) RNA binding and enzyme binding. An important paralog of this gene is ZFP36L2.

UniProtKB/Swiss-Prot for ZFP36 Gene

  • Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:9703499, PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:27193233, PubMed:23644599, PubMed:25815583). Acts as an 3-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:19188452, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077).

  • (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter.

Gene Wiki entry for ZFP36 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP36 Gene

Genomics for ZFP36 Gene

Regulatory Elements for ZFP36 Gene

Enhancers for ZFP36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G039397 2 FANTOM5 ENCODE dbSUPER 54.9 +0.3 262 20.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ENSG00000205041 EID2B ZFP36 FBL RPS16 SUPT5H ENSG00000269069 RN7SL566P ENSG00000269688 MED29
GH19G039427 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +25.3 25334 9.7 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 RPS16 ENSG00000205041 EID2B FBL ENSG00000269069 PLEKHG2 FBXO17 ZFP36 ACTN4 RN7SL566P
GH19G038673 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11 -711.9 -711927 42.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF573 ZNF607 EID2B ACTN4 ENSG00000267152 RN7SL566P RPS16 LOC100631378 CAPN12 SUPT5H
GH19G039933 1.7 FANTOM5 Ensembl ENCODE 11 +529.1 529093 3.9 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ENSG00000205041 FBL SERTAD3 FCGBP SNRPA PSMC4 ENSG00000269069 ZFP36 RN7SL566P RPS16
GH19G038829 1.4 ENCODE dbSUPER 12.2 -575.5 -575488 4.6 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 SP3 EID2B LOC100631378 ZFP36 LGALS7 FBXO17 RPS16 ACTN4 LGALS7B LRFN1 ENSG00000269050
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFP36 on UCSC Golden Path with GeneCards custom track

Promoters for ZFP36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109424 1487 4201 MLX AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3

Genomic Location for ZFP36 Gene

Chromosome:
19
Start:
39,406,813 bp from pter
End:
39,409,412 bp from pter
Size:
2,600 bases
Orientation:
Plus strand

Genomic View for ZFP36 Gene

Genes around ZFP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP36 Gene

Proteins for ZFP36 Gene

  • Protein details for ZFP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26651-TTP_HUMAN
    Recommended name:
    mRNA decay activator protein ZFP36
    Protein Accession:
    P26651
    Secondary Accessions:
    • B2RA54

    Protein attributes for ZFP36 Gene

    Size:
    326 amino acids
    Molecular mass:
    34003 Da
    Quaternary structure:
    • Associates with cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to trigger ARE-containing mRNA deadenylation and decay processes (By similarity). Part of a mRNA decay activation complex at least composed of poly(A)-specific exoribonucleases CNOT6, EXOSC2 and XRN1 and mRNA-decapping enzymes DCP1A and DCP2 (PubMed:15687258). Associates with the RNA exosome complex (PubMed:11719186). Interacts (via phosphorylated form) with 14-3-3 proteins; these interactions promote exclusion of ZFP36 from cytoplasmic stress granules in response to arsenite treatment in a MAPKAPK2-dependent manner and does not prevent CCR4-NOT deadenylase complex recruitment or ZFP36-induced ARE-containing mRNA deadenylation and decay processes (By similarity). Interacts with 14-3-3 proteins; these interactions occur in response to rapamycin in an Akt-dependent manner (PubMed:16702957). Interacts with AGO2 and AGO4 (PubMed:15766526). Interacts (via C-terminus) with CNOT1; this interaction occurs in a RNA-independent manner and induces mRNA deadenylation (PubMed:23644599). Interacts (via N-terminus) with CNOT6 (PubMed:15687258). Interacts with CNOT6L (By similarity). Interacts (via C-terminus) with CNOT7; this interaction occurs in a RNA-independent manner, induces mRNA deadenylation and is inhibited in a phosphorylation MAPKAPK2-dependent manner (PubMed:25106868). Interacts (via unphosphorylated form) with CNOT8; this interaction occurs in a RNA-independent manner and is inhibited in a phosphorylation MAPKAPK2-dependent manner (By similarity). Interacts with DCP1A (PubMed:15687258). Interacts (via N-terminus) with DCP2 (PubMed:15687258, PubMed:16364915). Interacts with EDC3 (PubMed:16364915). Interacts (via N-terminus) with EXOSC2 (PubMed:15687258). Interacts with heat shock 70 kDa proteins (PubMed:20221403). Interacts with KHSRP; this interaction increases upon cytokine-induced treatment (PubMed:16126846). Interacts with MAP3K4; this interaction enhances the association with SH3KBP1/CIN85 (PubMed:20221403). Interacts with MAPKAPK2; this interaction occurs upon skeletal muscle satellite cell activation (By similarity). Interacts with NCL (PubMed:20221403). Interacts with NUP214; this interaction increases upon lipopolysaccharide (LPS) stimulation (PubMed:14766228). Interacts with PABPC1; this interaction occurs in a RNA-dependent manner (PubMed:20221403). Interacts (via hypophosphorylated form) with PABPN1 (via RRM domain and C-terminal arginine-rich region); this interaction occurs in the nucleus in a RNA-independent manner, decreases in presence of single-stranded poly(A) RNA-oligomer and in a p38 MAPK-dependent-manner and inhibits nuclear poly(A) tail synthesis (By similarity). Interacts with PAN2 (By similarity). Interacts (via C3H1-type zinc finger domains) with PKM (PubMed:26926077). Interacts (via C3H1-type zinc finger domains) with nuclear RNA poly(A) polymerase (By similarity). Interacts with PPP2CA; this interaction occurs in LPS-stimulated cells and induces ZFP36 dephosphorylation, and hence may promote ARE-containing mRNAs decay (By similarity). Interacts (via C-terminus) with PRR5L (via C-terminus); this interaction may accelerate ZFP36-mediated mRNA decay during stress (PubMed:21964062). Interacts (via C-terminus) with SFN; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts (via extreme C-terminal region) with SH3KBP1/CIN85 (via SH3 domains); this interaction enhances MAP3K4-induced phosphorylation of ZFP36 at Ser-66 and Ser-93 and does not alter neither ZFP36 binding to ARE-containing transcripts nor TNF-alpha mRNA decay (PubMed:20221403). Interacts with XRN1 (PubMed:15687258). Interacts (via C-terminus and Ser-186 phosphorylated form) with YWHAB; this interaction occurs in a p38/MAPKAPK2-dependent manner, increases cytoplasmic localization of ZFP36 and protects ZFP36 from Ser-186 dephosphorylation by serine/threonine phosphatase 2A, and hence may be crucial for stabilizing ARE-containing mRNAs (By similarity). Interacts (via phosphorylated form) with YWHAE (By similarity). Interacts (via C-terminus) with YWHAG; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts with YWHAH; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts with YWHAQ; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts with (via C-terminus) YWHAZ; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts (via P-P-P-P-G repeats) with GIGYF2; the interaction is direct (By similarity).
    • (Microbial infection) Interacts (via C-terminus) with HTLV-1 TAX (via C-terminus); this interaction inhibits HTLV-1 TAX to transactivate viral long terminal repeat (LTR) promoter (PubMed:14679154).

    Three dimensional structures from OCA and Proteopedia for ZFP36 Gene

neXtProt entry for ZFP36 Gene

Post-translational modifications for ZFP36 Gene

  • Phosphorylated. Phosphorylation at serine and/or threonine residues occurs in a p38 MAPK- and MAPKAPK2-dependent manner (PubMed:16702957). Phosphorylated by MAPKAPK2 at Ser-60 and Ser-186; phosphorylation increases its stability and cytoplasmic localization, promotes binding to 14-3-3 adapter proteins and inhibits the recruitment of cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to the mRNA decay machinery, thereby inhibiting ZFP36-induced ARE-containing mRNA deadenylation and decay processes. Phosphorylation by MAPKAPK2 does not impair ARE-containing RNA-binding. Phosphorylated in a MAPKAPK2- and p38 MAPK-dependent manner upon skeletal muscle satellite cell activation; this phosphorylation inhibits ZFP36-mediated mRNA decay activity, and hence stabilizes MYOD1 mRNA (By similarity). Phosphorylated by MAPK1 upon mitogen stimulation (By similarity). Phosphorylated at Ser-66 and Ser-93; these phosphorylations increase in a SH3KBP1-dependent manner (PubMed:20221403). Phosphorylated at serine and threonine residues in a pyruvate kinase PKM- and p38 MAPK-dependent manner (PubMed:26926077). Phosphorylation at Ser-60 may participate in the PKM-mediated degradation of ZFP36 in a p38 MAPK-dependent manner (PubMed:26926077). Dephosphorylated by serine/threonine phosphatase 2A at Ser-186 (By similarity).
  • Ubiquitinated; pyruvate kinase (PKM)-dependent ubiquitination leads to proteasomal degradation through a p38 MAPK signaling pathway (PubMed:26926077).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP36 Gene

No data available for DME Specific Peptides for ZFP36 Gene

Domains & Families for ZFP36 Gene

Gene Families for ZFP36 Gene

Protein Domains for ZFP36 Gene

Suggested Antigen Peptide Sequences for ZFP36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26651

UniProtKB/Swiss-Prot:

TTP_HUMAN :
  • The C3H1-type zinc finger domains are necessary for ARE-binding activity (PubMed:10330172).
Domain:
  • The C3H1-type zinc finger domains are necessary for ARE-binding activity (PubMed:10330172).
genes like me logo Genes that share domains with ZFP36: view

Function for ZFP36 Gene

Molecular function for ZFP36 Gene

GENATLAS Biochemistry:
zinc finger protein,proline rich,insulin and growth factor inducible,homologous to mouse tristetraprolin (ZFp-36)
UniProtKB/Swiss-Prot Function:
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:9703499, PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:27193233, PubMed:23644599, PubMed:25815583). Acts as an 3-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:19188452, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter.
UniProtKB/Swiss-Prot Induction:
Up-regulated by T cell activation (PubMed:15634918). Up-regulated in keratinocytes in response to wounding (PubMed:27182009). Up-regulated by lipopolysaccharide (LPS) in a p38 MAPK- and ERK-dependent manner (at protein level) (PubMed:15187101, PubMed:16508015). Up-regulated strongly during epidermal repair after wounding in keratinocytes (PubMed:20166898). Up-regulated strongly by epidermal growth factor (EGF) and tumor necrosis factor (TNF-alpha) in keratinocytes (PubMed:20166898). Up-regulated moderately by granulocyte macrophage colony-stimulating factor (GM-CSF) and fibroblast growth factor (FGF1) in keratinocytes (PubMed:20166898). Up-regulated also by glucocorticoid dexamethasone in keratinocytes (PubMed:20166898). Up-regulated in keratinocytes in response to wounding (PubMed:27182009). Up-regulated by LPS in a p38 MAPK-dependent manner (PubMed:14766228, PubMed:15187101).

Gene Ontology (GO) - Molecular Function for ZFP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0003727 single-stranded RNA binding TAS 9703499
GO:0003729 mRNA binding IEA,IDA 11782475
GO:0005515 protein binding IPI 14679154
genes like me logo Genes that share ontologies with ZFP36: view
genes like me logo Genes that share phenotypes with ZFP36: view

Animal Models for ZFP36 Gene

MGI Knock Outs for ZFP36:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ZFP36

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFP36 Gene

Localization for ZFP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP36 Gene

Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=Shuttles between nucleus and cytoplasm in a CRM1-dependent manner (By similarity). Localized predominantly in the cytoplasm in a p38 MAPK- and YWHAB-dependent manner (By similarity). Colocalizes with SH3KBP1 and MAP3K4 in the cytoplasm (PubMed:20221403). Component of cytoplasmic stress granules (SGs) (By similarity). Localizes to cytoplasmic stress granules upon energy starvation (PubMed:15014438). Localizes in processing bodies (PBs) (PubMed:17369404). Excluded from stress granules in a phosphorylation MAPKAPK2-dependent manner (By similarity). Shuttles in and out of both cytoplasmic P-body and SGs (By similarity). {ECO:0000250 UniProtKB:P22893, ECO:0000269 PubMed:15014438, ECO:0000269 PubMed:17369404, ECO:0000269 PubMed:20221403}.
Nucleus. Cytoplasm. Note=(Microbial infection) Colocalizes with HTLV-1 TAX in the nucleus and the cytoplasm in a region surrounding the nucleus. {ECO:0000269 PubMed:14679154}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP36 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2

Gene Ontology (GO) - Cellular Components for ZFP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000178 NOT colocalizes_with exosome (RNase complex) IDA 11719186
GO:0000932 P-body IDA 17369404
GO:0005634 nucleus IDA,IEA 10330172
GO:0005737 cytoplasm IEA,IDA 10330172
GO:0005829 cytosol TAS,IEA --
genes like me logo Genes that share ontologies with ZFP36: view

Pathways & Interactions for ZFP36 Gene

genes like me logo Genes that share pathways with ZFP36: view

Pathways by source for ZFP36 Gene

1 Cell Signaling Technology pathway for ZFP36 Gene

Gene Ontology (GO) - Biological Process for ZFP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 21784977
GO:0000165 MAPK cascade ISS,IEA --
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA,IDA 23644599
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IEA,IMP 23644599
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZFP36: view

No data available for SIGNOR curated interactions for ZFP36 Gene

Drugs & Compounds for ZFP36 Gene

(8) Drugs for ZFP36 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for ZFP36 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZFP36: view

Transcripts for ZFP36 Gene

mRNA/cDNA for ZFP36 Gene

Unigene Clusters for ZFP36 Gene

ZFP36 ring finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ZFP36

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for ZFP36 Gene

GeneLoc Exon Structure for
ZFP36
ECgene alternative splicing isoforms for
ZFP36

Expression for ZFP36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFP36 Gene

This gene is overexpressed in Fallopian Tube (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of ZFP36 Gene:

ZFP36

SOURCE GeneReport for Unigene cluster for ZFP36 Gene:

Hs.534052

mRNA Expression by UniProt/SwissProt for ZFP36 Gene:

P26651-TTP_HUMAN
Tissue specificity: Expressed in both basal and suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (PubMed:27182009). Expressed strongly in mature dendritic cells (PubMed:18367721). Expressed in immature dendritic cells (at protein level) (PubMed:18367721).

Evidence on tissue expression from TISSUES for ZFP36 Gene

  • Pancreas(4.8)
  • Liver(4.5)
  • Intestine(3.4)
  • Nervous system(3.3)
  • Blood(2.9)
  • Lung(2.8)
  • Bone marrow(2.7)
  • Spleen(2.7)
  • Kidney(2.6)
  • Muscle(2.5)
  • Gall bladder(2.4)
  • Lymph node(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with ZFP36: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP36 Gene

Orthologs for ZFP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFP36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP36 34 35
  • 99.58 (n)
rat
(Rattus norvegicus)
Mammalia Zfp36 34
  • 85.44 (n)
mouse
(Mus musculus)
Mammalia Zfp36 16 35 34
  • 84.65 (n)
dog
(Canis familiaris)
Mammalia ZFP36 34 35
  • 84.35 (n)
cow
(Bos Taurus)
Mammalia ZFP36 34 35
  • 84 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFP36 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfp36 34
  • 53.28 (n)
zebrafish
(Danio rerio)
Actinopterygii ZFP36 35
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tis11 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ccch-2 35
  • 28 (a)
ManyToMany
ccch-5 35
  • 25 (a)
ManyToMany
C35D6.4 35
  • 23 (a)
ManyToMany
Y116A8C.19 35
  • 23 (a)
ManyToMany
Y116A8C.20 35
  • 22 (a)
ManyToMany
Y60A9.3 35
  • 22 (a)
ManyToMany
F38C2.7 35
  • 21 (a)
ManyToMany
dct-13 35
  • 20 (a)
ManyToMany
pos-1 35
  • 19 (a)
ManyToMany
moe-3 35
  • 19 (a)
ManyToMany
ccch-1 35
  • 17 (a)
ManyToMany
oma-1 35
  • 16 (a)
ManyToMany
oma-2 35
  • 16 (a)
ManyToMany
mex-1 35
  • 15 (a)
ManyToMany
mex-5 35
  • 12 (a)
ManyToMany
mex-6 35
  • 11 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIS11 35
  • 17 (a)
ManyToMany
CTH1 35
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6084 35
  • 22 (a)
OneToMany
Species where no ortholog for ZFP36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFP36 Gene

ENSEMBL:
Gene Tree for ZFP36 (if available)
TreeFam:
Gene Tree for ZFP36 (if available)

Paralogs for ZFP36 Gene

Paralogs for ZFP36 Gene

(1) SIMAP similar genes for ZFP36 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFP36: view

Variants for ZFP36 Gene

Sequence variations from dbSNP and Humsavar for ZFP36 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000958798 -- 39,405,932(+) TCCTT(C/T)TTGTC upstream-variant-2KB
rs1001299622 -- 39,404,951(+) AGCGC(A/G)ACTCC upstream-variant-2KB
rs1001372786 -- 39,409,597(+) AACCG(C/G)GGGAG downstream-variant-500B
rs1001448193 -- 39,409,767(+) CCAGA(A/G)CGAGC downstream-variant-500B, upstream-variant-2KB
rs1002350747 -- 39,406,743(+) GGGGG(A/C)GCGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZFP36 Gene

Variant ID Type Subtype PubMed ID
nsv1072352 CNV deletion 25765185

Variation tolerance for ZFP36 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP36 Gene

Human Gene Mutation Database (HGMD)
ZFP36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP36 Gene

Disorders for ZFP36 Gene

Relevant External Links for ZFP36

Genetic Association Database (GAD)
ZFP36
Human Genome Epidemiology (HuGE) Navigator
ZFP36
Tumor Gene Database (TGDB):
ZFP36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP36

No disorders were found for ZFP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP36 Gene

Publications for ZFP36 Gene

  1. ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. (PMID: 20166898) Hacker C. … Munz B. (Growth Factors 2010) 3 4 22 64
  2. Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. (PMID: 20221403) Kedar V.P. … Blackshear P.J. (PLoS ONE 2010) 3 4 22 64
  3. Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation. (PMID: 18367721) Emmons J. … Brooks S.A. (RNA 2008) 3 4 22 64
  4. TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. (PMID: 17369404) Franks T.M. … Lykke-Andersen J. (Genes Dev. 2007) 3 4 22 64
  5. Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. (PMID: 16262601) Cao H. … Blackshear P.J. (Biochem. J. 2006) 3 4 22 64

Products for ZFP36 Gene

Sources for ZFP36 Gene