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Aliases for YES1 Gene

Aliases for YES1 Gene

  • YES Proto-Oncogene 1, Src Family Tyrosine Kinase 2 3 5
  • V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 2 3
  • Proto-Oncogene C-Yes 3 4
  • EC 2.7.10.2 4 58
  • P61-YES 3 4
  • Yes 3 4
  • YES1 Proto-Oncogene, Src Family Tyrosine Kinase 3
  • Proto-Oncogene Tyrosine-Protein Kinase YES 3
  • Tyrosine-Protein Kinase Yes 3
  • Yamaguchi Sarcoma Oncogene 3
  • Cellular Yes-1 Protein 3
  • EC 2.7.10 58
  • HsT441 3
  • C-Yes 3

External Ids for YES1 Gene

Previous GeneCards Identifiers for YES1 Gene

  • GC22P022739
  • GC18M000709
  • GC18M000711

Summaries for YES1 Gene

Entrez Gene Summary for YES1 Gene

  • This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

GeneCards Summary for YES1 Gene

YES1 (YES Proto-Oncogene 1, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with YES1 include Sarcoma and Megaesophagus. Among its related pathways are phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SRC.

UniProtKB/Swiss-Prot for YES1 Gene

  • Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Gene Wiki entry for YES1 Gene

Additional gene information for YES1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YES1 Gene

Genomics for YES1 Gene

Regulatory Elements for YES1 Gene

Enhancers for YES1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H000806 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +1.5 1508 8 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ENOSF1 THOC1 ENSG00000273355 YES1 TYMS GC18P000814 GC18M000797 RNU1-109P
GH18H000708 1.7 FANTOM5 ENCODE dbSUPER 7.2 +101.5 101519 4 FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 SP5 ENOSF1 THOC1 TYMSOS TYMS RNU1-109P YES1 ENSG00000265490
GH18H000667 0.7 FANTOM5 dbSUPER 2.2 +144.7 144722 0 ENOSF1 TYMS THOC1 YES1 TYMSOS CLUL1 GC18M000704 PIR56960
GH18H000666 1 FANTOM5 dbSUPER 1.4 +146.1 146101 0 CTCF RB1 SOX6 REST RAD21 ZNF2 POLR2A SUPT5H ENOSF1 THOC1 YES1 TYMSOS GC18M000704 PIR56960
GH18H000706 0.2 dbSUPER 6.8 +105.1 105149 0 ENOSF1 TYMS TYMSOS RNU1-109P YES1 ENSG00000265490
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YES1 on UCSC Golden Path with GeneCards custom track

Promoters for YES1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099864 646 3001 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 SP3 ZC3H11A JUNB

Genomic Location for YES1 Gene

Chromosome:
18
Start:
721,588 bp from pter
End:
812,546 bp from pter
Size:
90,959 bases
Orientation:
Minus strand

Genomic View for YES1 Gene

Genes around YES1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YES1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YES1 Gene

Proteins for YES1 Gene

  • Protein details for YES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07947-YES_HUMAN
    Recommended name:
    Tyrosine-protein kinase Yes
    Protein Accession:
    P07947
    Secondary Accessions:
    • A6NLB3
    • D3DUH1

    Protein attributes for YES1 Gene

    Size:
    543 amino acids
    Molecular mass:
    60801 Da
    Quaternary structure:
    • Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for YES1 Gene

neXtProt entry for YES1 Gene

Selected DME Specific Peptides for YES1 Gene

P07947:
  • KTLKPGTM
  • FVALYDYE
  • KWTAPEA
  • KHYKIRKLD
  • NREVLEQVERGYRM
  • FLEDYFT
  • DMAAQIA
  • RGYRMPCP
  • NYIHRDLR
  • FTIKSDVWSFG
  • CKIADFGLAR
  • VSEEPIYIV
  • ERPTFEYIQS
  • EGDWWEARS
  • PIYIVTE
  • GTWNGTT
  • SLSIRDWD
  • DSIQAEEWY
  • VKHYKIR
  • GYIPSNYVA
  • ADFGLARLIED
  • EAQIMKKL
  • ERLLLNP
  • KGSLLDFLK
  • HRDLRAANILV
  • DNGGYYI
  • DLSFKKG
  • LRHDKLV
  • GGYYITTRAQF
  • KSDVWSFG
  • LPQLVDM
  • KFPIKWTAPE
  • PEAFLQEAQ
  • RESETTKGA
  • DAWEIPR
  • FGEVWMGTWN
  • KGRVPYPGM
  • GMAYIER
  • EPQYQPG

Post-translational modifications for YES1 Gene

  • Palmitoylation at Cys-3 promotes membrane localization.
  • Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.
  • Ubiquitination at Lys235
  • Modification sites at PhosphoSitePlus

Other Protein References for YES1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for YES1 (Yes)

Domains & Families for YES1 Gene

Gene Families for YES1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for YES1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07947

UniProtKB/Swiss-Prot:

YES_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with YES1: view

Function for YES1 Gene

Molecular function for YES1 Gene

GENATLAS Biochemistry:
Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 1
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Enzyme Numbers (IUBMB) for YES1 Gene

Phenotypes From GWAS Catalog for YES1 Gene

Gene Ontology (GO) - Molecular Function for YES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IPI 20624904
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS 19267251
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with YES1: view
genes like me logo Genes that share phenotypes with YES1: view

Animal Models for YES1 Gene

MGI Knock Outs for YES1:

Animal Model Products

  • Taconic Biosciences Mouse Models for YES1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for YES1
  • Applied Biological Materials Clones for YES1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YES1 Gene

Localization for YES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YES1 Gene

Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YES1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
golgi apparatus 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA 20605918
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with YES1: view

Pathways & Interactions for YES1 Gene

genes like me logo Genes that share pathways with YES1: view

Pathways by source for YES1 Gene

SIGNOR curated interactions for YES1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for YES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 2436037
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0015758 glucose transport IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with YES1: view

Drugs & Compounds for YES1 Gene

(11) Drugs for YES1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Inhibition, inhibitor, Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 289
Sprycel Approved June 2006 Pharma 0
AT9283 Investigational Pharma inhibitor Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
Saracatinib Investigational Pharma inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 32
Spebrutinib Investigational Pharma 0

(3) Additional Compounds for YES1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with YES1: view

Transcripts for YES1 Gene

Unigene Clusters for YES1 Gene

V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for YES1
  • Applied Biological Materials Clones for YES1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for YES1 Gene

No ASD Table

Relevant External Links for YES1 Gene

GeneLoc Exon Structure for
YES1
ECgene alternative splicing isoforms for
YES1

Expression for YES1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YES1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YES1 Gene

This gene is overexpressed in Breast (32.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YES1 Gene



Protein tissue co-expression partners for YES1 Gene

NURSA nuclear receptor signaling pathways regulating expression of YES1 Gene:

YES1

SOURCE GeneReport for Unigene cluster for YES1 Gene:

Hs.194148

mRNA Expression by UniProt/SwissProt for YES1 Gene:

P07947-YES_HUMAN
Tissue specificity: Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis.

Evidence on tissue expression from TISSUES for YES1 Gene

  • Nervous system(4.4)
  • Liver(2.5)
  • Kidney(2.4)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with YES1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for YES1 Gene

Orthologs for YES1 Gene

This gene was present in the common ancestor of animals.

Orthologs for YES1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YES1 33 34
  • 99.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia YES1 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YES1 33 34
  • 94.39 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia YES1 33 34
  • 91.81 (n)
mouse
(Mus musculus)
Mammalia Yes1 33 16 34
  • 91.37 (n)
rat
(Rattus norvegicus)
Mammalia Yes1 33
  • 90.86 (n)
chicken
(Gallus gallus)
Aves YES1 33 34
  • 84.47 (n)
lizard
(Anolis carolinensis)
Reptilia YES1 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yes1 33
  • 80.45 (n)
Str.7450 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68444 33
zebrafish
(Danio rerio)
Actinopterygii yes1 33 34
  • 72.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta Src64B 35
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea src-1 35
  • 49 (a)
C25A8.5 35
  • 34 (a)
F57B9.8 35
  • 33 (a)
F23C8.7 35
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5424 33
Species where no ortholog for YES1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YES1 Gene

ENSEMBL:
Gene Tree for YES1 (if available)
TreeFam:
Gene Tree for YES1 (if available)

Paralogs for YES1 Gene

Variants for YES1 Gene

Sequence variations from dbSNP and Humsavar for YES1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000033153 -- 780,994(+) CCAGG(C/G)GCGGT intron-variant
rs1000041115 -- 722,911(+) CACGG(A/T)GAAAC utr-variant-3-prime
rs1000060924 -- 806,223(+) CATAA(A/C)TTGGA intron-variant
rs1000070719 -- 806,439(+) GAGCT(A/C)TGAAA intron-variant
rs1000113407 -- 727,768(+) TTATA(A/G)ATTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YES1 Gene

Variant ID Type Subtype PubMed ID
dgv5810n54 CNV gain 21841781
esv1006381 OTHER inversion 20482838
esv2761984 CNV loss 21179565
esv3641496 CNV loss 21293372
esv3641497 CNV gain 21293372
esv3641507 CNV loss 21293372
esv3893055 CNV gain 25118596
nsv1055787 CNV loss 25217958
nsv1057808 CNV loss 25217958
nsv1060188 CNV gain 25217958
nsv482935 CNV loss 15286789
nsv528169 CNV loss 19592680
nsv576228 CNV loss 21841781
nsv576236 CNV gain 21841781
nsv576242 CNV gain 21841781
nsv833577 CNV gain+loss 17160897

Variation tolerance for YES1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YES1 Gene

Human Gene Mutation Database (HGMD)
YES1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
YES1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YES1 Gene

Disorders for YES1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for YES1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
megaesophagus
  • esophageal achalasia
- elite association - COSMIC cancer census association via MalaCards
Search YES1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for YES1

Genetic Association Database (GAD)
YES1
Human Genome Epidemiology (HuGE) Navigator
YES1
Tumor Gene Database (TGDB):
YES1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YES1
genes like me logo Genes that share disorders with YES1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YES1 Gene

Publications for YES1 Gene

  1. CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. (PMID: 11901164) Lee SW … So M (The Journal of cell biology 2002) 3 4 22 60
  2. The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway. (PMID: 21713032) Tauzin S … Legembre P (PLoS biology 2011) 3 4 60
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 45 60
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M … Janssen O (BMC immunology 2009) 3 4 60

Products for YES1 Gene

  • Addgene plasmids for YES1

Sources for YES1 Gene

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