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Aliases for YES1 Gene

Aliases for YES1 Gene

  • YES Proto-Oncogene 1, Src Family Tyrosine Kinase 2 3 5
  • V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 2 3
  • Proto-Oncogene C-Yes 3 4
  • EC 2.7.10.2 4 63
  • P61-YES 3 4
  • Yes 3 4
  • YES1 Proto-Oncogene, Src Family Tyrosine Kinase 3
  • Proto-Oncogene Tyrosine-Protein Kinase YES 3
  • Yamaguchi Sarcoma Oncogene 3
  • Cellular Yes-1 Protein 3
  • EC 2.7.10 63
  • HsT441 3
  • C-Yes 3

External Ids for YES1 Gene

Previous GeneCards Identifiers for YES1 Gene

  • GC22P022739
  • GC18M000709
  • GC18M000711

Summaries for YES1 Gene

Entrez Gene Summary for YES1 Gene

  • This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

GeneCards Summary for YES1 Gene

YES1 (YES Proto-Oncogene 1, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with YES1 include megaesophagus and sarcoma. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for YES1 Gene

  • Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Gene Wiki entry for YES1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YES1 Gene

Genomics for YES1 Gene

Regulatory Elements for YES1 Gene

Promoters for YES1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YES1 on UCSC Golden Path with GeneCards custom track

Genomic Location for YES1 Gene

Chromosome:
18
Start:
721,588 bp from pter
End:
812,546 bp from pter
Size:
90,959 bases
Orientation:
Minus strand

Genomic View for YES1 Gene

Genes around YES1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YES1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YES1 Gene

Proteins for YES1 Gene

  • Protein details for YES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07947-YES_HUMAN
    Recommended name:
    Tyrosine-protein kinase Yes
    Protein Accession:
    P07947
    Secondary Accessions:
    • A6NLB3
    • D3DUH1

    Protein attributes for YES1 Gene

    Size:
    543 amino acids
    Molecular mass:
    60801 Da
    Quaternary structure:
    • Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for YES1 Gene

neXtProt entry for YES1 Gene

Proteomics data for YES1 Gene at MOPED

Post-translational modifications for YES1 Gene

  • Palmitoylation at Cys-3 promotes membrane localization.
  • Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.
  • Ubiquitination at Lys 235
  • Modification sites at PhosphoSitePlus

Other Protein References for YES1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for YES1 (Yes)

Domains & Families for YES1 Gene

Suggested Antigen Peptide Sequences for YES1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07947

UniProtKB/Swiss-Prot:

YES_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with YES1: view

Function for YES1 Gene

Molecular function for YES1 Gene

GENATLAS Biochemistry:
Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 1
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Enzyme Numbers (IUBMB) for YES1 Gene

Gene Ontology (GO) - Molecular Function for YES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS 19267251
genes like me logo Genes that share ontologies with YES1: view
genes like me logo Genes that share phenotypes with YES1: view

Animal Models for YES1 Gene

MGI Knock Outs for YES1:

Animal Model Products

  • Taconic Biosciences Mouse Models for YES1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YES1 Gene

Localization for YES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YES1 Gene

Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YES1 Gene COMPARTMENTS Subcellular localization image for YES1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
golgi apparatus 5
plasma membrane 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for YES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with YES1: view

Pathways & Interactions for YES1 Gene

genes like me logo Genes that share pathways with YES1: view

SIGNOR curated interactions for YES1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for YES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 2436037
GO:0030154 cell differentiation IBA --
GO:0036120 cellular response to platelet-derived growth factor stimulus IEA --
GO:0038083 peptidyl-tyrosine autophosphorylation IBA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with YES1: view

Drugs & Compounds for YES1 Gene

(11) Drugs for YES1 Gene - From: HMDB, DGIdb, Novoseek, FDA Approved Drugs, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Inhibition, inhibitor, Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 268
Sprycel Approved June 2006 Pharma 0
Adenosine triphosphate Approved Nutra 0
AT9283 Investigational Pharma inhibitor Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
ENMD-2076 Pharma inhibitor Selective Aurora A/Flt3 inhibitor, Aurora A and VEGFR/FGFR kinase inhibitor, Kinase Inhibitors 0

(3) Additional Compounds for YES1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with YES1: view

Transcripts for YES1 Gene

Unigene Clusters for YES1 Gene

V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YES1 Gene

No ASD Table

Relevant External Links for YES1 Gene

GeneLoc Exon Structure for
YES1
ECgene alternative splicing isoforms for
YES1

Expression for YES1 Gene

mRNA expression in normal human tissues for YES1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YES1 Gene

This gene is overexpressed in Breast (32.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YES1 Gene



SOURCE GeneReport for Unigene cluster for YES1 Gene Hs.194148

mRNA Expression by UniProt/SwissProt for YES1 Gene

P07947-YES_HUMAN
Tissue specificity: Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis.
genes like me logo Genes that share expression patterns with YES1: view

Protein tissue co-expression partners for YES1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for YES1 Gene

Orthologs for YES1 Gene

This gene was present in the common ancestor of animals.

Orthologs for YES1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YES1 36
  • 100 (a)
OneToOne
YES1 35
  • 99.94 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia YES1 35
  • 91.81 (n)
  • 97.23 (a)
YES1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YES1 36
  • 98 (a)
OneToOne
YES1 35
  • 94.39 (n)
  • 97.97 (a)
mouse
(Mus musculus)
Mammalia Yes1 16
Yes1 35
  • 91.37 (n)
  • 96.3 (a)
Yes1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia YES1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yes1 35
  • 90.86 (n)
  • 94.98 (a)
chicken
(Gallus gallus)
Aves YES1 35
  • 84.47 (n)
  • 92.24 (a)
YES1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YES1 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68444 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7450 35
yes1 35
  • 80.45 (n)
  • 91.06 (a)
zebrafish
(Danio rerio)
Actinopterygii yes1 35
  • 72.31 (n)
  • 86.37 (a)
yes1 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Src64B 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea C25A8.5 37
  • 34 (a)
F23C8.7 37
  • 32 (a)
F57B9.8 37
  • 33 (a)
src-1 37
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5424 35
Species with no ortholog for YES1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YES1 Gene

ENSEMBL:
Gene Tree for YES1 (if available)
TreeFam:
Gene Tree for YES1 (if available)

Paralogs for YES1 Gene

Paralogs for YES1 Gene

Pseudogenes.org Pseudogenes for YES1 Gene

genes like me logo Genes that share paralogs with YES1: view

Variants for YES1 Gene

Sequence variations from dbSNP and Humsavar for YES1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs572600 -- 774,498(-) tcgag(A/T)tgggg intron-variant
rs581987 -- 771,365(-) ttgga(A/G)acaaa intron-variant
rs631811 -- 773,719(-) AAAGT(G/T)GGAAC intron-variant
rs564942 -- 722,868(+) CGGGC(A/G)GATCA utr-variant-3-prime
rs476393 -- 735,182(+) attat(A/T)tgaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YES1 Gene

Variant ID Type Subtype PubMed ID
nsv909288 CNV Loss 21882294
nsv909289 CNV Loss 21882294
nsv833577 CNV Gain+Loss 17160897
nsv528169 CNV Loss 19592680
esv1006381 OTHER Inversion 20482838

Variation tolerance for YES1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YES1 Gene

HapMap Linkage Disequilibrium report
YES1
Human Gene Mutation Database (HGMD)
YES1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YES1 Gene

Disorders for YES1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for YES1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
megaesophagus
  • esophageal achalasia
sarcoma
  • connective and soft tissue neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search YES1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for YES1

Genetic Association Database (GAD)
YES1
Human Genome Epidemiology (HuGE) Navigator
YES1
Tumor Gene Database (TGDB):
YES1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YES1
genes like me logo Genes that share disorders with YES1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YES1 Gene

Publications for YES1 Gene

  1. CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. (PMID: 11901164) Lee S.W. … So M. (J. Cell Biol. 2002) 3 4 23 67
  2. Dasatinib. (PMID: 20072833) Lindauer M. … Hochhaus A. (Recent Results Cancer Res. 2010) 25 26
  3. Identification of c-Yes expression in the nuclei of hepatocellular carcinoma cells: involvement in the early stages of hepatocarcinogenesis. (PMID: 17143518) Nonomura T. … Kuriyama S. (Int. J. Oncol. 2007) 3 23
  4. Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells. (PMID: 17898870) Barraclough J. … Welman A. (Neoplasia 2007) 3 23
  5. Are MAP kinases drug targets? Yes, but difficult ones. (PMID: 17541990) Margutti S. … Laufer S.A. (ChemMedChem 2007) 25 26

Products for YES1 Gene

Sources for YES1 Gene

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