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Aliases for XRCC2 Gene

Aliases for XRCC2 Gene

  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 2 2 3
  • X-Ray Repair Cross-Complementing Protein 2 4
  • RAD51-Like 2

External Ids for XRCC2 Gene

Previous GeneCards Identifiers for XRCC2 Gene

  • GC07M150590
  • GC07M151658
  • GC07M151735
  • GC07M151781
  • GC07M151974
  • GC07M152341
  • GC07M146154

Summaries for XRCC2 Gene

Entrez Gene Summary for XRCC2 Gene

  • This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]

GeneCards Summary for XRCC2 Gene

XRCC2 (X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 2) is a Protein Coding gene. Diseases associated with XRCC2 include hereditary breast cancer and acoustic neuroma. Among its related pathways are Homologous recombination. GO annotations related to this gene include DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot for XRCC2 Gene

  • Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

Gene Wiki entry for XRCC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC2 Gene

Genomics for XRCC2 Gene

Regulatory Elements for XRCC2 Gene

Genomic Location for XRCC2 Gene

Start:
152,644,779 bp from pter
End:
152,676,165 bp from pter
Size:
31,387 bases
Orientation:
Minus strand

Genomic View for XRCC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XRCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRCC2 Gene

Proteins for XRCC2 Gene

  • Protein details for XRCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43543-XRCC2_HUMAN
    Recommended name:
    DNA repair protein XRCC2
    Protein Accession:
    O43543
    Secondary Accessions:
    • B2R925

    Protein attributes for XRCC2 Gene

    Size:
    280 amino acids
    Molecular mass:
    31956 Da
    Quaternary structure:
    • Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA.

neXtProt entry for XRCC2 Gene

Proteomics data for XRCC2 Gene at MOPED

Post-translational modifications for XRCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XRCC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XRCC2 Gene

Domains for XRCC2 Gene

Protein Domains for XRCC2 Gene

Suggested Antigen Peptide Sequences for XRCC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43543

UniProtKB/Swiss-Prot:

XRCC2_HUMAN :
  • O43543
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with XRCC2: view

No data available for Gene Families for XRCC2 Gene

Function for XRCC2 Gene

Molecular function for XRCC2 Gene

GENATLAS Biochemistry: repair X-ray defect complementing defect in CHO cells,2,promoting the repair of DNA double strand breaks by homologous recombination
UniProtKB/Swiss-Prot Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

Gene Ontology (GO) - Molecular Function for XRCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000400 contributes_to four-way junction DNA binding IDA 20207730
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 10749867
GO:0005524 ATP binding IEA --
GO:0008094 DNA-dependent ATPase activity IEA --
genes like me logo Genes that share ontologies with XRCC2: view
genes like me logo Genes that share phenotypes with XRCC2: view

Animal Models for XRCC2 Gene

MGI Knock Outs for XRCC2:

miRNA for XRCC2 Gene

miRTarBase miRNAs that target XRCC2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for XRCC2 Gene

Localization for XRCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRCC2 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XRCC2 Gene COMPARTMENTS Subcellular localization image for XRCC2 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for XRCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005657 replication fork IDA 20207730
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21276791
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex IDA 11751635
genes like me logo Genes that share ontologies with XRCC2: view

Pathways for XRCC2 Gene

SuperPathways for XRCC2 Gene

Superpath Contained pathways
1 Homologous recombination
genes like me logo Genes that share pathways with XRCC2: view

Pathways by source for XRCC2 Gene

1 KEGG pathway for XRCC2 Gene

Gene Ontology (GO) - Biological Process for XRCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 21276791
GO:0000724 double-strand break repair via homologous recombination IMP 23149936
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0006200 obsolete ATP catabolic process --
genes like me logo Genes that share ontologies with XRCC2: view

Compounds for XRCC2 Gene

(4) Novoseek inferred chemical compound relationships for XRCC2 Gene

Compound -log(P) Hits PubMed IDs
mitomycin c 53 2
camptothecin 32.6 1
caffeine 11 4
cisplatin 0 3
genes like me logo Genes that share compounds with XRCC2: view

Transcripts for XRCC2 Gene

mRNA/cDNA for XRCC2 Gene

(20) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XRCC2 Gene

X-ray repair complementing defective repair in Chinese hamster cells 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XRCC2 Gene

No ASD Table

Relevant External Links for XRCC2 Gene

GeneLoc Exon Structure for
XRCC2
ECgene alternative splicing isoforms for
XRCC2

Expression for XRCC2 Gene

mRNA expression in normal human tissues for XRCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XRCC2 Gene

This gene is overexpressed in Testis (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for XRCC2 Gene

SOURCE GeneReport for Unigene cluster for XRCC2 Gene Hs.647093

genes like me logo Genes that share expressions with XRCC2: view

No data available for mRNA Expression by UniProt/SwissProt for XRCC2 Gene

Orthologs for XRCC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XRCC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XRCC2 35
  • 99.64 (n)
  • 99.29 (a)
XRCC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XRCC2 35
  • 84.95 (n)
  • 84.23 (a)
XRCC2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XRCC2 35
  • 86.38 (n)
  • 83.15 (a)
XRCC2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xrcc2 35
  • 79.14 (n)
  • 78.42 (a)
Xrcc2 16
Xrcc2 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XRCC2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XRCC2 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xrcc2 35
  • 79.62 (n)
  • 79.86 (a)
chicken
(Gallus gallus)
Aves XRCC2 35
  • 73.38 (n)
  • 71.58 (a)
XRCC2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XRCC2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xrcc2 35
  • 62.58 (n)
  • 62.45 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC553395 35
  • 57.67 (n)
  • 52.88 (a)
XRCC2 36
  • 47 (a)
OneToOne
Species with no ortholog for XRCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XRCC2 Gene

ENSEMBL:
Gene Tree for XRCC2 (if available)
TreeFam:
Gene Tree for XRCC2 (if available)

Paralogs for XRCC2 Gene

Selected SIMAP similar genes for XRCC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XRCC2: view

No data available for Paralogs for XRCC2 Gene

Variants for XRCC2 Gene

Sequence variations from dbSNP and Humsavar for XRCC2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1029423 -- 152,661,791(-) TCTCA(C/G)TGCTT intron-variant
rs2040639 -- 152,678,103(-) GTTGC(A/G)CTCAC upstream-variant-2KB
rs2106776 -- 152,675,839(-) GGCAG(C/T)CTGGA intron-variant
rs2237809 -- 152,667,972(-) CGGCT(C/T)ACTGC intron-variant
rs2237810 -- 152,667,901(-) acagg(C/T)gccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XRCC2 Gene

Variant ID Type Subtype PubMed ID
nsv889505 CNV Gain 21882294
nsv831193 CNV Loss 17160897
esv2644156 CNV Insertion 19546169
esv1178351 CNV Insertion 17803354
esv1318404 CNV Insertion 17803354

Relevant External Links for XRCC2 Gene

HapMap Linkage Disequilibrium report
XRCC2
Human Gene Mutation Database (HGMD)
XRCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC2 Gene

Disorders for XRCC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (7) Diseases for XRCC2 Gene including...

Search for XRCC2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for XRCC2 Gene

(2) Novoseek inferred disease relationships for XRCC2 Gene

Disease -log(P) Hits PubMed IDs
cancer 30.2 3
breast cancer 26.7 10

Relevant External Links for XRCC2

Genetic Association Database (GAD)
XRCC2
Human Genome Epidemiology (HuGE) Navigator
XRCC2
genes like me logo Genes that share disorders with XRCC2: view

No data available for UniProtKB/Swiss-Prot for XRCC2 Gene

Publications for XRCC2 Gene

  1. The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. (PMID: 9628903) Cartwright R. … Thacker J. (Nucleic Acids Res. 1998) 3 4 23
  2. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. (PMID: 9660962) Liu N. … Thompson L.H. (Mol. Cell 1998) 3 4 23
  3. The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. (PMID: 10422536) Cui X. … Chen D.J. (Mutat. Res. 1999) 2 3 23
  4. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PMID: 11744692) Miller K.A. … Albala J.S. (J. Biol. Chem. 2002) 3 4 23
  5. Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex. (PMID: 11834724) Kurumizaka H. … Shibata T. (J. Biol. Chem. 2002) 3 4 23

Products for XRCC2 Gene

Sources for XRCC2 Gene

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