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Aliases for XBP1 Gene

Aliases for XBP1 Gene

  • X-Box Binding Protein 1 2 3
  • XBP2 3 4 6
  • Tax-Responsive Element-Binding Protein 5 3 4
  • TREB-5 3 4
  • TREB5 3 4
  • XBP-1 3 4
  • X-Box-Binding Protein 1 3

External Ids for XBP1 Gene

Previous HGNC Symbols for XBP1 Gene

  • XBP2

Previous GeneCards Identifiers for XBP1 Gene

  • GC22M025886
  • GC22M027515
  • GC22M029190
  • GC22M012155

Summaries for XBP1 Gene

Entrez Gene Summary for XBP1 Gene

  • This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

GeneCards Summary for XBP1 Gene

XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include major affective disorder-7 and cavernous hemangioma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Translational Control. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for XBP1 Gene

  • Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).

  • Isoform 1: plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ENR1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5-GATGACGTG[TG]N(3)[AT]T-3 sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:2321018, PubMed:2196176, PubMed:1903538, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856).

  • Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5-CCACG-3 motif in the PPARG promoter (By similarity).

Gene Wiki entry for XBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XBP1 Gene

Genomics for XBP1 Gene

Regulatory Elements for XBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for XBP1 Gene

Start:
28,794,555 bp from pter
End:
28,800,597 bp from pter
Size:
6,043 bases
Orientation:
Minus strand

Genomic View for XBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XBP1 Gene

Proteins for XBP1 Gene

  • Protein details for XBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17861-XBP1_HUMAN
    Recommended name:
    X-box-binding protein 1
    Protein Accession:
    P17861
    Secondary Accessions:
    • Q8WYK6
    • Q969P1
    • Q96BD7

    Protein attributes for XBP1 Gene

    Size:
    261 amino acids
    Molecular mass:
    28695 Da
    Quaternary structure:
    • Isoform 2 interacts with SIRT1. Isoform 2 interacts with PIK3R1 and PIK3R2; the interactions are direct and induce translocation of XBP1 isoform 2 into the nucleus and the unfolded protein response (UPR) XBP1-dependent target genes activation in a ER stress- and/or insulin-dependent but PI3K-independent manner. Isoform 2 interacts with FOXO1; the interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway in hepatocytes (By similarity). Isoform 1 interacts with HM13 (PubMed:25239945). Isoform 1 interacts with RNF139; the interaction induces ubiquitination and degradation of isoform 1 (PubMed:25239945). Isoform 1 interacts (via luminal domain) with DERL1; the interaction obviates the need for ectodomain shedding prior HM13/SPP-mediated XBP1 isoform 1 cleavage (PubMed:25239945). Isoform 1 interacts with isoform 2; the interaction sequesters isoform 2 from the nucleus and enhances isoform 2 degradation in the cytoplasm (PubMed:16461360, PubMed:25239945). Isoform 1 interacts with HDAC3 and AKT1; the interactions occur in endothelial cell (EC) under disturbed flow (PubMed:25190803). Isoform 1 interacts with the oncoprotein FOS (PubMed:1903538). Isoform 2 interacts with ATF6; the interaction occurs in a ER stress-dependent manner and is required for DNA binding to the unfolded protein response element (UPRE) (PubMed:17765680). Isoform 2 interacts with PIK3R1; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus and the unfolded protein response (UPR) XBP1-dependent target genes activation in a ER stress- and/or insulin-dependent but PI3K-independent manner (PubMed:20348923).

    Alternative splice isoforms for XBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XBP1 Gene

Proteomics data for XBP1 Gene at MOPED

Post-translational modifications for XBP1 Gene

  • Isoform 1 is ubiquitinated, leading to proteasome-mediated degradation in response to ER stress (PubMed:11779464, PubMed:16461360, PubMed:25239945).
  • Isoform 2 is acetylated by EP300; acetylation positively regulates the transcriptional activity of XBP1 isoform 2 (PubMed:20955178). Isoform 2 is deacetylated by SIRT1; deacetylation negatively regulates the transcriptional activity of XBP1 isoform 2 (PubMed:20955178).
  • X-box-binding protein 1, cytoplasmic form and luminal form are produced by intramembrane proteolytic cleavage of ER membrane-anchored isoform 1 triggered by HM13/SPP in a DERL1-RNF139-dependent and VCP/p97-independent manner. X-box-binding protein 1, luminal form is ubiquitinated leading to proteasomal degradation (PubMed:25239945).
  • Ubiquitination at Lys236
  • Modification sites at PhosphoSitePlus

Other Protein References for XBP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for XBP1 (XBP1)
  • Cell Signaling Technology (CST) Antibodies for XBP1 (XBP1 iso2)

No data available for DME Specific Peptides for XBP1 Gene

Domains for XBP1 Gene

Gene Families for XBP1 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for XBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XBP1 Gene

Graphical View of Domain Structure for InterPro Entry

P17861

UniProtKB/Swiss-Prot:

XBP1_HUMAN :
  • P17861
Domain:
  • Isoform 1 and isoform 2 N-terminus domains are necessary for nuclear localization targeting. Isoform 1 C-terminus domain confers localization to the cytoplasm and is sufficient to impose rapid degradation (By similarity). Isoform 1 transmembrane signal-anchor domain is necessary for its own mRNA to be recruited to the endoplasmic reticulum (ER) which will undergo unconventional ERN1-dependent splicing in response to ER stress (PubMed:19394296, PubMed:21233347). Isoform 1 N-terminus and C-terminus regions are necessary for DNA-binding and weak transcriptional activity, respectively. Isoform 2 N-terminus and C-terminus regions are necessary for DNA-binding and strong transcriptional activity upon ER stress, respectively (PubMed:11779464, PubMed:8657566). Isoform 2 C-terminus region contains a nuclear exclusion signal (NES) at positions 186 through 208. Isoform 2 C-terminus region contains a degradation domain at positions 209 through 261 (PubMed:16461360).
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with XBP1: view

Function for XBP1 Gene

Molecular function for XBP1 Gene

GENATLAS Biochemistry: X-box protein 1,binding HLA-DRA,HLA-DRB promoter
UniProtKB/Swiss-Prot Function: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).
UniProtKB/Swiss-Prot Function: Isoform 1: plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ENR1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5-GATGACGTG[TG]N(3)[AT]T-3 sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:2321018, PubMed:2196176, PubMed:1903538, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856).
UniProtKB/Swiss-Prot Function: Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5-CCACG-3 motif in the PPARG promoter (By similarity).
UniProtKB/Swiss-Prot Induction: Isoform 1 is up-regulated at the recovery phase of the endoplasmic reticulum (ER) stress response and isoform 2 is up-regulated early during the ER stress response and gradually decreased at later phase of ER stress (PubMed:16461360). Isoform 1 and isoform 2 are down-regulated by laminar flow but up-regulated by disturbed flow in umbilical vein endothelial cells in vitro (at protein level) (PubMed:19416856). Down-regulated by the B-cell-specific transcription factor PAX5 (PubMed:8627152). Up-regulated by interleukin IL-6 in myeloma cells (PubMed:10375612). Up-regulated during plasma-cell differentiation, either through the CD40 receptor signaling pathway or mitogens such as lipopolysaccharide (LPS) (PubMed:11460154). Isoform 1 and isoform 2 are down-regulated by laminar flow but up-regulated by disturbed flow in umbilical vein endothelial cells in vitro (PubMed:25190803). Isoform 2 is up-regulated early during the ER stress response in a ATF6-dependent manner (PubMed:11779464, PubMed:17110785, PubMed:16461360). Isoform 2 is up-regulated by endostatin in a ERN1-dependent manner (PubMed:23184933). Isoform 2 is transiently up-regulated by the mitogenic vascular endothelial growth factor (VEGF) in endothelial cells (PubMed:23529610).

Gene Ontology (GO) - Molecular Function for XBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11779464
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IEA --
GO:0001047 core promoter binding ISS --
GO:0001085 RNA polymerase II transcription factor binding IEA --
GO:0001158 enhancer sequence-specific DNA binding IDA 2196176
genes like me logo Genes that share ontologies with XBP1: view
genes like me logo Genes that share phenotypes with XBP1: view

Animal Models for XBP1 Gene

MGI Knock Outs for XBP1:

Animal Model Products

CRISPR Products

Transcription Factor Targeting for XBP1 Gene

Selected GeneGlobe predicted Target genes for XBP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for XBP1 Gene

Localization for XBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XBP1 Gene

Endoplasmic reticulum. Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000269 PubMed:23529610}.
Isoform 1: Nucleus. Cytoplasm. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Membrane; Peripheral membrane protein. Note=Shows no preferential localization to either the nucleus or the cytoplasm (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:16461360). Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane (PubMed:19394296, PubMed:25190803). {ECO:0000250 UniProtKB:O35426, ECO:0000269 PubMed:16461360, ECO:0000269 PubMed:19394296, ECO:0000269 PubMed:25190803}.
Isoform 2: Nucleus. Cytoplasm. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (By similarity). {ECO:0000250 UniProtKB:O35426}.
X-box-binding protein 1, cytoplasmic form: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm and nucleus after HM13/SPP-mediated intramembranaire proteolytic cleavage of isoform 1 (PubMed:25239945). {ECO:0000269 PubMed:25239945}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XBP1 Gene COMPARTMENTS Subcellular localization image for XBP1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for XBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum IDA 23529610
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with XBP1: view

Pathways for XBP1 Gene

genes like me logo Genes that share pathways with XBP1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for XBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16461360
GO:0001525 angiogenesis ISS --
GO:0001889 liver development ISS --
GO:0001934 positive regulation of protein phosphorylation IDA 25190803
GO:0001935 endothelial cell proliferation IDA 23529610
genes like me logo Genes that share ontologies with XBP1: view

Compounds for XBP1 Gene

(19) Novoseek inferred chemical compound relationships for XBP1 Gene

Compound -log(P) Hits PubMed IDs
tunicamycin 75.9 7
thapsigargin 63.6 5
2-methoxyestradiol 56.8 2
cdp choline 46.3 1
2-deoxyglucose 44 1
genes like me logo Genes that share compounds with XBP1: view

Transcripts for XBP1 Gene

Unigene Clusters for XBP1 Gene

X-box binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XBP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for XBP1 Gene

GeneLoc Exon Structure for
XBP1
ECgene alternative splicing isoforms for
XBP1

Expression for XBP1 Gene

mRNA expression in normal human tissues for XBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XBP1 Gene

This gene is overexpressed in Pancreas (10.4) and Liver (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for XBP1 Gene

SOURCE GeneReport for Unigene cluster for XBP1 Gene Hs.437638

mRNA Expression by UniProt/SwissProt for XBP1 Gene

P17861-XBP1_HUMAN
Tissue specificity: Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856).
genes like me logo Genes that share expressions with XBP1: view

In Situ Assay Products

Orthologs for XBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for XBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XBP1 36
  • 48 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XBP1 35
  • 90.16 (n)
  • 85.9 (a)
XBP1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 29 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
XBP1 35
  • 90.96 (n)
  • 87.77 (a)
mouse
(Mus musculus)
Mammalia Xbp1 35
  • 85.19 (n)
  • 86.18 (a)
Xbp1 16
Xbp1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XBP1 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XBP1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xbp1 35
  • 86.72 (n)
  • 86.45 (a)
chicken
(Gallus gallus)
Aves XBP1 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xbp1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6630 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8787 35
zebrafish
(Danio rerio)
Actinopterygii xbp1 35
xbp1 36
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Xbp1 36
  • 13 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea xbp-1 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4536 36
  • 19 (a)
OneToOne
Species with no ortholog for XBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XBP1 Gene

ENSEMBL:
Gene Tree for XBP1 (if available)
TreeFam:
Gene Tree for XBP1 (if available)

Paralogs for XBP1 Gene

Pseudogenes.org Pseudogenes for XBP1 Gene

genes like me logo Genes that share paralogs with XBP1: view

No data available for Paralogs for XBP1 Gene

Variants for XBP1 Gene

Sequence variations from dbSNP and Humsavar for XBP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs14963 -- 28,794,655(-) TATGT(A/G)AATGC utr-variant-3-prime
rs1064181 -- 28,795,270(-) CCCTT(C/T)CCCCA missense, reference, utr-variant-3-prime
rs1803772 -- 28,795,348(-) ATCTG(C/T)TTTCA reference, missense, utr-variant-3-prime
rs2097461 -- 28,795,891(+) CATGT(C/T)CTATA intron-variant
rs2228260 -- 28,800,318(-) AGCCC(C/T)GAGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for XBP1 Gene

Variant ID Type Subtype PubMed ID
nsv834169 CNV Loss 17160897

Relevant External Links for XBP1 Gene

HapMap Linkage Disequilibrium report
XBP1
Human Gene Mutation Database (HGMD)
XBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XBP1 Gene

Disorders for XBP1 Gene

(1) OMIM Diseases for XBP1 Gene (194355)

UniProtKB/Swiss-Prot

XBP1_HUMAN
  • Major affective disorder 7 (MAFD7) [MIM:612371]: A major psychiatric disorder that is characterized by severe mood swings, with fluctuation between two abnormal mood states (manic or major depressive episode). Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for XBP1 Gene

(21) Novoseek inferred disease relationships for XBP1 Gene

Disease -log(P) Hits PubMed IDs
bipolar disorder 57.8 16
myeloma 44.5 10
lymphoma b-cell 42.2 9
plasmacytoma 25.1 2
breast cancer 23.8 15

Relevant External Links for XBP1

Genetic Association Database (GAD)
XBP1
Human Genome Epidemiology (HuGE) Navigator
XBP1
genes like me logo Genes that share disorders with XBP1: view

Publications for XBP1 Gene

  1. Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. (PMID: 12949534) Kakiuchi C. … Kato T. (Nat. Genet. 2003) 3 4 23
  2. X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onset. (PMID: 15331160) Hou S.J. … Hong C.J. (Neurosci. Lett. 2004) 3 23 48
  3. Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects. (PMID: 15380296) Kusumi I. … Koyama T. (Neurosci. Lett. 2004) 3 23 48
  4. Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia. (PMID: 16342282) JAPnsson E.G. … NAPthen M.M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 23 48
  5. The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. (PMID: 15936534) Morita Y. … Ozaki N. (Neurosci. Lett. 2005) 3 23 48

Products for XBP1 Gene

  • Addgene plasmids for XBP1

Sources for XBP1 Gene

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