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Aliases for WNT10B Gene

Aliases for WNT10B Gene

  • Wnt Family Member 10B 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 10B 2 3
  • WNT-10B Protein 3
  • Protein Wnt-10b 3
  • Protein Wnt-12 4
  • STHAG8 3
  • WNT-12 3
  • SHFM6 3
  • WNT12 4

External Ids for WNT10B Gene

Previous GeneCards Identifiers for WNT10B Gene

  • GC12P049449
  • GC12P049527
  • GC12M049075
  • GC12M047645
  • GC12M049359
  • GC12M046390

Summaries for WNT10B Gene

Entrez Gene Summary for WNT10B Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT10B Gene

WNT10B (Wnt Family Member 10B) is a Protein Coding gene. Diseases associated with WNT10B include Split-Hand/Foot Malformation 6 and Tooth Agenesis, Selective, 8. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Endometrial cancer. GO annotations related to this gene include receptor binding and receptor agonist activity. An important paralog of this gene is WNT10A.

UniProtKB/Swiss-Prot for WNT10B Gene

  • Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.

Gene Wiki entry for WNT10B Gene

Additional gene information for WNT10B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT10B Gene

Genomics for WNT10B Gene

Regulatory Elements for WNT10B Gene

Enhancers for WNT10B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H048881 1.5 FANTOM5 Ensembl ENCODE 6.7 +88.7 88663 2 ELF3 FOXA2 SIN3A BMI1 RAD21 RARA YY1 SP3 HMG20B SP5 FKBP11 ARF3 ENSG00000255863 WNT10B CCDC65 RND1 OR8S1 GC12M048893 RNU6-600P
GH12H048932 0.5 ENCODE 18.5 +37.8 37819 3 CTCF ZNF654 SMC3 PRDM10 RAD21 WNT10B CCDC65 ARF3 RNU6-940P WNT1 FKBP11 GC12M048929 ENSG00000255863
GH12H048977 1.2 Ensembl ENCODE 7.3 -7.9 -7871 5 PKNOX1 SIN3A ZNF2 GLIS2 ZNF143 FOS ATF7 RUNX3 ZNF592 SREBF1 ARF3 FKBP11 ENSG00000255863 WNT10B WNT1 GC12P049007
GH12H048956 1.1 ENCODE 7 +15.0 15040 2 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 ZNF548 CCNT1 KANSL2 LMBR1L LOC390314 DDX23 KMT2D SENP1 PRPF40B LOC101927267 CCDC65
GH12H048903 0.9 ENCODE 6.9 +68.0 67997 1 HDAC1 ZFP64 ARID4B SIN3A BMI1 RAD21 RARA SCRT2 ZNF143 RUNX3 PRPF40B LMBR1L SENP1 DDX23 BCDIN3D BCDIN3D-AS1 KMT2D LOC390314 CCDC184 ENSG00000257964
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WNT10B on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT10B Gene

Chromosome:
12
Start:
48,965,340 bp from pter
End:
48,971,858 bp from pter
Size:
6,519 bases
Orientation:
Minus strand

Genomic View for WNT10B Gene

Genes around WNT10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT10B Gene

Proteins for WNT10B Gene

  • Protein details for WNT10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00744-WN10B_HUMAN
    Recommended name:
    Protein Wnt-10b
    Protein Accession:
    O00744
    Secondary Accessions:
    • B2R7A5
    • O00747
    • Q4VAJ4
    • Q4VAJ5
    • Q8WZ97

    Protein attributes for WNT10B Gene

    Size:
    389 amino acids
    Molecular mass:
    43000 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT10B Gene

Post-translational modifications for WNT10B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn93 and posLast=335335
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT10B Gene

Antibody Products

  • Abcam antibodies for WNT10B

No data available for DME Specific Peptides for WNT10B Gene

Domains & Families for WNT10B Gene

Gene Families for WNT10B Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for WNT10B Gene

Suggested Antigen Peptide Sequences for WNT10B Gene

Graphical View of Domain Structure for InterPro Entry

O00744

UniProtKB/Swiss-Prot:

WN10B_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT10B: view

Function for WNT10B Gene

Molecular function for WNT10B Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 10B,Drosophila wingless (Wg) segment polarity gene homolog,expressed in breast carcinoma,heart,skeletal muscle,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function:
Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.

Gene Ontology (GO) - Molecular Function for WNT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005109 frizzled binding IBA --
GO:0048018 receptor agonist activity IC 17761539
genes like me logo Genes that share ontologies with WNT10B: view
genes like me logo Genes that share phenotypes with WNT10B: view

Human Phenotype Ontology for WNT10B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT10B Gene

MGI Knock Outs for WNT10B:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT10B

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WNT10B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for WNT10B Gene

Localization for WNT10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT10B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT10B gene
Compartment Confidence
extracellular 5
nucleus 2
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WNT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space NAS,IBA 15135146
genes like me logo Genes that share ontologies with WNT10B: view

Pathways & Interactions for WNT10B Gene

genes like me logo Genes that share pathways with WNT10B: view

SIGNOR curated interactions for WNT10B Gene

Gene Ontology (GO) - Biological Process for WNT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0002062 chondrocyte differentiation IEP 15135146
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with WNT10B: view

Drugs & Compounds for WNT10B Gene

(10) Drugs for WNT10B Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FH535 Pharma Wnt/B-catenin inhibitor 0
ICG 001 Pharma Wnt/β-catenin pathway inhibitor, Inhibits TCF/beta-catenin-mediated transcription 0
IWP-2 Pharma Wnt production inhibitor,PORCN inhibitor, PORCN inhibitor; inhibits Wnt processing and secretion 0
IWR-1-endo Pharma Potent Wnt signaling inhibitor 0
Kartogenin Pharma 0

(1) Additional Compounds for WNT10B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(9) ApexBio Compounds for WNT10B Gene

Compound Action Cas Number
FH535 Wnt/B-catenin inhibitor 108409-83-2
ICG 001 Wnt/β-catenin pathway inhibitor 847591-62-2
IWP-2 Wnt production inhibitor,PORCN inhibitor 686770-61-6
IWR-1-endo Potent Wnt signaling inhibitor 1127442-82-3
Kartogenin 4727-31-5
KY 02111 WNT signaling inhibitor 1118807-13-8
LGK-974 PORCN inhibitor,potent and specific 1243244-14-5
Salinomycin Polyether ionophore antibiotic;anti-cancer 53003-10-4
Wnt-C59 PORCN inhibitor,highly potent and selective 1243243-89-1
genes like me logo Genes that share compounds with WNT10B: view

Drug Products

Transcripts for WNT10B Gene

mRNA/cDNA for WNT10B Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT10B Gene

Wingless-type MMTV integration site family, member 10B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WNT10B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WNT10B Gene

No ASD Table

Relevant External Links for WNT10B Gene

GeneLoc Exon Structure for
WNT10B
ECgene alternative splicing isoforms for
WNT10B

Expression for WNT10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT10B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.9), Brain - Cortex (x6.2), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Putamen (basal ganglia) (x4.9), Brain - Frontal Cortex (BA9) (x4.9), Brain - Caudate (basal ganglia) (x4.1), and Brain - Amygdala (x4.0).

Protein differential expression in normal tissues from HIPED for WNT10B Gene

This gene is overexpressed in Cervix (45.1), Plasma (14.0), and Heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT10B Gene



Protein tissue co-expression partners for WNT10B Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT10B Gene:

WNT10B

SOURCE GeneReport for Unigene cluster for WNT10B Gene:

Hs.91985

mRNA Expression by UniProt/SwissProt for WNT10B Gene:

O00744-WN10B_HUMAN
Tissue specificity: Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.

Evidence on tissue expression from TISSUES for WNT10B Gene

  • Nervous system(4.4)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT10B Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • chin
  • cranial nerve
  • ear
  • eye
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • outer ear
  • skull
Abdomen:
  • kidney
Pelvis:
  • testicle
  • ureter
  • urinary bladder
Limb:
  • ankle
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with WNT10B: view

Primer Products

Orthologs for WNT10B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT10B 33 34
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia WNT10B 33
  • 93.21 (n)
cow
(Bos Taurus)
Mammalia WNT10B 33 34
  • 91.92 (n)
rat
(Rattus norvegicus)
Mammalia Wnt10b 33
  • 90.44 (n)
mouse
(Mus musculus)
Mammalia Wnt10b 33 16 34
  • 90.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia WNT10B 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt10b 33
  • 66.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia wnt10-A 33
zebrafish
(Danio rerio)
Actinopterygii wnt10b 33 34
  • 66.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta Wnt10 35 33 34
  • 54.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009731 33
  • 45.97 (n)
worm
(Caenorhabditis elegans)
Secernentea mom-2 34
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToMany
Species where no ortholog for WNT10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT10B Gene

ENSEMBL:
Gene Tree for WNT10B (if available)
TreeFam:
Gene Tree for WNT10B (if available)

Paralogs for WNT10B Gene

Paralogs for WNT10B Gene

(13) SIMAP similar genes for WNT10B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WNT10B: view

Variants for WNT10B Gene

Sequence variations from dbSNP and Humsavar for WNT10B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs121918349 Pathogenic, Split-hand/foot malformation 6 (SHFM6) [MIM:225300] 48,966,271(-) GGGGC(A/C/G/T)GGGCC reference, missense, utr-variant-3-prime
rs779326570 Pathogenic, Tooth agenesis, selective, 8 (STHAG8) [MIM:617073] 48,968,025(+) AATCC(C/T)GAGAG intron-variant, reference, missense
rs766021478 Pathogenic 48,966,479(+) GCCCT(C/T)CAGCA reference, utr-variant-3-prime, stop-gained
rs1000071972 -- 48,972,543(+) AGCCG(A/G)GAAAG upstream-variant-2KB
rs1000240555 -- 48,970,392(+) AGACC(C/G)CTCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WNT10B Gene

Variant ID Type Subtype PubMed ID
nsv558833 CNV loss 21841781
nsv832404 CNV gain 17160897

Variation tolerance for WNT10B Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT10B Gene

Human Gene Mutation Database (HGMD)
WNT10B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT10B Gene

Disorders for WNT10B Gene

MalaCards: The human disease database

(13) MalaCards diseases for WNT10B Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
split-hand/foot malformation 6
  • split hand-foot malformation 6
tooth agenesis, selective, 8
  • selective tooth agenesis 8
split hand-split foot malformation
  • lobster-claw deformity
tooth agenesis
  • familial tooth agenesis
split hand-foot malformation
  • lobster-claw deformity
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

WN10B_HUMAN
  • Split-hand/foot malformation 6 (SHFM6) [MIM:225300]: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. {ECO:0000269 PubMed:18515319}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Tooth agenesis, selective, 8 (STHAG8) [MIM:617073]: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG8 inheritance is autosomal dominant. {ECO:0000269 PubMed:27321946}. Note=The disease is caused by mutations affecting the gene represented in this entry. Potential genotype-phenotype correlation between variants and the positions of missing teeth. {ECO:0000269 PubMed:27321946}.

Relevant External Links for WNT10B

Genetic Association Database (GAD)
WNT10B
Human Genome Epidemiology (HuGE) Navigator
WNT10B
Tumor Gene Database (TGDB):
WNT10B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT10B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT10B
genes like me logo Genes that share disorders with WNT10B: view

No data available for Genatlas for WNT10B Gene

Publications for WNT10B Gene

  1. A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas. (PMID: 9121776) Bui TD … Lindsay S (Oncogene 1997) 2 3 4 22 60
  2. Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation. (PMID: 18515319) Ugur SA … Tolun A (Human molecular genetics 2008) 2 3 4 60
  3. Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45. (PMID: 11713588) Saitoh T … Katoh M (International journal of oncology 2001) 3 4 22 60
  4. Isolation, characterization and chromosomal localization of human WNT10B. (PMID: 9284937) Hardiman G … Bazan JF (Cytogenetics and cell genetics 1997) 2 3 4 60
  5. Mutations in WNT10B Are Identified in Individuals with Oligodontia. (PMID: 27321946) Yu P … Cai T (American journal of human genetics 2016) 3 4 60

Products for WNT10B Gene

Sources for WNT10B Gene

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