Aliases for WNT10B Gene
External Ids for WNT10B Gene
Previous GeneCards Identifiers for WNT10B Gene
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT10B Gene
WNT10B (Wnt Family Member 10B) is a Protein Coding gene. Diseases associated with WNT10B include Split-Hand/Foot Malformation 6 and Tooth Agenesis, Selective, 8. Among its related pathways are DNA Damage Response (only ATM dependent) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and receptor ligand activity. An important paralog of this gene is WNT10A.
UniProtKB/Swiss-Prot for WNT10B Gene
Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.