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Aliases for WNT7B Gene

Aliases for WNT7B Gene

  • Wingless-Type MMTV Integration Site Family, Member 7B 2 3

External Ids for WNT7B Gene

Previous GeneCards Identifiers for WNT7B Gene

  • GC22U990050
  • GC03M013836
  • GC00M9P0021
  • GC22M044638
  • GC22M046316
  • GC22M029261

Summaries for WNT7B Gene

Entrez Gene Summary for WNT7B Gene

  • This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]

GeneCards Summary for WNT7B Gene

WNT7B (Wingless-Type MMTV Integration Site Family, Member 7B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include extracellular matrix structural constituent and frizzled binding. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT7B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Wiki entry for WNT7B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT7B Gene

Genomics for WNT7B Gene

Regulatory Elements for WNT7B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WNT7B Gene

Start:
45,920,362 bp from pter
End:
45,977,129 bp from pter
Size:
56,768 bases
Orientation:
Minus strand

Genomic View for WNT7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT7B Gene

Proteins for WNT7B Gene

  • Protein details for WNT7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56706-WNT7B_HUMAN
    Recommended name:
    Protein Wnt-7b
    Protein Accession:
    P56706
    Secondary Accessions:
    • B8A596
    • Q96Q12

    Protein attributes for WNT7B Gene

    Size:
    349 amino acids
    Molecular mass:
    39327 Da
    Quaternary structure:
    • Interacts with PORCN.

neXtProt entry for WNT7B Gene

Proteomics data for WNT7B Gene at MOPED

Post-translational modifications for WNT7B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn83, Asn127, and Asn295
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT7B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT7B Gene

Domains for WNT7B Gene

Gene Families for WNT7B Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT7B Gene

Suggested Antigen Peptide Sequences for WNT7B Gene

Graphical View of Domain Structure for InterPro Entry

P56706

UniProtKB/Swiss-Prot:

WNT7B_HUMAN :
  • P56706
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT7B: view

Function for WNT7B Gene

Molecular function for WNT7B Gene

GENATLAS Biochemistry: wingless-type MMTV integration site 7B,Drosophila wingless (wg) segment polarity gene homolog,expressed in specific region of the forebrain,the kidney and the limb ectoderm,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

LifeMap Function Summary for WNT7B Gene

During embryonic development, WNT7B as signaling molecule is secreted from the following cells

Gene Ontology (GO) - Molecular Function for WNT7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT7B: view
genes like me logo Genes that share phenotypes with WNT7B: view

Animal Models for WNT7B Gene

MGI Knock Outs for WNT7B:

Animal Model Products

CRISPR Products

miRNA for WNT7B Gene

miRTarBase miRNAs that target WNT7B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT7B Gene

Localization for WNT7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT7B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT7B Gene COMPARTMENTS Subcellular localization image for WNT7B gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with WNT7B: view

Pathways for WNT7B Gene

genes like me logo Genes that share pathways with WNT7B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for WNT7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis --
GO:0001701 in utero embryonic development ISS --
GO:0001944 vasculature development --
GO:0003338 metanephros morphogenesis ISS --
GO:0007257 activation of JUN kinase activity IEA --
genes like me logo Genes that share ontologies with WNT7B: view

Transcripts for WNT7B Gene

Unigene Clusters for WNT7B Gene

Wingless-type MMTV integration site family, member 7B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT7B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT7B Gene

No ASD Table

Relevant External Links for WNT7B Gene

GeneLoc Exon Structure for
WNT7B
ECgene alternative splicing isoforms for
WNT7B

Expression for WNT7B Gene

mRNA expression in normal human tissues for WNT7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT7B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (6.5), Skin - Not Sun Exposed (Suprapubic) (6.5), and Esophagus - Mucosa (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WNT7B Gene

SOURCE GeneReport for Unigene cluster for WNT7B Gene Hs.512714

mRNA Expression by UniProt/SwissProt for WNT7B Gene

P56706-WNT7B_HUMAN
Tissue specificity: Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate
genes like me logo Genes that share expressions with WNT7B: view

In Situ Assay Products

Orthologs for WNT7B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT7B 35
  • 90.13 (n)
  • 87.31 (a)
WNT7B 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT7B 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT7B 35
  • 94.27 (n)
  • 99.14 (a)
WNT7B 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt7b 35
  • 91.4 (n)
  • 99.14 (a)
Wnt7b 16
Wnt7b 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT7B 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt7b 35
  • 90.74 (n)
  • 99.14 (a)
chicken
(Gallus gallus)
Aves WNT7B 35
  • 80.13 (n)
  • 95.42 (a)
WNT7B 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT7B 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.229 35
zebrafish
(Danio rerio)
Actinopterygii wnt7ba 36
  • 79 (a)
OneToMany
wnt7bb 35
  • 78.07 (n)
  • 88.79 (a)
wnt7bb 36
  • 85 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010283 35
  • 48.17 (n)
  • 42.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Wnt2 35
  • 59.02 (n)
  • 50.29 (a)
Wnt2 36
  • 48 (a)
OneToMany
Wnt5 37
  • 47 (a)
Wnt6 37
  • 43 (a)
Wnt2 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-44 37
  • 32 (a)
egl-20 37
  • 40 (a)
mom-2 37
  • 35 (a)
cwn-2 37
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for WNT7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WNT7B Gene

ENSEMBL:
Gene Tree for WNT7B (if available)
TreeFam:
Gene Tree for WNT7B (if available)

Paralogs for WNT7B Gene

Paralogs for WNT7B Gene

Selected SIMAP similar genes for WNT7B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WNT7B: view

Variants for WNT7B Gene

Sequence variations from dbSNP and Humsavar for WNT7B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4072104 -- 45,954,768(-) AGTGG(A/G)AACAC intron-variant
rs4072105 -- 45,954,646(-) TTCCC(C/T)GATGC intron-variant
rs4072175 -- 45,927,364(+) AGGGC(A/G)GGGGC intron-variant
rs4072176 -- 45,927,462(+) CCCCA(A/G)ATTCA intron-variant
rs4072177 -- 45,927,490(+) ggcaa(A/G)tgact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT7B Gene

Variant ID Type Subtype PubMed ID
dgv5004n71 CNV Loss 21882294
dgv5005n71 CNV Loss 21882294
nsv829281 CNV Gain 20364138
nsv829282 CNV Loss 20364138
dgv5006n71 CNV Loss 21882294
nsv829283 CNV Gain 20364138
nsv915320 CNV Loss 21882294
esv2724416 CNV Deletion 23290073
esv2043867 CNV Deletion 18987734
esv5358 CNV Deletion 18987735
esv2724418 CNV Deletion 23290073
nsv191273 CNV Loss 16902084
esv2671287 CNV Deletion 23128226
esv996787 CNV Deletion 20482838
esv2724419 CNV Deletion 23290073
esv2724420 CNV Deletion 23290073
esv2008251 CNV Deletion 18987734
esv2724421 CNV Deletion 23290073

Relevant External Links for WNT7B Gene

HapMap Linkage Disequilibrium report
WNT7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT7B Gene

Disorders for WNT7B Gene

(3) Novoseek inferred disease relationships for WNT7B Gene

Disease -log(P) Hits PubMed IDs
pancreatic cancer 25.4 1
breast cancer 4.36 1
cancer 0 1

Relevant External Links for WNT7B

Genetic Association Database (GAD)
WNT7B
Human Genome Epidemiology (HuGE) Navigator
WNT7B
genes like me logo Genes that share disorders with WNT7B: view

No data available for UniProtKB/Swiss-Prot for WNT7B Gene

Publications for WNT7B Gene

  1. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PMID: 8168088) Huguet E.L. … Harris A.L. (Cancer Res. 1994) 2 3 4 23
  2. Molecular cloning and characterization of human WNT7B. (PMID: 11562755) Kirikoshi H. … Katoh M. (Int. J. Oncol. 2001) 2 3 4 23
  3. Expression patterns of Wnt genes during development of an anterior part of the chicken eye. (PMID: 16258938) Fokina V.M. … Frolova E.I. (Dev. Dyn. 2006) 3 23
  4. Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. (PMID: 19734317) Salazar K.D. … Brody A.R. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 23
  5. Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization. (PMID: 9284940) van Bokhoven H. … Brunner H.G. (Cytogenet. Cell Genet. 1997) 2 3

Products for WNT7B Gene

Sources for WNT7B Gene

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