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Aliases for VTN Gene

Aliases for VTN Gene

  • Vitronectin 2 3
  • Serum Spreading Factor 2 3
  • Serum-Spreading Factor 3 4
  • Complement S-Protein 2 3
  • Somatomedin B 2 3
  • S-Protein 3 4
  • VNT 3 6
  • V75 3 4
  • VN 3 4
  • Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein) 2
  • Epibolin 3

External Ids for VTN Gene

Previous GeneCards Identifiers for VTN Gene

  • GC17M026549
  • GC17M028594
  • GC17M026839
  • GC17M023718
  • GC17M026692
  • GC17M026753
  • GC17M026890
  • GC17M026991
  • GC17M027137

Summaries for VTN Gene

Entrez Gene Summary for VTN Gene

  • The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]

GeneCards Summary for VTN Gene

VTN (Vitronectin) is a Protein Coding gene. Diseases associated with VTN include colonic disease and glanzmann thrombasthenia. Among its related pathways are PI3K-Akt signaling pathway and Proteoglycans in cancer. GO annotations related to this gene include heparin binding and scavenger receptor activity. An important paralog of this gene is ENSG00000273171.

UniProtKB/Swiss-Prot for VTN Gene

  • Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway

  • Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity

Gene Wiki entry for VTN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTN Gene

Genomics for VTN Gene

Regulatory Elements for VTN Gene

Genomic Location for VTN Gene

Start:
28,367,276 bp from pter
End:
28,373,091 bp from pter
Size:
5,816 bases
Orientation:
Minus strand

Genomic View for VTN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTN Gene

Proteins for VTN Gene

  • Protein details for VTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04004-VTNC_HUMAN
    Recommended name:
    Vitronectin
    Protein Accession:
    P04004
    Secondary Accessions:
    • B2R7G0
    • P01141
    • Q9BSH7

    Protein attributes for VTN Gene

    Size:
    478 amino acids
    Molecular mass:
    54306 Da
    Quaternary structure:
    • Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and C1QBP.

    Three dimensional structures from OCA and Proteopedia for VTN Gene

neXtProt entry for VTN Gene

Proteomics data for VTN Gene at MOPED

Post-translational modifications for VTN Gene

  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both
  • N- and O-glycosylated.
  • Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
  • Phosphorylation sites are present in the extracellular medium
  • Sulfated on 2 tyrosine residues.
  • Glycosylation at Asn86, Asn169, and Asn242
  • Modification sites at PhosphoSitePlus

Other Protein References for VTN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Protein Products

No data available for DME Specific Peptides for VTN Gene

Domains for VTN Gene

Gene Families for VTN Gene

HGNC:

Suggested Antigen Peptide Sequences for VTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04004

UniProtKB/Swiss-Prot:

VTNC_HUMAN :
  • P04004
Domain:
  • The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin
  • Contains 1 SMB (somatomedin-B) domain.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with VTN: view

Function for VTN Gene

Molecular function for VTN Gene

GENATLAS Biochemistry: vitronectin,complement S protein (75kDa),precursor of 65 and 10kDa chains
UniProtKB/Swiss-Prot Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway
UniProtKB/Swiss-Prot Function: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity

Gene Ontology (GO) - Molecular Function for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005178 integrin binding IPI 8837777
GO:0005515 protein binding IPI 16237761
GO:0008201 heparin binding IEA --
GO:0030247 polysaccharide binding IEA --
genes like me logo Genes that share ontologies with VTN: view
genes like me logo Genes that share phenotypes with VTN: view

Animal Models for VTN Gene

MGI Knock Outs for VTN:

miRNA for VTN Gene

miRTarBase miRNAs that target VTN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VTN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VTN Gene

Localization for VTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VTN Gene

Secreted, extracellular space.

Gene Ontology (GO) - Cellular Components for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 16502470
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with VTN: view

No data available for Subcellular locations from COMPARTMENTS for VTN Gene

Pathways for VTN Gene

genes like me logo Genes that share pathways with VTN: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response TAS 2418831
GO:0007155 cell adhesion TAS 2418831
GO:0007160 cell-matrix adhesion IDA 10022831
GO:0010811 positive regulation of cell-substrate adhesion IEA --
genes like me logo Genes that share ontologies with VTN: view

Compounds for VTN Gene

(1) Drugbank Compounds for VTN Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abciximab
  • 7E3
143653-53-6 target

(106) Novoseek inferred chemical compound relationships for VTN Gene

Compound -log(P) Hits PubMed IDs
lm 609 85.3 9
grgds 83.2 14
echistatin 80.6 17
fibrinogen 80.2 175
grgdsp 77.8 8
genes like me logo Genes that share compounds with VTN: view

Transcripts for VTN Gene

mRNA/cDNA for VTN Gene

(411) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VTN Gene

Vitronectin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VTN

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VTN Gene

No ASD Table

Relevant External Links for VTN Gene

GeneLoc Exon Structure for
VTN
ECgene alternative splicing isoforms for
VTN

Expression for VTN Gene

mRNA expression in normal human tissues for VTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VTN Gene

SOURCE GeneReport for Unigene cluster for VTN Gene Hs.2257

mRNA Expression by UniProt/SwissProt for VTN Gene

P04004-VTNC_HUMAN
Tissue specificity: Plasma
genes like me logo Genes that share expressions with VTN: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VTN Gene

Orthologs for VTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for VTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VTN 35
  • 99.37 (n)
  • 99.37 (a)
VTN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VTN 35
  • 80.71 (n)
  • 72.49 (a)
VTN 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VTN 35
  • 82.51 (n)
  • 77.52 (a)
VTN 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vtn 35
  • 79.38 (n)
  • 75.64 (a)
Vtn 16
Vtn 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VTN 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VTN 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vtn 35
  • 77.01 (n)
  • 76.34 (a)
chicken
(Gallus gallus)
Aves VTN 35
  • 64.95 (n)
  • 61.74 (a)
VTN 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VTN 36
  • 51 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9844 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15366 35
vtn 35
  • 60.67 (n)
  • 58.13 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11199 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13466 35
vtna 36
  • 41 (a)
OneToMany
vtnb 35
  • 55.89 (n)
  • 53.03 (a)
vtnb 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for VTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VTN Gene

ENSEMBL:
Gene Tree for VTN (if available)
TreeFam:
Gene Tree for VTN (if available)

Paralogs for VTN Gene

Paralogs for VTN Gene

Selected SIMAP similar genes for VTN Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VTN: view

Variants for VTN Gene

Sequence variations from dbSNP and Humsavar for VTN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs704 - 28,367,840(-) CGCCA(C/T)GTGGC reference, missense
rs916657 -- 28,367,869(-) CGCAA(C/T)CAGAA reference, synonymous-codon
rs2071377 -- 28,369,461(-) GGAGC(A/G)TCCCT intron-variant
rs2071378 -- 28,369,456(-) GTCCC(C/T)GCTCT intron-variant
rs2071379 -- 28,368,811(-) TCACA(C/T)TTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VTN Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680

Relevant External Links for VTN Gene

HapMap Linkage Disequilibrium report
VTN
Human Gene Mutation Database (HGMD)
VTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VTN Gene

Disorders for VTN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (8) Diseases for VTN Gene including...

Search for VTN Gene in MalaCards »

(92) Novoseek inferred disease relationships for VTN Gene

Disease -log(P) Hits PubMed IDs
glanzmann thrombasthenia 56.3 2
drusen 55.6 23
metastasis 48.4 14
melanoma 47.2 37
tumors 42.3 74

Relevant External Links for VTN

Genetic Association Database (GAD)
VTN
Human Genome Epidemiology (HuGE) Navigator
VTN
genes like me logo Genes that share disorders with VTN: view

No data available for UniProtKB/Swiss-Prot for VTN Gene

Publications for VTN Gene

  1. The phosphorylation of the two-chain form of vitronectin by protein kinase A is heparin dependent. (PMID: 1696913) Chain D. … Shaltiel S. (FEBS Lett. 1990) 3 4 23
  2. The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor. (PMID: 8900153) Lim B.L. … Preissner K.T. (J. Biol. Chem. 1996) 3 4 23
  3. Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. (PMID: 1704366) Seiffert D. … Loskutoff D.J. (J. Biol. Chem. 1991) 3 4 23
  4. Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading. (PMID: 9733784) Seger D. … Shaltiel S. (J. Biol. Chem. 1998) 3 4 23
  5. Identification of a PAI-1 binding site in vitronectin. (PMID: 7522053) Sigurdardottir O. … Wiman B. (Biochim. Biophys. Acta 1994) 3 4 23

Products for VTN Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate VTN
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for VTN
    • Block miRNA regulation of VTN using miScript Target Protectors
    • Addgene plasmids for VTN

    Sources for VTN Gene

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