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Aliases for VSNL1 Gene

Aliases for VSNL1 Gene

  • Visinin-Like 1 2 3
  • Hippocalcin-Like Protein 3 2 3 4
  • VILIP 3 4
  • VLP-1 3 4
  • HLP3 3 4
  • Visinin-Like Protein 1 3
  • HUVISL1 3
  • VILIP-1 3
  • HPCAL3 3
  • VISL1 4

External Ids for VSNL1 Gene

Previous GeneCards Identifiers for VSNL1 Gene

  • GC02P017607
  • GC02P017706
  • GC02P017643
  • GC02P017496
  • GC02P017720

Summaries for VSNL1 Gene

Entrez Gene Summary for VSNL1 Gene

  • This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for VSNL1 Gene

VSNL1 (Visinin-Like 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for VSNL1 Gene

  • Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

Gene Wiki entry for VSNL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSNL1 Gene

Genomics for VSNL1 Gene

Regulatory Elements for VSNL1 Gene

Genomic Location for VSNL1 Gene

Start:
17,539,126 bp from pter
End:
17,657,018 bp from pter
Size:
117,893 bases
Orientation:
Plus strand

Genomic View for VSNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VSNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSNL1 Gene

Proteins for VSNL1 Gene

  • Protein details for VSNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62760-VISL1_HUMAN
    Recommended name:
    Visinin-like protein 1
    Protein Accession:
    P62760
    Secondary Accessions:
    • D6W515
    • P28677
    • P29103
    • P42323
    • Q9UM20

    Protein attributes for VSNL1 Gene

    Size:
    191 amino acids
    Molecular mass:
    22142 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Probably binds three calcium ions

neXtProt entry for VSNL1 Gene

Proteomics data for VSNL1 Gene at MOPED

Post-translational modifications for VSNL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VSNL1 Gene

No data available for DME Specific Peptides for VSNL1 Gene

Domains for VSNL1 Gene

Gene Families for VSNL1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for VSNL1 Gene

Suggested Antigen Peptide Sequences for VSNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62760

UniProtKB/Swiss-Prot:

VISL1_HUMAN :
  • P62760
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with VSNL1: view

Function for VSNL1 Gene

Molecular function for VSNL1 Gene

GENATLAS Biochemistry: visinin-like peptide 1,homolog to Rat RNVP1
UniProtKB/Swiss-Prot Function: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

Gene Ontology (GO) - Molecular Function for VSNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with VSNL1: view

miRNA for VSNL1 Gene

miRTarBase miRNAs that target VSNL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VSNL1 Gene

Localization for VSNL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VSNL1 Gene COMPARTMENTS Subcellular localization image for VSNL1 gene
Compartment Confidence
cytosol 3
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for VSNL1 Gene

Pathways for VSNL1 Gene

SuperPathways for VSNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VSNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019722 calcium-mediated signaling IEA --
genes like me logo Genes that share ontologies with VSNL1: view

No data available for Pathways by source for VSNL1 Gene

Compounds for VSNL1 Gene

(1) HMDB Compounds for VSNL1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for VSNL1 Gene

Compound -log(P) Hits PubMed IDs
calcium 44.1 17
genes like me logo Genes that share compounds with VSNL1: view

Transcripts for VSNL1 Gene

mRNA/cDNA for VSNL1 Gene

Unigene Clusters for VSNL1 Gene

Visinin-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VSNL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5
SP1:
SP2: - -
SP3:

Relevant External Links for VSNL1 Gene

GeneLoc Exon Structure for
VSNL1
ECgene alternative splicing isoforms for
VSNL1

Expression for VSNL1 Gene

mRNA expression in normal human tissues for VSNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSNL1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (11.7), Brain - Anterior cingulate cortex (BA24) (9.1), Brain - Cortex (7.3), and Brain - Cerebellar Hemisphere (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VSNL1 Gene

SOURCE GeneReport for Unigene cluster for VSNL1 Gene Hs.444212

mRNA Expression by UniProt/SwissProt for VSNL1 Gene

P62760-VISL1_HUMAN
Tissue specificity: Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level).
genes like me logo Genes that share expressions with VSNL1: view

Orthologs for VSNL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VSNL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VSNL1 35
  • 99.13 (n)
  • 100 (a)
VSNL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VSNL1 35
  • 94.76 (n)
  • 100 (a)
VSNL1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vsnl1 35
  • 91.8 (n)
  • 100 (a)
Vsnl1 16
Vsnl1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VSNL1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VSNL1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vsnl1 35
  • 91.97 (n)
  • 99.48 (a)
chicken
(Gallus gallus)
Aves VSNL1 35
  • 89.18 (n)
  • 100 (a)
VSNL1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VSNL1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vsnl1 35
  • 85.17 (n)
  • 99.48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.335 35
zebrafish
(Danio rerio)
Actinopterygii vsnl1a 36
  • 96 (a)
OneToMany
vsnl1b 35
  • 83.77 (n)
  • 96.86 (a)
vsnl1b 36
  • 97 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nca 36
  • 71 (a)
OneToMany
Nca 37
  • 71 (a)
CG7646 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea ncs-2 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToMany
Species with no ortholog for VSNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VSNL1 Gene

ENSEMBL:
Gene Tree for VSNL1 (if available)
TreeFam:
Gene Tree for VSNL1 (if available)

Paralogs for VSNL1 Gene

genes like me logo Genes that share paralogs with VSNL1: view

Variants for VSNL1 Gene

Sequence variations from dbSNP and Humsavar for VSNL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs822 -- 17,595,796(+) ATGGC(C/T)GTCAT intron-variant
rs823 -- 17,595,823(+) GAAGC(C/T)ACATT intron-variant
rs391399 -- 17,560,233(-) TTGTG(G/T)CATTA intron-variant
rs405303 -- 17,559,420(+) AAAAA(A/C)AACAA intron-variant
rs405783 -- 17,565,840(-) attca(A/G)ttaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSNL1 Gene

Variant ID Type Subtype PubMed ID
esv2719748 CNV Deletion 23290073

Relevant External Links for VSNL1 Gene

HapMap Linkage Disequilibrium report
VSNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSNL1 Gene

Disorders for VSNL1 Gene

(1) Novoseek inferred disease relationships for VSNL1 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 37.4 2

Relevant External Links for VSNL1

Genetic Association Database (GAD)
VSNL1
Human Genome Epidemiology (HuGE) Navigator
VSNL1
genes like me logo Genes that share disorders with VSNL1: view

No data available for UniProtKB/Swiss-Prot for VSNL1 Gene

Publications for VSNL1 Gene

  1. Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1. (PMID: 8530085) Polymeropoulos M.H. … Lennon G.G. (Genomics 1995) 2 3 4 23
  2. Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes. (PMID: 10520747) Kobayashi M. … Takamatsu K. (DNA Seq. 1998) 3 4 23
  3. Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins. (PMID: 16703469) Jheng F.F. … Chang L.S. (Protein J. 2006) 3 23
  4. Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma. (PMID: 17615261) Xie Y. … Ren Y. (Carcinogenesis 2007) 3 23
  5. The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients. (PMID: 18703769) Lee J.M. … Ladenson J.H. (Clin. Chem. 2008) 4 23

Products for VSNL1 Gene

Sources for VSNL1 Gene

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