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Aliases for TRPV1 Gene

Aliases for TRPV1 Gene

  • Transient Receptor Potential Cation Channel Subfamily V Member 1 2 3
  • Transient Receptor Potential Cation Channel, Subfamily V, Member 1 2 3 5
  • Vanilloid Receptor Subtype 1 2 3
  • Osm-9-Like TRP Channel 1 3 4
  • Capsaicin Receptor 3 4
  • OTRPC1 3 4
  • VR1 3 4
  • Transient Receptor Potential Vanilloid 1a 3
  • Transient Receptor Potential Vanilloid 1b 3
  • Vanilloid Receptor 1 4
  • TrpV1 4

External Ids for TRPV1 Gene

Previous HGNC Symbols for TRPV1 Gene

  • VR1

Previous GeneCards Identifiers for TRPV1 Gene

  • GC17M003782
  • GC17M003419
  • GC17M003675
  • GC17M003415
  • GC17M003360
  • GC17M003469
  • GC17M003471

Summaries for TRPV1 Gene

Entrez Gene Summary for TRPV1 Gene

  • Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRPV1 Gene

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a Protein Coding gene. Diseases associated with TRPV1 include bladder disease and burning mouth syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and DAG and IP3 signaling. GO annotations related to this gene include transmembrane signaling receptor activity and ion channel activity. An important paralog of this gene is TRPV2.

UniProtKB/Swiss-Prot for TRPV1 Gene

  • Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel.

Tocris Summary for TRPV1 Gene

  • Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a member of the transient receptor potential (TRP) superfamily of ion channels, and have six members (TRPV1-6).

Gene Wiki entry for TRPV1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPV1 Gene

Genomics for TRPV1 Gene

Regulatory Elements for TRPV1 Gene

Transcription factor binding sites by QIAGEN in the TRPV1 gene promoter:

Genomic Location for TRPV1 Gene

Chromosome:
17
Start:
3,565,444 bp from pter
End:
3,609,411 bp from pter
Size:
43,968 bases
Orientation:
Minus strand

Genomic View for TRPV1 Gene

Genes around TRPV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPV1 Gene

Proteins for TRPV1 Gene

  • Protein details for TRPV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NER1-TRPV1_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily V member 1
    Protein Accession:
    Q8NER1
    Secondary Accessions:
    • A2RUA9
    • Q3LU47
    • Q9H0G9
    • Q9H303
    • Q9H304
    • Q9NQ74
    • Q9NY22

    Protein attributes for TRPV1 Gene

    Size:
    839 amino acids
    Molecular mass:
    94956 Da
    Quaternary structure:
    • Homotetramer. Interacts with TRPV3 (PubMed:12077606). Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with PIRT (By similarity). Interacts with TMEM100 (By similarity).
    Miscellaneous:
    • Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.
    SequenceCaution:
    • Sequence=AAG43467.1; Type=Frameshift; Positions=498; Evidence={ECO:0000305};

    Alternative splice isoforms for TRPV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPV1 Gene

Proteomics data for TRPV1 Gene at MOPED

Post-translational modifications for TRPV1 Gene

  • Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity (By similarity).
  • Glycosylation at Asn 604
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for TRPV1 (Vanilloid R1/TRPV1)

No data available for DME Specific Peptides for TRPV1 Gene

Domains & Families for TRPV1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NER1

UniProtKB/Swiss-Prot:

TRPV1_HUMAN :
  • The association domain (AD) is necessary for self-association.
  • Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
  • Contains 6 ANK repeats.
Domain:
  • The association domain (AD) is necessary for self-association.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with TRPV1: view

Function for TRPV1 Gene

Molecular function for TRPV1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity). The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca(2+) and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation (By similarity).
UniProtKB/Swiss-Prot Function:
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel.

Gene Ontology (GO) - Molecular Function for TRPV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005262 calcium channel activity TAS --
genes like me logo Genes that share ontologies with TRPV1: view
genes like me logo Genes that share phenotypes with TRPV1: view

Animal Models for TRPV1 Gene

MGI Knock Outs for TRPV1:

Animal Model Products

CRISPR Products

miRNA for TRPV1 Gene

miRTarBase miRNAs that target TRPV1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPV1 Gene

Localization for TRPV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPV1 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPV1 Gene COMPARTMENTS Subcellular localization image for TRPV1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRPV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 123456
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TRPV1: view

Pathways & Interactions for TRPV1 Gene

genes like me logo Genes that share pathways with TRPV1: view

Gene Ontology (GO) - Biological Process for TRPV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001660 fever generation IEA --
GO:0001774 microglial cell activation IEA --
GO:0002790 peptide secretion IEA --
GO:0006810 transport TAS 9349813
GO:0006816 calcium ion transport IEA --
genes like me logo Genes that share ontologies with TRPV1: view

No data available for SIGNOR curated interactions for TRPV1 Gene

Drugs & Compounds for TRPV1 Gene

(89) Drugs for TRPV1 Gene - From: Novoseek, IUPHAR, DGIdb, DrugBank, HMDB, Tocris, ApexBio, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist, Target 0
Aspartame Approved Nutra Target, inducer 0
Icosapent Approved Nutra Target, inducer 0
Lidocaine Approved Pharma Antagonist, Pore Blocker Anasthetic and class Ib antiarrhythmic agent 1103
Epinephrine Approved Pharma 834

(39) Additional Compounds for TRPV1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]resiniferatoxin
12S-HPETE
Activator
15S-HPETE
Activator
5-iodoresiniferatoxin
Channel blocker
AMG628
Channel blocker

(5) Tocris Compounds for TRPV1 Gene

Compound Action Cas Number
(E)-Capsaicin Prototypic vanilloid receptor agonist 404-86-4
AM 404 Anandamide transport inhibitor 198022-70-7
Anandamide (in Tocrisolve 100) Endogenous CB receptor agonist (in water-soluble emulsion) 94421-68-8
Olvanil Potent vanilloid receptor agonist 58493-49-5
Resiniferatoxin Potent vanilloid receptor agonist 57444-62-9

(5) ApexBio Compounds for TRPV1 Gene

Compound Action Cas Number
AMG-517 TRPV1 antagonist,potent and highly selective 659730-32-2
HC-030031 TRPA1 channel blocker,potent and selective 349085-38-7
Optovin 348575-88-2
SB705498 TRPV1 antagonist,potent and selective 501951-42-4
WS 3 39711-79-0
genes like me logo Genes that share compounds with TRPV1: view

Drug Products

Transcripts for TRPV1 Gene

Unigene Clusters for TRPV1 Gene

Transient receptor potential cation channel, subfamily V, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPV1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: - - -
SP6:

Relevant External Links for TRPV1 Gene

GeneLoc Exon Structure for
TRPV1
ECgene alternative splicing isoforms for
TRPV1

Expression for TRPV1 Gene

mRNA expression in normal human tissues for TRPV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPV1 Gene

This gene is overexpressed in Artery - Tibial (x6.3).

Protein differential expression in normal tissues from HIPED for TRPV1 Gene

This gene is overexpressed in Plasma (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRPV1 Gene



SOURCE GeneReport for Unigene cluster for TRPV1 Gene Hs.655380

mRNA Expression by UniProt/SwissProt for TRPV1 Gene

Q8NER1-TRPV1_HUMAN
Tissue specificity: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
genes like me logo Genes that share expression patterns with TRPV1: view

Protein tissue co-expression partners for TRPV1 Gene

Primer Products

In Situ Assay Products

Orthologs for TRPV1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPV1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRPV1 35
  • 88.1 (n)
  • 87.31 (a)
-- 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRPV1 35
  • 87.95 (n)
  • 89.5 (a)
TRPV1 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trpv1 35
  • 85.76 (n)
  • 86.99 (a)
Trpv1 16
Trpv1 36
  • 87 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TRPV1 35
  • 99.18 (n)
  • 99.35 (a)
-- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trpv1 35
  • 85.9 (n)
  • 86.14 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRPV1 35
  • 69.06 (n)
  • 70.06 (a)
TRPV1 36
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia trpv1 35
  • 64.47 (n)
  • 64.17 (a)
zebrafish
(Danio rerio)
Actinopterygii trpv1 35
  • 59.76 (n)
  • 52.19 (a)
trpv1 36
  • 44 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10404 35
fruit fly
(Drosophila melanogaster)
Insecta iav 36
  • 14 (a)
ManyToMany
nan 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea osm-9 37
  • 27 (a)
ocr-1 36
  • 18 (a)
ManyToMany
ocr-2 36
  • 18 (a)
ManyToMany
ocr-3 36
  • 19 (a)
ManyToMany
ocr-4 36
  • 20 (a)
ManyToMany
osm-9 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
Species with no ortholog for TRPV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPV1 Gene

ENSEMBL:
Gene Tree for TRPV1 (if available)
TreeFam:
Gene Tree for TRPV1 (if available)

Paralogs for TRPV1 Gene

Paralogs for TRPV1 Gene

genes like me logo Genes that share paralogs with TRPV1: view

Variants for TRPV1 Gene

Sequence variations from dbSNP and Humsavar for TRPV1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8065080 - 3,577,153(+) GACGA(C/T)GTAGA reference, missense
rs222749 - 3,592,080(-) ACGGC(C/T)CCACC reference, missense
rs224534 - 3,583,408(+) CTCCA(A/G)TTTTT reference, missense
rs17633288 - 3,580,491(+) CAGGG(C/T)CTTCA reference, missense
rs222747 - 3,589,906(-) CTGAT(C/G)CTGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRPV1 Gene

Variant ID Type Subtype PubMed ID
nsv907553 CNV Loss 21882294
nsv526175 CNV Gain 19592680
dgv3042n71 CNV Loss 21882294
nsv907565 CNV Loss 21882294
nsv516676 CNV Gain+Loss 19592680
esv2662311 CNV Deletion 23128226
nsv907567 CNV Gain 21882294
nsv907568 CNV Loss 21882294
esv2665638 CNV Deletion 23128226
esv2715530 CNV Deletion 23290073
esv2639824 CNV Insertion 19546169
esv2662762 CNV Deletion 23128226
dgv358n27 CNV Loss 19166990

Variation tolerance for TRPV1 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.00; 0.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPV1 Gene

HapMap Linkage Disequilibrium report
TRPV1
Human Gene Mutation Database (HGMD)
TRPV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPV1 Gene

Disorders for TRPV1 Gene

MalaCards: The human disease database

(31) MalaCards diseases for TRPV1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder disease
  • urinary bladder disease
burning mouth syndrome
  • orodynia
somatoform disorder
  • physiological malfunction arising from mental factor
dentin sensitivity
  • sensitive dentin
bone cancer
  • bone neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search TRPV1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRPV1

Genetic Association Database (GAD)
TRPV1
Human Genome Epidemiology (HuGE) Navigator
TRPV1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPV1
genes like me logo Genes that share disorders with TRPV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPV1 Gene

Publications for TRPV1 Gene

  1. Pharmacological differences between human and rat vanilloid receptor 1 (VR1). (PMID: 11226139) McIntyre P. … James I. (Br. J. Pharmacol. 2001) 3 4 23 67
  2. Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. (PMID: 17567713) Riera C.E. … le Coutre J. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007) 3 25 26
  3. The capsaicin receptor: a heat-activated ion channel in the pain pathway. (PMID: 9349813) Caterina M.J. … Julius D. (Nature 1997) 2 3 23
  4. Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation. (PMID: 20060270) Denda S. … Hibino T. (J. Dermatol. Sci. 2010) 3 23
  5. Distinct modulations of human capsaicin receptor by protons and magnesium through different domains. (PMID: 20145248) Wang S. … Chuang H.H. (J. Biol. Chem. 2010) 3 23

Products for TRPV1 Gene

Sources for TRPV1 Gene

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