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Aliases for VEGFC Gene

Aliases for VEGFC Gene

  • Vascular Endothelial Growth Factor C 2 3 5
  • Vascular Endothelial Growth Factor-Related Protein 2 3 4
  • Flt4-L 3 4
  • VRP 3 4
  • FLT4 Ligand DHM 3
  • Flt4 Ligand 4
  • LMPH1D 3
  • VEGF-C 4

External Ids for VEGFC Gene

Previous GeneCards Identifiers for VEGFC Gene

  • GC04M178492
  • GC04M178154
  • GC04M178300
  • GC04M177979
  • GC04M177841
  • GC04M177604
  • GC04M173355

Summaries for VEGFC Gene

Entrez Gene Summary for VEGFC Gene

  • The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

GeneCards Summary for VEGFC Gene

VEGFC (Vascular Endothelial Growth Factor C) is a Protein Coding gene. Diseases associated with VEGFC include lymphedema, hereditary, id and lymphangioma. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include growth factor activity and vascular endothelial growth factor receptor 3 binding. An important paralog of this gene is FIGF.

UniProtKB/Swiss-Prot for VEGFC Gene

  • Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

Gene Wiki entry for VEGFC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEGFC Gene

Genomics for VEGFC Gene

Regulatory Elements for VEGFC Gene

Promoters for VEGFC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VEGFC on UCSC Golden Path with GeneCards custom track

Genomic Location for VEGFC Gene

Chromosome:
4
Start:
176,683,534 bp from pter
End:
176,792,745 bp from pter
Size:
109,212 bases
Orientation:
Minus strand

Genomic View for VEGFC Gene

Genes around VEGFC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VEGFC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VEGFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEGFC Gene

Proteins for VEGFC Gene

  • Protein details for VEGFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49767-VEGFC_HUMAN
    Recommended name:
    Vascular endothelial growth factor C
    Protein Accession:
    P49767
    Secondary Accessions:
    • B2R9Q8

    Protein attributes for VEGFC Gene

    Size:
    419 amino acids
    Molecular mass:
    46883 Da
    Quaternary structure:
    • Homodimer; non-covalent and antiparallel.

    Three dimensional structures from OCA and Proteopedia for VEGFC Gene

neXtProt entry for VEGFC Gene

Proteomics data for VEGFC Gene at MOPED

Post-translational modifications for VEGFC Gene

  • Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • Glycosylation at Asn 175, Asn 205, and Asn 240
  • Modification sites at PhosphoSitePlus

Other Protein References for VEGFC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VEGFC (VEGFC)

Assay Products

  • Enzo Life Sciences assays for VEGFC

No data available for DME Specific Peptides for VEGFC Gene

Domains & Families for VEGFC Gene

Suggested Antigen Peptide Sequences for VEGFC Gene

Graphical View of Domain Structure for InterPro Entry

P49767

UniProtKB/Swiss-Prot:

VEGFC_HUMAN :
  • Belongs to the PDGF/VEGF growth factor family.
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with VEGFC: view

No data available for Gene Families for VEGFC Gene

Function for VEGFC Gene

Molecular function for VEGFC Gene

GENATLAS Biochemistry:
vascular endothelial growth factor C,expressed in heart,placenta,ovary,small intestine,with two alternatively spliced forms,PDGF family,hypoxia-inducible,involved in vasculogenesis,downregulated by VHL
UniProtKB/Swiss-Prot Function:
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

LifeMap Function Summary for VEGFC Gene

During embryonic development, VEGFC as signaling molecule is secreted from the following cells
It affects the following cells:
genes like me logo Genes that share phenotypes with VEGFC: view

Human Phenotype Ontology for VEGFC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for VEGFC Gene

MGI Knock Outs for VEGFC:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for VEGFC Gene

Localization for VEGFC Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEGFC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VEGFC Gene COMPARTMENTS Subcellular localization image for VEGFC gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for VEGFC Gene

Pathways & Interactions for VEGFC Gene

genes like me logo Genes that share pathways with VEGFC: view

Interacting Proteins for VEGFC Gene

Selected Interacting proteins: P49767-VEGFC_HUMAN for VEGFC Gene via UniProtKB I2D

SIGNOR curated interactions for VEGFC Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for VEGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0002052 positive regulation of neuroblast proliferation IEA --
GO:0002576 platelet degranulation TAS --
GO:0006929 substrate-dependent cell migration TAS 8617204
genes like me logo Genes that share ontologies with VEGFC: view

Drugs & Compounds for VEGFC Gene

(18) Drugs for VEGFC Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Avastin Approved July 2009 Pharma inhibitor 0
Bevacizumab Approved, Investigational Pharma antagonist, antibody, inhibitor VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 1875
Lenalidomide Approved Pharma Anti-angiogenic., inhibitor Anti-angiogenic. 674
Endostatins Pharma inhibitor 64
Lenalidomide, Bevacizumab Pharma antagonist Anti-angiogenic., VEGF antagonist 0

(15) Additional Compounds for VEGFC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VEGFC: view

Transcripts for VEGFC Gene

mRNA/cDNA for VEGFC Gene

Unigene Clusters for VEGFC Gene

Vascular endothelial growth factor C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VEGFC Gene

No ASD Table

Relevant External Links for VEGFC Gene

GeneLoc Exon Structure for
VEGFC
ECgene alternative splicing isoforms for
VEGFC

Expression for VEGFC Gene

mRNA expression in normal human tissues for VEGFC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VEGFC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VEGFC Gene



SOURCE GeneReport for Unigene cluster for VEGFC Gene Hs.435215

mRNA Expression by UniProt/SwissProt for VEGFC Gene

P49767-VEGFC_HUMAN
Tissue specificity: Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.
genes like me logo Genes that share expression patterns with VEGFC: view

Protein tissue co-expression partners for VEGFC Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VEGFC Gene

Orthologs for VEGFC Gene

This gene was present in the common ancestor of chordates.

Orthologs for VEGFC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VEGFC 35
  • 90.29 (n)
  • 88.31 (a)
VEGFC 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VEGFC 35
  • 90.53 (n)
  • 89.98 (a)
VEGFC 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vegfc 35
  • 87.71 (n)
  • 86.27 (a)
Vegfc 16
Vegfc 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VEGFC 35
  • 99.6 (n)
  • 99.52 (a)
VEGFC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vegfc 35
  • 87.55 (n)
  • 85.54 (a)
oppossum
(Monodelphis domestica)
Mammalia VEGFC 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves VEGFC 35
  • 79.78 (n)
  • 76.02 (a)
VEGFC 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VEGFC 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vegfc 35
  • 74.98 (n)
  • 74.28 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26450 35
vegfc 35
  • 63.94 (n)
  • 60.87 (a)
vegfc 36
  • 58 (a)
OneToOne
Species with no ortholog for VEGFC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VEGFC Gene

ENSEMBL:
Gene Tree for VEGFC (if available)
TreeFam:
Gene Tree for VEGFC (if available)

Paralogs for VEGFC Gene

Paralogs for VEGFC Gene

(1) SIMAP similar genes for VEGFC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VEGFC: view

Variants for VEGFC Gene

Sequence variations from dbSNP and Humsavar for VEGFC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs18131 -- 176,748,937(+) CATAT(A/G)GAATA intron-variant
rs580893 -- 176,716,676(-) ACCAT(A/G)GTATC intron-variant
rs585706 -- 176,727,510(+) ACATA(C/T)GTATA intron-variant
rs589936 -- 176,736,534(-) ATAAA(C/G)ACATC intron-variant
rs590490 -- 176,717,509(-) AGTAC(G/T)ATTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VEGFC Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV Deletion 23290073
nsv881066 CNV Loss 21882294
nsv4613 CNV Insertion 18451855
esv1655976 CNV Deletion 17803354
esv2728777 CNV Deletion 23290073
nsv289896 CNV Loss 16902084
esv2658768 CNV Deletion 23128226
esv2670195 CNV Deletion 23128226
nsv822850 CNV Gain 20364138

Variation tolerance for VEGFC Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VEGFC Gene

HapMap Linkage Disequilibrium report
VEGFC
Human Gene Mutation Database (HGMD)
VEGFC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEGFC Gene

Disorders for VEGFC Gene

MalaCards: The human disease database

(28) MalaCards diseases for VEGFC Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphedema, hereditary, id
  • lmph1d
lymphangioma
  • benign lymphangioma
lymphedema
  • lymphatic edema
tongue cancer
  • malignant neoplasm of anterior 2/3 of tongue unspecified
tongue squamous cell carcinoma
  • squamous-cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search VEGFC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VEGFC_HUMAN
  • Lymphedema, hereditary, 1D (LMPH1D) [MIM:615907]: A chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. {ECO:0000269 PubMed:23410910, ECO:0000269 PubMed:24744435}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for VEGFC

Genetic Association Database (GAD)
VEGFC
Human Genome Epidemiology (HuGE) Navigator
VEGFC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VEGFC
genes like me logo Genes that share disorders with VEGFC: view

No data available for Genatlas for VEGFC Gene

Publications for VEGFC Gene

  1. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (PMID: 8617204) Joukov V. … Alitalo K. (EMBO J. 1996) 2 3 4 23 67
  2. Allelic variations in angiogenic pathway genes are associated with preeclampsia. (PMID: 20223440) Srinivas S.K. … Elovitz M.A. (Am. J. Obstet. Gynecol. 2010) 3 23
  3. Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade. (PMID: 20429915) He M. … Fu X. (BMC Cancer 2010) 3 23
  4. [Expressions of VEGF-C and VEGF-D and their correlation with lymphangiogenesis and angiogenesis in gallbladder carcinoma]. (PMID: 20450586) Jiang L. … Wang X.X. (Zhonghua Zhong Liu Za Zhi 2010) 3 23
  5. Protein expression profiling of vascular endothelial growth factor and its receptors identifies subclasses of hepatocellular carcinoma and predicts survival. (PMID: 19066962) Jia J.B. … Tang Z.Y. (J. Cancer Res. Clin. Oncol. 2009) 3 23

Products for VEGFC Gene

  • Addgene plasmids for VEGFC

Sources for VEGFC Gene

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