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Aliases for VEGFC Gene

Aliases for VEGFC Gene

  • Vascular Endothelial Growth Factor C 2 3 5
  • Vascular Endothelial Growth Factor-Related Protein 2 3 4
  • Flt4-L 3 4
  • VRP 3 4
  • FLT4 Ligand DHM 3
  • Flt4 Ligand 4
  • LMPH1D 3
  • VEGF-C 4

External Ids for VEGFC Gene

Previous GeneCards Identifiers for VEGFC Gene

  • GC04M178492
  • GC04M178154
  • GC04M178300
  • GC04M177979
  • GC04M177841
  • GC04M177604
  • GC04M173355

Summaries for VEGFC Gene

Entrez Gene Summary for VEGFC Gene

  • The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

GeneCards Summary for VEGFC Gene

VEGFC (Vascular Endothelial Growth Factor C) is a Protein Coding gene. Diseases associated with VEGFC include Lymphedema, Hereditary, Id and Lymphangioma. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include growth factor activity and vascular endothelial growth factor receptor 3 binding. An important paralog of this gene is VEGFD.

UniProtKB/Swiss-Prot for VEGFC Gene

  • Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

Gene Wiki entry for VEGFC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEGFC Gene

Genomics for VEGFC Gene

Regulatory Elements for VEGFC Gene

Enhancers for VEGFC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G176788 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +0.7 690 7.7 TBP PKNOX1 SIN3A RAD21 YY1 ZNF121 GLIS2 GATA2 FOS ZSCAN16 VEGFC GC04P176765
GH04G176780 1.1 Ensembl ENCODE dbSUPER 6.4 +10.6 10574 3.2 JUND JUN CREB1 FOS ATF2 NR2F2 VEGFC GC04P176765
GH04G176769 1.1 Ensembl ENCODE dbSUPER 6.3 +22.9 22861 2.6 CTCF JUND JUN BHLHE40 FOS MAFK NFE2L2 VEGFC GC04P176765
GH04G176752 1 Ensembl ENCODE dbSUPER 6.2 +39.3 39305 2.5 JUND BHLHE40 SIN3A FOS MAFK VEGFC GC04P176765 GC04P176682
GH04G176777 0.8 ENCODE dbSUPER 6.4 +13.8 13821 2.1 JUND FOS HNF4A NFE2 NFE2L2 VEGFC GC04P176765
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VEGFC on UCSC Golden Path with GeneCards custom track

Promoters for VEGFC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000176464 945 3201 TBP CTCF MXI1 PKNOX1 SIN3A RBBP5 ZNF644 RAD21 YY1 E2F1

Genomic Location for VEGFC Gene

Chromosome:
4
Start:
176,683,534 bp from pter
End:
176,792,745 bp from pter
Size:
109,212 bases
Orientation:
Minus strand

Genomic View for VEGFC Gene

Genes around VEGFC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VEGFC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VEGFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEGFC Gene

Proteins for VEGFC Gene

  • Protein details for VEGFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49767-VEGFC_HUMAN
    Recommended name:
    Vascular endothelial growth factor C
    Protein Accession:
    P49767
    Secondary Accessions:
    • B2R9Q8

    Protein attributes for VEGFC Gene

    Size:
    419 amino acids
    Molecular mass:
    46883 Da
    Quaternary structure:
    • Homodimer; non-covalent and antiparallel.

    Three dimensional structures from OCA and Proteopedia for VEGFC Gene

neXtProt entry for VEGFC Gene

Post-translational modifications for VEGFC Gene

  • Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • Glycosylation at isoforms=175, posLast=205205, and isoforms=240
  • Modification sites at PhosphoSitePlus

Other Protein References for VEGFC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VEGFC (VEGFC)
  • Abcam antibodies for VEGFC
  • Cloud-Clone Corp. Antibodies for VEGFC

Assay Products

  • Enzo Life Sciences assays for VEGFC

No data available for DME Specific Peptides for VEGFC Gene

Domains & Families for VEGFC Gene

Gene Families for VEGFC Gene

Suggested Antigen Peptide Sequences for VEGFC Gene

Graphical View of Domain Structure for InterPro Entry

P49767

UniProtKB/Swiss-Prot:

VEGFC_HUMAN :
  • Belongs to the PDGF/VEGF growth factor family.
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with VEGFC: view

Function for VEGFC Gene

Molecular function for VEGFC Gene

GENATLAS Biochemistry:
vascular endothelial growth factor C,expressed in heart,placenta,ovary,small intestine,with two alternatively spliced forms,PDGF family,hypoxia-inducible,involved in vasculogenesis,downregulated by VHL
UniProtKB/Swiss-Prot Function:
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

LifeMap Function Summary for VEGFC Gene

During embryonic development, VEGFC as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for VEGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21130043
GO:0008083 growth factor activity IBA --
GO:0042056 chemoattractant activity IDA 19275959
GO:0043185 vascular endothelial growth factor receptor 3 binding IEA,IBA --
genes like me logo Genes that share ontologies with VEGFC: view
genes like me logo Genes that share phenotypes with VEGFC: view

Human Phenotype Ontology for VEGFC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for VEGFC Gene

MGI Knock Outs for VEGFC:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VEGFC

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for VEGFC Gene

Localization for VEGFC Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEGFC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VEGFC gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for VEGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
GO:0016020 membrane IEA --
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with VEGFC: view

Pathways & Interactions for VEGFC Gene

genes like me logo Genes that share pathways with VEGFC: view

Interacting Proteins for VEGFC Gene

SIGNOR curated interactions for VEGFC Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for VEGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IBA --
GO:0001666 response to hypoxia IBA --
GO:0001938 positive regulation of endothelial cell proliferation IBA --
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0002052 positive regulation of neuroblast proliferation IEA --
genes like me logo Genes that share ontologies with VEGFC: view

Drugs & Compounds for VEGFC Gene

(20) Drugs for VEGFC Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Avastin Approved July 2009 Pharma inhibitor 0
Bevacizumab Approved, Investigational Pharma antagonist, antibody, inhibitor VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 2020
Lenalidomide Approved Pharma Anti-angiogenic., inhibitor Anti-angiogenic. 736
Endostatins Pharma inhibitor 73
Lenalidomide, Bevacizumab Pharma antagonist Anti-angiogenic., VEGF antagonist 0

(13) Additional Compounds for VEGFC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VEGFC: view

Transcripts for VEGFC Gene

mRNA/cDNA for VEGFC Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(82) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VEGFC Gene

Vascular endothelial growth factor C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VEGFC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VEGFC Gene

No ASD Table

Relevant External Links for VEGFC Gene

GeneLoc Exon Structure for
VEGFC
ECgene alternative splicing isoforms for
VEGFC

Expression for VEGFC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VEGFC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VEGFC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VEGFC Gene



Protein tissue co-expression partners for VEGFC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VEGFC Gene:

VEGFC

SOURCE GeneReport for Unigene cluster for VEGFC Gene:

Hs.435215

mRNA Expression by UniProt/SwissProt for VEGFC Gene:

P49767-VEGFC_HUMAN
Tissue specificity: Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.

Evidence on tissue expression from TISSUES for VEGFC Gene

  • Skin(4.4)
  • Lymph node(3.3)
  • Heart(3)
  • Blood(2.4)
  • Lung(2.2)
  • Intestine(2)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for VEGFC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • reproductive
Organs:
Head and neck:
  • ear
  • eye
  • eyelid
  • face
  • head
Thorax:
  • heart
Abdomen:
  • intestine
  • large intestine
  • small intestine
Pelvis:
  • placenta
  • testicle
  • uterus
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • lymph node
  • lymph vessel
  • skin
genes like me logo Genes that share expression patterns with VEGFC: view

Primer Products

No data available for mRNA differential expression in normal tissues for VEGFC Gene

Orthologs for VEGFC Gene

This gene was present in the common ancestor of chordates.

Orthologs for VEGFC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VEGFC 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia VEGFC 34 35
  • 90.53 (n)
cow
(Bos Taurus)
Mammalia VEGFC 34 35
  • 90.29 (n)
mouse
(Mus musculus)
Mammalia Vegfc 34 16 35
  • 87.71 (n)
rat
(Rattus norvegicus)
Mammalia Vegfc 34
  • 87.55 (n)
oppossum
(Monodelphis domestica)
Mammalia VEGFC 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves VEGFC 34 35
  • 79.78 (n)
lizard
(Anolis carolinensis)
Reptilia VEGFC 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vegfc 34
  • 74.98 (n)
zebrafish
(Danio rerio)
Actinopterygii vegfc 34 35
  • 63.94 (n)
Dr.26450 34
Species where no ortholog for VEGFC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VEGFC Gene

ENSEMBL:
Gene Tree for VEGFC (if available)
TreeFam:
Gene Tree for VEGFC (if available)

Paralogs for VEGFC Gene

Paralogs for VEGFC Gene

(1) SIMAP similar genes for VEGFC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VEGFC: view

Variants for VEGFC Gene

Sequence variations from dbSNP and Humsavar for VEGFC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs587777566 Pathogenic 176,711,631(+) GAGAG(-/AA)GCACT reference, frameshift-variant
rs587777567 Pathogenic 176,711,575(+) GCATC(A/G)GCAGG reference, stop-gained
rs10000057 -- 176,768,923(+) ccccc(A/G)tgctg intron-variant
rs1000009667 -- 176,705,612(+) ATTTC(C/T)AAATC intron-variant
rs10000179 -- 176,769,170(+) ATGCC(C/T)AATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VEGFC Gene

Variant ID Type Subtype PubMed ID
esv1655976 CNV deletion 17803354
esv2658768 CNV deletion 23128226
esv2670195 CNV deletion 23128226
esv2728772 CNV deletion 23290073
esv2728777 CNV deletion 23290073
esv3603282 CNV loss 21293372
nsv1109654 CNV deletion 24896259
nsv289896 CNV deletion 16902084
nsv4613 CNV insertion 18451855
nsv822850 CNV gain 20364138

Variation tolerance for VEGFC Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VEGFC Gene

Human Gene Mutation Database (HGMD)
VEGFC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VEGFC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEGFC Gene

Disorders for VEGFC Gene

MalaCards: The human disease database

(39) MalaCards diseases for VEGFC Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphedema, hereditary, id
  • lmph1d
lymphangioma
  • benign lymphangioma
infiltrating angiolipoma
  • angiolipoma, infiltrating
lymphedema
  • lymphatic edema
tongue cancer
  • malignant neoplasm of anterior 2/3 of tongue unspecified
- elite association - COSMIC cancer census association via MalaCards
Search VEGFC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VEGFC_HUMAN
  • Lymphedema, hereditary, 1D (LMPH1D) [MIM:615907]: A chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. {ECO:0000269 PubMed:23410910, ECO:0000269 PubMed:24744435}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for VEGFC

Genetic Association Database (GAD)
VEGFC
Human Genome Epidemiology (HuGE) Navigator
VEGFC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VEGFC
genes like me logo Genes that share disorders with VEGFC: view

No data available for Genatlas for VEGFC Gene

Publications for VEGFC Gene

  1. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (PMID: 8617204) Joukov V. … Alitalo K. (EMBO J. 1996) 2 3 4 22 64
  2. Allelic variations in angiogenic pathway genes are associated with preeclampsia. (PMID: 20223440) Srinivas S.K. … Elovitz M.A. (Am. J. Obstet. Gynecol. 2010) 3 22 46 64
  3. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (PMID: 8612600) Joukov V. … Alitalo K. (EMBO J. 1996) 3 4 22 64
  4. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. (PMID: 8700872) Lee J. … Wood W.I. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64
  5. A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease. (PMID: 24744435) Balboa-Beltran E. … Barros F. (J. Med. Genet. 2014) 3 4 64

Products for VEGFC Gene

  • Addgene plasmids for VEGFC

Sources for VEGFC Gene

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