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Aliases for VEGFB Gene

Aliases for VEGFB Gene

  • Vascular Endothelial Growth Factor B 2 3
  • VRF 3 4 6
  • VEGF-Related Factor 3 4
  • VEGF-B 4
  • VEGFL 3

External Ids for VEGFB Gene

Previous HGNC Symbols for VEGFB Gene

  • VRF

Previous GeneCards Identifiers for VEGFB Gene

  • GC11P066518
  • GC11P065683
  • GC11P064253
  • GC11P063777
  • GC11P063758
  • GC11P064002
  • GC11P060330

Summaries for VEGFB Gene

Entrez Gene Summary for VEGFB Gene

  • This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for VEGFB Gene

VEGFB (Vascular Endothelial Growth Factor B) is a Protein Coding gene. Diseases associated with VEGFB include intracranial arteriovenous malformation and cleidocranial dysplasia. Among its related pathways are PI3K-Akt signaling pathway and RhoGDI Pathway. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is PGF.

UniProtKB/Swiss-Prot for VEGFB Gene

  • Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis

Gene Wiki entry for VEGFB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEGFB Gene

Genomics for VEGFB Gene

Regulatory Elements for VEGFB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VEGFB Gene

64,234,538 bp from pter
64,239,264 bp from pter
4,727 bases
Plus strand

Genomic View for VEGFB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VEGFB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEGFB Gene

Proteins for VEGFB Gene

  • Protein details for VEGFB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vascular endothelial growth factor B
    Protein Accession:
    Secondary Accessions:
    • Q16528

    Protein attributes for VEGFB Gene

    207 amino acids
    Molecular mass:
    21602 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Can also form heterodimer with VEGF.

    Three dimensional structures from OCA and Proteopedia for VEGFB Gene

    Alternative splice isoforms for VEGFB Gene


neXtProt entry for VEGFB Gene

Proteomics data for VEGFB Gene at MOPED

Post-translational modifications for VEGFB Gene

Other Protein References for VEGFB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VEGFB (VEGFB)

No data available for DME Specific Peptides for VEGFB Gene

Domains for VEGFB Gene

Graphical View of Domain Structure for InterPro Entry



  • P49765
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with VEGFB: view

No data available for Gene Families for VEGFB Gene

Function for VEGFB Gene

Molecular function for VEGFB Gene

GENATLAS Biochemistry:
vascular endothelial growth factor B,with two alternatively spliced forms differing at their C terminal,universally expressed,PDGF family,hypoxia-inducible,involved in vasculogenesis,downregulated by VHL
UniProtKB/Swiss-Prot Function:
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis

Gene Ontology (GO) - Molecular Function for VEGFB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11122379
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IEA --
GO:0042056 chemoattractant activity IDA 19275959
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with VEGFB: view
genes like me logo Genes that share phenotypes with VEGFB: view

Animal Models for VEGFB Gene

MGI Knock Outs for VEGFB:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VEGFB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for VEGFB Gene

Localization for VEGFB Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEGFB Gene

Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Subcellular locations from

Jensen Localization Image for VEGFB Gene COMPARTMENTS Subcellular localization image for VEGFB gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VEGFB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 12881472
GO:0005622 intracellular --
GO:0016020 membrane IEA --
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with VEGFB: view

Pathways for VEGFB Gene

genes like me logo Genes that share pathways with VEGFB: view

Pathways by source for VEGFB Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VEGFB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001938 positive regulation of endothelial cell proliferation IDA 11122379
GO:0002576 platelet degranulation TAS --
GO:0006493 protein O-linked glycosylation IEA --
GO:0007507 heart development --
genes like me logo Genes that share ontologies with VEGFB: view

Compounds for VEGFB Gene

(1) ApexBio Compounds for VEGFB Gene

Compound Action Cas Number
Nintedanib (BIBF 1120) VEGFR/PDGFR/FGFR inhibitor [928326-83-4]

(4) Novoseek inferred chemical compound relationships for VEGFB Gene

Compound -log(P) Hits PubMed IDs
vegf 87.3 98
tyrosine 49.7 8
heparin 1.16 2
oxygen 0 1
genes like me logo Genes that share compounds with VEGFB: view

Transcripts for VEGFB Gene

Unigene Clusters for VEGFB Gene

Vascular endothelial growth factor B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VEGFB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VEGFB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP2: -

Relevant External Links for VEGFB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VEGFB Gene

mRNA expression in normal human tissues for VEGFB Gene

Protein differential expression in normal tissues for VEGFB Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VEGFB Gene

SOURCE GeneReport for Unigene cluster for VEGFB Gene Hs.732095

mRNA Expression by UniProt/SwissProt for VEGFB Gene

Tissue specificity: Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas
genes like me logo Genes that share expressions with VEGFB: view

Expression partners for VEGFB Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VEGFB Gene

Orthologs for VEGFB Gene

This gene was present in the common ancestor of chordates.

Orthologs for VEGFB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VEGFB 35
  • 93.33 (n)
  • 92.94 (a)
  • 93 (a)
(Canis familiaris)
Mammalia VEGFB 35
  • 92.7 (n)
  • 93.49 (a)
  • 91 (a)
(Mus musculus)
Mammalia Vegfb 35
  • 89.96 (n)
  • 87.95 (a)
Vegfb 16
Vegfb 36
  • 87 (a)
(Pan troglodytes)
Mammalia VEGFB 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Vegfb 35
  • 90 (n)
  • 88.75 (a)
(Monodelphis domestica)
Mammalia VEGFB 36
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia VEGFB 36
  • 39 (a)
(Danio rerio)
Actinopterygii BX511266.1 36
  • 20 (a)
vegfbb 36
  • 34 (a)
Species with no ortholog for VEGFB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VEGFB Gene

Gene Tree for VEGFB (if available)
Gene Tree for VEGFB (if available)

Paralogs for VEGFB Gene

Paralogs for VEGFB Gene

Selected SIMAP similar genes for VEGFB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VEGFB: view

Variants for VEGFB Gene

Sequence variations from dbSNP and Humsavar for VEGFB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs594942 -- 64,238,820(-) CCTGG(A/G)CAGTG utr-variant-3-prime
rs2286610 -- 64,238,163(-) GGAGC(A/C)CCCAC intron-variant
rs2286611 -- 64,236,185(-) TGAAG(A/G)GAGAA intron-variant
rs2302260 -- 64,237,321(-) AAAAG(A/G)GAAAG intron-variant
rs3214290 -- 64,236,228(-) GGGGG(-/G)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VEGFB Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
dgv1167n71 CNV Loss 21882294
esv992196 CNV Deletion 20482838
nsv897674 CNV Loss 21882294
nsv897683 CNV Loss 21882294
esv24861 CNV Gain 19812545

Relevant External Links for VEGFB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEGFB Gene

Disorders for VEGFB Gene

(28) Novoseek inferred disease relationships for VEGFB Gene

Disease -log(P) Hits PubMed IDs
neovascularization 63.4 6
metastasis 41.8 13
tumors 41.7 28
cancer 29.8 1
glioblastoma 25.4 2

Relevant External Links for VEGFB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with VEGFB: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for VEGFB Gene

Publications for VEGFB Gene

  1. Cloning and characterization of a novel human gene related to vascular endothelial growth factor. (PMID: 8919691) Grimmond S. … Weber G. (Genome Res. 1996) 2 3 4 23
  2. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. (PMID: 8637916) Olofsson B. … Eriksson U. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  3. Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding. (PMID: 16616187) Iyer S. … Ravi Acharya K. (J. Mol. Biol. 2006) 3 4 23
  4. Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. (PMID: 8702615) Olofsson B. … Eriksson U. (J. Biol. Chem. 1996) 3 4 23
  5. Candidate gene analysis in primary lymphedema. (PMID: 18564921) Ferrell R.E. … Finegold D.N. (Lymphat Res Biol 2008) 3 48

Products for VEGFB Gene

Sources for VEGFB Gene

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