Aliases for VEGFA Gene
External Ids for VEGFA Gene
Previous HGNC Symbols for VEGFA Gene
Previous GeneCards Identifiers for VEGFA Gene
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for VEGFA Gene
VEGFA (Vascular Endothelial Growth Factor A) is a Protein Coding gene. Diseases associated with VEGFA include microvascular complications of diabetes 1 and poems syndrome. Among its related pathways are PI3K-Akt signaling pathway and RhoGDI Pathway. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PGF.
UniProtKB/Swiss-Prot for VEGFA Gene
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.