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Aliases for VEGFA Gene

Aliases for VEGFA Gene

  • Vascular Endothelial Growth Factor A 2 3 5
  • Vascular Permeability Factor 3 4
  • VEGF 3 4
  • VPF 3 4
  • Vascular Endothelial Growth Factor A121 3
  • Vascular Endothelial Growth Factor A165 3
  • Vascular Endothelial Growth Factor 2
  • VEGF-A 4
  • MVCD1 3

External Ids for VEGFA Gene

Previous HGNC Symbols for VEGFA Gene

  • VEGF

Previous GeneCards Identifiers for VEGFA Gene

  • GC06P043846
  • GC06P043458

Summaries for VEGFA Gene

Entrez Gene Summary for VEGFA Gene

  • This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]

GeneCards Summary for VEGFA Gene

VEGFA (Vascular Endothelial Growth Factor A) is a Protein Coding gene. Diseases associated with VEGFA include Microvascular Complications Of Diabetes 1 and Microvascular Complications Of Diabetes 1, Susceptibility. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PGF.

UniProtKB/Swiss-Prot for VEGFA Gene

  • Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

Gene Wiki entry for VEGFA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEGFA Gene

Genomics for VEGFA Gene

Regulatory Elements for VEGFA Gene

Enhancers for VEGFA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VEGFA on UCSC Golden Path with GeneCards custom track

Promoters for VEGFA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VEGFA on UCSC Golden Path with GeneCards custom track

Genomic Location for VEGFA Gene

Chromosome:
6
Start:
43,770,184 bp from pter
End:
43,786,487 bp from pter
Size:
16,304 bases
Orientation:
Plus strand

Genomic View for VEGFA Gene

Genes around VEGFA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VEGFA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VEGFA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEGFA Gene

Proteins for VEGFA Gene

  • Protein details for VEGFA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15692-VEGFA_HUMAN
    Recommended name:
    Vascular endothelial growth factor A
    Protein Accession:
    P15692
    Secondary Accessions:
    • B5BU86
    • H0Y2S8
    • H0Y407
    • H0Y414
    • H0Y462
    • H0Y8N2
    • H3BLW7
    • O60720
    • O75875
    • Q074Z4
    • Q16889
    • Q5UB46
    • Q6P0P5
    • Q96KJ0
    • Q96L82
    • Q96NW5
    • Q9H1W8
    • Q9H1W9
    • Q9UH58
    • Q9UL23

    Protein attributes for VEGFA Gene

    Size:
    232 amino acids
    Molecular mass:
    27042 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity).
    SequenceCaution:
    • Sequence=AAC63102.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC63143.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAC19512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAC19516.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VEGFA Gene

neXtProt entry for VEGFA Gene

Proteomics data for VEGFA Gene at MOPED

Post-translational modifications for VEGFA Gene

  • Glycosylation at Asn 101
  • Modification sites at PhosphoSitePlus

Protein Products

No data available for DME Specific Peptides for VEGFA Gene

Domains & Families for VEGFA Gene

Graphical View of Domain Structure for InterPro Entry

P15692

UniProtKB/Swiss-Prot:

VEGFA_HUMAN :
  • Belongs to the PDGF/VEGF growth factor family.
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with VEGFA: view

No data available for Gene Families for VEGFA Gene

Function for VEGFA Gene

Molecular function for VEGFA Gene

UniProtKB/Swiss-Prot Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
UniProtKB/Swiss-Prot Induction:
By hypoxia. Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoglycemia and oncogenic mutations.

LifeMap Function Summary for VEGFA Gene

It affects the following cells:

Gene Ontology (GO) - Molecular Function for VEGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005161 platelet-derived growth factor receptor binding IPI 17470632
GO:0005515 protein binding IPI 1312256
GO:0043183 vascular endothelial growth factor receptor 1 binding IPI 1312256
genes like me logo Genes that share ontologies with VEGFA: view
genes like me logo Genes that share phenotypes with VEGFA: view

Animal Models for VEGFA Gene

MGI Knock Outs for VEGFA:

miRNA for VEGFA Gene

miRTarBase miRNAs that target VEGFA

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VEGFA Gene

Localization for VEGFA Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEGFA Gene

Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VEGFA Gene COMPARTMENTS Subcellular localization image for VEGFA gene
Compartment Confidence
extracellular 5
nucleus 4
cytoskeleton 3
cytosol 3
mitochondrion 3
plasma membrane 3
endoplasmic reticulum 2
vacuole 2
endosome 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VEGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 14570917
genes like me logo Genes that share ontologies with VEGFA: view

Pathways & Interactions for VEGFA Gene

genes like me logo Genes that share pathways with VEGFA: view

SIGNOR curated interactions for VEGFA Gene

Activates:

Gene Ontology (GO) - Biological Process for VEGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18093989
GO:0001525 angiogenesis IDA 11427521
GO:0001541 ovarian follicle development ISS --
GO:0001569 patterning of blood vessels ISS --
GO:0001570 vasculogenesis TAS 15015550
genes like me logo Genes that share ontologies with VEGFA: view

Drugs & Compounds for VEGFA Gene

(105) Drugs for VEGFA Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ranibizumab Approved Pharma inhibitor, Target 463
Bevacizumab Approved, Investigational Pharma antagonist, antibody, inhibitor, Target VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 1910
pegaptanib Approved, Investigational Pharma 0
Vandetanib Approved April 2011 Pharma Target, inhibitor VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Minocycline Approved, Investigational Pharma Target, inhibitor 210

(35) Additional Compounds for VEGFA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7-Hydroxygliclazide
8-Hydroxycarvedilol

(1) ApexBio Compounds for VEGFA Gene

Compound Action Cas Number
Nintedanib (BIBF 1120) VEGFR/PDGFR/FGFR inhibitor 928326-83-4
genes like me logo Genes that share compounds with VEGFA: view

Transcripts for VEGFA Gene

Unigene Clusters for VEGFA Gene

Vascular endothelial growth factor A:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VEGFA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: -
SP7:

Relevant External Links for VEGFA Gene

GeneLoc Exon Structure for
VEGFA
ECgene alternative splicing isoforms for
VEGFA

Expression for VEGFA Gene

mRNA expression in normal human tissues for VEGFA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VEGFA Gene

This gene is overexpressed in Thyroid (x4.0).

Protein differential expression in normal tissues from HIPED for VEGFA Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VEGFA Gene



SOURCE GeneReport for Unigene cluster for VEGFA Gene Hs.73793

mRNA Expression by UniProt/SwissProt for VEGFA Gene

P15692-VEGFA_HUMAN
Tissue specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
genes like me logo Genes that share expression patterns with VEGFA: view

Protein tissue co-expression partners for VEGFA Gene

Orthologs for VEGFA Gene

This gene was present in the common ancestor of chordates.

Orthologs for VEGFA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VEGFA 35
  • 95.26 (n)
  • 94.74 (a)
VEGFA 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VEGFA 35
  • 94.39 (n)
  • 95.79 (a)
VEGFA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vegfa 35
  • 88.52 (n)
  • 83.93 (a)
Vegfa 16
Vegfa 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vegfa 35
  • 88.89 (n)
  • 84.22 (a)
oppossum
(Monodelphis domestica)
Mammalia VEGFA 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VEGFA 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves VEGFA 35
  • 78.29 (n)
  • 74.88 (a)
VEGFA 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VEGFA 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3662 35
African clawed frog
(Xenopus laevis)
Amphibia vegf-A 35
zebrafish
(Danio rerio)
Actinopterygii vegf 35
vegfab 35
  • 57.26 (n)
  • 50.99 (a)
vegfaa 36
  • 57 (a)
OneToMany
vegfab 36
  • 44 (a)
OneToMany
Species with no ortholog for VEGFA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VEGFA Gene

ENSEMBL:
Gene Tree for VEGFA (if available)
TreeFam:
Gene Tree for VEGFA (if available)

Paralogs for VEGFA Gene

Paralogs for VEGFA Gene

genes like me logo Genes that share paralogs with VEGFA: view

Variants for VEGFA Gene

Sequence variations from dbSNP and Humsavar for VEGFA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1049160 -- 43,786,051(+) TCCCC(A/G)ATCCC utr-variant-3-prime
rs1413711 -- 43,772,941(-) CAGGG(A/G)GCACA intron-variant
rs1570360 -- 43,770,093(+) GTGGA(A/G)GGGCT upstream-variant-2KB
rs1802040 -- 43,785,510(+) AGACA(C/T)ATTGT utr-variant-3-prime
rs1885657 -- 43,772,357(+) CCCAC(C/T)GGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VEGFA Gene

Variant ID Type Subtype PubMed ID
nsv885848 CNV Loss 21882294
nsv823682 CNV Gain 20364138
nsv885849 CNV Gain 21882294
nsv885850 CNV Loss 21882294

Variation tolerance for VEGFA Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VEGFA Gene

Human Gene Mutation Database (HGMD)
VEGFA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEGFA Gene

Disorders for VEGFA Gene

MalaCards: The human disease database

(198) MalaCards diseases for VEGFA Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search VEGFA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VEGFA_HUMAN
  • Microvascular complications of diabetes 1 (MVCD1) [MIM:603933]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. {ECO:0000269 PubMed:11978667}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for VEGFA

Genetic Association Database (GAD)
VEGFA
Human Genome Epidemiology (HuGE) Navigator
VEGFA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VEGFA
genes like me logo Genes that share disorders with VEGFA: view

No data available for Genatlas for VEGFA Gene

Publications for VEGFA Gene

  1. A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. (PMID: 11978667) Awata T. … Katayama S. (Diabetes 2002) 3 4 48 67
  2. Antiangiogenic drugs for chemotherapy of bladder tumours. (PMID: 16224178) Rocchetti R. … Possati L. (Chemotherapy 2005) 23 25 26
  3. Regulated expression of the renin-angiotensin-system in human granulosa lutein cells: angiotensin II increases VEGF expression but its synthesis is reduced by hCG. (PMID: 19521712) Herr D. … Wulff C. (Arch. Gynecol. Obstet. 2010) 3 23
  4. The role of VEGF pathways in human physiologic and pathologic angiogenesis. (PMID: 19577260) Lyons J.M. … Woltering E.A. (J. Surg. Res. 2010) 3 23
  5. Gingko biloba extract reduces VEGF and CXCL-8/IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallate. (PMID: 19597830) Trompezinski S. … Viac J. (Arch. Dermatol. Res. 2010) 3 23

Products for VEGFA Gene

Sources for VEGFA Gene

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