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Aliases for VCAM1 Gene

Aliases for VCAM1 Gene

  • Vascular Cell Adhesion Molecule 1 2 3
  • CD106 Antigen 3 4
  • INCAM-100 3 4
  • Vascular Cell Adhesion Protein 1 3
  • V-CAM 1 4
  • VCAM-1 4
  • CD106 3
  • L1CAM 4

External Ids for VCAM1 Gene

Previous GeneCards Identifiers for VCAM1 Gene

  • GC01P101976
  • GC01P100366
  • GC01P100476
  • GC01P100648
  • GC01P100897
  • GC01P101185
  • GC01P099309

Summaries for VCAM1 Gene

Entrez Gene Summary for VCAM1 Gene

  • This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for VCAM1 Gene

VCAM1 (Vascular Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with VCAM1 include mooren's ulcer and vasculitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and L1CAM interactions. GO annotations related to this gene include integrin binding and primary amine oxidase activity. An important paralog of this gene is CD22.

UniProtKB/Swiss-Prot for VCAM1 Gene

  • Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation

Gene Wiki entry for VCAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCAM1 Gene

Genomics for VCAM1 Gene

Regulatory Elements for VCAM1 Gene

Genomic Location for VCAM1 Gene

Start:
100,719,640 bp from pter
End:
100,739,045 bp from pter
Size:
19,406 bases
Orientation:
Plus strand

Genomic View for VCAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VCAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCAM1 Gene

Proteins for VCAM1 Gene

  • Protein details for VCAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19320-VCAM1_HUMAN
    Recommended name:
    Vascular cell adhesion protein 1
    Protein Accession:
    P19320
    Secondary Accessions:
    • A8K6R7
    • B4DKS4
    • E9PDD1
    • Q6NUP8

    Protein attributes for VCAM1 Gene

    Size:
    739 amino acids
    Molecular mass:
    81276 Da
    Quaternary structure:
    • Binds to ECMV-D capsid proteins and acts as a receptor for this virus.

    Three dimensional structures from OCA and Proteopedia for VCAM1 Gene

    Alternative splice isoforms for VCAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VCAM1 Gene

Proteomics data for VCAM1 Gene at MOPED

Post-translational modifications for VCAM1 Gene

Other Protein References for VCAM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for VCAM1 Gene

Domains for VCAM1 Gene

Gene Families for VCAM1 Gene

HGNC:
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • CD :CD molecules
  • ENDOLIG :Endogenous ligands
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Graphical View of Domain Structure for InterPro Entry

P19320

UniProtKB/Swiss-Prot:

VCAM1_HUMAN :
  • P19320
Domain:
  • Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion
  • Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with VCAM1: view

Function for VCAM1 Gene

Molecular function for VCAM1 Gene

GENATLAS Biochemistry: cell adhesion molecule,vascular 1,with alternative splicing forms,ligand for ITGA4 (VLA4A),endothelial sialoglycoprotein
UniProtKB/Swiss-Prot Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation
UniProtKB/Swiss-Prot Induction: By cytokines (e.g. IL-1, TNF-alpha)

Gene Ontology (GO) - Molecular Function for VCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IMP 19738201
GO:0005515 protein binding --
GO:0008131 primary amine oxidase activity IDA 23474851
GO:0050839 cell adhesion molecule binding IPI 12082081
genes like me logo Genes that share ontologies with VCAM1: view
genes like me logo Genes that share phenotypes with VCAM1: view

Animal Models for VCAM1 Gene

MGI Knock Outs for VCAM1:

Animal Model Products

CRISPR Products

miRNA for VCAM1 Gene

miRTarBase miRNAs that target VCAM1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCAM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VCAM1 Gene

Localization for VCAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VCAM1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VCAM1 Gene COMPARTMENTS Subcellular localization image for VCAM1 gene
Compartment Confidence
cytoskeleton 4
extracellular 4
plasma membrane 4
nucleus 3
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IDA 15220135
GO:0005615 extracellular space IDA 9290466
GO:0005769 early endosome IDA 23474851
GO:0005783 endoplasmic reticulum IDA 23474851
GO:0005794 Golgi apparatus IDA 23474851
genes like me logo Genes that share ontologies with VCAM1: view

Pathways for VCAM1 Gene

genes like me logo Genes that share pathways with VCAM1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for VCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002526 acute inflammatory response IEA --
GO:0002544 chronic inflammatory response IEA --
GO:0007155 cell adhesion IDA 16809613
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA 1715889
genes like me logo Genes that share ontologies with VCAM1: view

Compounds for VCAM1 Gene

(1) Drugbank Compounds for VCAM1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Carvedilol
72956-09-3 target inhibitor

(154) Novoseek inferred chemical compound relationships for VCAM1 Gene

Compound -log(P) Hits PubMed IDs
rantes 59.7 46
sele 59.5 6
gallin 53.3 1
pdtc 52.3 21
slex 51.1 11
genes like me logo Genes that share compounds with VCAM1: view

Transcripts for VCAM1 Gene

Unigene Clusters for VCAM1 Gene

Vascular cell adhesion molecule 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VCAM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VCAM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for VCAM1 Gene

GeneLoc Exon Structure for
VCAM1
ECgene alternative splicing isoforms for
VCAM1

Expression for VCAM1 Gene

mRNA expression in normal human tissues for VCAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VCAM1 Gene

This gene is overexpressed in Spleen (15.9), Adrenal Gland (4.2), and Kidney - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VCAM1 Gene

SOURCE GeneReport for Unigene cluster for VCAM1 Gene Hs.109225

mRNA Expression by UniProt/SwissProt for VCAM1 Gene

P19320-VCAM1_HUMAN
Tissue specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue
genes like me logo Genes that share expressions with VCAM1: view

In Situ Assay Products

Orthologs for VCAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VCAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VCAM1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC534578 35
  • 83.4 (n)
  • 77.4 (a)
VCAM1 36
  • 76 (a)
OneToMany
VCAM1 36
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia VCAM1 35
  • 84.21 (n)
  • 81.06 (a)
VCAM1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vcam1 35
  • 80.29 (n)
  • 75.78 (a)
Vcam1 16
Vcam1 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VCAM1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VCAM1 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vcam1 35
  • 80.88 (n)
  • 76.86 (a)
chicken
(Gallus gallus)
Aves VCAM1 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VCAM1 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii vcam1 35
  • 44.53 (n)
  • 27.83 (a)
vcam1 36
  • 23 (a)
OneToOne
Species with no ortholog for VCAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VCAM1 Gene

ENSEMBL:
Gene Tree for VCAM1 (if available)
TreeFam:
Gene Tree for VCAM1 (if available)

Paralogs for VCAM1 Gene

Paralogs for VCAM1 Gene

Selected SIMAP similar genes for VCAM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with VCAM1: view

Variants for VCAM1 Gene

Sequence variations from dbSNP and Humsavar for VCAM1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1041163 -- 100,718,269(+) AATTT(C/T)TCTGA upstream-variant-2KB
rs1409419 -- 100,717,840(+) ATTAA(C/T)CAGTA upstream-variant-2KB
rs1476408 -- 100,723,471(+) ATTCA(C/G)AACAT intron-variant
rs1800821 -- 100,718,268(+) CAATT(C/T)YTCTG upstream-variant-2KB
rs2209627 -- 100,733,591(+) AGAAG(A/G)CCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VCAM1 Gene

Variant ID Type Subtype PubMed ID
nsv871445 CNV Loss 21882294
nsv522064 CNV Gain 19592680

Relevant External Links for VCAM1 Gene

HapMap Linkage Disequilibrium report
VCAM1
Human Gene Mutation Database (HGMD)
VCAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCAM1 Gene

Disorders for VCAM1 Gene

(97) Novoseek inferred disease relationships for VCAM1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 80 112
atherosclerosis 78.6 109
necrosis 77.2 111
tumors 60.9 156
atherosclerotic plaque 57.3 23

Relevant External Links for VCAM1

Genetic Association Database (GAD)
VCAM1
Human Genome Epidemiology (HuGE) Navigator
VCAM1
genes like me logo Genes that share disorders with VCAM1: view

No data available for UniProtKB/Swiss-Prot for VCAM1 Gene

Publications for VCAM1 Gene

  1. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. (PMID: 1715583) Cybulsky M.I. … Collins T. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  2. Alternative splicing of human VCAM-1 in activated vascular endothelium. (PMID: 1707234) Cybulsky M.I. … Collins T. (Am. J. Pathol. 1991) 3 4 23
  3. Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. (PMID: 12393616) Taylor J.G. … Chanock S.J. (Blood 2002) 3 23 48
  4. Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PMID: 12871600) Adams G.T. … Kutlar A. (BMC Med. Genet. 2003) 3 23 48
  5. ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA). (PMID: 18420209) Bielinski S.J. … Arnett D. (Atherosclerosis 2008) 3 23 48

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