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Aliases for VCAM1 Gene

Aliases for VCAM1 Gene

  • Vascular Cell Adhesion Molecule 1 2 3 5
  • CD106 Antigen 3 4
  • INCAM-100 3 4
  • V-CAM 1 4
  • VCAM-1 4
  • CD106 3
  • L1CAM 4

External Ids for VCAM1 Gene

Previous GeneCards Identifiers for VCAM1 Gene

  • GC01P101976
  • GC01P100366
  • GC01P100476
  • GC01P100648
  • GC01P100897
  • GC01P101185
  • GC01P099309

Summaries for VCAM1 Gene

Entrez Gene Summary for VCAM1 Gene

  • This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for VCAM1 Gene

VCAM1 (Vascular Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with VCAM1 include viral encephalitis and thromboangiitis obliterans. Among its related pathways are Platelet activation, signaling and aggregation and Degradation of the extracellular matrix. GO annotations related to this gene include integrin binding and primary amine oxidase activity. An important paralog of this gene is IGSF10.

UniProtKB/Swiss-Prot for VCAM1 Gene

  • Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Gene Wiki entry for VCAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VCAM1 Gene

Genomics for VCAM1 Gene

Regulatory Elements for VCAM1 Gene

Promoters for VCAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VCAM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VCAM1 Gene

Chromosome:
1
Start:
100,719,640 bp from pter
End:
100,739,045 bp from pter
Size:
19,406 bases
Orientation:
Plus strand

Genomic View for VCAM1 Gene

Genes around VCAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VCAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VCAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VCAM1 Gene

Proteins for VCAM1 Gene

  • Protein details for VCAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19320-VCAM1_HUMAN
    Recommended name:
    Vascular cell adhesion protein 1
    Protein Accession:
    P19320
    Secondary Accessions:
    • A8K6R7
    • B4DKS4
    • E9PDD1
    • Q6NUP8

    Protein attributes for VCAM1 Gene

    Size:
    739 amino acids
    Molecular mass:
    81276 Da
    Quaternary structure:
    • Binds to ECMV-D capsid proteins and acts as a receptor for this virus.

    Three dimensional structures from OCA and Proteopedia for VCAM1 Gene

    Alternative splice isoforms for VCAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VCAM1 Gene

Proteomics data for VCAM1 Gene at MOPED

Post-translational modifications for VCAM1 Gene

  • Sialoglycoprotein.
  • Glycosylation at Asn 273, Asn 365, Asn 417, Asn 463, Asn 531, and Asn 561
  • Modification sites at PhosphoSitePlus

Other Protein References for VCAM1 Gene

Antibody Products

No data available for DME Specific Peptides for VCAM1 Gene

Domains & Families for VCAM1 Gene

Graphical View of Domain Structure for InterPro Entry

P19320

UniProtKB/Swiss-Prot:

VCAM1_HUMAN :
  • Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Domain:
  • Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
  • Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with VCAM1: view

Function for VCAM1 Gene

Molecular function for VCAM1 Gene

GENATLAS Biochemistry:
cell adhesion molecule,vascular 1,with alternative splicing forms,ligand for ITGA4 (VLA4A),endothelial sialoglycoprotein
UniProtKB/Swiss-Prot Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
UniProtKB/Swiss-Prot Induction:
By cytokines (e.g. IL-1, TNF-alpha).
genes like me logo Genes that share phenotypes with VCAM1: view

Animal Models for VCAM1 Gene

MGI Knock Outs for VCAM1:

Animal Model Products

miRNA for VCAM1 Gene

miRTarBase miRNAs that target VCAM1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VCAM1 Gene

Localization for VCAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VCAM1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VCAM1 Gene COMPARTMENTS Subcellular localization image for VCAM1 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
plasma membrane 5
cytosol 2
nucleus 2
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 23474851
GO:0005783 endoplasmic reticulum IDA 23474851
GO:0009897 external side of plasma membrane IDA 1377228
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with VCAM1: view

Pathways & Interactions for VCAM1 Gene

genes like me logo Genes that share pathways with VCAM1: view

Gene Ontology (GO) - Biological Process for VCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0007155 cell adhesion IEA,IDA 16809613
GO:0007159 leukocyte cell-cell adhesion IDA 1381355
GO:0007160 cell-matrix adhesion IDA 18308860
GO:0009308 amine metabolic process IDA 23474851
genes like me logo Genes that share ontologies with VCAM1: view

No data available for SIGNOR curated interactions for VCAM1 Gene

Drugs & Compounds for VCAM1 Gene

(82) Drugs for VCAM1 Gene - From: Novoseek, DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 1839
Carvedilol Approved, Investigational Pharma Antagonist, Target, inhibitor 153
AGI-1067 Investigational Pharma Target 0
AGI-1067, SUCCINOBUCOL Pharma 0

(77) Additional Compounds for VCAM1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Hydroxycarvedilol
genes like me logo Genes that share compounds with VCAM1: view

Transcripts for VCAM1 Gene

Unigene Clusters for VCAM1 Gene

Vascular cell adhesion molecule 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VCAM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for VCAM1 Gene

GeneLoc Exon Structure for
VCAM1
ECgene alternative splicing isoforms for
VCAM1

Expression for VCAM1 Gene

mRNA expression in normal human tissues for VCAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VCAM1 Gene

This gene is overexpressed in Spleen (x15.9), Adrenal Gland (x4.2), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for VCAM1 Gene

This gene is overexpressed in Serum (45.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VCAM1 Gene



SOURCE GeneReport for Unigene cluster for VCAM1 Gene Hs.109225

mRNA Expression by UniProt/SwissProt for VCAM1 Gene

P19320-VCAM1_HUMAN
Tissue specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
genes like me logo Genes that share expression patterns with VCAM1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for VCAM1 Gene

Orthologs for VCAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VCAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VCAM1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VCAM1 36
  • 76 (a)
OneToMany
VCAM1 36
  • 77 (a)
OneToMany
LOC534578 35
  • 83.4 (n)
  • 77.4 (a)
dog
(Canis familiaris)
Mammalia VCAM1 35
  • 84.21 (n)
  • 81.06 (a)
VCAM1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vcam1 16
Vcam1 36
  • 76 (a)
OneToOne
Vcam1 35
  • 80.29 (n)
  • 75.78 (a)
oppossum
(Monodelphis domestica)
Mammalia VCAM1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VCAM1 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vcam1 35
  • 80.88 (n)
  • 76.86 (a)
chicken
(Gallus gallus)
Aves VCAM1 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VCAM1 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii vcam1 35
  • 44.53 (n)
  • 27.83 (a)
vcam1 36
  • 23 (a)
OneToOne
Species with no ortholog for VCAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VCAM1 Gene

ENSEMBL:
Gene Tree for VCAM1 (if available)
TreeFam:
Gene Tree for VCAM1 (if available)

Paralogs for VCAM1 Gene

Paralogs for VCAM1 Gene

(1) SIMAP similar genes for VCAM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with VCAM1: view

Variants for VCAM1 Gene

Sequence variations from dbSNP and Humsavar for VCAM1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3783611 - 100,729,131(+) GATCT(C/T)CCCTG intron-variant, reference, missense
rs3783612 - 100,729,328(+) TGTGC(A/G)CAGTG intron-variant, reference, missense
rs3783613 - 100,731,231(+) GAGTG(A/C/G)TGGCC reference, missense
rs3783615 - 100,738,209(+) GAATG(A/T)TAATT reference, missense
rs34228330 - 100,719,914(+) ATAAT(A/G)TTTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for VCAM1 Gene

Variant ID Type Subtype PubMed ID
nsv871445 CNV Loss 21882294
nsv522064 CNV Gain 19592680

Variation tolerance for VCAM1 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VCAM1 Gene

HapMap Linkage Disequilibrium report
VCAM1
Human Gene Mutation Database (HGMD)
VCAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VCAM1 Gene

Disorders for VCAM1 Gene

MalaCards: The human disease database

(50) MalaCards diseases for VCAM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
viral encephalitis
  • arbovirus encephalitis
thromboangiitis obliterans
  • buerger's disease
acute chest syndrome
  • acute chest syndrome in sickle cell disease
dengue disease
  • dengue hemorrhagic fever
arteriosclerosis obliterans
  • arteriosclerosis obliterans [ambiguous]
- elite association - COSMIC cancer census association via MalaCards
Search VCAM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VCAM1

Genetic Association Database (GAD)
VCAM1
Human Genome Epidemiology (HuGE) Navigator
VCAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VCAM1
genes like me logo Genes that share disorders with VCAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VCAM1 Gene

Publications for VCAM1 Gene

  1. Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PMID: 12871600) Adams G.T. … Kutlar A. (BMC Med. Genet. 2003) 3 23 48 67
  2. Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. (PMID: 15374848) Chen J.W. … Lin S.J. (Arterioscler. Thromb. Vasc. Biol. 2004) 23 25 26
  3. Myoglobin induces vascular cell adhesion molecule-1 expression through c-Src kinase-activator protein-1/nuclear factor-kappaB pathways. (PMID: 19887846) Kim S.H. … Lee S.K. (Nephron Exp. Nephrol. 2010) 3 23
  4. A systemic network for Chlamydia pneumoniae entry into human cells. (PMID: 20233927) Wang A. … Dean D. (J. Bacteriol. 2010) 3 23
  5. Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65. (PMID: 20164172) Shimada H. … Rajagopalan L.E. (J. Biol. Chem. 2010) 3 23

Products for VCAM1 Gene

Sources for VCAM1 Gene

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