Aliases for VAV1 Gene
External Ids for VAV1 Gene
Previous Symbols for VAV1 Gene
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for VAV1 Gene
VAV1 (Vav 1 Guanine Nucleotide Exchange Factor) is a Protein Coding gene. Diseases associated with VAV1 include hiv-1 and cherubism. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV3.
UniProtKB/Swiss-Prot for VAV1 Gene
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation