Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USF2 Gene

Aliases for USF2 Gene

  • Upstream Transcription Factor 2, C-Fos Interacting 2 3
  • Class B Basic Helix-Loop-Helix Protein 12 3 4
  • Major Late Transcription Factor 2 3 4
  • FOS-Interacting Protein 3 4
  • BHLHb12 3 4
  • FIP 3 4
  • Upstream Transcription Factor 2 4
  • Upstream Stimulatory Factor 2 3
  • C-Fos Interacting Protein 3

External Ids for USF2 Gene

Previous GeneCards Identifiers for USF2 Gene

  • GC19P036377
  • GC19P036208
  • GC19P040435
  • GC19P040451
  • GC19P035759
  • GC19P032268

Summaries for USF2 Gene

Entrez Gene Summary for USF2 Gene

  • This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for USF2 Gene

USF2 (Upstream Transcription Factor 2, C-Fos Interacting) is a Protein Coding gene. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is USF1.

UniProtKB/Swiss-Prot for USF2 Gene

  • Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5-CACGTG-3) that is found in a variety of viral and cellular promoters

Gene Wiki entry for USF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USF2 Gene

Genomics for USF2 Gene

Regulatory Elements for USF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USF2 Gene

35,268,978 bp from pter
35,279,821 bp from pter
10,844 bases
Plus strand

Genomic View for USF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USF2 Gene

Proteins for USF2 Gene

  • Protein details for USF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Upstream stimulatory factor 2
    Protein Accession:
    Secondary Accessions:
    • O00671
    • O00709
    • Q05750
    • Q07952
    • Q15851
    • Q15852
    • Q6FI33
    • Q6YI47

    Protein attributes for USF2 Gene

    346 amino acids
    Molecular mass:
    36955 Da
    Quaternary structure:
    • Interacts with MAF (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). In vivo, the USF1/USF2A heterodimer represents over 66% of the usf binding activity whereas the USF1 and USF2A homodimers represent less than 10%. The USF1/USF2B heterodimer accounted for almost 15% in some cell.

    Alternative splice isoforms for USF2 Gene


neXtProt entry for USF2 Gene

Proteomics data for USF2 Gene at MOPED

Post-translational modifications for USF2 Gene

  • Ubiquitination at Lys250
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for USF2 Gene

Domains for USF2 Gene

Gene Families for USF2 Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for USF2 Gene

Suggested Antigen Peptide Sequences for USF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q15853
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with USF2: view

Function for USF2 Gene

Molecular function for USF2 Gene

GENATLAS Biochemistry: upstream stimulatory transcription factor 2,ubiquitously expressed,disrupted in t(6;19) with multicystic renal dysplasia (see also PUJO)
UniProtKB/Swiss-Prot Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5-CACGTG-3) that is found in a variety of viral and cellular promoters

Gene Ontology (GO) - Molecular Function for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0003677 DNA binding --
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 1589769
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IMP 8576131
genes like me logo Genes that share ontologies with USF2: view
genes like me logo Genes that share phenotypes with USF2: view

Animal Models for USF2 Gene

MGI Knock Outs for USF2:

Animal Model Products

CRISPR Products

Targeting motifs for USF2 Gene
HOMER Transcription Factor Regulatory Elements motif USF2
  • Consensus sequence: GTCACGTGGT Submotif: canonical Cell Type: C2C12 GeoId: GSE36030

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for USF2 Gene

Localization for USF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USF2 Gene

Subcellular locations from

Jensen Localization Image for USF2 Gene COMPARTMENTS Subcellular localization image for USF2 gene
Compartment Confidence
nucleus 5
cytosol 2
endosome 1

Gene Ontology (GO) - Cellular Components for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15358760
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with USF2: view

Pathways for USF2 Gene

genes like me logo Genes that share pathways with USF2: view

Pathways by source for USF2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose IC 8576131
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose ISS --
GO:0006351 transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter IMP 8576131
genes like me logo Genes that share ontologies with USF2: view

Compounds for USF2 Gene

(7) Novoseek inferred chemical compound relationships for USF2 Gene

Compound -log(P) Hits PubMed IDs
atpa 67 7
leucine 46.2 4
iron 4.56 1
pyruvate 0 1
glucose 0 8
genes like me logo Genes that share compounds with USF2: view

Transcripts for USF2 Gene

Unigene Clusters for USF2 Gene

Upstream transcription factor 2, c-fos interacting:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - -
SP8: - - - -
SP9: - - -

Relevant External Links for USF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USF2 Gene

mRNA expression in normal human tissues for USF2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USF2 Gene

SOURCE GeneReport for Unigene cluster for USF2 Gene Hs.454534

mRNA Expression by UniProt/SwissProt for USF2 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with USF2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USF2 Gene

Orthologs for USF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for USF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USF2 36
  • 91 (a)
(Bos Taurus)
Mammalia USF2 35
  • 92.87 (n)
  • 97.69 (a)
USF2 36
  • 98 (a)
(Canis familiaris)
Mammalia USF2 35
  • 90.17 (n)
  • 96.4 (a)
USF2 36
  • 99 (a)
(Mus musculus)
Mammalia Usf2 35
  • 92.49 (n)
  • 97.98 (a)
Usf2 16
Usf2 36
  • 98 (a)
(Monodelphis domestica)
Mammalia USF2 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Usf2 35
  • 92.2 (n)
  • 97.98 (a)
(Gallus gallus)
Aves -- 36
  • 78 (a)
(Anolis carolinensis)
Reptilia USF2 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14981 35
usf2 35
  • 76.59 (n)
  • 86.08 (a)
(Danio rerio)
Actinopterygii usf2 35
  • 73.09 (n)
  • 80.4 (a)
usf2 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Usf 36
  • 16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4872 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for USF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USF2 Gene

Gene Tree for USF2 (if available)
Gene Tree for USF2 (if available)

Paralogs for USF2 Gene

Paralogs for USF2 Gene

Selected SIMAP similar genes for USF2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with USF2: view

Variants for USF2 Gene

Sequence variations from dbSNP and Humsavar for USF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10561 -- 35,279,742(+) TCTTT(A/T)TGGAA utr-variant-3-prime, downstream-variant-500B
rs12742 -- 35,279,271(+) CCACC(A/G)CGCAG utr-variant-3-prime, downstream-variant-500B
rs14724 -- 35,279,739(+) TTTTC(A/T)TTATG utr-variant-3-prime, downstream-variant-500B
rs916145 -- 35,276,981(+) ATGTA(C/G)CTGCA intron-variant
rs916146 -- 35,277,559(+) GCCCA(A/C)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USF2 Gene

Variant ID Type Subtype PubMed ID
nsv510765 CNV Loss 20534489
dgv1080e1 CNV Complex 17122850
nsv911618 CNV Loss 21882294
dgv3850n71 CNV Loss 21882294
esv27788 CNV Loss 19812545
nsv911624 CNV Loss 21882294

Relevant External Links for USF2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USF2 Gene

Disorders for USF2 Gene

(1) University of Copenhagen DISEASES for USF2 Gene

(9) Novoseek inferred disease relationships for USF2 Gene

Disease -log(P) Hits PubMed IDs
iron overload 39.5 1
glioblastoma 20.7 1
breast cancer 3.82 1
tumors 1.29 10
carcinoma squamous cell 0 1

Relevant External Links for USF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with USF2: view

No data available for UniProtKB/Swiss-Prot for USF2 Gene

Publications for USF2 Gene

  1. Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia. (PMID: 8954795) Groenen P.M.A. … van de Ven W.J.M. (Genomics 1996) 2 3 4 23
  2. Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers. (PMID: 1450663) Sirito M. … Sawadogo M. (Gene Expr. 1992) 3 4 23
  3. Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. (PMID: 1589769) Blanar M.A. … Rutter W.J. (Science 1992) 3 4 23
  4. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. (PMID: 8576131) Viollet B. … Martinez A. (J. Biol. Chem. 1996) 3 4 23
  5. Isolation of a novel USF2 isoform: repressor of cathepsin B expression. (PMID: 15276216) Yan S. … Sloane B.F. (Gene 2004) 3 4 23

Products for USF2 Gene

Sources for USF2 Gene

Back to Top