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Aliases for USF2 Gene

Aliases for USF2 Gene

  • Upstream Transcription Factor 2, C-Fos Interacting 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 12 3 4
  • Major Late Transcription Factor 2 3 4
  • BHLHb12 3 4
  • FIP 3 4
  • Upstream Transcription Factor 2 4
  • C-Fos Interacting Protein 3
  • FOS-Interacting Protein 4

External Ids for USF2 Gene

Previous GeneCards Identifiers for USF2 Gene

  • GC19P036377
  • GC19P036208
  • GC19P040435
  • GC19P040451
  • GC19P035759
  • GC19P032268

Summaries for USF2 Gene

Entrez Gene Summary for USF2 Gene

  • This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]

GeneCards Summary for USF2 Gene

USF2 (Upstream Transcription Factor 2, C-Fos Interacting) is a Protein Coding gene. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is USF1.

UniProtKB/Swiss-Prot for USF2 Gene

  • Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5-CACGTG-3) that is found in a variety of viral and cellular promoters.

Gene Wiki entry for USF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USF2 Gene

Genomics for USF2 Gene

Regulatory Elements for USF2 Gene

Enhancers for USF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USF2 on UCSC Golden Path with GeneCards custom track

Promoters for USF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for USF2 Gene

35,268,978 bp from pter
35,279,821 bp from pter
10,844 bases
Plus strand

Genomic View for USF2 Gene

Genes around USF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USF2 Gene

Proteins for USF2 Gene

  • Protein details for USF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Upstream stimulatory factor 2
    Protein Accession:
    Secondary Accessions:
    • O00671
    • O00709
    • Q05750
    • Q07952
    • Q15851
    • Q15852
    • Q6FI33
    • Q6YI47

    Protein attributes for USF2 Gene

    346 amino acids
    Molecular mass:
    36955 Da
    Quaternary structure:
    • Interacts with MAF (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). In vivo, the USF1/USF2A heterodimer represents over 66% of the usf binding activity whereas the USF1 and USF2A homodimers represent less than 10%. The USF1/USF2B heterodimer accounted for almost 15% in some cell.

    Alternative splice isoforms for USF2 Gene


neXtProt entry for USF2 Gene

Proteomics data for USF2 Gene at MOPED

Post-translational modifications for USF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for USF2 Gene

Domains & Families for USF2 Gene

Gene Families for USF2 Gene

Protein Domains for USF2 Gene

Suggested Antigen Peptide Sequences for USF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with USF2: view

Function for USF2 Gene

Molecular function for USF2 Gene

GENATLAS Biochemistry:
upstream stimulatory transcription factor 2,ubiquitously expressed,disrupted in t(6;19) with multicystic renal dysplasia (see also PUJO)
UniProtKB/Swiss-Prot Function:
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5-CACGTG-3) that is found in a variety of viral and cellular promoters.

Gene Ontology (GO) - Molecular Function for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19505873
GO:0042803 protein homodimerization activity IPI 8576131
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with USF2: view
genes like me logo Genes that share phenotypes with USF2: view

Animal Models for USF2 Gene

MGI Knock Outs for USF2:

Animal Model Products

Transcription Factor Targets for USF2 Gene

Selected GeneGlobe predicted Target genes for USF2
Targeted motifs for USF2 Gene
HOMER Transcription Factor Regulatory Elements motif USF2
  • Consensus sequence: GTCACGTGGT Submotif: canonical Cell Type: C2C12 GEO ID: GSE36030

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for USF2 Gene

Localization for USF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USF2 Gene

Subcellular locations from

Jensen Localization Image for USF2 Gene COMPARTMENTS Subcellular localization image for USF2 gene
Compartment Confidence
nucleus 5
cytosol 2
endosome 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for USF2 Gene

Pathways & Interactions for USF2 Gene

genes like me logo Genes that share pathways with USF2: view

Pathways by source for USF2 Gene

Gene Ontology (GO) - Biological Process for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007595 lactation IEA --
GO:0019086 late viral transcription IC 8576131
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 8576131
genes like me logo Genes that share ontologies with USF2: view

No data available for SIGNOR curated interactions for USF2 Gene

Drugs & Compounds for USF2 Gene

(5) Drugs for USF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for USF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with USF2: view

Transcripts for USF2 Gene

Unigene Clusters for USF2 Gene

Upstream transcription factor 2, c-fos interacting:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - -
SP8: - - - -
SP9: - - -

Relevant External Links for USF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USF2 Gene

mRNA expression in normal human tissues for USF2 Gene

Protein differential expression in normal tissues from HIPED for USF2 Gene

This gene is overexpressed in CD8 Tcells (16.2), Blymphocyte (11.4), Pancreas (10.3), Peripheral blood mononuclear cells (10.2), Placenta (6.9), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USF2 Gene

SOURCE GeneReport for Unigene cluster for USF2 Gene Hs.454534

mRNA Expression by UniProt/SwissProt for USF2 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with USF2: view

Protein tissue co-expression partners for USF2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USF2 Gene

Orthologs for USF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for USF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USF2 35
  • 92.87 (n)
  • 97.69 (a)
USF2 36
  • 98 (a)
(Canis familiaris)
Mammalia USF2 35
  • 90.17 (n)
  • 96.4 (a)
USF2 36
  • 99 (a)
(Mus musculus)
Mammalia Usf2 35
  • 92.49 (n)
  • 97.98 (a)
Usf2 16
Usf2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Usf2 35
  • 92.2 (n)
  • 97.98 (a)
(Monodelphis domestica)
Mammalia USF2 36
  • 85 (a)
(Pan troglodytes)
Mammalia USF2 36
  • 91 (a)
(Gallus gallus)
Aves -- 36
  • 78 (a)
(Anolis carolinensis)
Reptilia USF2 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14981 35
usf2 35
  • 76.59 (n)
  • 86.08 (a)
(Danio rerio)
Actinopterygii usf2 35
  • 73.09 (n)
  • 80.4 (a)
usf2 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Usf 36
  • 16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4872 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for USF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USF2 Gene

Gene Tree for USF2 (if available)
Gene Tree for USF2 (if available)

Paralogs for USF2 Gene

Paralogs for USF2 Gene

(3) SIMAP similar genes for USF2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with USF2: view

Variants for USF2 Gene

Sequence variations from dbSNP and Humsavar for USF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12981457 -- 35,275,692(+) atttc(C/T)aaata intron-variant
rs916145 -- 35,276,981(+) ATGTA(C/G)CTGCA intron-variant, utr-variant-3-prime
rs916146 -- 35,277,559(+) GCCCA(A/C)CCCTC intron-variant, utr-variant-3-prime
rs1051995 -- 35,279,389(+) AAAAA(C/G/T)GGGGA downstream-variant-500B, utr-variant-3-prime
rs1052005 -- 35,279,498(+) CCCTC(A/G)CTAAG downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USF2 Gene

Variant ID Type Subtype PubMed ID
nsv510765 CNV Loss 20534489
dgv1080e1 CNV Complex 17122850
nsv911618 CNV Loss 21882294
dgv3850n71 CNV Loss 21882294
esv27788 CNV Loss 19812545
nsv911624 CNV Loss 21882294

Variation tolerance for USF2 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.37; 81.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for USF2 Gene

Disorders for USF2 Gene

Relevant External Links for USF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USF2 Gene

Publications for USF2 Gene

  1. Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia. (PMID: 8954795) Groenen P.M.A. … van de Ven W.J.M. (Genomics 1996) 2 3 4 23 67
  2. HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells. (PMID: 19089909) Wang L. … Weinstein I.B. (Int. J. Cancer 2009) 3 23
  3. Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis. (PMID: 18165439) Utsunomiya H. … Bulun S.E. (Mol. Endocrinol. 2008) 3 23
  4. Regulation of basal core promoter activity of human organic cation transporter 1 (OCT1/SLC22A1). (PMID: 18845576) Kajiwara M. … Inui K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2008) 3 23
  5. Upstream stimulatory factor 2 is implicated in the progression of biliary atresia by regulation of hepcidin expression. (PMID: 18970934) Huang Y.H. … Chen C.L. (J. Pediatr. Surg. 2008) 3 23

Products for USF2 Gene

Sources for USF2 Gene