Aliases for UQCRH Gene
Aliases for UQCRH Gene
External Ids for UQCRH Gene
- HGNC: 12590
- Entrez Gene: 7388
- Ensembl: ENSG00000173660
- OMIM: 613844
- UniProtKB: P07919
Previous GeneCards Identifiers for UQCRH Gene
- GC01P046463
- GC01P045726
- GC01P046155
- GC01P046139
- GC01P046481
- GC01P046541
- GC01P046769
- GC01P044885
Summaries for UQCRH Gene
GeneCards Summary for UQCRH Gene
UQCRH (Ubiquinol-Cytochrome C Reductase Hinge Protein) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is UQCRHL.
UniProtKB/Swiss-Prot for UQCRH Gene
-
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRH Gene
Genomics for UQCRH Gene
Regulatory Elements for UQCRH Gene
Enhancers for UQCRH Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around UQCRH on UCSC Golden Path with GeneCards custom track
Promoters for UQCRH Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around UQCRH on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for UQCRH Gene
- Chromosome:
- 1
- Start:
- 46,303,613 bp from pter
- End:
- 46,316,777 bp from pter
- Size:
- 13,165 bases
- Orientation:
- Plus strand
Genomic View for UQCRH Gene
Genes around UQCRH on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p33 by Ensembl
- 1p34.1 by Entrez Gene
- 1p34.1 by HGNC
UQCRH Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UQCRH Gene
Proteins for UQCRH Gene
-
Protein details for UQCRH Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07919-QCR6_HUMAN
- Recommended name:
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Protein Accession:
- P07919
- B2R4V9
- D3DQ18
- Q5TDF6
- Q6LDB8
- Q9BQ91
Protein attributes for UQCRH Gene
- Size:
- 91 amino acids
- Molecular mass:
- 10739 Da
- Quaternary structure:
-
- The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Protein Expression for UQCRH Gene
Post-translational modifications for UQCRH Gene
Other Protein References for UQCRH Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for UQCRH
- antibodies-online Antibodies for UQCRH: See all 7
- GeneTex Cdx1 antibody for UQCRH
-
Santa Cruz Biotechnology (SCBT) Antibodies for UQCRH
Protein Products
-
OriGene Purified Proteins for UQCRH
- Search Origene for MassSpec and Protein Over-expression Lysates for UQCRH
- Origene Custom Protein Services for UQCRH
- antibodies-online Proteins for UQCRH: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for UQCRH
Assay Products
No data available for DME Specific Peptides for UQCRH Gene
Domains & Families for UQCRH Gene
Gene Families for UQCRH Gene
Protein Domains for UQCRH Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for UQCRH Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07919- Family:
-
- Belongs to the UQCRH/QCR6 family.
Function for UQCRH Gene
Molecular function for UQCRH Gene
- UniProtKB/Swiss-Prot Function:
- This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
Phenotypes for UQCRH Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for UQCRH gene
-
ViGene Biosciences ready-to-package AAV shRNAs for UQCRH gene
- Search ViGene Biosciences for UQCRH
CRISPR Products
-
OriGene CRISPR knockouts for UQCRH
-
Santa Cruz Biotechnology (SCBT) CRISPR for UQCRH
- GenScript: Design CRISPR guide RNA sequences for UQCRH
miRNA for UQCRH Gene
- miRTarBase miRNAs that target UQCRH
-
- hsa-mir-4762-3p (MIRT459004)
- hsa-mir-6819-5p (MIRT459005)
- hsa-mir-6812-5p (MIRT459006)
- hsa-mir-6737-5p (MIRT459007)
- hsa-mir-3192-3p (MIRT459008)
- hsa-mir-6747-5p (MIRT459009)
- hsa-mir-608 (MIRT459010)
- hsa-mir-4651 (MIRT459011)
- hsa-mir-4664-5p (MIRT459012)
- hsa-mir-342-5p (MIRT459013)
- hsa-mir-7155-5p (MIRT459014)
- hsa-mir-4502 (MIRT459015)
- hsa-mir-1245b-3p (MIRT459016)
- hsa-mir-4778-5p (MIRT459017)
- hsa-mir-1272 (MIRT459018)
- hsa-mir-4463 (MIRT459019)
miRNA Products
- Search ViGene Biosciences for UQCRH
Clone Products
- OriGene clones in human for UQCRH
- OriGene ORF clones in human,mouse,rat for UQCRH
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for UQCRH gene
-
ViGene Biosciences lentiviral particle packaged cDNA for UQCRH gene
-
ViGene Biosciences ready-to-package AAV shRNAs for UQCRH gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCRH Gene
Localization for UQCRH Gene
Subcellular locations from UniProtKB/Swiss-Prot for UQCRH Gene
- Mitochondrion inner membrane.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| extracellular | 3 |
| cytosol | 1 |
| nucleus | 1 |
No data available for Gene Ontology (GO) - Cellular Components for UQCRH Gene
Pathways & Interactions for UQCRH Gene
More details on SuperPathways for UQCRH| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
| 2 | Alzheimer's disease | ||
| 3 | Metabolism |
.38
|
|
| 4 | Cardiac muscle contraction |
Pathways by source for UQCRH Gene
1 BioSystems pathway for UQCRH Gene
7 KEGG pathways for UQCRH Gene
Interacting Proteins for UQCRH Gene
Selected Interacting proteins:
ENSP00000309565
P07919-QCR6_HUMAN
for UQCRH Gene via
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0022904 | respiratory electron transport chain | TAS | -- |
| GO:0055114 | oxidation-reduction process | TAS | 2826252 |
No data available for SIGNOR curated interactions for UQCRH Gene
Drugs & Compounds for UQCRH Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ubiquinone-2 | Experimental | Pharma | Target | 0 | ||
| (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE | Experimental | Pharma | Target | 0 | ||
| 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | Experimental | Pharma | Target | 0 | ||
| 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE | Experimental | Pharma | Target | 0 | ||
| 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| QH2 |
|
56275-39-9 |
|
Transcripts for UQCRH Gene
mRNA/cDNA for UQCRH Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (656) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for UQCRH Gene
CRISPR Products
-
OriGene CRISPR knockouts for UQCRH
-
Santa Cruz Biotechnology (SCBT) CRISPR for UQCRH
- GenScript: Design CRISPR guide RNA sequences for UQCRH
miRNA Products
- Search ViGene Biosciences for UQCRH
Clone Products
- OriGene clones in human for UQCRH
- OriGene ORF clones in human,mouse,rat for UQCRH
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for UQCRH
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for UQCRH Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Heart (Cardiovascular System)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for UQCRH Gene
This gene is overexpressed in Heart - Left Ventricle (x4.3).
This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Islet of Langerhans (9.2), Brain (8.6), and Heart (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRH Gene
SOURCE GeneReport for Unigene cluster for UQCRH Gene Hs.481571
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for UQCRH
-
OriGene qPCR primer pairs and template standards for UQCRH
No data available for mRNA Expression by UniProt/SwissProt for UQCRH Gene
Orthologs for UQCRH Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | UQCRH 35 |
|
||
| UQCRH 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | UQCRH 35 |
|
||
| UQCRH 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gm9763 35 |
|
||
| Gm9763 16 |
|
|
|||
| Uqcrh 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | UQCRH 35 |
|
||
| UQCRHL 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | UQCRH 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | UQCRH 35 |
|
||
| UQCRH 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | UQCRH 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100492979 35 |
|
||
| Str.603 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4986 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.24476 35 |
|
||
| uqcrh 35 |
|
||||
| uqcrh 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG30354 36 |
|
OneToMany | |
| Ucrh 36 |
|
OneToMany |
- Species with no ortholog for UQCRH:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for UQCRH Gene
Pseudogenes.org Pseudogenes for UQCRH Gene
Variants for UQCRH Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs34813470 | - | 46,310,224(-) | GAGCT(C/G/T)TAGCC | reference, missense | |
| rs324412 | -- | 46,317,275(-) | cccag(C/G)ctgga | downstream-variant-500B | |
| rs192972 | -- | 46,317,228(-) | cctcc(A/C)gggtt | downstream-variant-500B | |
| rs438663 | -- | 46,311,090(+) | aaaaa(A/T)aaTAA | intron-variant | |
| rs3766248 | -- | 46,307,816(-) | TAAAA(A/T)CCCTT | intron-variant |
Residual Variation Intolerance Score:
60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.17;
69.59% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UQCRH Gene
Disorders for UQCRH Gene
Relevant External Links for UQCRH
No disorders were found for UQCRH Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCRH Gene
Publications for UQCRH Gene
- An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein. (PMID: 2826252) Ohta S. … Kagawa Y. (FEBS Lett. 1987) 2 3 4 67
- UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. (PMID: 12881716) Modena P. … Sozzi G. (Oncogene 2003) 3 23
- Elevated expression of the human mitochondrial hinge protein gene in cancer. (PMID: 7684318) Liu A.Y. … Bradner R.C. (Cancer Res. 1993) 3 23
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
Products for UQCRH Gene
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- OriGene qPCR primer pairs for UQCRH
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- Novus Biologicals Antibodies for UQCRH
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for UQCRH: See all 7
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- antibodies-online Proteins for UQCRH: See all 13
- Search antibodies-online for peptides
- GeneTex Cdx1 antibody for UQCRH
- Search GeneTex for Proteins for UQCRH
- ViGene Biosciences adenoviral particle packaged cDNA for UQCRH gene
- ViGene Biosciences lentiviral particle packaged cDNA for UQCRH gene
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- ViGene Biosciences ready-to-package AAV shRNAs for UQCRH gene
- ViGene Biosciences ready-to-package AAV shRNAs for UQCRH gene
- ViGene Biosciences ready-to-package AAV shRNAs for UQCRH gene
- Search ViGene Biosciences for UQCRH
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- Santa Cruz Biotechnology (SCBT) Antibodies for UQCRH
- Search Santa Cruz Biotechnology (SCBT) for UQCRH siRNA/shRNA
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Sources for UQCRH Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon