Aliases for UQCRH Gene
Aliases for UQCRH Gene
External Ids for UQCRH Gene
- HGNC: 12590
- Entrez Gene: 7388
- Ensembl: ENSG00000173660
- OMIM: 613844
- UniProtKB: P07919
Previous GeneCards Identifiers for UQCRH Gene
- GC01P046463
- GC01P045726
- GC01P046155
- GC01P046139
- GC01P046481
- GC01P046541
- GC01P046769
- GC01P044885
Summaries for UQCRH Gene
GeneCards Summary for UQCRH Gene
UQCRH (Ubiquinol-Cytochrome C Reductase Hinge Protein) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is UQCRHL.
UniProtKB/Swiss-Prot for UQCRH Gene
-
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRH Gene
Genomics for UQCRH Gene
GeneHancer (GH) Regulatory Elements for UQCRH Gene
Promoters and enhancers for UQCRH Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around UQCRH on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for UQCRH Gene
Genomic Locations for UQCRH Gene
- chr1:46,303,613-46,316,777
- (GRCh38/hg38)
- Size:
- 13,165 bases
- Orientation:
- Plus strand
- chr1:46,769,303-46,782,448
- (GRCh37/hg19)
Genomic View for UQCRH Gene
Genes around UQCRH on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p33 by Ensembl
- 1p33 by Entrez Gene
- 1p33 by HGNC
UQCRH Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UQCRH Gene
Proteins for UQCRH Gene
-
Protein details for UQCRH Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07919-QCR6_HUMAN
- Recommended name:
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Protein Accession:
- P07919
- B2R4V9
- D3DQ18
- Q5TDF6
- Q6LDB8
- Q9BQ91
Protein attributes for UQCRH Gene
- Size:
- 91 amino acids
- Molecular mass:
- 10739 Da
- Quaternary structure:
-
- The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Protein Expression for UQCRH Gene
Post-translational modifications for UQCRH Gene
No Post-translational modifications
Other Protein References for UQCRH Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for UQCRH
-
Abcam antibodies for UQCRH
- Invitrogen Antibodies for UQCRH
- Search GeneTex for Antibodies for UQCRH
Protein Products
-
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-
ProSci Proteins for UQCRH
-
Abcam proteins for UQCRH
Assay Products
No data available for DME Specific Peptides for UQCRH Gene
Domains & Families for UQCRH Gene
Gene Families for UQCRH Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for UQCRH Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for UQCRH Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07919- Family:
-
- Belongs to the UQCRH/QCR6 family.
Function for UQCRH Gene
Molecular function for UQCRH Gene
- UniProtKB/Swiss-Prot Function:
- This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
Phenotypes From GWAS Catalog for UQCRH Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008121 | contributes_to ubiquinol-cytochrome-c reductase activity | IBA,TAS | -- |
Phenotypes for UQCRH Gene
Animal Model Products
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-
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- Search ViGene Biosciences for UQCRH
CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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- GenScript: Design CRISPR guide RNA sequences for UQCRH
miRNA for UQCRH Gene
- miRTarBase miRNAs that target UQCRH
-
- hsa-mir-4762-3p (MIRT459004)
- hsa-mir-6819-5p (MIRT459005)
- hsa-mir-6812-5p (MIRT459006)
- hsa-mir-6737-5p (MIRT459007)
- hsa-mir-3192-3p (MIRT459008)
- hsa-mir-6747-5p (MIRT459009)
- hsa-mir-608 (MIRT459010)
- hsa-mir-4651 (MIRT459011)
- hsa-mir-4664-5p (MIRT459012)
- hsa-mir-342-5p (MIRT459013)
- hsa-mir-7155-5p (MIRT459014)
- hsa-mir-4502 (MIRT459015)
- hsa-mir-1245b-3p (MIRT459016)
- hsa-mir-4778-5p (MIRT459017)
- hsa-mir-1272 (MIRT459018)
- hsa-mir-4463 (MIRT459019)
miRNA Products
- Search ViGene Biosciences for UQCRH
Inhibitory RNA Products
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-
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Cell Line Products
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Horizon Cell Lines for UQCRH
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ViGene Biosciences adenoviral particle packaged cDNA for UQCRH gene
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ViGene Biosciences lentiviral particle packaged cDNA for UQCRH gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCRH Gene
Localization for UQCRH Gene
Subcellular locations from UniProtKB/Swiss-Prot for UQCRH Gene
- Mitochondrion inner membrane.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| extracellular | 3 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | HDA,IEA | 20833797 |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005746 | mitochondrial respiratory chain | TAS | 2826252 |
| GO:0005750 | mitochondrial respiratory chain complex III | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for UQCRH Gene
Pathways & Interactions for UQCRH Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
| 2 | Metabolism |
.37
|
|
| 3 | Cardiac muscle contraction | ||
Pathways by source for UQCRH Gene
1 BioSystems pathway for UQCRH Gene
7 KEGG pathways for UQCRH Gene
Interacting Proteins for UQCRH Gene
Selected Interacting proteins:
P07919-QCR6_HUMAN
ENSP00000309565
for UQCRH Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006119 | oxidative phosphorylation | TAS | 2826252 |
| GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c | TAS | -- |
| GO:0009060 | aerobic respiration | TAS | 2826252 |
| GO:0055114 | oxidation-reduction process | TAS | 2826252 |
| GO:1902600 | hydrogen ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for UQCRH Gene
Drugs & Compounds for UQCRH Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ubiquinone-2 | Experimental | Pharma | Target | 0 | ||
| (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE | Experimental | Pharma | Target | 0 | ||
| 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | Experimental | Pharma | Target | 0 | ||
| 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE | Experimental | Pharma | Target | 0 | ||
| 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| QH2 |
|
56275-39-9 |
|
Transcripts for UQCRH Gene
mRNA/cDNA for UQCRH Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (656) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for UQCRH Gene
CRISPR Products
-
OriGene CRISPR knockouts for UQCRH
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for UQCRH
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miRNA Products
- Search ViGene Biosciences for UQCRH
Inhibitory RNA Products
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-
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Clone Products
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- Applied Biological Materials Clones for UQCRH
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for UQCRH Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Heart (Cardiovascular System)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for UQCRH Gene
This gene is overexpressed in Heart - Left Ventricle (x4.3).
This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Islet of Langerhans (9.2), Brain (8.6), and Heart (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UQCRH Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of UQCRH Gene:
UQCRHSOURCE GeneReport for Unigene cluster for UQCRH Gene:
Hs.481571Evidence on tissue expression from TISSUES for UQCRH Gene
- Lung(4.6)
- Pancreas(4.3)
- Nervous system(4.2)
- Liver(3.6)
- Muscle(2.9)
- Heart(2.7)
- Skin(2.7)
- Eye(2.6)
- Intestine(2.4)
- Kidney(2.4)
- Spleen(2.1)
- Bone marrow(2)
- Lymph node(2)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for UQCRH
-
OriGene qPCR primer pairs for UQCRH
- genomics-online: primer clones - Search results for available Uqcrh gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UQCRH Gene
Orthologs for UQCRH Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | UQCRHL 34 |
|
OneToOne | |
| UQCRH 33 |
|
||||
| mouse (Mus musculus) |
Mammalia | Uqcrh 34 |
|
OneToOne | |
| Gm9763 33 |
|
||||
| Uqcrh-ps1 16 |
|
|
|||
| dog (Canis familiaris) |
Mammalia | UQCRH 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | UQCRH 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | UQCRH 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | UQCRH 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | UQCRH 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100492979 33 |
|
||
| Str.603 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4986 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | uqcrh 33 34 |
|
||
| Dr.24476 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG30354 34 |
|
OneToMany | |
| Ucrh 34 |
|
OneToMany |
- Species where no ortholog for UQCRH was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for UQCRH Gene
Pseudogenes.org Pseudogenes for UQCRH Gene
Variants for UQCRH Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000106401 | -- | 46,302,431(+) | C/G/T | upstream_transcript_variant | |
| rs1000258252 | -- | 46,308,499(+) | G/A | intron_variant | |
| rs1000709907 | -- | 46,313,514(+) | A/T | intron_variant | |
| rs1000833304 | -- | 46,307,535(+) | T/A | intron_variant | |
| rs1000882462 | -- | 46,307,195(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.17;
69.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UQCRH Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UQCRH
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCRH Gene
Disorders for UQCRH Gene
Additional Disease Information for UQCRH
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for UQCRH Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCRH Gene
Publications for UQCRH Gene
- Elevated expression of the human mitochondrial hinge protein gene in cancer. (PMID: 7684318) Liu AY … Bradner RC (Cancer research 1993) 3 4 22 58
- An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein. (PMID: 2826252) Ohta S … Kagawa Y (FEBS letters 1987) 2 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
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Sources for UQCRH Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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