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Aliases for COL14A1 Gene

Aliases for COL14A1 Gene

  • Collagen, Type XIV, Alpha 1 2 3
  • UND 3 4 6
  • Undulin 2 4
  • Undulin (Fibronectin-Tenascin-Related) 3
  • Collagen Alpha-1(XIV) Chain 3

External Ids for COL14A1 Gene

Previous HGNC Symbols for COL14A1 Gene

  • UND

Previous GeneCards Identifiers for COL14A1 Gene

  • GC08P120129
  • GC08P121129
  • GC08P120740
  • GC08P121028
  • GC08P121093
  • GC08P121188
  • GC08P116458

Summaries for COL14A1 Gene

Entrez Gene Summary for COL14A1 Gene

  • This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013]

GeneCards Summary for COL14A1 Gene

COL14A1 (Collagen, Type XIV, Alpha 1) is a Protein Coding gene. Diseases associated with COL14A1 include keratoderma, palmoplantar, punctate type ia and odontogenic myxoma. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include extracellular matrix structural constituent and collagen binding. An important paralog of this gene is MATN1.

UniProtKB/Swiss-Prot for COL14A1 Gene

  • Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).

Gene Wiki entry for COL14A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COL14A1 Gene

Genomics for COL14A1 Gene

Regulatory Elements for COL14A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COL14A1 Gene

Start:
120,059,780 bp from pter
End:
120,373,472 bp from pter
Size:
313,693 bases
Orientation:
Plus strand

Genomic View for COL14A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COL14A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COL14A1 Gene

Proteins for COL14A1 Gene

  • Protein details for COL14A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05707-COEA1_HUMAN
    Recommended name:
    Collagen alpha-1(XIV) chain
    Protein Accession:
    Q05707
    Secondary Accessions:
    • B2RU07
    • O00260
    • O00261
    • O00262
    • Q05708
    • Q5XJ18
    • Q96C67
    • Q9UDF6

    Protein attributes for COL14A1 Gene

    Size:
    1796 amino acids
    Molecular mass:
    193515 Da
    Quaternary structure:
    • Homotrimer.
    SequenceCaution:
    • Sequence=AAA36795.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; Sequence=AAH14640.1; Type=Frameshift; Positions=1047; Evidence={ECO:0000305};

    Alternative splice isoforms for COL14A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COL14A1 Gene

Proteomics data for COL14A1 Gene at MOPED

Post-translational modifications for COL14A1 Gene

  • Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.
  • May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.
  • Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Glycosylation at Asn94, Asn137, Asn372, Thr643, Asn1384, Asn1388, Lys1476, Lys1485, Lys1523, Lys1526, Lys1601, Lys1698, and Lys1701
  • Modification sites at PhosphoSitePlus

Other Protein References for COL14A1 Gene

No data available for DME Specific Peptides for COL14A1 Gene

Domains for COL14A1 Gene

Gene Families for COL14A1 Gene

HGNC:
  • COLLAGEN :Collagens
  • FN3 :Fibronectin type III domain containing

Suggested Antigen Peptide Sequences for COL14A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05707

UniProtKB/Swiss-Prot:

COEA1_HUMAN :
  • Q05707
Domain:
  • Contains 4 collagen-like domains.
  • Contains 8 fibronectin type-III domains.
  • Contains 1 laminin G-like domain.
  • Contains 2 VWFA domains.
Family:
  • Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
genes like me logo Genes that share domains with COL14A1: view

Function for COL14A1 Gene

Molecular function for COL14A1 Gene

GENATLAS Biochemistry: collagen,type XIV,alpha 1,fibril-associated collagen with interrupted triple helices (FACIT) homotrimerizing,expressed in extracellular matrix,related to collagen type XIV,involved in supramolecular organization of fibril bundles
UniProtKB/Swiss-Prot Function: Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).

Gene Ontology (GO) - Molecular Function for COL14A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent NAS 2187872
GO:0005515 protein binding --
GO:0005518 collagen binding NAS 2187872
GO:0030674 protein binding, bridging NAS 9427527
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with COL14A1: view

Phenotypes for COL14A1 Gene

MGI mutant phenotypes for COL14A1:
inferred from 1 alleles
GenomeRNAi human phenotypes for COL14A1:
genes like me logo Genes that share phenotypes with COL14A1: view

Animal Models for COL14A1 Gene

MGI Knock Outs for COL14A1:

Animal Model Products

CRISPR Products

miRNA for COL14A1 Gene

miRTarBase miRNAs that target COL14A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for COL14A1 Gene

Localization for COL14A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COL14A1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COL14A1 Gene COMPARTMENTS Subcellular localization image for COL14A1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
golgi apparatus 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COL14A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix NAS 2187872
GO:0005581 collagen trimer NAS 9427527
GO:0005596 collagen type XIV trimer NAS 9427527
GO:0005614 interstitial matrix IEA --
genes like me logo Genes that share ontologies with COL14A1: view

Pathways for COL14A1 Gene

genes like me logo Genes that share pathways with COL14A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for COL14A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003229 ventricular cardiac muscle tissue development IEA --
GO:0016337 single organismal cell-cell adhesion NAS 9427527
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030199 collagen fibril organization NAS 2187872
genes like me logo Genes that share ontologies with COL14A1: view

Compounds for COL14A1 Gene

(2) Novoseek inferred chemical compound relationships for COL14A1 Gene

Compound -log(P) Hits PubMed IDs
procollagen 66.7 5
hyaluronic acid 28.7 1
genes like me logo Genes that share compounds with COL14A1: view

Transcripts for COL14A1 Gene

Unigene Clusters for COL14A1 Gene

Collagen, type XIV, alpha 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COL14A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for COL14A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COL14A1 Gene

No ASD Table

Relevant External Links for COL14A1 Gene

GeneLoc Exon Structure for
COL14A1
ECgene alternative splicing isoforms for
COL14A1

Expression for COL14A1 Gene

mRNA expression in normal human tissues for COL14A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COL14A1 Gene

This gene is overexpressed in Artery - Tibial (10.6), Artery - Aorta (9.7), and Artery - Coronary (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COL14A1 Gene

SOURCE GeneReport for Unigene cluster for COL14A1 Gene Hs.409662

genes like me logo Genes that share expressions with COL14A1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for COL14A1 Gene

Orthologs for COL14A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COL14A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COL14A1 35
  • 99.54 (n)
  • 99.67 (a)
COL14A1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COL14A1 35
  • 86.99 (n)
  • 90.92 (a)
COL14A1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COL14A1 35
  • 89.9 (n)
  • 91.87 (a)
COL14A1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Col14a1 35
  • 86.26 (n)
  • 89.85 (a)
Col14a1 16
Col14a1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COL14A1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Col14a1 35
  • 86 (n)
  • 89.29 (a)
chicken
(Gallus gallus)
Aves COL14A1 35
  • 74.64 (n)
  • 76.63 (a)
COL14A1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10198 35
zebrafish
(Danio rerio)
Actinopterygii col14a1a 35
  • 62.87 (n)
  • 62.5 (a)
col14a1a 36
  • 60 (a)
OneToOne
wufb93g03 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10963 36
  • 20 (a)
OneToMany
Species with no ortholog for COL14A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COL14A1 Gene

ENSEMBL:
Gene Tree for COL14A1 (if available)
TreeFam:
Gene Tree for COL14A1 (if available)

Paralogs for COL14A1 Gene

Paralogs for COL14A1 Gene

Selected SIMAP similar genes for COL14A1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for COL14A1 Gene

genes like me logo Genes that share paralogs with COL14A1: view

Variants for COL14A1 Gene

Sequence variations from dbSNP and Humsavar for COL14A1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2429 -- 120,371,924(-) GAACA(A/C)ACTGC utr-variant-3-prime
rs9402 -- 120,371,953(-) TCCCC(A/G)TAGAT utr-variant-3-prime
rs764085 -- 120,317,629(+) TAGTT(C/T)GGTGA intron-variant
rs897527 -- 120,334,585(+) ACAAA(A/C)ACACA intron-variant
rs921861 -- 120,209,328(+) ACTGC(A/C)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COL14A1 Gene

Variant ID Type Subtype PubMed ID
nsv891418 CNV Gain 21882294
nsv6364 CNV Loss 18451855
dgv7872n71 CNV Gain 21882294

Relevant External Links for COL14A1 Gene

HapMap Linkage Disequilibrium report
COL14A1
Human Gene Mutation Database (HGMD)
COL14A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COL14A1 Gene

Disorders for COL14A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for COL14A1 Gene including...

Search for COL14A1 Gene in MalaCards »

(4) Novoseek inferred disease relationships for COL14A1 Gene

Disease -log(P) Hits PubMed IDs
collagen fibril 67.7 10
liver fibrosis 61.6 4
cirrhosis 8.45 1
hyperplasia 3.93 3

Relevant External Links for COL14A1

Genetic Association Database (GAD)
COL14A1
Human Genome Epidemiology (HuGE) Navigator
COL14A1
genes like me logo Genes that share disorders with COL14A1: view

No data available for UniProtKB/Swiss-Prot for COL14A1 Gene

Publications for COL14A1 Gene

  1. Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins. (PMID: 1716629) Just M. … Schuppan D. (J. Biol. Chem. 1991) 2 3 4 23
  2. Complete primary structure of human collagen type XIV (undulin). (PMID: 9427527) Bauer M. … Schuppan D. (Biochim. Biophys. Acta 1997) 2 3 4 23
  3. Undulin, an extracellular matrix glycoprotein associated with collagen fibrils. (PMID: 2187872) Schuppan D. … Hahn E. (J. Biol. Chem. 1990) 3 4 23
  4. The COL12A1 and COL14A1 genes and Achilles tendon injuries. (PMID: 17960519) September A.V. … Collins M. (Int J Sports Med 2008) 3 23 48
  5. Complete primary structure and genomic organization of the mouse Col14a1 gene. (PMID: 15065570) Gerecke D.R. … Birk D.E. (Matrix Biol. 2004) 3 23

Products for COL14A1 Gene

  • antibodies-online proteins for COL14A1
  • antibodies-online antibodies for COL14A1
  • antibodies-online kits for COL14A1

Sources for COL14A1 Gene

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