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Aliases for UGT2B17 Gene

Aliases for UGT2B17 Gene

  • UDP Glucuronosyltransferase Family 2 Member B17 2 3
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B17 3 5
  • C19-Steroid-Specific UDP-Glucuronosyltransferase 3 4
  • C19-Steroid-Specific UDPGT 3 4
  • EC 4 63
  • UDP Glycosyltransferase 2 Family, Polypeptide B17 2
  • UDP Glycosyltransferase 2 Family, Member B17 3
  • UDP-Glucuronyltransferase, Family 2, Beta-17 3
  • UDPGT 2B17 4
  • UDPGT2B17 3
  • EC 2.4.1 63
  • BMND12 3

External Ids for UGT2B17 Gene

Previous GeneCards Identifiers for UGT2B17 Gene

  • GC04U990053
  • GC04M069386
  • GC04M069406
  • GC04M069231
  • GC04M069085

Summaries for UGT2B17 Gene

Entrez Gene Summary for UGT2B17 Gene

  • This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]

GeneCards Summary for UGT2B17 Gene

UGT2B17 (UDP Glucuronosyltransferase Family 2 Member B17) is a Protein Coding gene. Diseases associated with UGT2B17 include Bone Mineral Density Qtl 12, Osteoporosis and Ugt2b17-Related Altered Drug Metabolism. Among its related pathways are Phase II conjugation and Statin Pathway - Generalized, Pharmacokinetics. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT2B17 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

Gene Wiki entry for UGT2B17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B17 Gene

Genomics for UGT2B17 Gene

Regulatory Elements for UGT2B17 Gene

Enhancers for UGT2B17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UGT2B17 on UCSC Golden Path with GeneCards custom track

Genomic Location for UGT2B17 Gene

68,537,184 bp from pter
68,568,527 bp from pter
31,344 bases
Minus strand

Genomic View for UGT2B17 Gene

Genes around UGT2B17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B17 Gene

Proteins for UGT2B17 Gene

  • Protein details for UGT2B17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-glucuronosyltransferase 2B17
    Protein Accession:

    Protein attributes for UGT2B17 Gene

    530 amino acids
    Molecular mass:
    61095 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UGT2B17 Gene

Proteomics data for UGT2B17 Gene at MOPED

Post-translational modifications for UGT2B17 Gene

  • Glycosylation at Asn 65, Asn 316, and Asn 483
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT2B17 Gene

Protein Domains for UGT2B17 Gene

Suggested Antigen Peptide Sequences for UGT2B17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UDP-glycosyltransferase family.
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B17: view

Function for UGT2B17 Gene

Molecular function for UGT2B17 Gene

GENATLAS Biochemistry:
UDP-glucoronosyltransferase (B17),expressed in several extrahepatic steroid tissues,including prostate,active or C19 steroids
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

Enzyme Numbers (IUBMB) for UGT2B17 Gene

Gene Ontology (GO) - Molecular Function for UGT2B17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
genes like me logo Genes that share ontologies with UGT2B17: view

Phenotypes for UGT2B17 Gene

genes like me logo Genes that share phenotypes with UGT2B17: view

Animal Model Products

CRISPR Products

miRNA for UGT2B17 Gene

miRTarBase miRNAs that target UGT2B17

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B17 Gene

Localization for UGT2B17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B17 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for UGT2B17 Gene COMPARTMENTS Subcellular localization image for UGT2B17 gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 2
peroxisome 2
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT2B17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane TAS 8798464
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT2B17: view

Pathways & Interactions for UGT2B17 Gene

genes like me logo Genes that share pathways with UGT2B17: view

Pathways by source for UGT2B17 Gene

Interacting Proteins for UGT2B17 Gene

Gene Ontology (GO) - Biological Process for UGT2B17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052696 flavonoid glucuronidation IBA --
genes like me logo Genes that share ontologies with UGT2B17: view

No data available for SIGNOR curated interactions for UGT2B17 Gene

Drugs & Compounds for UGT2B17 Gene

(19) Drugs for UGT2B17 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 519
Losartan Approved Pharma Antagonist, Enzyme, substrate 277
Codeine Approved, Illicit Pharma Full agonist, Agonist 69
Estradiol Approved, Investigational Pharma Sex hormone 1235
Estriol Approved Pharma Agonist 0

(90) Additional Compounds for UGT2B17 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NNAL
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
genes like me logo Genes that share compounds with UGT2B17: view

Transcripts for UGT2B17 Gene

mRNA/cDNA for UGT2B17 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UGT2B17 Gene

UDP glucuronosyltransferase 2 family, polypeptide B17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B17 Gene

No ASD Table

Relevant External Links for UGT2B17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UGT2B17 Gene

mRNA expression in normal human tissues for UGT2B17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B17 Gene

This gene is overexpressed in Colon - Transverse (x33.4) and Small Intestine - Terminal Ileum (x14.3).

Protein differential expression in normal tissues from HIPED for UGT2B17 Gene

This gene is overexpressed in Rectum (30.2), Colon (25.2), and Gallbladder (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UGT2B17 Gene

SOURCE GeneReport for Unigene cluster for UGT2B17 Gene Hs.575083

mRNA Expression by UniProt/SwissProt for UGT2B17 Gene

Tissue specificity: Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate.
genes like me logo Genes that share expression patterns with UGT2B17: view

Protein tissue co-expression partners for UGT2B17 Gene

Primer Products

Orthologs for UGT2B17 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B17 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UGT2B4 35
  • 81.12 (n)
  • 75.19 (a)
-- 36
  • 75 (a)
(Canis familiaris)
Mammalia LOC100856068 35
  • 83.14 (n)
  • 77.92 (a)
-- 36
  • 78 (a)
(Mus musculus)
Mammalia Ugt2b1 35
  • 77.33 (n)
  • 71.32 (a)
Ugt2b1 16
Ugt2b36 36
  • 70 (a)
(Pan troglodytes)
Mammalia UGT2B17 35
  • 98.46 (n)
  • 97.88 (a)
UGT2B17 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ugt2b1 35
  • 76.96 (n)
  • 71.04 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta BEST:GH06505 37
  • 29 (a)
BEST:GH09393 37
  • 34 (a)
CG10168 37
  • 25 (a)
CG10178 37
  • 28 (a)
CG11289 37
  • 32 (a)
CG15661 37
  • 29 (a)
CG17323 37
  • 25 (a)
CG5724 37
  • 24 (a)
CG5999 37
  • 25 (a)
CG6475 37
  • 35 (a)
Ugt35a 37
  • 35 (a)
Ugt35b 37
  • 31 (a)
Ugt36Ba 37
  • 29 (a)
Ugt36Bb 37
  • 28 (a)
Ugt36Bc 37
  • 30 (a)
Ugt37a1 37
  • 30 (a)
Ugt37b1 37
  • 27 (a)
Ugt37c1 37
  • 28 (a)
Ugt86Da 37
  • 34 (a)
Ugt86Dc 37
  • 35 (a)
Ugt86Dd 37
  • 29 (a)
Ugt86De 37
  • 26 (a)
Ugt86Dg 37
  • 35 (a)
Ugt86Dh 37
  • 24 (a)
Ugt86Di 37
  • 33 (a)
Ugt86Dj 37
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007028 35
  • 40.67 (n)
  • 29.11 (a)
(Caenorhabditis elegans)
Secernentea AC3.2 37
  • 25 (a)
C08B6.1 37
  • 23 (a)
C17G1.3 37
  • 24 (a)
C33A12.6 37
  • 24 (a)
C44H9.1 37
  • 25 (a)
F01D4.1 37
  • 24 (a)
F35H8.6 37
  • 28 (a)
F56B3.7 37
  • 24 (a)
M88.1 37
  • 30 (a)
T03D3.1 37
  • 23 (a)
T07C5.1a 37
  • 23 (a)
T19H12.11 37
  • 23 (a)
Y37E11AR.5 37
  • 24 (a)
ZC443.5 37
  • 26 (a)
ZC455.3 37
  • 24 (a)
Species with no ortholog for UGT2B17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B17 Gene

Gene Tree for UGT2B17 (if available)
Gene Tree for UGT2B17 (if available)

Paralogs for UGT2B17 Gene Pseudogenes for UGT2B17 Gene

genes like me logo Genes that share paralogs with UGT2B17: view

Variants for UGT2B17 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B17 Gene

Copy-number variation of UGT2B17 defines the bone mineral density quantitative trait locus 12 (BMND12) [MIM:612560]. Variance in bone mineral density is a susceptibility factor for osteoporotic fractures.

Sequence variations from dbSNP and Humsavar for UGT2B17 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1823867 -- 68,566,659(-) AGTTC(C/T)ACATG intron-variant
rs2278916 -- 68,560,408(-) ATCTG(C/T)TCAAA intron-variant
rs2278918 -- 68,560,044(-) CCATG(C/T)ATTGG intron-variant
rs4860303 -- 68,548,018(+) tgtgg(A/C/T)gattc intron-variant
rs4860304 -- 68,554,279(+) gaaaa(C/G)aagaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B17 Gene

Variant ID Type Subtype PubMed ID
dgv1626e1 CNV Complex 17122850
dgv1628e1 CNV Complex 17122850
dgv5580n71 CNV Loss 21882294
dgv1629e1 CNV Complex 17122850
dgv5581n71 CNV Loss 21882294
nsv879230 CNV Gain 21882294
dgv5582n71 CNV Gain 21882294
dgv5583n71 CNV Gain 21882294
dgv5584n71 CNV Loss 21882294
nsv442910 CNV CNV 18776908
dgv5585n71 CNV Gain 21882294
dgv5586n71 CNV Gain+Loss 21882294
dgv5588n71 CNV Gain+Loss 21882294
dgv5589n71 CNV Loss 21882294
nsv820369 CNV Deletion 20802225
nsv822582 CNV Loss 20364138
dgv951e199 CNV Deletion 23128226
esv1010584 CNV Loss 20482838
nsv10516 CNV Gain 18304495
esv28502 CNV Gain 19812545
esv2727770 CNV Deletion 23290073
esv33605 CNV Loss 17666407
dgv1631e1 CNV Complex 17122850
dgv875n67 CNV Loss 20364138
esv30002 CNV Gain 17803354
esv2421501 CNV Deletion 20811451
esv29960 CNV Gain 18421352
dgv5590n71 CNV Gain 21882294
dgv5591n71 CNV Gain 21882294
nsv514223 CNV Loss 21397061
nsv511249 CNV Loss 21212237
dgv876n67 CNV Loss 20364138
dgv5592n71 CNV Gain 21882294
dgv26n14 CNV Loss 18776910
dgv5593n71 CNV Gain 21882294
dgv5594n71 CNV Loss 21882294
dgv5595n71 CNV Loss 21882294
dgv89n17 CNV Loss 16327808
dgv5596n71 CNV Gain+Loss 21882294
dgv5597n71 CNV Gain 21882294
dgv5598n71 CNV Loss 21882294
nsv879330 CNV Gain 21882294
nsv879332 CNV Gain+Loss 21882294
dgv5599n71 CNV Gain 21882294
dgv877n67 CNV Loss 20364138
nsv436941 CNV Loss 16327808
dgv91n17 CNV Loss 16327808
nsv879339 CNV Loss 21882294
esv2669141 CNV Deletion 23128226
nsv822592 CNV Loss 20364138

Variation tolerance for UGT2B17 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT2B17 Gene

Human Gene Mutation Database (HGMD)

Disorders for UGT2B17 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UGT2B17 Gene - From: OMIM, GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bone mineral density qtl 12, osteoporosis
ugt2b17-related altered drug metabolism
  • osteoporosis, postmenopausal, susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT2B17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with UGT2B17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT2B17 Gene

Publications for UGT2B17 Gene

  1. Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. (PMID: 18992858) Yang T.-L. … Deng H.-W. (Am. J. Hum. Genet. 2008) 3 4 23 48 67
  2. Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme. (PMID: 9364925) Beaulieu M. … Hum D.W. (DNA Cell Biol. 1997) 3 23 26
  3. Isolation and characterization of a novel cDNA encoding a human UDP- glucuronosyltransferase active on C19 steroids. (PMID: 8798464) Beaulieu M. … Belanger A. (J. Biol. Chem. 1996) 2 3 23
  4. Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids. (PMID: 20429943) Deshmukh N. … Naughton D.P. (Subst Abuse Treat Prev Policy 2010) 3 23
  5. Substantial advantage of a combined Bayesian and genotyping approach in testosterone doping tests. (PMID: 19056415) Schulze J.J. … Rane A. (Steroids 2009) 3 23

Products for UGT2B17 Gene

Sources for UGT2B17 Gene